马磊副教授硕导
电话:021-64253691
传真:021-64253691
E-mail:maleiATecustDOTeduDOTcn

一．简历
马磊，男，1979年9月生，中共党员。2007年6月毕业于中国药科大学天然药物化学专业，获理学博士学位，师从中国科学院上海药物研究所胡立宏研究员。同年8月，应聘为华东理工大学药学院讲师，2010年9月晋升为副教授，硕士研究生导师。目前以第一作者或通讯作者发表SCI论文30余篇，申请国家专利2项。研究方向为天然产物的结构修饰及其全合成。科研基金方面，目前作为负责人承担国家自然科学基金青年基金项目1项，“上海市联盟计划难题招标专项”项目1项，校优秀青年教师科研专项基金1项以及与上海医工院合作科研项目1项，并作为主要参与者参与国家科技重大专项：国家重大新药创制项目1项以及“111”计划项目1项。

二．近年来（2006－2011）发表的研究论文和申请专利

（一）发表的学术论文(*为通讯联系人)

1.JunhuaLiu,AbdulLatif,MumtazAli,GuipingZhang,WenjuanXiang,LeiMa,MohammadArfan*,LihongHu*,DiterpenoidsfromEuphorbianeriifolia,Phytochemistry,2012,75,153-158.
2.MinLei,LeiMa*,LihongHu*.One-PotSynthesisof1H-BenzimidazoleDerivativesUsingThiamineHydrochlorideasaReusableOrganocatalyst,SyntheticCommunications,2012,inpress.
3.LixiaPei,YuanwuBao,LeiMa,QiqiWang,YiyiYe,XianghuiHan,ShengLiu*,XiupingChen*,ASensitiveMethodforDeterminationofPlatycodinDinRatPlasmaUsingLiquidChromatography/TandemMassSpectrometryanditsApplicationtoaPharmacokineticStudy,PlantaMedica,2012,78,244-251.
4.LeiMa,WenjuanXiang,PhamVanKhang,YangLiang,YapingXiao*,LihongHu*,Newdammarane-typeglycosidesfromtherootsofGynostemmapentaphyllum,PlantaMedica,2012(inpress)
5.WeibinSong,PengLiu,MinLei,HanyunYou,XubingChen,HuChen,LeiMa*,LihongHu*.FeCl₃andMorpholineasanEfficientCo-CatalystfortheOne-StepSynthesisofQuinoxalinesFromα-Hydroxyketonesand1,2-Diamines.SyntheticCommunications,2012,42,236-245.
6.XubingChen,JingjingZhuang,JunhuaLiu,MinLei,LeiMa,JingChen,XuShen,LihongHu,PotentialAMPKactivatorsofcucurbitanetriterpenoidsfromSiraitiagrosvenoriiSwingle.Bioorganic&MedicinalChemistry2011,195776–5781
7.LeiMa,ZhengyiYang,ChenjingLi,ZhiyuanZhu,XuShen,LihongHu*Design,synthesisandSARstudyofhydroxychalconeinhibitorsofhumanb-secretase(BACE1).JournalofEnzymeInhibitionandMedicinalChemistry2011,26643-648.
8.KunZhao,MinLei,LeiMa,LihongHu*Afacileprotocolforthesynthesisof4-aryl-1,4,7,8-tetrahydro-3,5-dimethyldipyrazolo[3,4-b:4’,3’-e]pyridinederivativesbyaHantzsch-typereaction.MonatsheftefürChemie2011,142,1169-1173.
9.MinLei,LeiMa*,LihongHu*.HighlyChemoselectiveCondensationofβ-Naphthol,Aldehyde,andUreaCatalyzedbyThiamineHydrochloride.SyntheticCommunications,2011,41,3424-3432.
10.WeibinSong,LeiMa*,LihongHu*.HClO4-SiO2asanEfficientandRecyclableCatalystfortheSynthesisofAmideDerivatives.SyntheticCommunications,2011,41,3186-3196.
11.MinLei,LeiMa*,LihongHu*.Cu(ClO₄)₂·6H₂OasanEfficientCatalystfortheSynthesisof3,4-Dihydropyrimidin-2(1H)-onesUnderSolvent-FreeConditions.SyntheticCommunications,2011,41,3071-3077.
12.PengLiu,MinLei,LeiMa,*LihongHu*AnEfficientProcedurefortheSynthesisof2-Aminofuran-3-CarbonitrilesviaCascadeStetter-CyclizationReactionCatalyzedbyN-HeterocyclicCarbene.SYNLETT2011,1133-1136.
13.MinLei,LeiMa*,LihongHu*.Agreen,efficient,andrapidprocedureforthesynthesisof2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-onederivativescatalyzedbyammoniumacetateTetrahedronLetters,2011,52,2597-2600.
14.MinLei,LeiMa*,LihongHu*.ThiamineHydrochloride-CatalyzedOne-PotSynthesisof1,4-DihydropyridineDerivativesUnderSolvent-FreeConditions.SyntheticCommunications,2011,41,1969-1976.
15.LijuanSun,JianwenLiu*,PingLiu*,YoujunYu,LeiMa,LihongHuImmunosuppressioneffectofWithangulatinAfromPhysalisangulataviahemeoxygenase1-dependentpathways.ProcessBiochemistry2011,46,482-488.
16.WenjuanXiang,LeiMa*,LihongHu*.NeolignansandflavonoidsfromtherootbarkofIlliciumhenryi.Fitoterapia,2010,81,1228-1231.
17.MinLei,LeiMa*,LihongHu*.VB₁-Al₂O₃catalyzedone-potcondensationofaromaticketone,aromaticaldehydeandamideTetrahedronLetters,2010,51,5746-5749.
18.MinLei,LeiMa*,LihongHu*.AnefficientandenvironmentallyfriendlyprocedureforsynthesisofpyrimidinonederivativesbyuseofaBiginelli-typereaction.MonatsheftefürChemie2010,141,1005-1008.
19.MinLei,LeiMa*,LihongHu*.AConvenientOne-potSynthesisofFormamideDerivativesUsingThiamineHydrochlorideasaNovelCatalyst.TetrahedronLetters,2010,51,4186-4188.
20.WenjuanXiang,ChunyuGuo,LeiMa*,LihongHu*.Dammarane-typeGlycosidesandLongchainSesquiterpeneGlycosidesfromGynostemmayixingense.Fitoterapia,2010,81,248-252.
21.LijuanSun,JianwenLiu,*DalingCui,JiyuLi,*YoujunYu,LeiMa,LihongHu.Anti-InflammatoryFunctionofWithangulatinAbyTargetedInhibitingCOX-2ExpressionviaMAPKandNF-kBPathways.JournalofCellularBiochemistry2010,109,532–541.
22.YoujunYu,LijuanSun,LeiMa,JiyuLi,LihongHu,JianwenLiu*.InvestigationoftheimmunosuppressiveactivityofPhysalinHonTlymphocytes.Internationalimmunopharmacology,2010,10,290-297.
23.WenjuanXiang,LeiMa*,LihongHu*.C21SteroidalGlycosidesfromCynanchumwilfordii.HelveticaChimicaActa.2009,92,2659-2674.
24.MinLei,LeiMa*,LihongHu*.ThiamineHydrochlorideasanEfficientCatalystfortheSynthesisofAmidoalkylNaphthols.TetrahedronLetters2009,6393-6397.
25.HaigangLiu,XiongHuang,GuanghuiXie,LeiMa*,LihongHu*.OneNewC21SteroidalGlycosidefromtheRootsofCynanchumauriculatum.JournalofChinaPharmaceuticalUniversity,2009,40,34-36.
26.ChaofengHuang,LeiMa(co-firstauthor)2009,1415-1426.,LijuanSun,MumtazAli,MohammadArfan,JianwenLiu*,LihongHu*.ImmunosuppressiveWithanolidesfromWithaniacoagulans,Chemistry&Biodiversity,
27.XianwenGan,LeiMa,QigangChen,QiuqunChen,QiangYu,LihongHu*.TerpenoidsfromRootsofChloranthushenryi.PlantaMedica,2009,75,1344–1348.
28.HaoGan,WenjuanXiang,LeiMa*,LihongHu*.SixNewC21SteroidalGlycosidesfromCynanchumbungeiDecne,HelveticaChimicaActa,2008,91,2222-2234.
29.YinhuaYin,LeiMa(co-firstauthor),LihongHu*.Cassane-TypeDiterpenoidsfromtheSeedsofCaesalpiniamagnifoliolata,HelveticaChimicaActa,2008,91,972-977.
30.YinanZhang,ShileiZhang,LeiMa,YuZhang,XuShen,WeiWang,LihongHu*.TotalSynthesisof(+)-Rutamarin.AdvancedSynthesis&Catalysis,2008,350,2373-2379
31.ChaofengHuang,XianwenGan,HaiyunBai,LeiMa,LihongHu*.SchoepfinA,B,C:threenewchalconeC-glycosidesfromSchoepfiachinensis.NaturalProductResearch,2008,22,623-627
32.LiliWang,JianpingZuo,LeiMa,XiachangWangandLihongHu*.TwoNewXanthoneGlycosidesfromVentilagoleiocarpaBenth.NaturalProductCommunications,2008,3,795-798.
33.LeiMa,XianwenGan,QingpingHe,HaiyunBai,MohammadArfan,FengchangLou,LihongHu*.CytotoxicwithaphysalinfromPhysalisminima.HelveticaChimicaActa,2007,90,1406-1419.
34.LeiMa,MumtazAli,MohammadArfan,Li-GuangLou,andLi-HongHu*.WithaphysanolideA,anovelC-27norwithanolideskeleton,andothercytotoxiccompoundsfromPhysalisdivericata.TetrahedronLetters2007,48,449-452.
35.Guanghuixie,LeiMa,ZongpingZheng,LihongHu*.LignanafromGardneriamultiflora.Chin.J.Nat.Med.,2007,5,255-258.
36.QingpingHe,LeiMa,JieyingLuo,FuyuanHe,LiguangLou,LihongHu*.CytotoxicWithanolidesfromPhysalisangulataL.Chemistry&Biodiversity,2007,4,443-449.
37.LeiMa,FengchangLou*Chin.J.Nat.Med.,2006,4,151-153..TheAnticancerActivityinvitroofConstituentsfromFruitsofSophorajaponica.
38.LeiMa,ChuanmingXie,JiaLi,Feng-ChangLou,LihongHu*.DaturametelinsH,IandJ:ThreeNewWithanolideGlycosidesfromDaturametelL.Chemistry&Biodiversity,2006,3,180-186.
39.XianwenGan,HaiyunBai,QigangChen,LeiMa,LihongHu*.AZwitterionicAlkaloid,ContainingaRareCyclopentadienylAnionUnit,fromtheStemBarksofDaphniphyllummacropodum.Chemistry&Biodiversity,2006,3,1255-1259.
40.DongmeiLi,LeiMa,GuangmingLiu,LihongHu*.CassaneDiterpene-lactonesfromtheSeedofCaesalpiniaminaxHance.Chemistry&Biodiversity,2006,3,1260-1265.

教学论文和参编教材
41.马磊，胡立宏.生源合成途径在天然药物化学教学中的重要性探讨.化工高等教育，2010,3,82-84+96.
42.马磊，胡立宏.天然药物化学实验，药学专业实验教程，华东理工大学出版社，2010，95－114.

（二）申请专利
1.专利名称：含Withanolide型化合物的免疫抑制剂；发明人：马磊、刘建文、胡立宏、孙丽娟、于有军；申请时间：2007.11.2；申请号：200710047733.0；范围：国内。
2.专利名称：线型呋喃香豆素衍生物、其制备方法和用途以及包含该衍生物的药物组合物；发明人：胡立宏、沈旭、蒋华良、张余、马磊；申请时间：2007.05.16；申请号：200710040733.8；范围：国内。

三、近年（2007-2010）承担项目情况
1.国家自然科学基金青年科学基金项目：“天然PPM1A激动剂的发现及抗肝纤维化的构效关系研究”，执行年限：2011.1－2013.12，承担类别：项目负责人；
2.上海市联盟计划难题招标专项：“高纯度明月草查尔酮提取工艺研究”，执行年限：2010.6-2011.5，承担类别：项目负责人；
3.校优秀青年教师专项基金“Withanolide型化合物免疫抑制活性研究”执行年限：2008.1-2009.12，承担类别：项目负责人；
4.国家科技重大专项：国家重大新药创制“新长春碱类抗肿瘤药物候选物F-XA7的临床前研究”执行年限：2009.1-2010.12，承担类别：主要参加者；
5.111计划：“几种重要的神经退行性疾病相关蛋白酶抑制剂的发现”，执行年限：2009.5-2011.12，承担类别：主要参加者；
6.上海医药工业研究院横向项目：“大黄素的结构修饰”，执行年限：2009.10-2010.10，承担类别：项目负责人。