张元兴
生物化工专业：博士生导师/硕士生导师
生物化学与分子生物学专业：博士生导师
海洋生物学专业：硕士生导师
微生物与生化药学专业：硕士生导师
生物工程领域：工程硕士生导师

1982年1月毕业于华东化工学院化学工程系，获学士学位。1984年7月毕业于华东化工学院生物化工系，获硕士学位，1995年9月评为华东理工大学教授。1997年评为博士生导师。1998年享受国务院政府特殊津贴。
现任职务有生物工程学院院长，上海阿华生物工程研究所所长，任国家自然科学基金委员会专家评审组专家，国务院学位委员会生物工程临时学科评议组专家，曾任国家863高技术计划海洋技术领域专家组副组长。受聘为生物反应器工程国家重点实验室学术委员会副主任，中科院海洋生物资源可持续利用重点实验室、农业部海洋渔业资源可持续利用重点实验室、农业部农业微生物资源利用综合性重点实验室、农业部海洋与河口渔业资源及生态重点开放实验室、中国水产科学研究院渔业环境与养殖生态重点开放实验室学术委员会委员。担任国家现代农业技术体系(鲆鲽类)岗位科学家。为本科生讲授上海市精品课程生物化学，为硕士研究生讲授动物细胞培养课程，为博士研究生开设生物反应器设计与放大课程，已指导50名硕士研究生和35名博士研究生毕业获得学位，5名博士后出站，正在指导硕士研究生15名，博士研究生9名。已在国内外发表论文320余篇，其中SCI收录137篇，出版著作2部，参编著作6部，获省部级科技进步奖6项，中国石油和化学工业优秀科技图书一等奖1项，申请国家发明专利47项，其中获得授权32项；申请国际专利3项，其中获得授权美国专利1项。
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学术梯队：
1.周祥山，博士，教授，博士生导师，上海市科技启明星，中组部“****”第一批科技创新领军人才。承担国家自然科学基金、国家863计划和国家新药创制重大专项项目，主要从事微生物发酵和生物制药的研究。
2.刘琴，博士，教授，博士生导师，上海市科技启明星，教育部新世纪人才。承担国家自然科学基金项目，参加国家863项目和国家支撑计划项目，主要从事海洋生物技术的研究。
3.吴海珍，博士，副教授。承担国家863计划项目和国家自然科学基金项目。主要从事海洋生物技术和重组蛋白表达的研究。
4.王启要，博士，副教授。承担国家自然科学基金项目，参加国家863项目和国家鲆鲽类农业技术体系项目，主要从事海洋生物技术的研究。
5.马悦，博士。承担国家自然科学基金项目，参加国家863计划和国家鲆鲽类农业技术体系项目，主要从事海洋生物技术的研究。
6.肖婧凡，博士。承担国家自然科学基金项目，参加国家863计划研究项目，主要从事海洋生物技术的研究。
7.蔡孟浩，博士。参加国家863计划研究项目，主要从事海洋微生物的研究。
8.范卫民，高级工程师。参加国家863计划研究项目，主要从事生物反应器的研究和设计。
9.陆健，学士，高级工程师。参加国家863计划研究项目，主要从事生物反应器的研究和设计。
10.马纪梅，硕士。实验室管理工作。
11.胡晓，学士。实验室管理工作。
主要研究方向：
1.海洋生物技术。研究海洋病原微生物的特性，掌握其致病规律，在分子水平上阐明细胞通讯相关的条件致病现象，确定致病相关功能基因，从基因水平上进行改造，开发减毒活疫苗和多效价疫苗。目前承担着国家863计划研究项目、国家自然科学基金项目和现代农业产业技术体系岗位科学家项目。
2.生物制药工程。利用生物反应器，通过基因重组微生物的高密度培养和基因调控，高表达重组产物，生产高纯度的药用蛋白。在甲醇酵母的发酵中，研究基因诱导水平的精密控制和关键酶的合成，产物蛋白的酶水解机制，提高产物蛋白的表达。在海洋微生物培养中，阐明丝状菌次级代谢调控的规律，调控菌丝形态，高效合成活性化合物。目前承担着国家新药创制重大专项项目、国家863计划研究项目和企业委托项目。
著作：
1.王启要，刘琴，张元兴(2008)群体感应：细菌之间的语言.叶勤主编：生物科学与工程.北京：科学出版社.p43-67.
2.张元兴(2008)动物细胞培养工程.叶勤主编：生物科学与工程.北京：科学出版社.p160-171.
3.张元兴，易小萍，张立，孙祥明(2007)动物细胞培养工程.北京：化工出版社.
4.张元兴，许学书(2007).生物反应工程基础.朱炳辰主编：化学反应工程.第四版.北京：化学工业出版社.p337-359.
5.张元兴，许学书(2001)生物反应器工程.上海：华东理工大学出版社.
6.朱开宏，李伟，张元兴译(2004)化学反应器的设计、优化和放大.北京：中国石化出版社.
7.张元兴(2003)动物细胞培养.俞俊棠，唐孝宣，邬行彦，李友荣，金青萍主编：新编生物工艺学.第10章.北京：化学工业出版社.264-288.
8.许学书，张元兴(2003)生物反应器.叶勤主编：现代生物技术原理及其应用.第5章.北京：中国轻工业出版社.155-186.
9.张元兴(2003)动物细胞培养.叶勤主编：现代生物技术原理及其应用.第10章.北京：中国轻工业出版社.299-336.
10.张元兴,许学书(2001)生物反应工程.朱炳辰主编：化学反应工程.北京：化学工业出版社.416-457.
11.张元兴(2001)生物反应工程(习题).丁百全，房鼎业，张海涛主编：化学反应工程例题与习题.北京：化学工业出版社.247-268.
12.张元兴，陈国豪，王国政(1991)动植物细胞大量培养.俞俊棠，唐孝萱主编：生物工艺学(上).上海：华东化工学院出版社.214-235.
13.张元兴(1992)生物反应器及其操作特性.俞俊棠，唐孝萱主编：生物工艺学(下).上海：华东化工学院出版社.1-9.

2012年发表和出版中论文:

1.XiaoyongLi,HaizhenWu*,MengZhang,ShunqingLiang,JingfanXiao,QinLiu,QiyaoWang,YuanxingZhang(2012)Secretedglyceraldehyde-3-phosphatadehydrogenaseasabroadspectrumvaccinecandidateagainstmicrobialinfectioninaquaculture.LettersinAppliedMicrobiology54(1):1-9.
2.XiaodanCao,SarahV.Studer,KarenWassarman,YuanxingZhang,EdwardG.Ruby*,TimMiyashiro(2012)Thenovelsigmafactor-likeRpoQregulatesluminescence,chitinaseactivityandmotilityinVibriofischeri.mBio3(1):e00285-11.
3.ChaoYu,MenghaoCai,LiKang,YuanxingZhang,XiangshanZhou*(2012)Significanceofseedculturemethodsonmycelialmorphologyandproductionofanovelanti-canceranthraquinonebymarinemangroveendophyticfungusHaloroselliniasp.(No.1403).ProcessBiochemistry47(3):422-427.
4.YuanzhiLv,JingfanXiao,QinLiu,HaizhenWu,YuanxingZhang,QiyaoWang*(2012)Systematicmutationanalysisoftwo-componentsignaltransductionsystemsrevealsEsrA-EsrBandPhoP-PhoQasthemajorvirulenceregulatorsinEdwardsiellatarda.VeterinaryMicrobiology157(1-2):190-199.
5.JingfanXiao,TaoChen,QiyaoWang*,YuanxingZhang(2012)ComparativeanalysisoftherolesofcatalasesKatBandKatGinthephysiologicalfitnessandpathogenesisoffishpathogenEdwardsiellatarda.LettersinAppliedMicrobiology54(5):425?432.
6.LiliSheng,QiyaoWang*,QinLiu,YuanxingZhang(2012)QuorumsensingandalternativesigmafactorRpoNregulatetypeVIsecretionsysteminfishpathogenVibrioalginolyticus.ArchivesofMicrobiology194(5):379-390.
7.MinjunYang,YuanzhiLv,JingfanXiao,HaizhenWu,HuajunZheng,QinLiu,YuanxingZhang,QiyaoWang*(2012)Edwardsiellacomparativephylogenomicsrevealthenewintra/inter-speciestaxonomicrelationships,virulenceevolutionandnicheadaptationmechanisms.PLoSOne7(5):e36987.
8.MengZhang,HaizhenWu*,XiaoyongLi,MinjunYang,TaoChen,QiyaoWang,QinLiu,YuanxingZhang(2012)EdwardsiellatardaflagellarproteinFlgD:aprotectiveimmunogenagainstedwardsiellosis.Vaccine30(26):3849-3856.
9.HuanLiu,DanGu,XiaodanCao,QinLiu,QiyaoWang*,YuanxingZhang*(2012)CharacterizationofanewquorumsensingregulatorluxTanditsrolesintheextracellularproteaseproduction,motility,andvirulenceinfishpathogenVibrioalginolyticus.ArchivesofMicrobiology194(6):439-452.
10.ZhihuiZhang,HaizhenWu*,JingfanXiao,QiyaoWang,QinLiu,YuanxingZhang(2012)Immuneresponsesofzebrafish(Daniorerio)inducedbybath-vaccinationwithaliveattenuatedVibrioanguillarumvaccinecandidate.Fish&ShellfishImmunology33(1):36-41.
11.HuanLiu,DanGu,LiliSheng,QiyaoWang*,YuanxingZhang(2012)InvestigationoftherolesofT6SSgenesinmotility,biofilmformation,andextracellularproteaseAspproductioninVibrioalginolyticuswithmodifiedGateway-compatibleplasmids.LettersinAppliedMicrobiology55(1):73-81.
12.LiliSheng,MingmingPu,ManjunathHegde,YuanxingZhang,ArulJayaraman,ThomasK.Wood*(2012)InterkingdomadenosinesignalreducesPseudomonasaeruginosapathogenicity.MicrobialBiotechnology5(4):560-572.
13.MingLiu,ShuangWang,TingguangSun,JiguoSu,YuanxingZhang*,JunjieYue*,ZhiweiSun*(2012)Insightintothestructure,dynamicsandtheunfoldingpropertyofamylosucrases:Implicationsofrationalengineeringonthermostability.PLoSONE7(7):e40441.
14.YanZheng,YanXiao,HaizhenWu,QiyaoWang,JingfanXiao,YuanxingZhang,QinLiu*(2012)DifferentapproachestoexpressingEdwardsiellatardaantigenGAPDHinattenuatedVibrioanguillarumformultivalentfishvaccines.JournalofFishDiseases35(8):569-577.
15.JingfanXiao,TaoChen,MinjunYang,YuanxingZhang,QiyaoWang*(2012)IdentificationofqseEGFgeneticlocusanditsrolesincontrollinghemolyticactivityandinvasioninfishpathogenEdwardsiellatarda.LettersinAppliedMicrobiology55(2):91-98.
16.ZheFang,YingZhang,MenghaoCai,JianZhang,YuanxingZhang,XiangshanZhou*(2012)Improvedgenetargetingfrequencyinmarine-derivedfilamentousfungusAspergillusglaucusbydisruptingLigD.JournalofAppliedGenetics53(3):355-362.
17.DahaiYang,QinLiu*,MingjunYang,HaizhenWu,QiyaoWang,JingfanXiao,YuanxingZhang*(2012)RNA-seqlivertranscriptomeanalysisrevealsanactivatedMHC-IpathwayandaninhibitedMHC-IIpathwayattheearlystageofvaccineimmunizationinzebrafish.BMCGenomics13:319.
18.ChuanpengNiu,MenghaoCai,YuanxingZhang,XiangshanZhou*(2012)Biosyntheticoriginofthecarbonskeletonofanovelanti-tumorcompound,haloroquinone,fromamarine-derivedfungus,Haloroselliniasp.BiotechnologyLetters34(11):2119-2124.
19.MenghaoCai,XiangshanZhou*,JianLu,WeiminFan,JiushunZhou,ChuanpengNiu,LiKang,XunqianSun,YuanxingZhang*(2012)Anintegratedcontrolstrategyforthefermentationofthemarine-derivedfungusAspergillusglaucusfortheproductionofanti-cancerpolyketide.MarineBiotechnology14(6):665-671.
20.ShunqingLiang,HaizhenWu*,BingLiu,JingfanXiao,QiyaoWang,YuanxingZhang(2012)Immuneresponseofturbot(ScophthalmusmaximusL.)toabroadspectrumvaccinecandidate,recombinantglyceraldehyde-3-phosphatedehydrogenaseofEdwardsiellatarda.VeterinaryImmunologyandImmunopathology150(3-4):198-205.
21.MenghaoCai,XueqianSun,XiangshanZhou*,YuanxingZhang*(2012)Rolesofcobaltinbiosynthesisstimulationofacytotoxiccompoundfrommarine-derivedAspergillusglaucus.ProcessBiochemistry47(12):2267-2274.
22.SanyingWang,QinLiu*,MenghaoCai,QiyaoWang,YuanxingZhang(2013)FermentationpreparationofrecombinantVibrioanguillarumvaccinewithheterogeneousantigendisplay.PreparativeBiochemistryandBiotechnology43(1):79-94.
23.YuanzhiLv,JunyuanZheng,MinjunYang,YuanxingZhang,QiyaoWang*(2013)AnEdwardsiellatardamutantlackingUDP-glucosedehydrogenaseshowspleiotropicphenotypes,attenuatedvirulence,andpotentialasavaccinecandidate.VeterinaryMicrobiology,accepted.
24.LiliSheng,QiyaoWang*,HonghongHe,QinLiu,MinjunYang,YuanzhiLv,YuanxingZhang*(2013)ConnectingtypeVIsecretion,quorumsensing,andc-di-GMPproductioninfishpathogenVibrioalginolyticusthroughphosphatasePppA.VeterinaryMicrobiology,accepted.
25.YaminWang,QiyaoWang*,WeizhengYang,BingLiu,YuanxingZhang(2013)FunctionalcharacterizationofEdwardsiellatardatwin-argininetranslocationsystemrevealsitsessentialrolesinresponsetosaltstressandpotentialuseasnovelbiologicalcontainmentforliveattenuatedvaccineinmarinefishvaccinology.AppliedMicrobiologyandBiotechnology,accepted.
26.王三营,刘琴*,王启要,张元兴(2012)利用响应面法优化鳗弧菌载体疫苗MVAV6203A-1冷冻干燥保护剂配方.水产科学31(2):93-97.
27.马悦,张元兴(2012)海水养殖鱼类疫苗开发市场分析.水产前沿(5):55-59.
28.马悦,张元兴(2012)如何给工业化养殖鲆鲽鱼接种疫苗.水产前沿(11):72-76.
29.龚迪,易小萍*,张元兴(2012)MDCK细胞微载体悬浮培养放大工艺研究.中国生物工程杂志32(9):55-60.
30.牛传朋,蔡孟浩,李晓霞,周祥山*,张元兴(2012)海洋真菌Xylariasp.(No.2508)生产xyloketalB的发酵优化.工业微生物42(4):43-47.

2011年以前发表的主要文章:

1.MenghaoCai,XiangshanZhou*,JianLu,WeiminFan,ChuanpengNiu,JiushunZhou,XueqianSun,LiKang,YuanxingZhang*(2011)EnhancingaspergiolideAproductionfromashear-sensitiveandeasy-foamingmarine-derivedfilamentousfungusAspergillusglaucusbyoxygencarrieradditionandimpellercombinationinabioreactor.BioresourceTechnology102(3):3584-3586.
2.XiaodanCao,QiyaoWang,QinLiu*,HaopengRui,HuanLiu,YuanxingZhang*(2011)IdentificationofaluxO-regulatedextracellularproteinPepanditsrolesinmotilityinVibrioalginolyticus.MicrobialPathogenesis50(2):123-131.
3.LuCheng,XiangmingSun,XiaopingYi,YuanxingZhang*(2011)TransientgeneexpressionofamousehomologofFc?-Fc?fusionproteinforanti-allergicfunctionassay.ProcessBiochemistry46(4):858-863.
4.XinWang,QiyaoWang*,MinjunYang,JingfanXiao,QinLiu,HaizhenWu,YuanxingZhang*(2011)QseBCcontrolsflagellarmotility,fimbrialhemagglutinationandintracellularvirulenceinfishpathogenEdwardsiellatarda.Fish&ShellfishImmunology30(3):944-953.
5.HonghongHe,QiyaoWang,LiliSheng,QinLiu*,YuanxingZhang*(2011)FunctionalcharacterizationofVibrioalginolyticustwin-argininetranslocationsystem:itsrolesinstressadaptationandvirulencetowardsfish.CurrentMicrobiology62(4):1193-1199.
6.YanhuaPan,WeiWei,HongyanXu,QiyaoWang,QinLiu,HaizhenWu*,YuanxingZhang*(2011)DifferentialgeneexpressioninJapaneseflounder(Paralichthysolivaceus)inducedbyliveattenuatedVibrioanguillarum.AquacultureResearch42(7):1042-1049.
7.HuanLiu,QiyaoWang*,QinLiu,XiaodanCao,CunbinShi,YuanxingZhang*(2011)RolesofHfqinthestressadaptationandvirulenceinfishpathogenVibrioalginolyticusanditspotentialapplicationasatargetforliveattenuatedvaccine.AppliedMicrobiologyandBiotechnology91(2):353-364.
8.LingyuGuan,WeiMu,JonathanChampeimont,QiyaoWang,HaizhenWu,JingfanXiao,WernerLubitz,YuanxingZhang,QinLiu*(2011)Iron-regulatedlysisofrecombinantEscherichiacoliinhostreleasesprotectiveantigenandconfersbiologicalcontainment.InfectionandImmunity79(7):2608-2618.
9.PinLv,YingjieZhao,FeiQi,XiangshanZhou*,JinhuaYou,YufengQin,YuanxingZhang(2011)AuthenticationofequineDNAfromhighlyprocesseddonkey-hideglue(collacoriiasini)usingSINEelement.JournalofFoodandDrugAnalysis19(2):123-130.
10.LuCheng,XiangmingSun,XiaopingYi,YuanxingZhang*(2011)Large-scaleplasmidpreparationfortransientgeneexpression.BiotechnologyLetters33(8):1559-1564.
11.YanZhao,QinLiu*,XiuhuaWang,LingyunZhou,QiyaoWang,YuanxingZhang*(2011)SurfacedisplayofAeromonashydrophilaGAPDHinattenuatedVibrioanguillarumtodevelopanovelmultivalentvectorvaccine.MarineBiotechnology13(5):963-970.
12.JingfanXiao,TaoChen,QiyaoWang*,QinLiu,XinWang,YuanzhiLv,HaizhenWu,YuanxingZhang*(2011)Searchforliveattenuatedvaccinecandidateagainstedwardsiellosisbymutatingvirulence-relatedgenesoffishpathogenEdwardsiellatarda.LettersinAppliedMicrobiology53(4):430-437.
13.XiaonuoTeng,XiaopingYi,XiangmingSun,YuanxingZhang*(2011)Modelingandapplicationofcontrolled-fedperfusioncultureofCHOcellsinabioreactor.ChemicalandBiochemicalEngineeringQuarterly25(3):385-394.
14.YanXiao,QinLiu*,HaoChen,YuanxingZhang(2011)AstableplasmidsystemforheterologousantigenexpressioninattenuatedVibrioanguillarum.Vaccine29(40):6986-6993.
15.LiKang,MenghaoCai,ChaoYu,YuanxingZhang,XiangshanZhou*(2011)Improvedproductionoftheanticancercompound1403CbyglucosepulsefeedingofmarineHaloroselliniasp.(No.1403)insubmergedculture.BioresourceTechnology102(22):10750?10753.
16.WeiMu,LingyuGuan,YijianYan,QinLiu*,YuanxingZhang(2011)AnovelinvivoinducibleexpressionsysteminEdwardsiellatardaforpotentialapplicationinbacterialpolyvalencevaccine.Fish&ShellfishImmunology31(6):1097-1105.
17.YaminWang,QiyaoWang*,JingfanXiao,QinLiu,HaizhenWu,YuanxingZhang(2011)GeneticrelationshipsofEdwardsiellastrainsisolatedinChinaaquaculturerevealedbyrep-PCRgenomicfingerprintingandinvestigationofEdwardsiellavirulencegenes.JournalofAppliedMicrobiology111(6):1337-1348.
18.WeiWei,HaizhenWu*,HongyanXu,TengChu,ChangwenWu,KangmeiChang,YuanxingZhang*(2010)CloningandmolecularcharacterizationoflycC1INHgenesinlargeyellowcroaker(Pseudosciaenacrocea).Fish&ShellfishImmunology28(1):221-227.
19.XueqianSun,XiangshanZhou*,MenghaoCai,JiushunZhou,YuanxingZhang*(2010)Significantstimulationofo-phthalicacidinbiosynthesisofaspergiolideAbyamarinefungusAspergillusglaucus.BioresourceTechnology101(10):3609-3616.
20.LingyunZhou,XiuhuaWang,QinLiu*,QiyaoWang,YanZhao,YuanxingZhang*(2010)Anovelmultivalentvaccinebasedonsecretaryantigen-deliveryinducesprotectiveimmunityagainstVibrioanguillarumandAeromonashydrophila.JournalofBiotechnology146(1-2):25-30.
21.HaopengRui,JenniferM.Ritchie,RoderickT.Bronson,JohnJ.Mekalanos,YuanxingZhang,MatthewK.Waldor*(2010)Reactogenicityoflive-attenuatedVibriocholeraevaccinesisdependentonflagellins.ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica107(9):4359-4364.
22.XiaodanCao,QiyaoWang,QinLiu*,HuanLiu,HonghongHe,YuanxingZhang*(2010)VibrioalginolyticusMviNisaLuxO-regulatedproteinandaffectscytotoxicitytowardEPCcell.JournalofMicrobiologyandBiotechnology20(2):271-280.
23.XiaoZhang,WeiWei,HaizhenWu*,HongyanXu,KangmeiChang,YuanxingZhang*(2010)GenecloningandcharacterizationofferritinHandMsubunitsfromlargeyellowcroaker(Pseudosciaenacrocea).Fish&ShellfishImmunology28(5-6):735-742.
24.MenghaoCai,XiangshanZhou*,JiushunZhou,ChuanpengNiu,XueqianSun,YuanxingZhang*(2010)EfficientstrategyforenhancingaspergiolideAproductionbycitratefeedingsanditseffectsonsexualdevelopmentandgrowthofmarine-derivedfungusAspergillusglaucus.BioresourceTechnology101(15):6059-6068.
25.CuihongDu,XiaopingYi,YuanxingZhang*(2010)ExpressionandpurificationofsolublerecombinanthumanendostatininEscherichiacoli.BiotechnologyandBioprocessEngineering15(2):229-235.
26.PingZhang,WenwenZhang,XiangshanZhou*,PengBai,JamesM.Cregg,YuanxingZhang*(2010)CataboliterepressionofAoxinPichiapastorisisdependentonhexosetransporterPpHxt1andpexophagy.AppliedandEnvironmentalMicrobiology76(18):6108-6118.
27.XinWang,QiyaoWang,JingfanXiao,QinLiu*,HaizhenWu,YuanxingZhang*(2010)HemolysinEthAinEdwardsiellatardaisessentialforfishinvasioninvivoandinvitroandregulatedbytwo-componentsystemEsrA-EsrBandnucleoidproteinHhaEt.FishandShellfishImmunology29(6):1082-1091.
28.SuxiaLi,HaizhenWu,JianZhao,LingOu,YuanxingZhang*(2010)Abiochemistryandmolecularbiologyexperimentandevaluationsystemforbiotechnologyspecialtystudents.BiochemistryandMolecularBiologyEducation38(4):271-275.
29.LiliXu,QiyaoWang,JingfanXiao,QinLiu*,XinWang,TaoChen,YuanxingZhang*(2010)CharacterizationofEdwardsiellatardawaaL:rolesinlipopolysaccharidebiosynthesis,stressadaptation,andvirulencetowardfish.ArchivesofMicrobiology192(12):1039-1047.
30.QiyaoWang,MinjunYang,JingfanXiao,HaizhenWu,XinWang,YuanzhiLv,LiliXu,HuajunZheng,ShengyueWang,GuopingZhao,QinLiu*,YuanxingZhang*(2009)GenomesequenceoftheversatilefishpathogenEdwardsiellatardaprovidesinsightsintoitsadaptationtobroadhostrangesandintracellularniches.PLoSOne4(10):e7646.
31.HaopengRui,QinLiu,QiyaoWang,YueMa,HuanLiu,CunbinShi,YuanxingZhang*(2009)RoleofalkalineserineproteaseAspinVibrioalginolyticusvirulenceandregulationofitsexpressionbyLuxO-LuxRregulatorysystem.JournalofMicrobiologyandBiotechnology19(5):431-438.
32.WeiWei,HaizhenWu,HongyanXu*,TaoXu,XiaoZhang,KangmeiChang,YuanxingZhang*(2009)CloningandmolecularcharacterizationoftwocomplementBf/C2genesinlargeyellowcroaker(Pseudosciaenacrocea).Fish&ShellfishImmunology27(2):285-295.
33.XinWang,QiyaoWang*,JingfanXiao,QinLiu,HaizhenWu,LiliXu,YuanxingZhang*(2009)EdwardsiellatardaT6SScomponentevpPisregulatedbyesrBandiron,andplaysessentialrolesintheinvasionoffish.FishandShellfishImmunology27(3):469-477.
34.YuanxingZhang(2009)Approachestooptimizinganimalcellcultureprocess:substratemetabolismregulationandproteinexpressionimprovement.AdvancesinBiochemicalEngineering/Biotechnology113:177-215.
35.QiyaoWang,ZhaoYang,QinLiu*,YuanxingZhang*(2009)Surface-exposedexpressionofEdwardsiellatardaEseBinliveattenuatedVibrioanguillarumbasedonnovelsurfacedisplaysystems.AquacultureResearch40(13):1459-1467.
36.JingfanXiao,QiyaoWang,QinLiu,XinWang,HuanLiu,YuanxingZhang*(2009)IsolationandidentificationoffishpathogenEdwardsiellatardafrommaricultureinChina.AquacultureResearch40(1):13-17.
37.MenghaoCai,XiangshanZhou*,XueqianSun,KejingTao,YuanxingZhang*(2009)StatisticaloptimizationofmediumcompositionforaspergiolideAproductionbymarine-derivedfungusAspergillusglaucus.JournalofIndustrialMicrobiology&Biotechnology36(3):381-389.
38.JingfanXiao,QiyaoWang*,QinLiu,LiliXu,XinWang,HaizhenWu,YuanxingZhang*(2009)CharacterizationofEdwardsiellatardarpoS:itsrolesincontrollingserumresistance,chondroitinaseactivity,biofilmformation,andautoinducersynthetasesexpression.AppliedMicrobiologyandBiotechnology83(1):151-160.
39.WeiWei,HongyanXu*,QiyaoWang,XiaoZhang,KangmeiChang,ChangwenWu,YuanxingZhang*(2009)Identificationofdifferentiallyexpressedgenesinlargeyellowcroaker(Pseudosciaenacrocea)inducedbyattenuatedliveVibrioanguillarum.Aquaculture291(1-2):124-129.
40.XueqianSun,XiangshanZhou*,MenghaoCai,KejingTao,YuanxingZhang*(2009)IdentifiedbiosyntheticpathwayofaspergiolideAandanovelstrategytoincreaseitsproductioninamarine-derivedfungusAspergillusglaucusbyfeedingofbiosyntheticprecursorsandinhibitorssimultaneously.BioresourceTechnology100(18):4244-4251.
41.JingYe,YueMa,QinLiu,DonglingZhao,QiyaoWang,YuanxingZhang*(2008)RegulationofVibrioalginolyticusvirulencebytheLuxSquorum-sensingsystem.JournalofFishDiseases31(3):161-169.
42.ChunWei,XiangshanZhou,YuanxingZhang*(2008)ImprovingintracellularproductionofrecombinantproteininPichiapastorisusinganoptimizedpreinductionglycerol-feedingscheme.AppliedMicrobiologyandBiotechnology78(2):257-264.
43.ZheyongMa,XiaopingYi,YuanxingZhang*(2008)EnhancedintracellularaccumulationofrecombinantHBsAginCHOcellsbydimethylsulfoxide.ProcessBiochemistry43(6):690-695.
44.WeiyuanZhang,XiaopingYi,XiangmingSun,YuanxingZhang*(2008)Surfacemodificationofnon-wovenpoly(ethyleneterephthalate)fabricscaffoldforimprovingcellattachmentinanimalcellculture.JournalofChemicalTechnologyandBiotechnology83(6):904-911.
45.YangTian,QiyaoWang,QinLiu,YueMa,XiaodanCao,LingyuGuan,YuanxingZhang*(2008)InvolvementofLuxSintheregulationofmotilityandflagellarbiogenesisinVibrioalginolyticus.Bioscience,Biotechnology,andBiochemistry72(4):1063-1071.
46.LingyunZhou,QinLiu*,QiyaoWang,YueMa,YuzhouXu,ZhaoYang,YanZhao,YuanxingZhang*(2008)SecretarydeliveryofheterologousproteinsinattenuatedVibrioanguillarumforpotentialuseinvaccinedesign.AppliedMicrobiologyandBiotechnology79(6):1027-1034.
47.ZhaoYang,QinLiu,QiyaoWang,YuanxingZhang*(2008)Genecloningandexpressionofmajorcapsidproteinoflargeyellowcroakeriridovirusanditssecretionbasedon?-haemolysintransportsystem.JournaloftheWorldAquacultureSociety39(6):774-780.
48.ZhaoYang,QinLiu*,QiyaoWang,YuanxingZhang*(2008)NovelbacterialsurfacedisplaysystemsbasedonoutermembraneanchoringelementsfromthemarinebacteriumVibrioanguillarum.AppliedandEnvironmentalMicrobiology74(14):4359-4365.
49.TingXie,QinLiu*,FushengXie,HaifengLiu,YuanxingZhang*(2008)SecretoryexpressionofinsulinprecursorinPichiapastorisandsimpleprocedureforproducingrecombinanthumaninsulin.PreparativeBiochemistryandBiotechnology38(3):308-317.
50.HaopengRui,QinLiu,YueMa,QiyaoWang,YuanxingZhang*(2008)RolesofLuxRinextracellularalkalineserineproteaseAexpression,extracellularpolysaccharideproductionandmobilityofVibrioalginolyticus.FEMSMicrobiologyLetters285(2):155-162.
51.YuzhouXu,QinLiu*,LingyunZhou,ZhaoYang,YuanxingZhang*(2008)SurfacedisplayofGFPbyPseudomonassyringaetruncatedicenucleationproteininattenuatedVibrioanguillarumstrain.MarineBiotechnology10(6):701-708.
52.YangTian,QiyaoWang,QinLiu,YueMa,XiaodanCao,YuanxingZhang*(2008)RoleofRpoSinstresssurvival,synthesisofextracellularautoinducer2,andvirulenceinVibrioalginolyticus.ArchivesofMicrobiology190(5):585-594.
53.QiyaoWang,QinLiu,XiaodanCao,MinjunYang,YuanxingZhang*(2008)CharacterizationoftwoTonBsystemsinmarinefishpathogenVibrioalginolyticus:theirrolesinironutilizationandvirulence.ArchivesofMicrobiology190(5):595-603.
54.HongzhongWu,XinLiang,YishiFang,XiaoranQin,YuanxingZhang*,JianwenLiu*(2008)Resveratrolinhibitshypoxia-inducedmetastasispotentialenhancementbyrestrictinghypoxia-inducedfactor-1?expressionincoloncarcinomacells.Biomedicine&Pharmacotherapy62(9):613-621.
55.WenyingWang,XiaopingYi,YuanxingZhang*(2007)Genetranscriptionacceleration:maincauseofhepatitisBsurfaceantigenproductionimprovementbydimethylsulfoxideinthecultureofChinesehamsterovarycells.BiotechnologyandBioengineering97(3):526-535.
56.HongzhongWu,FanYang,ShuyaCui,YufengQin,JianwenLiu*,YuanxingZhang*(2007)Hematopoieticeffectoffractionsfromtheenzyme-digestedcollacoriiasinionmicewith5-fluorouracilinducedanemia.TheAmericanJournalofChineseMedicine35(5):853-866.
57.LuYang,YueMa,YuanxingZhang*(2007)Freeze-dryingofliveattenuatedVibrioanguillarummutantforvaccinepreparation.Biologicals35(4):265-269.
58.XiangmingSun,YuanxingZhang*(2007)Acell-detachingreactorforinoculationofanchorage-dependentCHOandVerocellsbetweenstepwise-expandedbioreactors.BiotechnologyLetters29(5):697-701.
59.QinLiu,PengboWang,YueMa,YuanxingZhang*(2007)CharacterizationofVibrioalginolyticusfurgeneandlocalizationofessentialaminoacidsitesinFurbyinvitrosite-directedmutagenesis.JournalofMolecularMicrobiologyandTechnology13(1-3):15-21.
60.LimingOuyang,LingOu,YuanxingZhang*(2007)Anintegratedteachingstrategyforteachingbiochemistrytobiotechnologyspecialtystudents.BiochemistryandMolecularBiologyEducation35(4):267-271.
61.QiyaoWang,QinLiu,YueMa,HaopengRui,YuanxingZhang*(2007)LuxOcontrolsextracellularprotease,hemolyticactivitiesandsiderophoreproductioninfishpathogenVibrioalginolyticus.JournalofAppliedMicrobiology103(5):1525-1534.
62.QiyaoWang,QinLiu,YueMa,YuanxingZhang*(2007)Isolation,sequencingandcharacterizationofclustergenesinvolvedinthebiosynthesisandtransportationofthesiderophoreofmarinefishpathogenVibrioalginolyticus.ArchivesofMicrobiology188(4):433-439.
63.HaiyanHuang,YihuaYu,XiaopingYi,YuanxingZhang*(2007)NitrogenmetabolismofasparagineandglutamateinVerocellsstudiedby1H/15NNMRspectroscopy.AppliedMicrobiologyandBiotechnology77(2):427-436.
64.FangZhang,XiangmingSun,XiaopingYi,YuanxingZhang*(2006)MetaboliccharacteristicsofrecombinantChinesehamsterovarycellsexpressingglutaminesynthetaseinpresenceandabsenceofglutamine.Cytotechnology51(1):21-28.
65.AnfengXiao,XiangshanZhou,LiZhou,YuanxingZhang*(2006)ImprovementofcellviabilityandhirudinproductionbyascorbicacidinPichiapastorisfermentation.AppliedMicrobiologyandBiotechnology72(4):837-844.
66.HaiyanHuang,XiaopingYi,YuanxingZhang*(2006)ImprovementofVerocellgrowthinglutamate-basedculturebysupplementingammoniageniccompounds.ProcessBiochemistry41(12):2386-2392.
67.HechunZhang,JixunZhan,KemanSu,YuanxingZhang*(2006)AkindofpotentialfoodadditiveproducedbyStreptomycescoelicolor:characteristicsofbluepigmentandidentificationofanovelcompound,?-actinorhodin.FoodChemistry95(2):186-192.
68.JunhuiLi,ZhengyuHuang,XiangmingSun,PengyuanYang,YuanxingZhang*(2006)UnderstandingtheenhancedeffectofdimethylsulfoxideonhepatitisBsurfaceantigenexpressioninthecultureofChinesehamsterovarycellsonthebasisofproteomeanalysis.EnzymeandMicrobiolTechnology38(3-4):372-380.
69.JunhuiLi,XiangmingSun,YuanxingZhang*(2006)ImprovementofhepatitisBsurfaceantigenexpressionbydimethylsulfoxideinthecultureofrecombinantChinesehamsterovarycells.ProcessBiochemistry41(2):317-322.
70.QinLiu,YueMa,LingyunZhou,YuanxingZhang*(2006)Genecloning,expressionandfunctionalcharacterizationofanacylcarrierproteinAcpVfromVibrioanguillarum.ArchivesofMicrobiology185(2):159-163.
71.HaifengLiu,XiangshanZhou,YuanxingZhang*(2006)Acomparativeinvestigationondifferentrefoldingstrategiesofrecombinanthumantissue-typeplasminogenactivatorderivative.BiotechnologyLetters28(7):457-463.
72.QinLiu,YueMa,LingyunZhou,YuanxingZhang*(2005)GenecloningandfunctionalcharacterizationofaphosphopantetheinyltransferasefromVibrioanguillarumserotypeO1.AchievesofMicrobiology183(1):37-44.
73.SubiaoLu,XiangmingSun,YuanxingZhang*(2005)InsightintometabolismofCHOcellsatlowglucoseconcentrationonthebasisofthedeterminationofintracellularmetabolites.ProcessBiochemistry40(5):1917-1921.
74.JuxingChen,XiangmingSun,YuanxingZhang*(2005)GrowthandmetabolismofmarinefishChinooksalmonembryocells:Responsetolackofglucoseandglutamine.BiotechnologyLetters27(6):395-401.
75.JuxingChen,XiangmingSun,LiZhang,XiaopingYi,YuanxingZhang*(2005)MasscultivationofmarinefishChinooksalmonembryocellsinbioreactorwithlow-serummedium.Aquaculture249(1-4):35-45.
76.MingfeiShao,YueMa,QinLiu,YuanxingZhang*(2005)SecretoryexpressionofrecombinantproteinsinanattenuatedVibrioanguillarumstrainforpotentialuseinvaccines.JournalofFishDiseases28(6):723-728.
77.XiangmingSun,YuanxingZhang*(2004)GlutaminecannotsupportrecombinantCHOcellgrowthandmaintenanceintheabsenceofglucose.ProcessBiochemistry39(6):719-722.
78.LiZhang,HongShen,YuanxingZhang*(2004)Fed-batchcultureofhybridomacellsinserum-freemediumusinganoptimizedfeedingstrategy.JournalofChemicalTechnologyandBiotechnology79(2):171-181.
79.XiaopingYi,XiangmingSun,YuanxingZhang*(2004)EffectsofosmoticpressureonrecombinantBHKcellgrowthandvonwillebrandfactor(vWF)expression.ProcessBiochemistry39(11):1817-1823.
80.QinLiu,YueMa,HaizhenWu,MingfeiShao,HaifengLiu,YuanxingZhang*(2004)Cloning,identificationandexpressionofanentEhomologueangEfromVibrioanguillarumserotypeO1.ArchivesofMicrobiology181(4):287-293.
81.WeibinZhou,YuanxingZhang*(2004)PurificationandidentificationofrecombinanthirudinanditsdegradationderivativesexpressedinPichiapastoris.PreparativeBiochemistry&Biotechnology34(3):239-252.
82.JizhongYang,XiangshanZhou,YuanxingZhang*(2004)ImprovementofrecombinanthirudinproductionbycontrollingNH4+concentrationinPichiapastorisfermentation.BiotechnologyLetter26(12):1013-1017.
83.YuanxingZhang*,LinDai,XiangmingSun(2003)KineticaspectofhepatitisBsurfaceantigenproductioninrecombinantSaccharomycescerevisiaefermentation.ProcessBiochemistry38(11):1593-1598.
84.XiangmingSun,YuanxingZhang*(2003)Estimationofcelldensityinpacked-bedbioreactorbylactateproductionrate.BiotechnologyLetters25(11):853-857.
85.SubiaoLu,XiangmingSun,ChaoouShi,YuanxingZhang*(2003)Determinationoftricarboxylicacidcycleacidsandotherrelatedsubstancesinculturedmammaliancellsbygradiention-exchangechromatographywithsuppressedconductivitydetection.JournalofChromatographyA1012(2):161-168.
86.XiangshanZhou,JianLu,WeiminFan,YuanxingZhang*(2002)DevelopmentofaresponsivemethanolsensoranditsapplicationinPichiapastorisfermentation.BiotechnologyLetters24(8):643-646.
87.XiangshanZhou,YuanxingZhang*(2002)DecreaseofproteolyticdegradationofrecombinanthirudinproducedbyPichiapastorisbycontrollingthespecificgrowthrate.BiotechnologyLetters24(17):1449-1453.
88.JingliXie,YuanxingZhang*,YonghongWang,YuanguangLi(2001)MixotrophiccultivationofPlatymonassubcordiformis.JournalofAppliedPhycology13(4):343-347.
89.XiangmingSun,YuanxingZhang*,WensongTan,YajingZhou,PingHua(2000)AttachmentkineticsofVerocellsontoCT3microcarriers.JournalofBioscienceandBioengineering90(1):32-36.

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上海市梅陇路130号华东理工大学生物工程学院，200237
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