梁欣 博士


副教授，硕士生导师

邮箱：xin.liang@ecust.edu.cn
地址：上海市徐汇区梅陇路130号实验十八楼633室；
邮编：200237
个人简历：
2003.9-2007.6 华东理工大学生物工程专业，工学学士
2007.9-2012.3 华东理工大学生物化工专业，工学博士
2012.7-2015.5 美国埃默里大学（Emory University）Renhao Li’s Lab 博士后
2015.7-2016.8 华东理工大学药学院，讲师
2016.9至今 华东理工大学药学院，副教授
作为项目负责人主持国家自然科学基金，上海市自然科学基金，教育部基本科研业务费探索研究基金等。已在Journal of Hematology & Oncology，Molecular Therapy，British Journal of Cancer，Arterioscler Thromb Vasc Biol等国际SCI期刊发表论文36篇，SCI他引500余次。

研究方向：
主要研究领域为肿瘤转移以及微环境的相互作用研究。包括血小板参与肿瘤转移微环境形成的机制研究，miRNA在肿瘤转移以及微环境中的相互作用研究，小分子化合物或抗体药物的抗肿瘤机制研究。

代表性论文：
1. Zhao Y, Xu J, Le V, Gong Q, Li S, Gao F, Ni L*, Liu J*,Liang X*.Epcam aptamer-functionalized cationic liposome-based nanoparticles loaded with mir-139-5p for targeted therapy in colorectal cancer. MolecularPharmaceutics. 2019, 16(11): 4696-4710.
2. Xu K*, Zhan Y, Yuan Z, Qiu Y, Wang H, Fan G, Wang J, Li W, Cao Y, Shen X, Zhang J, Liang X*, Yin P*. HypoxiaInducesDrug Resistancein Colorectal Cancer through the HIF-1α/miR-338-5p/IL-6 Feedback Loop.Molecular Therapy. 2019, 27(10): 1810-1824.
3.Qi Y, Chen W, Liang X, Xu K*, Gu X, Wu F, Fan X, Ren S, Liu J, Zhang J, Li R, Liu J*, Liang X*. Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction. Journal of Hematology & Oncology. 2018, 11(1):117.
4.Liang X, Chen W, Shi H, Gu X, Li Y, Qi Y, Xu K*, Zhao A*, Liu J*. PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing. Cell Death & Disease. 2018, 9:569.
5.Liang X, Shi H, Yang L, Qiu C, Lin S, Qi Y, Li J*, Zhao A*, Liu J*. Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5- fluorouracil in gastric cancer cells. British Journal of Cancer. 2017, 116(7):903-911.
6.Liang X, Wang J, Chen W, Ma X, Wang Y, Nagao N, Weng W*, Huang J*, Liu J*. Inhibition of airway remodeling and inflammation by isoforskolin in PDGF-induced rat ASMCs and OVA-induced rat asthma model. Biomed Pharmacother. 2017, 95:275-286.
7. Xu K, Chen G, Li X, Wu X, Chang Z, Xu J, Zhu Y, Yin P, Liang X*, Dong L*. MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling. Sci Rep. 2017, 7:41718.
8. Lin S, Yang L, Shi H, Du W, Qi Y, Qiu C, Liang X*, Shi W*, Liu J*. Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy. Int J Biochem Cell Biol.2017 Jun;87: 54-68.
9.Chen W¹, Liang X¹, Syed AK, Jessup P, Church WR, Ware J, Josephson CD, Li R*. Inhibiting GPIbα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage. Arterioscler Thromb Vasc Biol. 2016, 36(9):1821-1828.
10. Liang X, Syed AK, Russell SR, Ware J, Li R*. Dimerization of glycoprotein Ib is not sufficient to induce platelet clearance. J Thromb Haemost. 2016,14: 381-386.
11. Li Q¹, Liang X¹, Wang Y, Meng X, Xu Y, Cai S, Wang Z*, Liu J*, Cai G*. miR-139-5p Inhibits the Epithelial- Mesenchymal Transition and Enhances the Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating BCL2. Sci Rep. 2016, 6: 27157.
12. Zou F, Mao R, Yang L, Lin S, Lei K, Zheng Y, Ding Y, Zhang P, Cai G*, Liang X*, Liu J*. Targeted deletion of miR-139-5p activates MAPK, NF-kB and STAT3 signaling and promotes intestinal inflammation and colorectal cancer. FEBS J. 2016, 283(8): 1438-1452.
13. Zheng Y, Yin G, Le V, Zhang A, Chen S, Liang X*, Liu J*.Photodynamic-therapy Activates Immune Response by disrupting Immunity Homeostasis of Tumor Cells, which Generates Vaccine for Cancer Therapy. Int J Biol Sci. 2016, 12(1): 120-132.
14. Lin S, Lei K, Du W, Yang L, Shi H, Gao Y, Yin P^*, Liang X*, Liu J*. Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism. Int J Biochem Cell Biol. 2016, 71:24-34.
15. Mao R, Zou F, Yang L, Lin S, Li Y, Ma M, Yin P^*, Liang X*, Liu J*. The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling. Int J Biochem Cell Biol.2015, 69: 153-161.
16. Liang X, Russell SR, Estelle S, Jones LH, Cho S, Kahn ML, Berndt MC, Bunting ST, Ware J, Li R*. Specific inhibition of ectodomain shedding of glycoprotein Ibα by targeting its juxtamembrane shedding cleavage site. J Thromb Haemost.2013, 11(12): 2155-2162.
注：¹共同第一作者， ^＊通讯作者