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生命科学学院??????


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个人资料
部门： 生命科学学院
毕业院校：
学位：
学历：
邮编：
联系电话：
传真：
电子邮箱： wwei@bio.ecnu.edu.cn
办公地址： 生命科学学院404
通讯地址：

教育经历

工作经历

个人简介

社会兼职


研究方向
主要从事新型组蛋白酯酰化修饰与疾病发生发展的研究


开授课程


科研项目
1. Supported by the National Natural Science Foundation of China (Grant No. **) , 201901-202112.
2. Supported by China Postdoctoral Science Foundation (Grant No. 2017M621414)，201709-201908.



学术成果
1. Wei Wei^#, Xiaoguang Liu^#, Jiwei Chen^#, Shennan Gao, Lu Lu, Huifang Zhang, Guangjin Ding, Zhiqiang Wang, Zhongzhou Chen, Tieliu Shi, Jiwen Li, Jianjun Yu*, Jiemin Wong*. Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription. Cell Res. 2017, 27(7):898-915.（SCI, IF=15.606）
2. Wei Wei，Anqi Mao，Bin Tang，Qiufang Zeng，Shennan Gao，Xiaoguang Liu，Lu Lu，Wenpeng Li，James X. Du，Jiwen Li，Jiemin Wong*，Lujian Liao*. Large-scale identification of protein crotonylation reveals its role in multiple cellular functions. J Proteome Res. 2017, 16(4):1743-1752.（SCI, IF=4.268）
3. Xiaoguang Liu^#, Wei Wei^#, Yuting Liu, Xueli Yang, Jian Wu, Yang Zhang, Qiao Zhang, Tieliu Shi, James X Du, Yingming Zhao, Ming Lei, Jin-Qiu Zhou, Jiwen Li*，Jiemin Wong*. MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase-deficient and crotonyltransferase-competent CBP/p300. Cell Discov. 2017, 3:17016-17033. ( #Co-first authors)
4. Meng Wu^#，Wei Wei^#，Jiwei Chen，Rong Cong，Tieliu Shi，Jiwen Li，Jiemin Wong*，James X. Du*. Acidic domains differentially read histone H3 lysine 4 methylation status and are widely present in chromatin-associated proteins. Sci China Life Sci. 2017, 60(2):138-151. ( #Co-first authors)
5.Lan Fang, Ling Zhang, Wei Wei, Xueling Jin, Ping Wang, Yufeng Tong, Jiwen Li, James X.Du and Jiemin Wong. A Methylation-Phosphorylation Switch Determines Sox2 Stability and Function in ES cell Maintenance or Differentiation. Mol Cell. 2014 Aug 21;55(4):537-51.
6.Zhao Q^#, Zhang J^#, Chen R^#, Wang L^#, Li B, Cheng H, Duan X, Zhu H, Wei Wei, Li J, Wu Q, Han JD, Yu W, Gao S, Li G*, Wong J*. Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals. Nat Commun. 2016.24;7:12464. doi: 10.1038/ncomms12464



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