林金萍
生物化学与分子生物学专业：硕士生导师
生物化工专业：硕士生导师
生物工程领域：工程硕士生导师
2006年毕业于华东理工大学生物化工专业，获工学博士学位。现任华东理工大学生物工程学院、生物反应器工程国家重点实验室副研究员。2016年入选上海市青年科技英才。主持和参与国家自然科学基金、“973”课题、重大专项等项目14项。发表SCI论文40余篇。申请发明专利 12项，其中授权9项。获得国家技术发明二等奖1项、上海市技术发明一等奖1项和上海市科技进步奖一等奖2项。获得国家新药临床批件2项、生产批文2项和新药证书1项，实现成果转让1项。

主要研究方向：
1．酶的筛选、发酵、纯化和功能表征
2．酶的结构和功能解析与酶分子改造
3．生物催化与生物转化合成手性化合物、药物、精细化学品、食品添加剂及高值生物基产品

代表性论文（*通讯作者）：
1.Kangling Chen, Kefei Li, Jian Deng, Baoqi Zhang, Jinping Lin*, Dongzhi Wei. Carbonyl reductase identification and development of whole-cell biotransformation for highly efficient synthesis of (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol. Microbial Cell Factories. 2016.15(1):191
2.Huan Zhang, Lulu Shi, Xinlei Mao, Jinping Lin*, Dongzhi Wei. Enhancement of cell growth and glycolic acid production by overexpression of membrane-bound alcohol dehydrogenase in Gluconobacter oxydans DSM 2003. Journal of Biotechnology. 2016, 237: 18-24
3.Jian Deng, Kangling Chen, Zhiqiang Yao, Jinping Lin*, Dongzhi Wei*. Towards the computational design and engineering of enzymeenantioselectivity: A case study by a carbonyl reductase from Gluconobacter oxydans. Journal of biotechnology.2016,217:31-40
4.Kefei Li, Xinlei Mao, Liu Liu, Jinping Lin*, Ming Sun, Dongzhi Wei and Shengli Yang. Overexpression of membrane?bound gluconate?2?dehydrogenase to enhance the production of 2?keto?d?gluconic acid by Gluconobacter oxydans. Microbial Cell Factories. 2016, 15(1):121-130
5.Yuanyuan Shi, Kefei Li, Jinping Lin*, Dongzhi Wei, Shengli Yang. Engineered expression vectors significantly enhanced the production of 2-keto-D-gluconic acid by Gluconobacter oxydans. Journal of Agricultural and Food Chemistry.2015, 63(22): 5492?5498
6.Xingxing Zhang, Baoqi Zhang, Jinping Lin*, Dongzhi Wei. Oxidation of ethylene glycol to glycolaldehyde using a highly selective alcohol dehydrogenase from Gluconobacter oxydans. Journal of Molecular Catalysis B: Enzymatic. 2015,112: 69–75
7.Rong Chen, Xu Liu, Jiale Wang, Jinping Lin*, Dongzhi Wei*. Cloning, expression, and characterization of an anti-Prelog stereospeci?c carbonyl reductase from Gluconobacter oxydans DSM2343. Enzyme and Microbial Technology. 2015, 70: 18–27
8.Jian Deng, Kangling Chen, Zhiqiang Yao, Jinping Lin?, Dongzhi Wei*. Efficient synthesis of optically active halogenated aryl alcohols at highsubstrate load using a recombinant carbonyl reductase fromGluconobacter oxydans. Journal of Molecular Catalysis B: Enzymatic.2015, 118:1–7
9.Xu Liu, Rong Chen, Zhongwei Yang, Jiale Wang, Jinping Lin*, Dongzhi Wei. Characterization of a Putative Stereoselective Oxidoreductase from Gluconobacter oxydans and Its Application in Producing Ethyl (R)-4-Chloro-3-Hydroxybutanoate Ester. Molecular Biotechnology, 2014, 56:285–295
10.Daihuan Li, Jinping Lin*, Dongzhi Wei. Improving Gluconobacter oxydans performance in the in situ removal of the inhibitor for asymmetric resolution of racemic 1-phenyl-1,2-ethanediol. Bioresource Technology, 2014, 159: 327–333
11.Lulu Shi, Kefei Li, Huan Zhang, Xu Liu, Jinping Lin*, Dongzhi Wei*. Identification of a novel promoter gHp0169 for gene expression in Gluconobacter oxydans. Journal of Biotechnology. 2014, 175:69-74
12.Xu Liu, Chao Wang, Lujia Zhang, Zhiqiang Yao, Dongbing Cui, Liang Wu, Jinping Lin* , Y. Adam Yuan, Dongzhi Wei. Structural and mutational studies on an aldo-keto reductase AKR5C3 from Gluconobacter oxydans. Protein science. 2014 ,23(11):1540-9
13.Xu Liu, Zuanning Yuan, Y. Adam Yuan, Jinping Lin*, Dongzhi Wei. Biochemical and structural analysis of Gox2181, a new member of the SDR superfamily from Gluconobacter oxydans. Biochemical and Biophysical Research Communications. 2011,415: 410-415
14.Jian Wu, Minhua Li, Jinping Lin*, Dongzhi Wei. Highly Selective Oxidation of Benzyl Alcohol Using Engineered Gluconobacter Oxydans in Biphasic System. Current Microbiology. 2011, 62:1123-1127
15.Jian Wu, Jiale Wang, Minhua Li, Jinping Lin*, Dongzhi Wei*. Optimization of immobilization for selective oxidation of benzyl alcohol by Gluconobacter oxydans using response surface methodology. Bioresource Technology. 2010, 101:8936-8941
16.Minghua Li, Jian Wu, Xu Liu, Jinping Lin*, Dongzhi Wei*, Hao Chen. Enchanced production of dihydroxyacetone from glycerol by overexpression of glycerol dehydrogenase in an alcohol dehydrogenase-deficient mutant of Gluconobacter oxydans. Bioresource Technology. 2010, 101:8294-8299

发明专利：
1.林金萍, 魏东芝，张行星。一种醇脱氢酶氧化二元伯醇的方法。ZL8.5
2.林金萍, 魏东芝，张行星。一种应用微生物细胞催化法制备羟基醛的方法。ZL7.9
3.林金萍, 魏东芝，李克非。一种微生物细胞转化法生产2-酮基-D-葡萄糖酸的方法。ZL9.7
4.林金萍, 魏东芝，施露露。一种氧化葡萄糖酸杆菌启动子及其应用。ZL7.X
5.林金萍, 魏东芝，杨圆圆。一种硝基还原酶在芳香族硝基化合物降解还原中国的应用。ZL1.3
6.林金萍，魏东芝，吴建。一种同时分析微生物发酵液中甘油和二羟基丙酮的方法。ZL4.9
7.林金萍, 魏东芝, 李明华, 吴建。一种氧化葡萄糖酸杆菌（G.oxydans）的基因工程菌及其应用。ZL.1
8.魏东芝，林金萍，高琼。一种微生物不对称拆分制备(S)-苯乙二醇的方法。ZL9.0
9.魏东芝，林金萍，张敏洁。一种酶法连续生产聚（ε-己内酯）的方法。ZL 1.5

获奖：
1. 定向转化多元醇的生物催化剂创制及其应用关键技术。国家技术发明二等奖，2015
2. 定向转化多元醇的细胞催化剂创制及其应用关键技术。上海市技术发明奖，一等奖，2013
3. 手性非天然氨基酸生物催化制备技术及其应用。上海市科技进步奖，一等奖，2012
4. 工业酶制剂的开发与应用关键技术。上海市科技进步奖，一等奖，2010
联系方式：
上海市梅陇路130号311信箱 邮编:200237
办公室：鲁华生物技术研究所（实验14楼东楼）402室；
电话: ； 传真:
E-mail: jplin@ecust.edu.cn