刘顺英 研究员/教授
化学与分子工程学院??????


导航
个人资料
研究方向
开授课程
科研项目
学术成果
荣誉及奖励







个人资料
部门： 化学与分子工程学院
毕业院校： 武汉大学/香港浸会大学
学位： 博士
学历： 研究生
邮编： 课题组主页
联系电话：
传真：
电子邮箱： syliu@sist.ecnu.edu.cn
办公地址： 中山北路理科大楼B1503室
通讯地址： 中山北路3663号

教育经历


2017-2018 哈佛大学/MIT访问**** 导师：Pentlute L.Bradley 教授
2008-2009 牛津大学博士后 导师： Paul D. Beer教授
2005-2006 香港浸会大学联合培养学生、博后 导师：Chan Yong Hong教授
2001-2006 武汉大学硕士博士导师：何永炳教授
1997-2001 湖北师范学院 本科导师：陈年有教授


工作经历

2006年加入华东师范大学至今


个人简介

社会兼职
无

研究方向


主要针对罕见恶性肿瘤，通过基础研究中反应方法学发展高效合成技术，构建特色共价键抑制剂化合物库，结合药物化学及化学生物学等手段开展靶向小分子药物发现的应用研究，主要包括三个方面：

研究方向一：针对含亲电共价键弹头单元的立体多样性化合物库构建的反应方法学研究，属有机合成化学

研究方向二：基于上述共价键抑制剂库针对罕见肿瘤和抗病毒药物的表型药物筛选发现研究，属药物化学

研究方向三：基于上述发现的原创性抗罕见肿瘤新活性化合物的药物探针靶点发现与确证研究，属化学生物学






开授课程
《化学生物学》
《高等有机与药物合成》
《有机合成实验》


科研项目
1. 国家自然科学基金委员会，面上项目，**，基于活泼中间体捕捉的手性季碳构建方法研究，主持
2. 上海市科学与技术委员会，自然科学基金，15ZR**，Rh(I)催化C=C双键捕捉铵基叶立德的多组分反应研究，主持
3. 武汉理工大学，国家重点实验室开放基金，2015-KF-11，纳米材料在多组分反应选择性调控中的应用研究，主持
4. 上海市科学与技术委员会，基础重点项目，12JC**，以高效构建生物活性化合物为导向的高选择性多组分反应，参加
5. 科技部，“973”项目（子课题），2011CB808600，不饱和烃高效转化中的前沿科学问题，参加
6. 国家自然科学基金委员会，青年项目，**，多功能复合阴离子受体的合成及光化学性质研究，主持
7. 上海市科学与技术委员会，科学专项基金，0752nm022，肺癌早期诊断的高靶向纳米复合粒子的制备及其应用研究，共同主持
8. 上海市科学与技术委员会，自然科学基金，07ZR14034，复合材料的多功能阴离子受体的合成及光学传感性质研，主持
9. 企业委托项目，新型抗骨肉瘤小分子靶向药物开发，2000万，主持
10. 企业委托项目，达比加群酯的合成工艺申报及新药注册，370，参与


学术成果

书籍和专利:
1. 《Innovative Drug Synthesis》部分章节撰写， Wiley-VCH, 2015
2. 《现代药物合成》，“十三五国家重点图书”，主笔翻译，华东理工大学出版社，2016
3. 申请国家发明专利45项，已获授权19项。

代表论文：
1.Shunyin Liu, Wenfeng Yao, Yuan Liu, Qinghua Wei, Jianghui Chen, Xiang Wu, Fei Xia*, Wenhao Hu*. ?A Rh(II)-Catalyzed Multicomponent Reaction by Trapping an α-Amino Enol Intermediate in a Traditional Two-component Reaction Pathway. Sci. Adv. 2017, 3, DOI: 10.1126/scieadv.**.
2.Xiaochu Ma, Jun Jiang, Siying Lv, Wenfeng Yao, Yang Yang, Shunying Liu*, Fei Xia and Wenhao Hu*, A YlideTransformation of Rh(I) Carbene: Enantioselective Three-component Reaction via Trapping of Rh(I) Associated Ammonium Ylides by β-Nitroacrylates, Angew. Chem. Int. Ed.53(48), 13136-13139, 2014.
3.Mingfeng Li, Xin Guo, Weifeng Jin, Qing Zheng, Shunying Liu* and Wenhao Hu.* Enantioselective Three-component Reaction of Diazoacetates with Indoles and Enals by Iridium/Iminium Co-catalysis.Chem. Commun., 52, 2736-2739, 2016.
4.Lin Qiu,Xin Guo,Yu Qian,Changcheng Jing,Chaoqun Ma,Shunying Liu,* and Wenhao Hu.* Enantioselective oxidative functionalization of the Csp3–H bond adjacent to a nitrogen atom for rapid access to b-hydroxyl-a-amino acid derivativesChem. Commun., 52, 52(79), 11831-11833, 2016,
5.Lin Qiu,Xin Guo,Chaoqun Ma,Huang Qiu,Shunying Liu,*Liping Yanga andWenhao Hu*. Efficient synthesis of chiral cyclic acetals by metal and Br?nsted acid co-catalyzed enantioselective four-component cascade reactions, Chem. Commun., 50, 2196-2198, 2014.
6.Jiang Jun, Ma Xiaochu, Ji Changge, Guo Zhengqiu, Shi Taodao, Liu Shunying*, Hu Wenhao*. Ruthenium(II)/Chiral Br?nsted Acid Co-Catalyzed Enantioselective Four-Component Reaction/Cascade Aza-Michael Addition for Efficient Construction of 1,3,4-Tetrasubstituted Tetrahydroisoquinolines,Eur. Chem. J.20(6), 1505-1509, 2014.
7.Bo Jiang, Li-Jun Chen, Lin Xu, Shun-Ying Liu* and Hai-Bo Yang*. A series of new star-shaped or branched platinum–acetylide derivatives: synthesis, characterization, and their aggregation behavior, Chem. Commun., 49, 6977-6979, 2013.
8.Suzheng Dong, Yubing Lei,Shikun Jia,Lixin Gao,Jia Li, Tong Zhu, Shunying Liu, * Wenhao Hu.* Discovery of Core-structurally Novel PTP1B Inhibitors with Specific Selectivity Containing Oxindole-fused Spirotetrahydrofurochroman by One-pot Reaction, Bioorg. Med. Chem. Lett.http://dx.doi.org/10.1016/j.bmcl.2016.11.055, 2016.
9.Lin Qiu, Dongwei Wang, Yubing Lei, LixinGao, Shunying Liu,* Jia Li and Wenhao Hu.* Diastereoselective Three-component Cascade Reaction to Construct Novel Oxindole-Fused Spirotetrahydrofuro-Chroman Scaffolds for Drug Discovery. Eur. J. Org. Chem. 2671-2680, 2016.
10.Min Tang, Yong Wu, Yuan Liu, Maoqiang Cai, Fei Xia, Shunying Liu,* and Wenhao Hu.* One-pot Enantioselective Multi-component Cascade Reactions for Synthesis of Chiral Functionalized Hydro-epoxyisochromenes: A Rapid Access to Molecular Complexity.Acta Chim. Sin.74(1), 54-60, 2016. (cover paper)
11.Shi-Kun Jia, Yu-Bing Lei, Long-Long Song, Shun-Ying Liu *, Wen-Hao Hu*, Enantioselective trapping of oxonium ylide intermediates by N-benzhydryl-a-imino ester: Synthesis of b-tetrasubstituted a-amino acids, Chin. Chem. Lett., http://dx.doi.org/10.1016/j.cclet.2016.06.053, 2016.
12.Lin Qiu, Lixin Gao, Jixing Tang, Dongwei Wang, Xin Guo, Shunying Liu,*, Liping Yang, Jia Li, and Wenhao Hu*, Regio- and Diastereoselective Construction of αSulfonylimines, J. Org. Chem.79, 4142?4147, 2014.
13.Zhongshi Liang, Xingui Li, Yegui Xie and Shunying Liu.* ‘Smart’ gold nanoshells for combined cancer chemotherapy and hyperthermia, Biomed. Mater.9, 025012-025022, 2014.
14.Lin Qiu, Dongwei Wang, Fengping Lv, Xin Guo, Wenhao Hu, Liping Yang, Shunying Liu.*Three-component reactions based on trapping ammonium ylides with N-sulfonyl aldimines via cooperative catalysis of squaramides and Rh₂(OAc)₄, Tetrahedron, 70 (71), 1471-1477, 2014.
15.Ni Yi,Guo Xin,Hu Wenhao,Liu Shunying *. Asymmetric N-H Insertion Reaction of α-Diazoesters and Carbamates through Co-catalyzed by Dirhodium Acetate, Sufonic Acid and Chiral Sul-fonamide Urea,Chin. J. Org. Chem.34 (1), 107-111, 2014. (in Chinese)
16.Wang, Chengjin; Liu, Shunying*; Xing, Dong; Wang, Xin; Wu, Xiang; Hu, Wenhao*. Efficient synthesis of a-aryl serine derivatives via three-component reactions of aryldiazoacetates, anilines and formaldehyde. Tetrahedron. 69 (52), 11203-11208, 2013.
17.Lin Qiu, Xin Guo, Jun Zhou, Shunying Liu*, Liping Yang, Xiang Wu and Wenhao Hu*.A Stereoselective Synthesis of Fully Substituted Tetrahydrofurans through 1,3-Dipolar Cycloadditions with Cinnamaldehydes：An Easy Access to Chroman Derivatives.RSC Adv. 3, 20065-20070, 2013.
18.Jun Jiang, Xiaoyu Guan, Shunying Liu, Baiyan Ren, Xiaochu Ma, Xin Guo, Fengping Lv, Xiang Wu, and Wenhao Hu.* Highly Diastereoselective Multicomponent Cascade Reactions: Efficient Synthesis of Functionalized 1-Indanols. Angew. Chem. Int. Ed.52, 1539-1542, 2013.
19.Jun Jiang, Xiaochu Ma, Shunying Liu, Yu Qian, Fengping Lv, Lin Qiu, Wenhao Hu*. Enantioselective Trapping of Phosphoramidate Ammonium Ylides with Imino Esters for Synthesis of -Diamino succinic Acid Derivatives. Chem. Commun. 49 (39), 4238 – 4240, 2013.
20.Yu Qian, Changcheng Jing, Shunying Liu, Wenhao Hu*. A Highly Enantioselective Four-Component Reaction for the Efficient Construction of Chiral ?-Hydroxy-a-Amino Acid Derivatives. Chem. Commun., 49 (26), 2700-2702, 2013.
21.Fengping Lv, Shunying Liu, and Wenhao Hu*. Recent Advances for Chiral Br?nsted Acids as Cooperative Catalysts in Cascade and Multicomponent Reactions. Asian J. Org. Chem. 2 (10), 824-836, 2013.
22.Ma Chaoqun, Xing Dong, Zhai Changwei, Che Jiuwei, Liu Shunying, Wang Jue, Hu Wenhao *, Iron Porphyrin-Catalyzed Three-Component Reaction of Ethyl Diazoacetate with Aliphatic Amines and beta,gamma-Unsaturated alpha-Keto Esters, Org. Lett., 15(24), 6140-6143, 2013.
23.Qiu Huang, Zhang Dan, Liu Shun-ying, Qiu Lin, Zhou Jun, Qian Yu, Zhai Chang-wei, Hu Wen-hao*, Asymmetric C-H functionalization of indoles via enantioselective protonation, Acta Chim. Sinica, 70(24): 2484-2488,2012.(cover paper)
24.Jiang Jun, Guo ZhenQiu, Zhang ZhiYong, Liu ShunYing, Ma XiaoChu, Zeng YunXiang & Hu WenHao. Rh2(OAc)4-AuCl3 synergistic catalysis in cyclization/three-component reactions for concise synthesis of isochromenes,Chin. Sci. Bull.58, 18, 1695-1700, 2013 (in Chinese). (cover paper)
25.Liang Zhongshi, Wu xianrong, Liu Shunying *, Xie Yegui. A Facile Approach to Fabricate Water-soluble Au-Fe3O4 Nanoparticle for Liver Cancer Cells Imaging. Chin. J Chem., 30(7), 1387-1392, 2012.
26.Liang Zhongshi, Liu Yun, Liu Shunying*, Li Xianyang. Surface-modified gold nanoshells for enhanced cellular uptake，J. Biomed. Mater. Res. A, 98(4), 479-487, 2011.
27.Liang Zhongshi, Liu Yun, Liu Shunying* ，The effect of pH value on the formation of gold nanoshells ，J. Nanopart. Res.,13(8), 3301-3311, 2011.
28.Liu Yanyun, Liu Yun, Liu Shunying*, Yu Jiahui*. Enhanced Sensitivity and Selectivity of Chemosensor for Malonate by Anchoring on Gold Nanoparticles，Chin. J Chem., 29(3), 531-538, 2011.
29.梁重时, 段孔荣，余家会，刘顺英*。小分子化合物表面修饰对金/二氧化硅纳米核壳粒子结构的影响，功能材料, 41(9), 1511-1515, 2011.
30.Liu SY, Liang ZS, Gao F, Luo SF, Lu GY. In Vitro Photothermal Study of Gold Nanoshells Functionalized with Small Targeting Peptides to Liver Cancer Cells, J. Mater. Sci. Mater. Med.,21, 665-674, 2010.
31.Liu SY, Liang ZS, Gao F, Yu JH, Luo SF, Calata JN, LU GQ. A Facile Approach to the Synthesis of Gold Nanoshells with Near Infrared Responsive Properties, Chin. J. Chem., 7, 1-10, 2009.
32.Liu SY, Liang ZS, Zhang SY, Gao F, Yu JH, Luo SF. Size Control of Silica Nanoparticles by Optimizing the method of St?ber,J. East Chi. Normal Uni.,2, 112-121, 2009.
33.Liu SY, He YB, Chan WH, Lee A. W. M., Cholic Acid-based High Sensitivity Fluorescent Sensor for α,ω- Dicarboxylate: an intramolecular excimer emission quenched by complexation, Tetrahedron, 62, 11687- 11696, 2006.
34.Liu SY, Law KY, He YB, Chan WH, Fluorenscent enantioselective receptor for S-mandelate anion based on cholic acid,Tetrahedron Lett., 47, 7857-7860, 2006.
35.Liu SY, Fang L, He YB, Chan WH, Yang RH. A cholic acid-based fluorescent sensor for dicarboxylates and acidic amino acids in aqueous solutions. Org. Lett., 7, 5825-5828, 2005.
36.Liu SY, He YB, Qing GY, Xu KX, Qin HJ. Fluorescent sensors for amino acid anions based on calix[4]arenes bearing two dansyl groups，Tetrahedron Asym., 16, 1527-1534, 2005.
37.Liu SY, He YB, Wu JL, Wei LH, Qin HJ, Meng LZ, Hu L. Calix[4]arenes containing thiourea and amide moieties: neutral receptors towards alpha,omega-dicarboxylate anions, Org. Biomol. Chem.2 , 1582-1586, 2004.
38.Liu SY, Xu KX, He YB, Qin HJ, Meng LZ. New neutral receptors for fluoride based on calix[4]arene bearing thiourea and amide, Chin. J. Chem., 23, 321-325, 2005.
39.Liu SY, Wang FJ, Wei LH, Xiao W, Meng LZ, He YB. Synthesis and anion recognition of neutral receptors based on multiamide calix[4]arene,Sci. Chin. Ser. B Chem. 47, 145-151, 2004.
40.Hong J, HuangJ, Liu SY, et al. ,J. Appl. Polymer Sci. 111, 2844-2850, 2009.
41.Wang CY, Gong YB, Fan NQ, Liu SY, Luo SF, Yu JH, Huang J. Fabrication of Polymer-Platinum (II) Complex Nanomicelle from mPEG-g-α, β-Poly [(N-amino acidyl)-DL-aspartamide] and cis-Dichlorodiammine Platinum (II) and Its Cytotoxicity, Colloids Surf.B:Biointer,70, 84-90, 2009.
42.Gong YB, Fan MX, Gao F, Hong J, Liu SY, Luo SF, Yu JH, Huang J, Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications, Colloids Surf.B:Biointer, 71, 243-247, 2009.
43.Qing GY, Liu SY, He YB, , Prog. Chem. 20, 1933-1944, 2008.
44.舒婕，李建齐，徐敏，罗淑芳，刘顺英，余家会，丛蓉，杜冰，肝组织特异性非离子型高分子磁共振造影剂的制备及性能评价, 高分子学报, 2, 116-122, 2008.
45.宫彦宝，王成运，刘顺英，罗淑芳，黄进，余家会，刘仕远，光聚合一步可控合成表面氨化的核壳型超顺磁性纳米凝胶及其表征，核技术, 31, 751-755, 2008.
46.Wang CY, Gong YB, Liu SY,et al. , Chem. J. Chin. Univ. Chin.29, 1665-1670, 2008.
47.XuKX, He YB, QingGY, Qin HJ, Liu SY, Meng LZ, Synthesis and enantioselective discrimination of chiral fluorescence receptors bearing anion acid units, Chin. J. Chem. 25, 390-394, 2007.
48.Qing GY, He YB, Zhao Y, Hu CG, Liu SY, Yang X. Calix[4]arene-based Chromogenic Chemosensor for Alpha-phenylglycine anion: Synthesis and chiral recognition，Eur. J. Org, Chem., 1574-1580, 2006.
49.Xu KX, Liu SY, He YB, Qin HJ, Qing GY, Hu L, Study on Synthesis and Chiral Recognition of Chiral Hosts Containing Amino Acid Unit, Acta Chin. Sin. , 64, 2205-2209, 2006.
50.Wei LH, He YB, Xu KX, Liu SY, Meng LZ, Chiral fluorescent receptors based on (R)-1,1 ''-binaphthylene-2,2 ''-bisthiourea: Synthesis and chiral recognition,Chin. J. Chem., 23, 757-761, 2005.
51.Xu KX, Wu XJ, He YB, Liu SY, Qing GY, Meng LZ. Synthesis and chiral recognition of novel chiral fluorescence receptors bearing 9-anthryl moieties, Tetrahedron Asym.16, 833-839, 2005.
52.Xu KX, He YB, Qin HJ, Qing GY, Liu SY. Enantioselective recognition by ptically active chiral fluorescence sensors bearing amino acid units, Tetrahedron Asym. 16, 3042-3048, 2005.
53.Zeng ZY, Xu KX, He YB, Liu SY, Wu JL, Wei LH, Meng LZ. Amide-based fluorescent macrocyclic anion receptors, Chin. J. Chem. 22, 1372-1376, 2004.
54.Wu JL, He YB, Wei LH, Liu SY, Meng LZ, Hu L. Anionic fluororeceptors based on thiourea and hydrazide: Synthesis and recognition properties, Supramol. Chem.,16, 353-359, 2004.
55.Zeng ZY, He YB, Wu JL, Wei LH, Liu SY, Huang YY, Meng LZ, Hu L. A multi-armed neutral receptor for alpha, omega-dicarboxylate anions, Supramol. Chem.,16, 233-238, 2004.
56.Wu JL, Wei LH, Zeng ZY, Liu SY, Gong R, Meng LZ, He YB. Synthesis of novel anioni c receptors with (Thio) urea and amide binding sites and the recognition properties for anions, Chin. J. Chem. 21, 1553-1557, 2003.


荣誉及奖励
1.上海市自然科学奖一等奖，第二完成人（2016年度）；
2.教育部自然科学奖二等奖?第三完成人（2009年度）；
3.国际学术杂志Tetrahedron: Asymmetry2005-2008年度最高引用论文奖?第一作者（2008年度）；
4.第一届“中国百篇最具影响优秀国际学术论文”奖?第一作者（2007年度）；
5.环保型纸浆漂白剂中试项目获武汉市科学技术成果鉴定?主要参与者（2004年度）。



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