司长梅

天然药物学, 青年副研究员, 硕士生导师



姓名
司长梅
性别
女

职称
青年副研究员
学历
博士

电话


传真


电子邮件
sicm@fudan.edu.cn
个人主页


通讯地址
上海市浦东新区张衡路826号化学南楼205


教育经历 2007.09 – 2011.06 西北农林科技大学理学院（学士，应用化学专业）
2011.09 – 2016.06 西北农林科技大学理学院（博士，化学生物学专业）

工作经历
2016.07 – 2018.12 复旦大学药学院，博士后
2019.01 – 至今 复旦大学药学院，青年副研究员

承担科研项目情况
1.国家自然基金青年科学基金项目，基于串联环合反应高效合成苯并杂环类生物碱及其活性评价研究（No. **，2018/01-2020/12，26万元，主持）
2. 复旦大学引进人才科研基金（2019/01-2021/12，50万元）
3.北京工商大学植物资源研究开发北京市重点实验室开放基金，具有抗氧化作用核苷类衍生物的研究（No. PRRD-2019-YB2，2019/07-2020/06，5万，主持）
4. 中国博士后科学基金第60批1级资助，基于ADC”弹头“的两种抗癌手性肽的多样性研究（No. 2016M600287，2016/09-2018/08，8万元，结题）

研究方向 以活性为导向，开展中药活性组分的不对称合成、结构修饰与改造、活性评价等。

代表性论著
1. Xue-Mei Wang, Yi-Wen Liu, Rui-Jun Ma,Chang-Mei Si*and Bang-Guo Wei* Synthesis of 1,4- and 1,5-Amino Alcohols via Nucleophilic Addition of SemicyclicN,O-Acetal with Organozinc Reagents.J. Org. Chem.2019,84, 11261-11267
2. Xue-Mei Wang, Yi-Wen Liu, Qiao-E Wang, Zhu Zhou,Chang-Mei Si*and Bang-Guo Wei* A divergent method to key unit of tubulysin V through one-pot diastereoselective Mannich process ofN,O-acetal with ketone.Tetrahedron2019,75, 260-268;
3. Wen Zhou, Yan-Xue Zhang, Xiao-Di Nie,Chang-Mei Si,*Xun Sun and Bang-Guo Wei*Approach to Chiral 1?Substituted Isoquinolone and 3?Substituted Isoindolin-1-one by Addition?Cyclization ProcessJ. Org. Chem.2018,83, 9879-9889;
4. Zhuo-Ya Mao, Yi-Wen Liu, Pan Han, Han-Qing Dong,Chang-Mei Si,*Bang-Guo Wei,* and Guo-Qiang Lin Regio- and Stereoselective Cascades via Aldol Condensation and 1,3-Dipolar Cycloaddition for Construction of Functional Pyrrolizidine DerivativesOrg. Lett.2018,20,1090-1093;
5. Pan Han,Zhu Zhou,Chang-Mei Si,*Xian-Yi Sha, Zheng-Yi Gu,* Bang-Guo Wei,* and Guo-Qiang Lin Asymmetric Synthesis of Rupestonic Acid and Pechueloic AcidOrg. Lett.2017,1,6732-6735;
6. Wen Zhou, Xiao-Di Nie, Yu Zhang,Chang-Mei Si*, Zhu Zhou, Xun Sun, Bang-Guo Wei* A practical approach to asymmetric synthesis of dolastatin 10.Org. Biomol. Chem.,2017,15, 6119-6131.
7. Yi-Wen Liu, Pan Han, Wen Zhou, Zhuo-Ya Mao,Chang-Mei Si*,Bang-Guo Wei* Asymmetric syntheses of epohelmins A and B by In-mediated allylation.Org. Biomol. Chem.,2016,14, 10714-10722.
8.Chang-Mei Si, Wei Huang, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Diastereoconvergent Synthesis oftrans-5-Hydroxy-6-Substituted-2-Piperidinones by Addition?Cyclization?Deprotection Process.Org. Lett.,2014,16, 4328-4331.
9.Chang-Mei Si,Zhuo-Ya Mao,Han-Qing Dong, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Divergent Method totrans-5-Hydroxy-6-alkynyl/alkenyl-2-piperidinones: Syntheses of (-)-Epiquinamide and (+)-Swainsonine.J. Org. Chem.,2015,80, 5824-5833.
10.Chang-Mei Si, Zhuo-Ya Mao, Yi-Wen Liu, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Stereoselective Formation of Chiraltrans-4-Hydroxy-5-Substituted 2-Pyrrolidinones: Syntheses of Streptopyrrolidine and 3-epi-Epohelmin A.Org. Chem. Front.,2015,2,1485-1499.
11.Chang-Mei Si, Lu-Ping Shao, Zhuo-Ya Mao, Wen Zhou, Bang-Guo Wei* An efficient approach totrans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (-)-hapalosin.Org. Biomol. Chem.,2017,15, 649-661.
12. Lu-Ping Shao#,Chang-Mei Si#, Zhuo-Ya Mao, Wen Zhou, Tadeusz F. Molinski,* Bang-Guo Wei* and Guo-Qiang Lin Synthesis and structure revision of symplocin AOrg. Chem. Front.,2017,4, 995–1004.(# co-first author)