吕伟 教授 职称：
直属机构： 化学与分子工程学院
学科：





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个人资料
部门： 化学与分子工程学院
性别： 男
专业技术职务： 教授
毕业院校： 中国科学院上海药物研究所
学位： 理学博士
学历： 博士研究生
联系电话：
电子邮箱： wlu@chem.ecnu.edu.cn
办公地址： 中山北路校区 理科大楼B414室
通讯地址： 上海市中山北路3663号 理科大楼B423
邮编： 200062
传真：

教育经历
1988.7-1992.7 大连理工大学 化工学院 工学学士
1992.9-1995.7 大连理工大学 化工学院 工学硕士
1995.9-1998.7 中国科学院上海药物研究所 理学博士


工作经历
1998.8-1999.8 威斯康星大学 药学院 研究助理
1999.9-2001.12 中国科学院上海药物研究所 副研究员 课题组长
2002.1-2005.6 中国科学院上海药物研究所 研究员 课题组长
2005.7-至今 华东师范大学 研究员



个人简介
研究组成员介绍：

吕伟教授：
长期从事抗肿瘤药物研究，在天然化合物结构多样性合成?拓扑异构酶I抑制类抗肿瘤药物?以及以生物活性为导向建立多样性小分子化合物库等方面开展了大量卓有成效的工作?发明了抗肿瘤新药喜明替康。发表研究论文150多篇?获得发明专利20多项。2006年入选教育部新世纪人才计划，2001年入选上海市青年启明星计划。 目前研究方向：课题组的研究内容主要集中于新型给药体系的建立，包括抗体药物偶联物（ADC）给药体系、蛋白嵌合降解（PROTAC）体系、特异性前药、微型药物药物偶联物给药体系。

副研究员：王磊

博士后：朱书雷 金稽煜


在读博士生(毕业院校)

曹玉婷(河南师范大学) 程祉扬(西安交通大学）

在读硕士生(毕业院校)





甄臻(东华大学)周帅(中国药科大学) 丁梦园(南京中医药大学)
何婷婷(河南大学) 陆莹馨(上海师范大学) 李亚龙(湖北工业大学)

已毕业学生
博士后：何训贵(2004)
博士：丁红霞(2006) 高河勇(2006) 罗宇(2007) 李云飞(2007) 黄维刚(2007) 肖锋(2009) 张仰明(2009) 余善宝(2011) 张梅(2012) 顾明(2012) 丰祥军(2013) 陈太杰(2013) 张翾(2014) 唐开勇(2015) 王磊(2016), 鲍彬(2017) 金沉(2017) 张秋萌(2017) 金稽煜(2018) 祝奇文(2018) 车锐(2018) 刘艺(2019) 肖栋槐(2020) 朱书雷(2020)
硕士：阳海(2002) 蒋映艳(2003) 梅玉华(2008) 薛亚东(2009) 陈艳(2009) 刘郝敏(2010) 姚佳萍(2010) 夏文品(2010) 刘海艳(2011) 张丽娟(2011) 袁薇(2012) 宋阳(2012) 梅铁文(2013) 黄颖(2013) 刘新桂(2014) 史培忠(2014) 叶智华(2014) 刘雅倩(2015) 于秀华(2015) 潘雯(2015) 陈世光(2016) 马陇君(2016) 喻杰(2017) 李娇(2017) 文帅(2017) 刘双喜(2018) 余旭勐(2019) 颜幸佳(2019) 邵平譞(2020)

2019年教师节活动：





社会兼职


研究方向


本课题组从事药物化学方向研究工作，建立了领先的药物化学研究平台。研究方向主要是致力于解决抗肿瘤药物和抗衰老药物的非脱靶性问题，主要集中于以下三个方面：1、非脱靶毒性问题；2、非脱靶药物耐药问题；3、非脱靶效能不足问题。目前，课题组的研究内容主要集中于新型给药体系的建立，包括抗体药物偶联物（ADC）给药体系、蛋白嵌合降解（PROTAC）体系、特异性前药、微型药物药物偶联物给药体系。
课题组建立的超高活性拓扑异构酶I抑制剂ADC给药体系，具有循环时间长，肿瘤组织识别性高，高旁观者效应，游离药物血液中失活迅速等优点，授权企业合作进行新药开发；基于蛋白降解技术选择罕见疾病靶点，构建PROTAC体系，具有高效降解罕见病相关蛋白的优点；基于生物体和肿瘤本身分泌的内源性物质作为药物载体，以体内代谢相关疾病的药物分子作为活性分子，构建微型药物药物偶联物给药体系，具有肿瘤和肿瘤组织识别性高，生物相容性强等优点。
实验室的主要目标为相关新概念的提出、技术平台的建立、新药候选化合物体外和体内生物学评价、以及相关专利的授权和技术转让。

2021年硕士研究生招生专业：药物化学
2021年博士研究生招生专业：有机化学(药物化学方向)
实验室招收相关专业的博士后及研究助理


开授课程
抗肿瘤药物


科研项目


学术成果

近期论文：

165.A water-soluble probe with p-hydroxybenzyl quaternary ammonium linker for selective imaging in senescent cells, Zhen, Z; Zhu, SL; Jin, JY; Wang, L*; Lu, W*,Analytica Chimica Acta, 2020, 1133, 99-108
164. Short protecting group-free syntheses of CDE synthon of racemic camptothecin, Shao, PX; Lu, W; Wang, L*, Current Organic Synthesis, 2020, DOI:10.2174/**740
163. The design of a novel near-infrared fluorescent HDAC inhibitor and image of tumor cells,Huang, Y; Ru, HB; Bao, B; Yu, JH; Li, J; Zang, Y*; Lu, W*, Bioorganic & Medicinal Chemistry, 2020, 28, 115639
162. A Novel Multifunctional 2-Nitroinmidazole-based Bioreductive Linker and its Application in Hypoxia-Activated Prodrug, Huang, Y; Jin, C; Yu, JH, Wang, L*,Lu, W*, Bioorganic Chemistry, 2020,101, 193975
161. Design, synthesis and biological evaluation of HSP90 inhibitor–SN38 conjugates for targeted drug accumulation，Zhu, SL; Shen, QQ; Gao, YL; Wang, L; Fang, YF*; Chen, Y; Lu, W*, Journal of Medicinal Chemistry, 2020, 53, 5421-5441
160. Dynamic core crosslinked camptothecin prodrug micelles with reduction sensitivity and boronic acid-mediated enhanced endocytosis: An intelligent tumor-targeted delivery nanoplatform, Huang, YS; Zhang, WL; Xu, YY; Zhu, SL; Wu, YQ; Chen, TD; Xiao, Y; Lu, W; Zhang, XW; Yu, JH*,International Journal of Pharmaceutics, 2020, 580, 119250
159. Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells,Liu, Y; Zhu, KX; Cao, L; Xie, ZF; Gu, M; Lu, W*; Li, JY*; Nan, FJ*, Acta Pharmacologica Sinica, 2020, 41, 813-824
158. Design and synthesis of new lenalidomide analogs via Suzuki cross-coupling reaction, Xiao, DH; Wang, YJ; Wang, HL; Zhuo, YB; Li, J*; Lu, W*; Jin, JY*, Arch. Pharm, 2020, 353, e**
157.Synthesis and fluorescent studies of a low molecular weight rotor for living cancer cell imaging, Zhu, SL; Yu, SM; He, Y; Ma, ML*; Lu, W*,Dyes and Pigments178 (2020) 108353
156. Optimized HSP90 mediated fluorescent probes for cancer-specific bioimaging,Zhu, SL; Li, YL; Huang, YS; Zhang, MM; Gu, XF; He, Y; Liu, HC, Ma, ML*; Lu, W*, Journal of Materials Chemistry B, 2020, 8, 1878—1896
155. Enhanced cellular uptake efficiency of DCM probes or SN38 conjugating with phenylboronic acids, Zhang, QM; Che, R; Lu, W*, Bioorganic & Medicinal Chemistry, 2020, 28, 115377
154. Co-Prodrugs of 7?Ethyl-10-hydroxycamptothecin and Vorinostat with in Vitro Hydrolysis and Anticancer Effects,Liu, SX; Liu, ZL; Zhang, QM*; Zhu, QW; Chen, Y*; Lu, W*; ACS Omega, 2020, 5, 350?357
153. Poly(ethylene glycol) shell-sheddable TAT-modified core cross-linked nanomicelles: TAT-enhanced cellular uptake and lysosomal pH-triggered doxorubicin release, Zhang, YL; Xiao, Y; Huang, YS; He, Y; Xu, YY; Lu, W; Yu, JH*, Colloids and Surfaces B: Biointerfaces188 (2020) 110772

152. 4-Carboxyphenylboronic acid-decorated, redox-sensitive rod-shaped nanomicelles fabricated through co-assembling strategy for active targeting and synergistic co-delivery of camptothecin and gemcitabine, Xu, YY; Huang, YS; Lu, W; Liu, SY; Xiao, Y*; Yu, JH*, European Journal of Pharmaceutics and Biopharmaceutics144 (2019) 193–206
151. Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SARMs,Shao, PX; Zhou, Y; Yang, DH; Wang, MW*; Lu, W; Jin, JY*, Molecules2019, 24, 4227
150.Novel amides modified rupestonic acid derivatives as anti-influenza virus reagents,Li, G; Obula, M; Zhao,JY; Liu GY;Lu, W*; Aisa HA*,Bioorganic & Medicinal Chemistry Letters,29(2019) 126605
149.Bioinspired nanoplatform for enhanced delivery efficiency of doxorubicin into nucleus with fast endocytosis, lysosomal pH-triggered drug release, and reduced efflux, Huang, YS; Xu, YY; Wu, YQ; Chen, TD; Lu, W; Yu, JH*,Colloids and Surfaces B: Biointerfaces,183, 110413,1 November 2019
148. Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities, Xiao, DH; Wang, YJ; Hu, XB; Kan, WJ; Zhang, QM; Jiang, XF; Zhou, YB; Li, J*; Lu, W*, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 176，419-430 AUG 15 2019
147. Synthesis and biological evaluation of paclitaxel and vorinostat co-prodrugs for overcoming drug resistance in cancer therapy in vitro,Liu, SX; Zhang, KL; Zhu, QW; Shen, QQ; Zhang, QM; Yu, JH; Chen, Y*; Lu, W*,BIOORGANIC & MEDICINAL CHEMISTRY，27(7), 1405-1413 APR 1 2019
146.Design and synthesis of further simplified pyripyropene A based ACAT2 selective inhibitors, Liu, Y; Zhang, XW; Zhan, Y; Li, BL*; Lu, W*; Nan, FJ*,TETRAHEDRON, 75(12), 1819-1825 MAR 22 2019
145.Rod-Shaped Micelles Based on PHF-g-(PCL-PEG) with pH-Triggered Doxorubicin Release and Enhanced Cellular Uptake, Wu, YQ; Xiao, Y; Huang, YS; Xu, YY; You, DL; Lu, W; Yu, JH*, BIOMACROMOLECULES, 20(3), 1167-1177 MAR 2019
144.Fabrication of Cellulose-Nanocrystal-Based Folate Targeted Nanomedicine via Layer-by-Layer Assembly with Lysosomal pH-Controlled Drug Release into the Nucleus, Li, N; Zhang, H; Xiao, Y; Huang, YS; Xu, MD; You, DL; Lu, W; Yu, JH*,BIOMACROMOLECULES, 20(2), 937-948 FEB 2019


143. Jin, JY; Zhou, Y; Yang, DH; Zhang, QM; Wang, MW*; Lu, W*,Synthesis of androgen receptor antagonists containing a pentafluorosulfanyl (SF5) moiety, ARCHIV DER PHARMAZIE, 351(11), e** NOV 2018
142. Xu, YY; Huang, YS; Zhang, XW; Lu, W; Yu, JH*; Liu, SY,Carrier-free Janus nano-prodrug based on camptothecin and gemcitabine: Reduction-triggered drug release and synergistic in vitro antiproliferative effect in multiple cancer cells,INTERNATIONAL JOURNAL OF PHARMACEUTICS, 550(1-2), 45-56 OCT 25 2018
141. Li, N; Lu, W;Yu, JH; Xiao, Y; Liu, SY; Gan, L; Huang, J, Rod-like cellulose nanocrystal/cis-aconityl- doxorubicin prodrug: A fluorescence-visible drug delivery system with enhanced cellular uptake and intracellular drug controlled release, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FORBIOLOGICAL APPLICATIONS, 91, 179-189 OCT 1 2018
140.A series of camptothecin prodrugs exhibit HDAC inhibition activity,Qiwen Zhua, Xumeng Yua, Qianqian Shen, Qiumeng Zhang, Mingbo Su, Yubo Zhou,Jia Li, Yi Chen^?, Wei Lu^?,Bioorganic & Medicinal Chemistry26 (2018) 4706–4715
139.Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as newmulti-targeted inhibitors of Aurora A/B and KDR, Qiumeng Zhang, Qianqian Shen, Lixin Gao, Linjiang Tong, Jia Li, Yi Chen*, Wei Lu*,European Journal of Medicinal Chemistry, 2018, 158, 428-441
138.Synthesis of New Branched 2?Nitroimidazole as a Hypoxia SensitiveLinker for Ligand-Targeted Drugs of Paclitaxel,Qiumeng Zhang, Chen Jin, Jiahui Yu, Wei Lu*,ACS Omega, 2018, 3, 8813?8818
137.Design and synthesis of aryloxypropanolamine as b3-adrenergic receptor antagonist in cancer and lipolysis,Jiyu Jin, Chunxiao Miao, Zhilong Wang, Wanli Zhang, Xiongwen Zhang*, Xin Xie*, Wei Lu*,EuropeanJournal of Medicinal Chemistry, 2018, 150, 757-770
136. Maleimidation of dextran and the application in designing a dextran–camptothecin conjugate,Qiwen Zhu, Bin Bao, Qiumeng Zhang,* Jiahui Yu, Wei Lu*, RSC Advances,2018, 8, 2818-2823
135. Nanomicelle drug with acid-triggered doxorubicin release and enhanced cellular uptake ability based on mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid copolymers,Li Cao, Yi Xiao, Wei Lu, Shiyuan Liu, Lin Gan, Jiahui Yu*, Jin Huang, JOURNAL OF BIOMATERIALS APPLICATIONS, 2018, 32(6), 826-838
134. Facile preparation of core cross-linked nanomicelles based on graft copolymers with pH responsivity and reduction sensitivity for doxorubicin delivery,Tiandong Chen , Yi Xiao, Wei Lu, Shiyuan Liu, Lin Gan, Jiahui Yu*, Jin Huang, Colloids and surfaces. B, Biointerfaces, 2018, 161, 606-613

133. Reduction-Triggered Release of CPT from Acid-Degradable Polymeric Prodrug Micelles Bearing Boronate Ester Bonds with Enhanced Cellular Uptake,Yushu Huang, Ya Gao, Tiandong Chen, Yanyun Xu, Wei Lu, Jiahui Yu*, Yi Xiao*, Shiyuan Liu, ACS BIOMATERIALS SCIENCE & ENGINEERING, 2017, 3(12), 3364-3373
132:Design and synthesis of Atglistatin derivatives as adipose triglyceride lipase inhibitors, Jiyu Jin, Suling Huang, Lei Wang, Ying Leng*, Wei Lu*,Chem Biol Drug Des.2017;90:1122–1133.
131：Syntheses of two kinds of disaccharide subunits of antitumor antibiotic bleomycins,Rui Che, Qiwen Zhu, Jie Yu, Jiao Li, Jiahui Yu, Wei Lu*,TETRAHEDRON, 2017, 73, 6172-6180
130：Synthesis and Biological Evaluation of Paclitaxel and Camptothecin Prodrugs on the Basis of 2-Nitroimidazole, Chen Jin, Shuai Wen, Qiumeng Zhang, Qiwen Zhu, Jiahui Yu, Wei Lu*, ACS Medicinal Chemistry Letters, 2017, 8 (7), 762–765,DOI: 10.1021/acsmedchemlett.7b00189
129:Discovery of new BTK inhibitors with B cell suppression activity bearing a 4,6-substituted thieno[3,2-d]pyrimidine sca?old, Qiumeng Zhang, Luyao Zhang, Jie Yu, Heng Li, Shijun He, Wei Tang, Jianping Zuo*, Wei Lu*,RSC Adv.,2017, 7, 26060–26069
128: Design, Synthesis and Anti-Proliferative Activities of 2,6-Substituted Thieno[3,2-d]pyrimidine Derivatives Containing Electrophilic Warheads,Qiumeng Zhang, Zonglong Hu, Qianqian Shen, Yi Chen*, Wei Lu*, Molecules, 2017, 22, 788
127:Synthesis and biological evaluation of hypoxia-activated prodrugs of SN-38, Jin Chen; Qiumeng Zhang, Lu Wei*, European Journal of Medicinal Chemistry,2 017, 132, 26, 135–141
126: Selective turn-on near-infrared fluorescence probe for hypoxic tumor cell imaging,Jin Chen; Zhang Qiumng; Lu Wei*, RSC ADVANCES, 2017, 7, 18217-18223
125:Synthesis of 1,3,4,6-Tetra-O-acetyl-l-gulose, Che Rui; Liu Xingui; Lu Wei*, Chinese Journal of Chemistry, 2017,35(2), 237-241
124:Carbamoylmannose enhances the tumor targeting ability of supramolecular nanoparticles formed through host–guest complexation of a pair of homopolymers,Yao Xikuang; Zhu Qiwen; Li Cheng; Yuan Kangjun; Che Rui; Zhang Peng; Yang Chenchen; Lu Wei*; Wu Wei; Jiang Xiqun*, Journal of Materials Chemistry B, 2017, 5,83
123: Characterization of a near-infrared fluorescent DCPO-tagged glucose analogue for cancer cell imaging, Fang Yanfen; Zhang Wanli; Zhu Mengli; Chen Shiguang; Liu Xuan; Lu Wei*; Zhang Xiongwen*, Journal of Photochemistry & Photobiology, B: Biology, 2017, 166, 264–271


122: 10-Boronic acid substituted camptothecin as prodrug of SN-38, Wang Lei; Xie Shao; Ma Longjun; Chen Yi*; Lu Wei*, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 116, 84-89
121:Design and Synthesis of 2-Alkylpyrimidine-4,6-diol and 6-Alkylpyridine- 2,4-diol as Potent GPR84 Agonists,Liu Yang; Zhang Qing; Chen Lin-Hai; Yang Hui; Lu Wei; Xie Xin*; Nan Fa-Jun*, ACS Medicinal Chemistry Letters, 2016, 7(6), 579-583
120: Design, Synthesis, and Biological Evaluation of New Cathepsin B-Sensitive Camptothecin Nanoparticles Equipped with a Novel Multifuctional Linker,Zhang Xuan; Tang Kaiyong; Wang Hong; Liu Yaqian; Bao Bin; Fang Yanfen; Zhang Xiongwen*; Lu Wei*, Bioconjugate Chemistry, 2016, 27(5), 1267-1275
119: Nanomicelles based on a boronate ester-linked diblock copolymer as the carrier of doxorubicin with enhanced cellular uptake, Xu Yan; Lu Yuanyuan; Wang Lei;Lu Wei; Huang Jin; Muir Ben; Yu Jiahui*, COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 141, 318-326
118:NIR fluorescent DCPO glucose analogues and their application in cancer cell imaging, Chen Shiguang; Fang Yanfen; Zhu Qiwen; Zhang Wanli; Zhang Xiongwen*; Lu Wei*,RSC ADVANCES,2016, 6(85), 81894-81901
117: DCPO based nanoparticles as a near-infrared fluorescent probe for Cathepsin B, Bao Bin; Liu Yaqian; Wang Lei;Lu Wei*, RSC ADVANCES,2016, 6(73), 69540-69545

全部论文：
htth://www.researcherid.com/rid/P-6066-2104






荣誉及奖励