邵黎明

药物化学, 教授, 博士生导师


姓名
邵黎明
性别
男

职称
教授
学历
博士

电话
 
传真


电子邮件
limingshao@fudan.edu.cn
个人主页


通讯地址
上海市浦东新区张衡路826号科研楼裙西108室


教育经历 1978.09 – 1982.07复旦大学化学系, 有机化学专业，理学学士
1987.09 – 1990.03日本东京大学工学部, 工业化学专业，工学硕士
1990.03 – 1993.03日本东京大学工学部, 工业化学专业，工学博士
1993.04 – 1996.08哈佛大学, 化学和化学生物系, 博士后研究员
工作经历 1982.08 – 1987.05世界卫生组织人类生殖研究中心/上海计划生育研究所, 药物研究室，助理研究员
1998.09 – 2010.10Sepracor公司, 药物研发及临床前研究部 (美国, 马萨诸塞州)
2008-2010资深总监
2005-2008总监
2001-2005副总监
2000-2001资深科学家
1998-2000科学家
2010.10 – 2012.05Sunovion公司, 临床前研究及转化医学部 (美国, 马萨诸塞州)资深总监
2012.06 –至今复旦大学药学院，教授
专家类别 教授
职务 博士生导师、上海市药物研发协同创新中心主任、复旦大学医药健康产业发展战略研究中心主任
主要科研贡献
参与和主持了各类药物的研究与开发工作，其中4个化合物获美国FDA认准进入临床试验，曾参与避孕药的研发，其中一个药物获得中国FDA 批准上市
研究方向
1. 中枢神经系统疾病诊断治疗药物的合理设计、合成与研究开发
2. 恶性肿瘤治疗药物的研究开发
3. 药物发现新方法（合成新方法、成药性、结构生物学）的研究开发
4. 药物研究中转化医学手段的探索研究


代表性论著
1.Li Xiao , Yujun Wang, Mumei Zhang, Weiwei Wu, Linghui Kong, Yan Ma, Xuejun Xu, Xiao Liu, Qian He, Yuanyuan Qian, Huijiao Sun, Haihao Wu, Cheng Lin, Huoming Huang, Rongrong Ye, Shuang Jiang, Rufeng Ye, Congmin Yuan, Shengyang Fang, Dengqi Xue, Xicheng Yang, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie, Lan Zheng, Wei Fu, Wei Li*, Zhuibai Qiu, Jinggen Liu*, Liming Shao*. Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl- 6,14-endoethano-tetrahydro- northebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept. J. Med. Chem., 2019, 62(24): 11054-70.
2.Shengyang Fang, Haihua Yu, Xicheng Yang, Jianqi Li*, Liming Shao*. Nickel-Catalyzed Construction of 2,4-Disubstituted Imidazoles via C-C Coupling and C-N Condensation Cascade Reactions. Adv. Synth. Catal., 2019, 361, 3312-3317.
3.Yilin Zheng, Li Xiao, Qiong Xie, Liming Shao*. Palladium-Catalyzed Synthesis of beta,beta-Diaryl alpha,beta-Unsaturated Ketones. Synthesis-Stuttgart., 2019, 51, 1455-1465.
4.Dengqi Xue, Yulong Xu, Haihua Yu, Liming Shao*. Metal-Free Radical Cyclization of Vinyl Isocyanides with Alkanes: Synthesis of 1-Alkylisoquinolines. Synthesis-Stuttgart., 2019, 51, 874-884.
5.Li-li Xu, Huijun Gao, Kenneth I. Kaitin, Liming Shao*. Reforming China's drug regulatory system. Nat. Rev. Drug. Discov., 2018, 17, 858.
6.Xicheng Yang, Jian Shen, Lulu Jiang, Wei Li, Mingcheng Yu, Guanxing Pan, Yu-rong Yan, Chenghan Zhang, Wanwan Jia, Li Xiao, Haihua Yu, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie*, Lu Zhou*, Liming Shao*. Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing alpha-7 nAChR activities. Eur. J. Med. Chem., 2018, 160, 37-48.
7.Xicheng Yang, Haihua Yu, Yulong Xu, Liming Shao*. Regioselective Access to 3-Aryl-1-aminoisoquinolines via Nickel(I)-Catalyzed C-C and C-N Cascade Coupling Reactions from the Substituted 2-(Cyanomethyl)benzonitriles. J. Org. Chem., 2018, 83, 9682-9695.
8.HuiJiao Sun, Yuhua Wang, Congmin Yuan, Linghui Kong, Xuejun Xu, Yujun Wang, Haihao Wu, Cheng Lin, Yuanyuan Qian, Huoming Huang, Li Xiao, Xiao Liu, Qian He, Shengyang Fang, Dengqi Xue, Xicheng Yanga, Hao Chen, Yilin Zheng, Lan Zheng, Linqian Yu, Qiong Xie, Wei Fu, Wei Li*, Jinggen Liu*, Zhuibai Qiu, Liming Shao*. 7β-methyl substituent is a structural locus associated with activity cliff for nepenthone analogues. Bioorg. Med. Chem., 2018, 26 (14), 4254-4263.
9.Yulong Xu, Hao Chen, Wei Li, Qiong Xie, Linqian Yu, Liming Shao*. Synthetic access to isoxazoline-functionalized isoquinolines via microwave-assisted iminoxyl radical-participated cascade cyclization of vinyl isocyanides. Org. Biomol. Chem., 2018, 16 (27): 4996-5005.
10.Yulong Xu, Xicheng Yang, Yiyi Chen, Hao Chen, Huijiao Sun, Wei Li, Qiong Xie, Linqian Yu, Liming Shao*. Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib. Bioorg. Med. Chem. Lett., 2018, 28 (12), 2148-2152.
11.Dengqi Xue, Hao Chen, Yulong Xu, Haihua Yu, Linqian Yu, Wei Li, Qiong Xie*, Liming Shao*. Microwave-assisted synthesis of hydroxyl-containing isoquinolines by metal-free radical cyclization of vinyl isocyanides with alcohols. Org. Biomol. Chem., 2017, 15(47), 10044-10052.
12.Li Xiao, Yilin Zheng, Qiong Xie*, Liming Shao*. Palladium-Catalyzed Cascade Saegusa-Heck Reaction: Synthesis of beta,beta-Diarylacroleins from Arylpropanals and Aryl Iodides. Eur. J. Org. Chem., 2017, 5880-5883.
13.Hongpeng Sun, Li Xiao, Wei Li, Qiong Xie*, Liming Shao*. On-Water Silver(I)-Catalyzed Cycloisomerization of Acetylenic Free Amines/Amides towards 7-Azaindole/Indole/Isoquinolone Derivatives. Synthesis-Stuttgart, 2017, 49, 4845-4852.
14.Qing Liu, Xiaoqing Cai, Dehua Yang, Yi Chen, Yafang Wang, Li-ming Shao*, Ming-wei Wang*. Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors. Bioorg. Med. Chem., 2017, 25, 4579-4594.
15.Yulong Xu, Hao Chen, Wei Li, Qiong Xie, Linqian Yu, Liming Shao*. Microwave-Assisted Radical Insertion/Cyclization of Vinyl Isocyanides for the Synthesis of Multi-Substituted Isoquinolines. Chemistryselect, 2017, 2, 8033-8038.
16.Haihua Yu, Li Xiao, Xicheng Yang, Liming Shao*. Controllable access to multi-substituted imidazoles via palladium(II)-catalyzed C-C coupling and C-N condensation cascade reactions. Chem. Commun., 2017, 53, 9745-9748.
17.Jian Shen#, Xicheng Yang#, Mingcheng Yu, Li Xiao, Xunjie Zhang, Huijiao Sun, Hao Chen, Guanxin Pan, Yurong Yan, Sichen Wang, Wei Li*, Lu Zhou*, Qiong Xie, Linqian Yu, Yonghui Wang, Liming Shao*. Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands. Acta. Pharmacol. Sin., 2017, 38(1): 146-155.
18.Yulong Xu, Yiyi Chen, Wei Li, Qiong Xie, Liming Shao*. Microwave-Assisted Synthesis of Phenanthridines by Radical Insertion/Cyclization of Biphenyl Isocyanides. J. Org. Chem., 2016; 81: 8426-35.
19. Liming Shao*, Lili Xu. Qiu Li, R. Chakravarth, Ziling Yang & Kenneth I Kaitin, REGULATORY WATCH Innovative drug availability in China. Nat. Rev. Drug. Discov., 2016, 15, 739-740.
20. Liming Shao, Una C. Campbell, Q. Kevin Fang, Noel A. Powell, John E. Campbell, Philip G. Jones, Taleen Hanania, Vadim Alexandrov, Irene Morganstern, Emily Sabath, Hua M. Zhong, Thomas H. LargeKerry L. Spear*. In vivo phenotypic drug discovery: applying a behavioral assay to the discovery and optimization of novel antipsychotic agents. Med. Chem. Commun., 2016, 7, 1093-1101.
21.Yulong Xu, Qiong Xie, Wei Li, Hongpeng Sun, Yonghui Wang, Liming Shao*, A convenient aqueous copper-catalyzed synthesis of quinazolinones. Tetrahedron, 2015, 72(29):4853-4958.