周胜敏

生物化工专业：硕士生导师
生物化学与分子生物学专业：硕士生导师
生物工程领域：工程硕士生导师

河北石家庄人，博士，副教授，生物反应器工程国家重点实验室固定成员。2009年3月取得东京大学博士学位。2009年4月至2014年8月先后在东京大学和日本筑波大学做博士后研究工作。2011年4月至 2013年3月期间任职日本学术振兴会(JSPS)特别研究员。2014年11月受聘于华东理工大学生物工程学院纳米生物工程实验室“****”团队。入选上海市浦江人才（A类），华理青年英才引进与培育计划，生工学院优秀青年教师培育计划。主持国家自然科学基金面上项目，上海市浦江人才项目，国家重点实验室开放课题等多个项目。骨干参与科技部新药创制重大专项、国家重点研发计划（中日合作)，以一作身份在《自然》子刊Nature Chemical Biology等期刊上发表论文多篇。
研究方向及内容：
研究类别：生命科学、合成生物学、化学生物学
研究对象：模式霉菌、病原真菌、工业真菌
研究内容：1.探索生物体内环境胁迫、信号传导、次级代谢调控、细胞凋亡等过程涉及的诸多功能基因，研究其作用机理，活用这些基因使之服务于工业、农业、医疗卫生等领域；2.以真菌为研究对象，从分子水平阐明其逃逸人体免疫杀菌系统进而感染人体的生物过程，同时挖掘致病因子，为新型抗真菌药物开发提供分子靶标；3.氧化应激及与之对应的信号传导、细胞凋亡与衰老等相关机制研究；4.阐述真菌的集群效应(Quorum sensing)和生物被膜(Biofilm)发生、发展分子机制，开发集群效应基因模块，使之服务于医药卫生和绿色制造5.真菌基因编辑技术(CRISPR-Cas)的开发、基于纳米技术的生物探针的开发是本课题组近期重点发展方向。
具体课题：
1. 基于CRISPR-Cas和纳米技术的新型基因编辑技术开发
2. 智能型真菌蛋白表达体系的开发及其在天然药物产物合成生物学领域的应用
3. 基因编码型纳米生物探针的开发
4. 真菌耐药和抗应激机制的解析及新型杀菌靶点的探索
5. 真菌产生生物被膜(biofilm)的分子机制，及其在绿色制造和生物医药领域的应用开发
研究业绩：
一作或通讯作者文章：
1. Yangyi Liu, Haoxiang Li, Jingyi Li, Yao Zhou, Zhemin Zhou, Ping Wang, Shengmin Zhou*. Characterization of the promoter of the nitrate transporter-encoding gene nrtAin Aspergillus nidulans.Mol. Genet. Genomics. 295(5):1269-1279, 2020.
2. Yu H, Li H, Zhou Y, Zhou S*, Wang P.Ultra-Sensitive Hydrogen Peroxide Sensor Based on Peroxiredoxin and Fluorescence Resonance Energy Transfer.Appl. Sci. 2020, 10(10), 3508, 2020.
3. Yang Y, Zhou Y, Li J, Yu H, Takaya N, Wang P, Zhou S*. Novel peroxiredoxin-based sensor for sensitive detection of hydrogen peroxide. Biochem. Biophys. Res. Commun. 517(2):260-265, 2019.
4. H Yu, H Li, C Chen, Zhou S*, P Wang*.Water-sensitive phase-transition of a carbon dot–calcium carbonate composite for moisture detection in organic solvents.Analytical Methods. 11, 2634-2638, 2019.
5. He H, Liu Y, Zhou Z, Guo C, Wang HY, Wang Z, Wang X, Zhang Z, Wu FG, Wang H, Chen D, Yang D, Liang X, Chen J, Zhou S*, Liang X, Qian X, Yang Y*. A Photo-Triggered and Photo-Calibrated Nitric Oxide Donor: Rational Design, Spectral Characterizations, and Biological Applications.Free Radical Biology and Medicine.123: 1-7, 2018.
6. He H,Xia Y, Qi Y, Wang HY, Wang Z, Bao J, Zhang Z, Wu FG, Wang H, Chen D, Yang D, Liang X, Chen J, Zhou S*, Liang X, Qian X, Yang Y*. A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications. Bioconjugate Chemistry.18;29(4):1194-1198, 2018.
7. Xia Y, Yu H, Zhou Z, Takaya N, Zhou S*, Wang P*. Peroxiredoxin system of Aspergillus nidulansresists inactivation by high concentration of hydrogen peroxide-mediated oxidative stress. Journal of Microbiology and Biotechnology.28(1): 145-156, 2018.
8. Yu H, Chen C, Cao X, Liu Y, Zhou S*, Wang P*. Ratiometric fluorescent pH nanoprobes based on in situ assembling of fluorescence resonance energy transfer between fluorescent proteins.Analytical and Bioanalytical Chemistry，409(21):5073-5080, 2017.
9. Zhou Y, Zhou S*, Yu H, Li J, Xia Y, Li B, Wang X, Wang P*. Cloning and characterization of filamentous fungal S-nitrosoglutathione reductase from Aspergillus nidulans.Journal of Microbiology and Biotechnology. 26 (5): 928-937, 2016.
10. Zhou S and Takaya N. Novel fungal nitrosothionein peptide involved in tolerance to nitric oxide.Bioscience&industry. 72(2): 55-56, 2014.
11. Zhou S, Narukami T, Masuo S, Shimizu M, Fujita T, Doi Y, Kamimura Y, Takaya N. NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin.Nature Chemical Biology. 9(10): 657-663, Aug, 2013.
12. Zhou S, Narukami T, Nameki M, Ozawa T, Kamimura Y, Hoshino T, Takaya N. Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulansfrom nitrosative stress. Applied and Environmental Microbiology. 78(1): 103-109, Jan, 2012.
13. Zhou S, Fushinobu S, Kim SW, Nakanishi Y, Maruyama J, Kitamoto K, Wakagi T, Shoun H. Functional analysis and subcellular location of two flavohemoglobins from Aspergillus oryzae. Fungal Genetics and Biology. 48(2): 200-207, Feb, 2011.
14. Zhou S, Nakanishi Y, Kim SW, Fushinobu S, Maruyama J, Kitamoto K, Wakagi T, Shoun H. A eukaryotic copper-containing nitrite reductase derived from a NirK homolog gene of Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry.74(5):984-991, May, 2010.
15. Zhou S, Fushinobu S, Kim SW, Nakanishi Y, Wakagi T, Shoun H. Aspergillus oryzae flavohemoglobins promote oxidative damage by hydrogen peroxide.Biochem. Biophys. Res. Commun. 394(3):558-561, 2010.
16. Zhou S, Fushinobu S, Nakanishi Y, Kim SW, Wakagi T, Shoun H. Cloning and characterization of two flavohemoglobins from Aspergillus oryzae.Biochem. Biophys. Res. Commun. 381 (1): 7-11, Jan, 2009.
合作文章：
17. Li Liu, Bin Yu, Wenjun Sun, Caice Liang, Hanjie Ying, Shengmin Zhou, Huanqing Niu, Yibing Wang, Dong Liu, Yong Chen. Calcineurin signaling pathway influences Aspergillus nigerbiofilm formation by affecting hydrophobicity and cell wall integrity. Biotechnol Biofuels. 13:54, 2020.
18. Pang B, Zhou L, Cui W, Liu Z, Zhou S, Xu J, Zhou Z. A Hyperthermostable Type II Pullulanase from a Deep-Sea Microorganism Pyrococcus yayanosii CH1. J. Agric. Food. Chem. 67(34):9611-9617,2019
19. Shunsuke Masuo,Airi Komatsuzaki, Takeshita Norio, Eriko Itoh, Okazoe Takaaki, Shengmin Zhou, Naoki Takaya*. Spatial heterogeneity of glycogen and its metabolizing enzymes in Aspergillus nidulanshyphal tip cells. Fungal Genetics and Biology.110:48-55, 2018.
20. Shunsuke Masuo, Shengmin Zhou, Tatsuo Kaneko, Naoki Takaya*. Bacterial fermentation platform for producing artificial aromatic amines. Scientific Report, 11:6, 2016.
21. Motoyuki Shimizu, Shunsuke Masuo, Eriko Itoh, Shengmin Zhou, Masashi Kato, Naoki Takaya*. Thiamine synthesis regulates the fermentation mechanisms in the fungus Aspergillus nidulans.Bioscience, Biotechnology, and Biochemistry. 80(9), 1768-1775, 2016
22. Jia Wei, Xiaodan Cao,Shengmin Zhou, Chao Chen, Haijun Yu, Yao Zhou, Ping Wang. Soluble expression and purification of the catalytic domain of human vascular endothelial growth factor receptor 2 in Escherichia coli. Journal of Microbiology and Biotechnology.25(8): 1227-1233, 2015
23. Shunsuke Masuo, Lisa Osada,Shengmin Zhou, Tomoya Fujita, Naoki Takaya. Aspergillus oryzaepathways that convert phenylalanine into the flavor volatile 2-phenylethanol.Fungal Genetics and Biology. 77: 22-30, 2015.
24. Masanori Toyofuku, Shengmin Zhou, Isao Sawada, Naoki Takaya, Hiroo Uchiyama and Nobuhiko Nomura. Membrane vesicle formation is associated with pyocin production under denitrifying conditions in Pseudomonas aeruginosaPAO1.Environmental Microbiology. 16(9):2927-2938,2014
25. Tomoya Fujita, HieuDuc Nguyen, Takashi Ito, Shengmin Zhou, Lisa Osada, Seiji Tateyama, Tatsuo Kaneko, Naoki Takaya. Microbial monomers custom-synthesized to build true bio-derived aromatic polymers.Applied Microbiology and Biotechnology. 97(20):8887-8894, Aug, 2013.
26. Wenjing Cui, Xiaoyan Yang, Yueqin Fang,Shengmin Zhou, Song Liu, Guocheng Du, Kun Du, Jian Chen, Guanjun Tao and Zhemin Zhou. Discovery of two transglutaminases derived from same zymogen for the Streptomyces hygroscopicusand analysis of their formation processes. Journal of the Science of Food and Agriculture. 93(7): 1711-1717, May, 2013.
27. Morio Miyahara, Sang-Wan Kim,Shengmin Zhou, Shinya Fushinobu, Takeshi Yamada, Wakako Ikeda-Ohtsubo, Akira Watanabe, Keisuke Miyauchi, Ginro Endo and Hirofumi Shoun. Survival of the aerobic denitrifier Pseudomonas stutzeri strain TR2 during co-culture with activated sludge under denitrifying conditions. Bioscience, Biotechnology, and Biochemistry. 76(3): 495-500, Mar, 2012
28. Sang-Wan Kim, Shinya Fushinobu,Shengmin Zhou,Takayoshi Wakagi and Hirofumi Shoun. The possible involvement of copper-containing nitrite reductase (NirK) and flavohemoglobin in denitrification by the fungus Cylindrocarpon tonkinense.Bioscience, Biotechnology, and Biochemistry.74 (7): 1403-1407, Jul, 2010
29. Sang-Wan Kim, Shinya Fushinobu, Shengmin Zhou, Takayoshi Wakagi, and Hirofumi Shoun. Eukaryotic nirK genes encoding copper-containing nitrite reductase: originating from the protomitochondrion?Applied and Environmental Microbiology. 75 (9): 2652-2658, Mar, 2009.
科研项目：
1. 主持国家自然科学基金面上项目，76万，**，2017.01-2020.12
2. 主持上海市浦江人才项目(A类)，20万，16PJ**，2016.07-2018.07
3. 主持生工学院优秀青年教师培育计划项目，20万，2015.07-2017.07
4. 主持国家重点实验室开放课题，10万，2015.01-2017.01
5. 参与国家自然科学基金重点项目，145万/300万，**，2017.01-2021.12
6. 参与科技部新药创制重大专项，130万/2000万，2018.4-2023.3
7. 参与国家重点研发计划（中日合作)，80万/230万，2020.4-2023.3
学术荣誉：
2011年日本教育部JSPS特别研究员
2016年上海市浦江****（A类）
严谨的学风，活跃的气氛，前沿的研究，充足的经费，舒适的环境。
欢迎加盟！
联络：梅陇路130号实验18号楼1413室
电邮:zhoushengmin@ecust.edu.cn


第一页 <<上一页 下一页>> 尾页
页码 1/2