施小新(Xiao-XinShi)教授博士生导师
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电话:02164252052
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传真:
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E-mail:xxshi@ecust.edu.cn
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个人简介
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1985年本科毕业于苏州大学化学系；1991年于中国科学院上海有机化学研究所获得理学博士学位；1991-1993年期间在中国科学院上海有机化学研究所工作，任助理研究员；1993-1996年期间在美国佛罗里达工学院（FIT,FloridaInstituteofTechnology）健康与治疗研究中心进行博士后研究工作；1996-2000年期间，回中国科学院上海有机化学研究所工作，任副研究员，2000-2001年期间，在华东理工大学工作，任副教授；2001年至今，继续在华东理工大学工作，任教授；2003年起，为博士生导师。

研究方向
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不对称合成和合成药物化学。

获奖成果
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参加并获得2002年度上海市科技进步一等奖和2003年度国家自然科学二等奖。
2003年度上海市教委的曙光计划。

代表性论著
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1,Jin-YuLai,Xiao-XinShiandLi-XinDai*,“ReversalofRegiochemistryofWacker-TypeReactionsOrientedbyHeteroatoms”,J.Org.Chem.,1992,57,3485.
2,Xiao-XinShiandLi-XinDai*,“HalogenationofStablizedEsterEnolatesbyCupricHalides”,J.Org.Chem.,1993,58,4596.
3,Jin-YuLai,Xiao-XinShi,Yan-ShenGongandLi-XinDai*,“Palladium-CatalyzedSynthesisofOpticallyActiveTetrahydro-1,4-oxazineDerivatives”,J.Org.Chem.,1993,58,4775.
4,StevenS.Wang,Xiao-XinShi,WilliamS.Powell,TamaraTieman,StevenJ.FeinmarkandJoshuaRokach*,“TotalSynthesesofProinflammatoryDihydro-12-KETEMetabolites”,TetrahedronLett.,1995,36,513.
5,Xiao-XinShi,SubhashP.KhanapureandJoshuaRokach*,“DeblockingofDithioacetalsandOxathioacetalsUsingPeriodicAcidunderMildNonaqueousConditions”,TetrahedronLett.,1996,37,4331.
6,SubhashP.Khanapure,Xiao-XinShi,WilliamS.PowellandJoshuaRokach*,“TotalSynthesesofaPotentProinflammatory5-Oxo-ETEandIts6,7-DihydroBiotransformationProduct”,J.Org.Chem.,1998,63,337.
7,SubhashP.Khanapure,Xiao-XinShi,WilliamS.PowellandJoshuaRokach*,“TotalSynthesesofTritiatedandDeuterated5-Oxo-ETE,aNovelInflammatoryMediator”,J.Org.Chem.,1998,63,4098.
8,Xiao-XinShi*andQing-QuanWu,“DeblockingofDithianeswithDiacetoxyiodobenzene”,Syn.Commun.,2000,30,4081.
9,Xiao-XinShi*,Qing-QuanWuandXiaLu,“ASynthesisof(4S)-2-(acetoxymethyl)-4-(tert-butyl-diphenylsilyloxy)-2-cycpenten-1-one”,Tetrahedron:Asymmetry,2002,13,461-464.
10,Xiao-XinShi*,WeiHe,Qing-QuanWu,JieYin,FengNiandXiao-ZhouJin,“Asymmetricsynthesisof(1S,6R,7S,9R)-7,9-bis(tert-butyldiphenylsilyloxy)-3-oxabicyclo[4,3,0]nonan-2-one”,Tetrahedron:Asymmetry,2004,15,2327-2331.
11,Xiao-XinShi*,Jian-ZhongYao,LiKang,Chun-LiShenandFeiYi,“AsymmetricSynthesesofBothEnantiomersofAmphetamineHydrochlorideviaBakers’YeastReductionofPhenylacetone”,J.Chem.Res.,2004,10,681.
12,Zhao-XiaWang,Xiao-XinShi,Guo-RongChen*,Zhi-HuaRen,LeiLuoandJingYan,“Anewsynthesisofα-arbutinviaLewisacidcatalyzedselectiveglycosylationoftetra-O-benzyl-α-D-glucopyranosyltrichloroacetimidatewithhydroquinone”,CarbohydrateRes.,2006,341,1945-1947.
13,MinzeZhu,ChuantaoCha,Wei-PingDeng*andXiao-XinShi*,“AmildandefficientcatalystfortheBeckmannrearrangement,BOP-Cl”,TetrahedronLett.,2006,47,4861-4863.
14,Xiao-XinShi*,FengNi,Hai-XiaShang,Ming-LeYanandJun-QuanSu,“Racemizationof(S)-(+)-10,11-dimethoxyaporphineand(S)-(+)-aporphine:efficientpreparationsof(R)-(-)-apomorphineand(R)-(-)-aporphineviaarecycleprocessofresolution”,Tetrahedron:Asymmetry,2006,17,2210-2215.
15,Xiao-XinShi*,Shi-LingLiu,WeiXu,andYu-LanXu,"HighlystereoselectivePictet-SpenglerreactionofD-tryptophanmethylesterwithpiperonal:convenientsynthesesofCialis(Tadalafil),12a-epi-Cialisandtheirdeuteratedanalogues",Tetrahedron:Asymmetry,2008,19,435-442.
16,Liang-DengNie,Xiao-XinShi*,"Anovelasymmetricsynthesisofoseltamivirphosphate(Tamiflu)from(-)-shikimicacid",Tetrahedron:Asymmetry,2009,20,124-129.
17,Shi-LingLiu,Xiao-XinShi,*Yu-LanXu,WeiXu,JingDong,"Asymmetricsynthesesof(-)-methylshikimateand(-)-5a-carba-β-D-gulopyranosefromD-ArabinoseviaMukaiyama-typeintramolecularaldolization",Tetrahedron:Asymmetry,2009,20,78-83.
18,SenXiao,XiaLu,Xiao-XinShi*,YuSun,Li-LiLiang,Xin-HongYuandJingDong,"Synthesesofchiral1,3-disubstitutedtetrahydro-β-carbolinesviaCIATprocess:highlystereoselectivePictet-SpenglerreactionofD-tryptophanesterhydrochlorideswithvariousaldehydes",Tetrahedron:Asymmetry,2009,20,430-439.
19,Liang-DengNie,Xiao-XinShi*,KwangHyokKoandWei-DongLu,"AShortandPracticalSynthesisofOseltamivirPhosphate(Tamiflu)from(-)-ShikimicAcid",J.Org.Chem.2009,74,3970-3973.
20,SenXiao,Xiao-XinShi*,JingXing,Jing-JingYan,Shi-LingLiuandWei-DongLu,"Synthesisoftadalafil(Cialis)fromL-tryptophane",Tetrahedron:Asymmetry,2009,20,2090-2096.
21,SenXiao,Xiao-XinShi*,FengNi,JingXing,Jing-JingYan,andShi-LingLiu,"Anefficientandgeneralmethodforthestereodivergentsynthesesoftadalafil-liketetracycliccompounds",Eur.J.Org.Chem.,2010,1711-1716.
22,Xiao-XinShi*,Chun-LiShen,Jian-ZhongYao,Liang-DengNie,andNaQuan,"InversionofsecondarychiralalcoholsintoluenewiththetunablecomplexofR3N-R'COOH",Tetrahedron:Asymmetry,2010,21,277-284.
23,SenXiao,andXiao-XinShi*,"ThefirsthighlystereoselectiveapproachtothemitotickinesinEg5inhibitorHR22C16anditsanalogues",Tetrahedron:Asymmetry,2010,21,226-231.
24，JingDong,Xiao-XinShi*,Jing-JingYan,JingXing,QiangZhang,andSenXiao,“Efficientandpracticalone-potconversionsofN-tosyltetrahydroisoquinolinesintoisoquinolinesandN-tosyltetrahydro-β-carbolinesintoβ-carbolinesviatandemβ-eliminationandaromatization”,Eur.J.Org.Chem.,2010,6987-6992.
25,NaQuan,Xiao-XinShi*,Liang-DengNie,JingDong,Rui-HengZhu,“Agreenchemistrymethodfortheregenerationofcarbonylcompoundsfromoximesbyusingcupricchloridedihydrateasarecoverablepromoterforhydrolysis”,Synlett2011,1028-1032.
26,Rui-HengZhu,Xiao-XinShi*,“PracticalandhighlystereoselectivemethodforthepreparationofseveralchiralarylsulfinamidesandarylsulfinatesbasedonspontaneouscrystallizationofdiastereomericallypureN-benzyl-N-(1-phenylethyl)-arylsulfinamides”,Tetrahedron:Asymmetry2011,22,387-393.
27,Xiao-PengHe,ZhuoSong,Zhi-ZhouWang,Xiao-XinShi*,KaixianChen*,Guo-RongChen*,“Creationof3,4-bis-triazolocoumarian-sugarconjugatesviaflourogenicdualclickchemistryandtheirquenchingspecificitywithsilver(I)inaqueousmedia”,Tetrahedron2011,67,3343-3347.
28,JingDong,TienHaTrieu,Xiao-XinShi*,QiangZhang,SenXiao,XiaLu,“AgeneralstrategyforthehighlystereoselectivesynthesisofHR22C16-likemitotickinesinEg5inhibitorsfrombothL-andD-tryptophans”,Tetrahedron:Asymmetry2011,22,1865-1873.
29,Liang-DengNie,Xiao-XinShi*,NaQuan,Fei-FengWang,XiaLu,“Novelasymmetricsynthesisofoseltamivirphosphate(Tamiflu)from(-)-shikimicacidviacyclicsulfiteintermediates”,Tetrahedron:Asymmetry2011,22,1692-1699.
30,Rui-HengZhu,Xiao-XinShi*,“SynthesisofdiaryldisulfidesviamildreductionofarylsulfinateswithhydrazinemonohydrateinDMSO”,Synth.Commun.2012,42,1108-1114.
31,JingDong,Xiao-XinShi*,JingXing,Jing-JingYan,“Mildandefficientsynthesesof1-aryl-3,4-dihydroisoquinolinesand1-aryl-3,4-dihydro-β-carbolinesviaregiospecificβ-eliminationsofthecorrespondingN-tosyl-1,2,3,4-tetrahydroisoquinolinesandN-tosyl-1,2,3,4-tetrahydro-β-carbolines”,Synth.Commun.2012,42,2806-2817.

32，QiangZhang,JingDong,Xiao-XinShi*,XiaLu,“TotalSynthesesofDichotominesA–DandtheStereochemicalRevisionofDichotominesB–D”.Eur.J.Org.Chem.2012,3317-3325.

33，Liang-DengNie,WeiDing,Xiao-XinShi*,NaQuan,XiaLu,“Anovelandhigh-yieldingasymmetricsynthesisofoseltamivirphosphate(Tamiflu)startingfrom(-)-shikimicacid”.Tetrahedron:Asymmetry2012,23,742-747.
34,NaQuan,LiangdengNie,XiaoxinShi*,RuihengZhu,XiaLu,“NovelandEfficientSynthesesofFourUsefulShikimate-derivedEpoxyChiralBuildingBlocksviaCyclicSulfiteIntermediates”,Chin.J.Chem.2012,30,2759-2766.
35.JianxinYang,JingDong,XiaLu,Qiang,Zhang,WeiDing,XiaoxinShi*,“Ethylenediamine:AHighlyEffectiveCatalystforOne-PotSynthesisofArylNitroalkenesviaHenryReactionandDehydration”,Chin.J.Chem.2012,30,2827-2833.

译著：1,《当代新药合成》，施小新、秦川译，荣国斌校.2005年华东理工大学出版社出版。
2,《工业不对称催化》，施小新、冀亚飞、邓卫平译，邓卫平校.华东理工出版社，2006年。