刘建文教授博士生导师
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电话:021-64252044
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传真:021-64252044
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E-mail:liujian@ecust.edu.cn
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个人简介
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刘建文，1994年毕业于上海中医药大学肿瘤药理学专业，获得医学博士学位；1995年应日本国科学技术厅邀请，作为STAFellow在大阪生物科学研究所(OsakaBioscienceInstitute)和日本理化学研究所(InstituteofPhysicalandChemicalResearch)进行客座研究。研究天然药物对血管内皮细胞纤溶活性因子的基因调空作用。2001年毕业于日本广岛大学(省立)遗传子制御工学研究室，研究自由基与癌转移的过程及实验药物干预的分子机理，获得应用生物科学博士学位。主要研究领域为：新物质的生物活性和药理药效学研究。
现主要研究方向：自由基损伤与疾病的产生及抗氧化剂的研究，通过整体动物水平，离体细胞和分子水平研究新物质的药理和药效学。研究主要包括肿瘤药理学研究和天然药物中抗氧化活性物质的应用基础研究。研究新物质对靶细胞作用后的蛋白水平，基因水平的影响。建立了以肿瘤学和心脑血管疾病为主的分子细胞药理学研究特色。首次在国际肿瘤治疗学领域发现了通过抑制肿瘤细胞内的ROS(ReactiveOxygenSpecies)，可以达到抑制癌细胞浸润转移的目的，该研究为开发非杀伤性抗癌转移的药物提出新的科学依据。论文被学术界引用和国际学术会议交流。
现主持国家课题1项、省部级科研项目2项，参加过省部级科研项目6项。获省部级科研成果2等奖2项、3等奖2项，申请发明专利11项，国际发明专利1项，发表国内外论文近80篇，其中SCI收录34篇。
主编《药理实验方法学—新技术与新方法》，《生物资源中活性物质的开发与利用》，参编《血管内皮细胞与疾病》，《生物抗氧化剂》（日文）。

研究方向
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现主要研究领域：
分子细胞药理学，毒理学，肿瘤学，细胞生物学，分子生物学，中药学
现主要研究方向：
1，细胞周期阻滞及凋亡诱导剂的发现与作用机理研究
2，肿瘤细胞凋亡microRNA表达、调控的研究及其在新药研发中的应用
3.基于分子模型的建立及先导化合物的发现研究
4，生物抗氧化剂的应用基础研究
4.抗自身免疫性疾病的活性物质研究
5.纳米材料与技术在生命科学中的应用基础研究

获奖成果
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湖北省科研成果（1992年）三等奖
上海市科技进步（1995年）二等奖
高等学校科学技术奖自然科学（2006年）二等奖
上海医学科技奖（2007）三等奖
中华中医药学会科学技术奖（2007）三等奖
上海市科技进步（2007）二等奖

代表性论著
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参编著作：1.盛民立，刘建文等:《血管内皮细胞与疾病》上海医科大学出版社（上海，1993,12.）ISBN7－5627－0176－8/R.167
2.三羽信比古，刘建文等:《生物抗氧化剂》日本Fragrance杂志社1999,9,30.（日文）ISBN4－89479－017－3
3.刘建文主编《药理实验方法学—新技术与新方法》化学工业出版社生物医药出版中心（北京，2003.5）ISBN7－5025－3271－4
4.三羽信比古，刘建文等:《美肤，皮肤防护与生物技术》日本CMC杂志社2003.7（日文）ISBN4－88231－408－8
5.刘建文，贾伟主编《生物资源中活性物质的开发与利用》化学工业出版社（北京，2005.5）ISBN7－5025－7133－7
6.李仪奎主编，刘建文参编《中药药理实验方法学》上海科学技术出版社(上海，2006.5）
7.刘建文主编《药理实验方法学—新技术与新方法》化学工业出版社生物医药出版中心（北京，2008.1第二版）
主要论文
51.JingZhang,YalingShen,JianwenLiu*andDongzhiWei:AntimetastaticeffectofprodigiosinthroughinhibitionoftumorinvasionBiochemicalPharmacology200569:1February,407-414.
52.JingyaYang,DongzhiWei,JianwenLiu.RepressionsofMMP-9expressionandNF-jBlocalizationareinvolvedininhibitionoflungcarcinoma95-Dcellinvasionby(–)-epigallocatechin-3-gallateBiomedicine&Pharmacotherapy2005;59(3):98–103.
56.XiujuanXin,JianjiangZhong,DongzhiWeiandJianwenLiu*Protectioneffectof20(S)-ginsenosideRg2extractedfromculturedPanaxnotoginsengcellsonhydrogenperoxide-inducedcytotoxityofhumanumbilicalcordveinendothelialcellsinvitroProcessBiochemistry2005,40(10),3202-3205.
57.YanZhang,JianwenLiu*,WeiJia,AiHuaZhao,TingLi:DistinctimmunosuppressiveeffectbyIsodonSerraextracts.InternationalImmunopharmacology2005，5(13-14),1957-1965
62.JianwenLiu*,XiaodongZhang,FanYang,TingLi,DongzhiWei,YuhongRenAnti-metastaticeffectofalipophilicascorbicacidderivativewithantioxidationthroughinhibitionoftumorinvasionCancerChemotherapyandPharmacology2006,57(5):584-590
65.ShuihuaZhang,GuangJi,JianwenLiu*Reversalofchemical-inducedliverfibrosisinWistarratsbypuerarinJournalofNutritionalBiochemistry2006,17,485-491
70.WenTang,Jian-WenLiu*,Wei-MingZhao,Dong-ZhiWei,Jian-JiangZhong*:GanodericacidTfromGanodermalucidummyceliainducesmitochondriamediatedapoptosisinlungcancercellsLifeSciences80(2006)2050–211
71.TingLi,JianwenLiu*,XiaodongZhang,GuangJi::Anti-diabeticactivityoflipophilic(-)-epigallocatechin-3-gallatederivativeunderitsroleinα-glucosidaseinhibitionBiomedicine&PharmacotherapyBiomedicine&Pharmacotherapy61(2007)91-96
72.GuanWang,JianZhao,JianwenLiu*,YongpingHuang,JianjiangZhong*,,WenTang：EnhancementofIL-2andIFN-γexpressionandNaturalKillercellsactivityinvolvedintheanti-tumoreffectofGanodericacidMeinvivoInternationalImmunopharmacology2007：7864–870
73.JianwenLiu*,FanYang,YanZhang,JiyuLi：StudiesontheCell-immunosuppressiveMechanismofOridoninfromIsodonSerraInternationalImmunopharmacology2007,7:945–954
75.Yuan-LiLi,Guo-PingGan,Hui-ZhanZhang,He-ZhenWu,Chang-LongLi，Yong-PingHuang,Yan-WenLiu,Jian-WenLiu*:AflavonoidglycosideisolatedfromSmilaxchinaL.rhizomeinvitroanticancereffectsonhumancancercelllinesJournalofEthnopharmacologyJournalofEthnopharmacology2007,113:115–124
82.JianwenLiu*,YoujunYu,PeiyongZheng,XiaodongZhang,TingLi,YanCao,MingchuanGuo
SynergisticprotectiveeffectofpicrosideIIandNGFonPC12cellsagainstoxidativestressinducedbyH2O2PharmacologicalReports2007.59.573-579
84.WenXu,JianwenLiu*,ChanglongLi,He-ZhenWu,Yan-WenLiu:Kaempferol-7-O-β-D-glucoside(KG)isolatedfromSmilaxchinaL.rhizomeinducesG2/MphasearrestandapoptosisonHeLacellsinap53-independentmannerCancerLetters2008,264:229–240
85.XingXiu,WuHezhen,WangXiaoming,HuangYongping,LiQing,LiChanglong,YangYanfang,LiuYanwen,LiuJianwen:InhibitionoftumourcellproliferationbyColeonCJournalofChemotherapy2008,20(2):238–245
86.A.-P.Hu,J.-M.Du,J.-Y.LiandJianwenLiu*:OridoninpromotesCD4+/CD25+Tregdifferentiation,modulatesTh1/Th2balanceandinducesHO-1inratspleniclymphocytes.Inflamm.Res.2008,57:163–170
87.LiChangLong,WuHeZhen,HuangYongPing,YangYanFang,LiuYanWen,LiuJianWen*:6-O-Angeloylenolininducesapoptosisthroughamitochondrial/caspaseandNF-kBpathwayinhumanleukemiaHL60cellsBiomedicine&Pharmacotherapy2008,62:401-409
90.HongzhongWu,XingLiang,YishiFang,XiaoranQing,YuanxingZhang,JianwenLiu*Resveratrolinhibitshypoxia-inducedmetastasispotentialenhancementbyrestrictinghypoxia-inducedfactor-1aexpressionincoloncarcinomacells.Biomedicine&Pharmacotherapy2008,62:613-621
91.DongmeiShan,YishiFang,YiyiYe,JianwenLiu*:EffectofreducingsusceptibilitytocholesterolgallstoneformationbyEGCGJournalofChemotherapy2008,62:677-683
101.JinWang,AibinWu,YufangXu,JianwenLiu*,XuhongQian*M2-A,anovelamonafideanalogue,inducesapoptosisandG2-MarrestviainhibitingPI3K/AktpathwayonHL60cellsCancerLetters283(2009)193–202
104.YiyiYe,JianwenLiu*,LijuanSun,MingcangChen,MinboLan*:InvitrotoxicityofsilicananoparticlesinmyocardialcellsEnvironmentalToxicologyandPharmacology2010,29:131–137
105.LijuanSun,JianwenLiu,*DalingCui,JiyuLi,YoujunYu,LeiMa,andLihongHu:
Anti-inflammatoryfunctionofWithangulatinAbytargetedinhibitingCOX-2expressionviaMAPKandNF-κBpathways.JournalofCellularBiochemistry2010,109(3):532-541
106.YoujunYu,LijuanSun,LeiMa,JiyuLi*,LihongHu*,JianwenLiu*InvestigationoftheimmunosuppressiveactivityofPhysalinHonmouseTlymphocytesInternationalImmunopharmacology2010,10:290–297
107.YiyiYe,JianwenLiu*,MingcangChen,LijuanSun,MinboLan,*:InvitrotoxicityofsilicananomaterialsinmyocardialH9c2(2-1)cellsToxicologyinVitro24(2010)751–758
109.MingcangChen,YiyiYe,JianwenLiu,*GuangJiHesperidinUpregulatesHemeOxygenase-1ToAttenuateHydrogenPeroxide-InducedCellDamageinHepaticL02CellsJ.Agric.FoodChem2010,58,3330–3335
110.KeXu,XinLiang,FengGao,JianjiangZhong,JianwenLiu*:AntimetastaticeffectofganodericacidTinvitrothroughinhibitionofcancercellinvasionProcessBiochemistry2010,45:1261–1267
111.YichunXu,ZijingJiang,GuangJi,JianwenLiu*:InhibitionofBoneMetastasisfromBreastCarcinomabyRosmarinicAcidPlantaMedica2010;76:956–962
112.MingcangChen,HonggangGu,YiyiYe,BingLin,LijuanSun,WeipingDeng,JingzheZhang,JianwenLiu*:Protectiveeffectsofhesperidinagainstoxidativestressoftert-butylhydroperoxideinhumanhepatocytesFoodandChemicalToxicology2010;48:2980–2987
113.YichunXu,GuanglinXu,LiLiu,DeshengXu,andJianwenLiu*:Anti-InvasionEffectofRosmarinicAcidviatheExtracellularSignal-RegulatedKinaseandOxidation–ReductionPathwayinLs174-TCellsJournalofCellularBiochemistry111:370–379(2010)
114.Nian-HongChen,Jian-WenLiu,Jian-JiangZhong*.GanodericacidTinhibitstumorinvasioninvitroandinvivothroughinhibitionofMMPexpression.PharmacologicalReports,62(2010):150-163
115.XinLiang,AibinWu,YufangXu,KeXu,JianwenLiu*,XuhongQian*:B1,anovelnaphthalimide-basedvisiblelightactivatablephotonuclease,inducescellcyclearrestandapoptosisviaChk2-p53pathwayinHeLacellsInvestNewDrugs(inpress)
116.LijuanSun,JianwenLiu?,PingLiu,YoujunYu,LeiMa,LihongHu:ImmunosuppressioneffectofWithangulatinAfromPhysalisangulataviahemeoxygenase1-dependentpathwaysProcessBiochemistry（inpress)
117.XinLiang,YufangXu,KeXu,JianwenLiu,andXuhongQian:B1,aNovelAmonafideAnalogue,OvercomestheResistanceConferred3byBcl-2inHumanPremyelocyticLeukemiaHL60CellsMolecularCancer(inpress)