黄瑾
--------------------------------------------------------------------------------
电话:+86-21-64253681
--------------------------------------------------------------------------------
传真:+86-21-64253681
--------------------------------------------------------------------------------
E-mail:huangjin@ecust.edu.cn
--------------------------------------------------------------------------------

个人简介
--------------------------------------------------------------------------------
黄瑾，上海市浦江人才，中国化学学会会员，上海市新药设计重点实验室成员。2004年于南京大学获博士学位，2004-2006年在美国St.JudeChildren’sResearchHospital进行博士后研究。2006年进入华东理工大学药学院，在药物先导物发现方面开展了一系列工作，主要从事药物筛选及分子药理学方面的研究，目前已在JMedChem,JBiolChem,JBiolInorgChem等权威杂志发表论文SCI论文30余篇。负责国家自然科学基金、教育部、上海市教委和科委等多项科研项目，已指导毕业研究生多名。欢迎有志青年学生报考本课题组研究生！


研究方向
--------------------------------------------------------------------------------
结构生物学，肿瘤及炎症相关的定靶药物筛选及药理学研究


获奖成果
--------------------------------------------------------------------------------


代表性论著
--------------------------------------------------------------------------------
1.DeyanWu,FangfangJin,WeiqiangLu,JinZhu,CuiLi,WeiWang,YunTang,HualiangJiang,JinHuang*,GuixiaLiu,*JianLi*.Synthesis,structure-activityrelationshipandpharmacophoremodelingstudiesofpyrazole-3-carbohydrazonederivativesasdipeptidylpeptidaseIVinhibitors.ChemBiolDrugDes2012inpress
2.CuiLi,WeiqiangLu,ChunhuaLu,WenXiao,XuShen,JinHuang*,GuixiaLiu,*YunTang.IdentificationofdiversedipeptidylpeptidaseIVinhibitorsviastructure-basedvirtualscreening.JMolModel2012inpress
3.JuanZou,Li-BinYang,JingJiang,Yan-YanDiao,Xiao-NianLi,JinHuang,JianHongYang,HongLinLi,Wei-LieXiao,XueDu,Shan-ZhaiShang,Jian-XinPu,Han-DongSun.LanostaneTriterpenoidsfromtheStemsofSchisandraglaucescens.PlantaMed2012.DOI:10.1055/s-0031-1298214.
4.HuangHuang,WeiqiangLu,XiLi,XiaoliCong,HongmeiMa,XiaofengLiu,YuZhang,PengChe,RuoqunMa,HonglinLi,XuShen,HualiangJiang,JinHuang*,JinZhu*.Designandsynthesisofsmallmoleculardualinhibitoroffalcipain-2anddihydrofolatereductaseasantimalarialagent.BioorgMedChemLett2012,22(2):958-962.
5.ShoudeZhang,WeiqiangLu,XiaofengLiu,YanyanDiao,FangBai,LeiShan,JinHuang*,HonglinLi*,WeidongZhang*.Fastandeffectiveidentificationofthebioactivecompoundsandtheirtargetsformthemedicinalplantsviacomputationalchemicalbiologyapproach.MedChemComm,2011,2(6),471-477.
6.VeronikaEhmke,FalcoKilchmann,CorneliaHeind,KunqiangCui,JinHuang,TanjaSchirmeister,FrançoisDiederich,Peptidomimeticnitrilesasselectiveinhibitorsforthemalarialcysteineproteasefalcipain-2,MedChemCommun,2011,2,800-804.
7.ShenyiZhang,ChunmeiYang,WeiqiangLu,JinHuang,WeipingZhu,HonglinLi,YufangXu*andXuhongQian*Ahighlyselectivespace-foldedphoto-inducedelectrontransferfluorescentprobeforcarbonicanhydraseisozymesIXanditsapplicationsforbiologicalimaging.ChemCommun(Camb)2011,47(29):8301-8303.
8.WeiqiangLu,XiaofengLiu,XianwenCao,MengzhuXue,KangdongLiu,ZhenjiangZhao,XuShen,HualiangJiang,YufangXu,JinHuang*,HonglinLi*.SHAFTS:ahybridapproachfor3Dmolecularsimilaritycalculation.2.Prospectivecasestudyinthediscoveryofdiversep90ribosomalS6proteinkinase2inhibitorstosuppresscellmigration.JMedChem2011,54(10):3564-3574.
9.WeiqiangLu,PengChe,YanyanZhang,HonglinLi,ShienZou,JinZhu,JingDeng,XuShen,HualiangJiang,JianLi,JinHuang*.HL005--anewselectivePPARgammaantagonistspecificallyinhibitstheproliferationofMCF-7.JSteroidBiochemMolBiol2011,124(3-5):112-120.
10.YangLiu,KunqiangCui,WeiqiangLu,WeiLuo,JianWang,JinHuang,ChunGuo.Synthesisandantimalarialactivityofnoveldihydro-artemisininderivatives.Molecules2011,16(6):4527-4538.
11.ShiliangLi,YiZhou,WeiqiangLu,YeZhong,WenlongSong,KangdongLiu,JinHuang*,ZhenjiangZhao,YufangXu,XiaofengLiu*,HonglinLi.Identificationofinhibitorsagainstp90ribosomalS6kinase2(RSK2)throughstructure-basedvirtualscreeningwiththeinhibitor-constrainedrefinedhomologymodel.JChemInfModel2011,51(11):2939-2947.
12.JieShen,ChengfangTan,YanyanZhang,XiLi,WeihuaLi,JinHuang*,XuShen,YunTang*.Discoveryofpotentligandsforestrogenreceptorbetabystructure-basedvirtualscreening.JMedChem2010,53(14):5361-5365.
13.JinZhu,TongChen,JieLiu,RuoqunMa,WeiqiangLu,JinHuang*,HonglinLi*,JianLi*,HualiangJiang.2-(3,4-dihydro-4-oxothieno[2,3-d]pyrimidin-2-ylthio)acetamidesasanewclassoffalcipain-2inhibitors.3.design,synthesisandbiologicalevaluation.Molecules2009,14(2):785-797.
14.JinZhu,TongChen,LiliChen,WeiqiangLu,PengChe,JinHuang*,HonglinLi*,JianLi*,HualiangJiang.2-amido-3-(1H-indol-3-yl)-N-substituted-propanamidesasanewclassoffalcipain-2inhibitors.1.Design,synthesis,biologicalevaluationandbindingmodelstudies.Molecules2009,14(1):494-508.
15.ShuaishuaiNi#,YaxiaYuan#,JinHuang#,XiaonaMao,MaoshengLv,JinZhu,XuShen,JianfengPei*,LuhuaLai,HualiangJiang,JianLi*.DiscoveringpotentsmallmoleculeinhibitorsofcyclophilinAusingdenovodrugdesignapproach.JMedChem2009,52(17):5295-5298.
16.YongtaoLi,LiLi,JingChen,TiancenHu,JinHuang,Yue-weiGuo,Hua-liangJiang,XuShen.7-Chloroarctinone-basanewselectivePPARgammaantagonistpotentlyblocksadipocytedifferentiation.ActaPharmacolSin2009,30(9):1351-1358.
17.HonglinLi#,JinHuang#,LiliChen,XiaofengLiu,TongChen,JinZhu,WeiqiangLu,XuShen,JianLi*,RolfHilgenfeld*andHualiangJiang*.Identificationofnovelfalcipain-2inhibitorsaspotentialantimalarialagentsthroughstructure-basedvirtualscreening.JMedChem2009,52(15):4936-4940.
18.GangZou,ZhentingGao,JidongWang,YuZhang,HongDing,JinHuang,LiliChen,YueweiGuo*,HualiangJiang,XuShen*.DeoxyelephantopininhibitscancercellproliferationandfunctionsasaselectivepartialagonistagainstPPARγ..Biochem.Pharmacol.2008,75(6):1381-1392.
19.Butyl4-(butyryloxy)benzoatefunctionsasanewselectiveestrogenreceptorbagonistandinducesGLUT4expressioninCHO-K1cells.ZhaohuLin,HongShen,JinHuang*,ShuaiChen,LiliChen,JingChen,Guixialiu,HualiangJiang,XuShen*.J.Steroid.Biochem.Mol.Biol.2008,110(1-2):150-156.
20.StructuralInsightintotheMechanismsofWntSignalingAntagonismbyDkk.LijunChen,KeWang,YoumingShao,JinHuang,XiaofengLi,JufangShan,DianqingWu*,JieZheng*.J.Biol.Chem.2008,283(34):23