姓名：高谦 博士
职称：教授
E-MAIL: qiangao@fudan.edu.cn
WWW: http://202.120.64.50/


研究方向
1.结核病的分子流行病学: 利用分子流行病学方法研究结核病的传播规律，为政府制定有效的控制措施提供科学依据。研究方向包括以人群为基础的结核病分子流行病学；结核分枝杆菌菌株表型与基因型的关系；结核分枝杆菌临床菌株的基因组差异及其进化等。
2.结核分枝杆菌功能基因组:
以海分枝杆菌为对象，利用细胞和斑马鱼模型研究结核分枝杆菌致病基因及其致病机理。结核分枝杆菌细胞壁成分和结构与其形态、致病及潜伏感染密切相关。目前主要课题包括研究与结核分枝杆菌形态相关的致病基因及其功能；结核分枝杆菌菌株的基因组差异及其进化等。
重要学术贡献
荣誉与获奖
获奖情况
获奖项目名称 奖励名称 奖励等级 年度 本人排位
耐药结核菌传播和遗传变异特征及其控制策略研究 上海市科学技术奖 三 2016 第二
耐药结核病流行特征及耐药结核菌遗传变异研究 上海市科学进步奖 三 2015 第二
结核病持留与潜伏感染的机制及临床诊治 中华医学会 三 2013 第三
国内外学术团体任职
中国防痨协会第十一届国际交流工作委员会 副主任委员
中国防痨协会第十一届结核病基础专业分会 常委
上海市结核病（肺）重点实验室第四届学术委员会 委员
中华医学会结核病学分会第十七届委员会基础学组 委员
受邀审稿学术刊物
2011.11 ~ Tuberculosis Section Editor
2014~2017 BMC Infection disease Editorial Board Member
2013.5~ PloS ONE Editorial Board Member
2015-2020 结核病与肺部健康杂志 副主编
中华结核和呼吸杂志 编委
中华检验医学杂志 编委
校内学术机构任职
无
受邀学术报告
2012 报告题目，会议名称，地点
1.May 18-19,2016 Title of the presentation: Evolutionary dynamics of M.tuberculosis in vivo during treatment through deep whole genome sequencing ,name of the conference :2nd Australia-China Symposium on Immunity In Tuberculosis, place: The University of Sydney,
2.19-23 September, 2016 Title of the presentation: Origin of M. tuberculosis Beijing Family Strains and Its Potential Hypervirulent Determinants. name of the conference : EMBO Conference Tuberculosis 2016 “Interdisciplinary research on Tuberculosis and pathogenic mycobateria“, place: the Institut Pasteur
3.Title of the presentation: Introduction to Molecular Epidemiology of Tuberculosis name of the conference : 6th Conferernce of International Union Against Tuberculosis and Lung Disease Asia Pacific Region,2017, place: Tokyo International Forum ,date: 22-25 March, 2017
4.Title of the presentation: Transmission of Multidrug Resistance Tuberculosis in China. name of the conference :Meeting of molecular eqidemiology in tuberculosis, place: Tokyo, date:21-22 August,2017 (主题报告)
发表论文
1.The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy. Trauner A, Liu Q, Via LE, Liu X, Ruan X, Liang L, Shi H, Chen Y, Wang Z, Liang R, Zhang W, Wei W, Gao J, Sun G, Brites D, England K, Zhang G, Gagneux S, Barry CE 3rd, Gao Q *. Trauner et al. Genome Biology (2017) 18:71.DOI 10.1186/s13059-017-1196-0.IF: 11.313
2.Chongguang Yang, Tao Luo, Xin Shen, Jie Wu, Mingyu Gan, Peng Xu, Zheyuan Wu, Senlin Lin, Jiyun Tian , Qingyun Liu, ZhengAn Yuan, Jian Mei, Kathryn DeRiemer, and Gao Q * ,Whole-Genome Sequencing Reveals Recent Transmission of Multidrug-Resistant Mycobacterium tuberculosis in Shanghai, China: a retrospective observational Study，2016, Lancet Infect Dis. 2016 Dec 2. IF: 21.372
3.Yang C, Shen X, Peng Y, Lan R, Zhao Y, Long B, Luo T, Sun G, Li X, Qiao K, Gui X, Wu J, Xu J, Li F, Li D, Liu F, Shen M, Hong J, Mei J,DeRiemer K, Gao Q *.Transmission of Mycobacterium tuberculosis in China: A Population-Based Molecular Epidemiologic Study. Clin Infect Dis. 2015 Jul 15;61(2):219-27. IF: 8.886
4.Tao Luo, In?aki Comas, Dan Luo, Bing lu, Jie Wu, Lanhai Wei, Chonguang Yang, Qingyun Liu, Mingyu Gan, Gang Sun, Xin Shen, Feiying Liu, Sebastien Gagneux, Jian Mei, Rushu Lan, Kanglin Wan, Gao Q *,Southern East Asian origin and coexpansion of Mycobacterium tuberculosis Beijing family with Han Chinese, PNAS 2015.卷: 112 期: 26 页: 8136-8141, IF: 9.674
5.Comas I, Coscolla M, Luo T, Borrell S, Holt KE, Kato-Maeda M, Parkhill J, Malla B, Berg S, Thwaites G, Yeboah-Manu D, Bothamley G, Mei J, Wei L, Bentley S, Harris SR, Niemann S, Diel R, Aseffa A, Gao Q *, Young D, Gagneux S. Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nat Genet. 2013 Sep 1. doi: 10.1038/ng.2744. IF: 35.532
6.Yang C, Luo T, Sun G, Qiao K, Sun G, Deriemer K, Mei J, Gao Q *. Mycobacterium tuberculosis Beijing Strains Favor Transmission but Not Drug Resistance in China. Clin Infect Dis. 2012 Nov;55(9):1179-87 IF: 8.886
7.Sun G, Luo T, Yang C, Dong X, Li J, Zhu Y, Zheng H, Tian W, Wang S, Barry CE, Mei J, Gao Q *. Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients. J Infect Dis. 2012 Oct;93(2):207-12. IF: 6.410
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