李浩

电话:(021)64253299
传真:(021)64253299
E-mail:hli77@ecust.edu.cn

个人简介
1999年7月获得复旦大学化学系理学学士学位后，在中科院上海有机化学研究所工作，2007年获美国新墨西哥大学化学和生物化学系博士学位，被评为优秀博士毕业生，毕业后到美国杜克大学化学系从事博士后研究，2011年到华东理工大学药学院工作，并入选上海市浦江人才计划,2012年入选上海市高校特聘教授-“东方学者”,博士生导师。

研究方向
1，有机催化和金属催化新型方法学的研究及应用.
设计并合成结构全新的手性双官能团有机催化剂,催化多种不对称有机催化反应;运用金属催化剂的广谱性设计并催化新型的有机合成反应。将这些发展的新型方法学运用于合成拥有“优势结构”的分子，并从这些优势结构高效合成复杂的有机分子包括药物分子,进一步对这些化合物进行药物活性测试,以期发现有活性的潜在药物分子,用更快更高效的方法达到发现潜在药物的目的。
2，靶向性设计和合成相关疾病的潜在药物活性分子.
利用传统化疗药物良好的药效、药代等性能和分子靶向药物定向选择作用位点来相结合发生作用,设计、合成、筛选传统化疗和分子靶向治疗合二为一的化合物，作用于两个或多个靶标，兼具传统化疗和分子靶向治疗的优点。将这个理念运用于开发其他疾病的双功能潜在药物,由于这些新化合物有老药的结构成分，成药的可能性大大提高。

研究成果
已在SCI收录国际期刊杂志发表论文50余篇，被国内外同行引用超过2000次，多篇论文被评为“Most-cited”Papers或/和“Hot”Papers，发表国际专利一项。

代表性论著
1.Liu,L.;Wu,D.;Zheng,S.;Li,T.;Li,X.;Wang,S.;Li,J.;Li,H.;*,Wang,W.*SynthesisofHighlyFunctionalizedChiral3,3′-DisubstitutedOxindolesviaanOrganocatalyticEnantioselectiveMichaelAdditionofNitroalkanestoIndolylidenecyanoacetatesOrg.Lett.,2012,14,134–137.
2.Li,H.;Song,F.;Widenhoefer,R.A.*Gold(I)-CatalyzedIntramolecularHydroaminationofN-AllylicN'-ArylureastoformImidazolidin-2-ones.AdvancedSynthesis&Catalysis2011,353,955-962.
3.Zhang,S.;Xie,H.;Zhu,J.;Li,H.;Zhang,X.;Li,J.;*Wang,W.*Organocatalyticenantioselectiveb-functionalizationofaldehydesbyoxidationofenaminesandtheirapplicationincascadereactions.NatureCommunications2011,2,1214/1-1214/7.
4.Li,H.;Lee,S.;Widenhoefer,R.A.*Gold(I)-catalyzedenantioselectiveintramolecularhydroaminationofalleneswithureas.JournalofOrganometallicChemistry2010,696,316-320.
5.Li,H.;Ji,Y.-F.;Li,J.;Zhang,S.-L.;Yu,C.-G.;Wang,W.*“OrganocatalyticEnantioselectiveMichaelAdditionReactionsofFluoromalonateswitha,b-UnsaturatedAldehydes”ScienceChina–Chemistry,2010,53,135-139.
6.Li,H.;Widenhoefer,R.*“IntramoleculardiaminationandalkoxyaminationofalkeneswithN-sulfonylureasemployingN-iodosuccinimide”Tetrahedron2010,4827-4831.
7.Li,H.;Zu,L.;Xie,H.;Wang,W.*“OrganocatalyticEnantioselectiveConjugateAdditionof2-FluoromalonatetoNitroolefins:DirectSynthesisofChiralFluorinatedg-NitroCarboxylicAcidDerivatives”Synthesis,2009,1525-1530,invitedSpecialTopics.
8.Li,H.;Widenhoefer,R.*“Gold(I)-CatalyzedIntramolecularDihydroaminationofAlleneswithN,N′-DisubstitutedUreasToFormBicyclicImidazolidin-2-ones”Org.Lett.,2009,11,2671-2674.
9.Li,H.;Zhang,S.-L.;Yu,C.G.;Song,X.-X.;Wang,W.*“SynthesisofChiralFluorinatedQuaternaryCarbonContainingb-Ketoesters”Chem.Commun.,2009,2136-2138.
10.Li,H.;Zu,L.-S.;Xie,H.-X.;Wang,J.;Wang,W.*“HighlyEnantio-andDiastereoselectiveOrganocatalyticCascadeaza-Michael-MichaelReactions:ADirectMethodfortheSynthesisofTrisubstitutedChiralPyrrolidines”Chem.Commun.,2008,5636-5638.ThisworkhasbeenhighlightedinOrganicChemistryHighlightsas“NewmethodsforC-Nringconstruction.”byOrganicChemistry
11.Fu,Z.;Malureanu,L.;Huang,J.;Wang,W.;Li,H.;vanDeursen,J.M.;Tindall,D.J.;*Chen,J.*“Plk1-dependentPhosphorylationofFoxM1RegulatesaTranscriptionalProgramRequiredforMitoticProgression”NatureCellBiol.,2008,10,1076-1082.
12.Wang,J.;Xie,H.-X.;Li,H.;Zu,L.-S.;Wang,W.*“AHighlyStereoselectiveHydrogen-bondMediatedCascadeMichael-MichaelProcessthroughDynamicKineticResolution”Angew.Chem.Int.Ed.,2008,47,4177-4179.Thisworkhasbeenselectedas“hot”paperbyAngew.Chem.Editors.
13.Li,H.;Zu,L.-S.;Xie,H.-X.;Wang,J.;Jiang,W.;Wang,W.*“EnantioselectiveOrganocatalyticDoubleMichaelAdditionReactions”Org.Lett.,2007,9,1833-1835.ThisworkhasbeenhighlightedinSynfactsandOrganicChemistryHighlights
14.Li,H.;Wang,J.;Xie,H.-X.;Zu,L.-S.;Jiang,W.;Duesler,E.N.;Wang,W.*“EnantioselectiveOrganocatalyticCascadeReactions:FacileSynthesisofChiral1,2-Dihydroquinolines”Org.Lett.,2007,9,965-968.Thisworkhasbeenrecognizedasthe“Most-cited”and“Hot”paperofOL.
15.Li,H.;Wang,J.;E-Nunu,T.;Zu,L.-S.;Jiang,W.;Wei,S.-H.;Wang,W.*“One-PotApproachtoChiralChromenesviaEnantioselectiveOrganocatalyticDominoOxa-Michael-AldolReaction”Chem.Commun.,2007,507-509.Thisworkhasbeenrecognizedastop5(number2)the“Mostcited”paperpublishedonChem.Commun.since2007.
16.Wang,J.;Li,H.;Xie,H.-X.;Zu,L.-S.;Shen,X.;Wang,W.*“OrganocatalyticEnantioselectiveCascadeMichael-Aldol-DehydrationReactions:EfficientAssemblyofDenselyFunctionalizedChiralCyclopentenes”Angew.Chem.Int.Ed.,2007,46,9050-9053.Thisarticlehasbeenselectedas“Hotpaper”byACIE.
17.Xie,H.-X.;Zu,L.-S.;Li,H.;Wang,J.;Wang,W.*“OrganocatalyticEnantioselectiveCascadeMichael-AlkylationReactions.SynthesisofChiralCyclopropanesandInvestigationofUnexpectedOrganocatalyzedStereoselectiveRingOpeningofCyclopropanes”J.Am.Chem.Soc.,2007,129,10886-10894.ThisworkhasbeenhighlightedinSynfacts.
18.Zu,L.-S.;Wang,J.;Li,H.;Xie,H.-X.;Jiang,W.;Wang,W.*“CascadeMichael-aldolReactionsPromotedbyHydrogen-BondingMediatedCatalysis”J.Am.Chem.Soc.,2007,129,1036-1037.Thisworkhasbeenrecognizedasthe“Most-cited”and“Hot”paperofJACS.
19.Zu,L.-S.;Li,H.;Xie,H.-X.;Wang,J.;Jiang,W.;Tang,T.;Wang,W.*“SynthesisofHighlyFunctionalizedChiralCyclopentanesbyCatalyticEnantio-andDiastereoselectiveDoubleMichaelAdditionReactions”AngewChem.Int.Ed.,2007,46,3732-3734.ThisworkhasbeenhighlightedinSynfacts.
20.Wang,J.;Li,H.;Zu,L.-S.;Jiang,W.;Xie,H.-X.;Duan,W.-H.;Wang,W.*“EnantioselectiveOrganocatalyticConjugateAdditionstoEnones”J.Am.Chem.Soc.,2006,128,12652-12653.Thisworkhasbeenrecognizedasthe“Most-cited”and“Hot”PaperofJ.Am.Chem.Soc..
21.Wang,W.;*Li,H.;Wang,J.;Zu,L.-S.;“EnantioselectiveOrganocatalyticTandemMichael-AldolReactions:One-PotSynthesisofChiralThiochromenes”J.Am.Chem.Soc.,2006,128,10354-10355.Thisworkhasbeenrecognizedasthe“Most-cited”and“Hot”PaperofJ.Am.Chem.Soc.andhighlightedinSynfacts.

22.Wang,W.;*Wang,J.;andLi,H.“Direct,HighlyEnantioselectivePyrrolidineSulfonamideCatalyzedMichaelAdditionReactionsofAldehydestoNitrostyrenes”Angew.Chem.Int.Ed.,2005,44,1369-1371.ThisworkisthemostcitedpaperofAngew.Chem.Int.Ed.inyear2005/2006andhasbeenhighlightedinOrg.Chem.Highlights2006,January30.
23.Li,H.;Wang,J.;Zu,L.-S.;Wang,W.*“OrganocatalyticAsymmetricConjugateAdditionofThioaceticAcidtob-Nitrostyrenes”TetrahedronLett.,2006,47,2585-2589.

24.Li,H.;Zu,L.-S.;Wang,J.;Wang,W.*“OrganocatalyticAsymmetricConjugateAdditionofThioaceticAcidto?Enones”TetrahedronLett.,2006,47,3145-3148.
25.Wang,W.;*Li,H.;Wang,J.“Enantioselective,OrganocatalyticMukaiyama-MichaelAdditionofSilylEtherstoa,b-UnsaturatedAldehydes”Org.Lett.,2005,7,1637-1639.

26.Wang,W.;*Li,H.;Wang,J.“PyrrolidineSulfonamidePromotedDirect,EnantioselectiveAldolReactionsofa,a-DialkylAldehydes:SynthesisofQuaternaryCarbon-Containingb-HydroxyCarbonylCompounds”TetrahedronLett.,2005,46,5077-5079.
27.Wang,W.;*Li,H.;Wang,J.,Liao,L.-X.“Direct,Organocatalyticalpha-SulfenylationofAldehydesandKetones”TetrahedronLett.,2004,45,8229-8231.

28.Wang,W.;*Li,H.“AnEfficientSynthesisoftheIntrinsicFluorescentPeptideLabels,(S)and(R)(6,7-Dimethoxyl-4-coumaryl)alaninesviaAsymmetricHydrogenations”TetrahedronLett.,2004,45,8479-8481.