导师类别 博、硕导
性 别 男
出生年月 1964年9月
联系电话
通讯地址 成都市人民南路四段九号
Email zhanggl@cib.ac.cn

个人简介
张国林，男，1964年9月生，四川大竹人。理学博士，研究员。1984年于四川大学获理学学士学位；1987年于兰州大学获理学硕士学位；1993年于德国波恩大学获理学博士学位。1995-1996年在北京大学化学与分子工程学院从事博士后研究。1987-1990年中国科学院成都生物研究所从事植物化学研究，1996年至今在成都生物所工作，从事天然药物研究。被聘为副研究员、研究员和博士生导师；历任研究中心副主任、主任、所长助理和副所长。获得中国科学院优秀教师、四川省优秀回国人员、中国科学院青年科学家奖、四川省青年科技奖等荣誉或奖励，入选国家百千****才工程、中国科学院“****”和四川省学术技术带头人。

工作经历
1987.07-1990.09 中国科学院成都生物研究所，从事植物化学研究，助研（1989.07）
1993.09-1994.12 波恩大学数学——自然科学学院药物研究所，从事抗肿瘤活性天然产物的研究
1995.01-1996.11 北京大学化学与分子工程学院，有机化学研究所，博士后,从事天然有机化学的研究
1996.11- 中国科学院成都生物研究所从事天然药物化学的研究，研究员（1998.3-）、
博士生导师（1999-），天然产物中心主任（2002-2008），副所长（2008.4-2015.10）

教育经历
1980.09-1984.07 四川大学化学系，获理学学士学位
1984.09-1987.07 兰州大学化学系有机合成专业，获理学硕士学位，导师：李裕林、潘鑫复教授
1990.09-1993.09 波恩大学数学——自然科学学院药物研究所，获理学博士学位，导师：Prof.Gerhard Ruecker, Prof.Eberhard Breitmaier

获奖、荣誉称号
1997 入选中国科学院“****”
1999 入选“百千****才工程”（第一、二层次，人事部等部委）
2001 中国科学院青年科学家奖
2003 入选“四川省学术技术带头人”
2004 第七届四川省青年科技奖
2004 成都市有突出贡献的优秀专家
2006 中国科学院优秀教师
2006 四川省优秀回国人员
2006 国务院政府津贴
2013 四川省科学技术进步奖，一等奖，2013，四川省人民政府。张国林（2/9）

社会、学会及学术兼职
学术兼职
a.《天然产物研究与开发》，编委
b.《应用与环境生物学报》，副主编
c. 《Chinese Journal of Natural Medicines》（SCI），编委
d. 《Journal of Asian Natural Products Research》（SCI），编委，
d. 《Natural Products Research and Prospecting》，编委
e. 《African Journal of Traditional Complementary and Alternative Medicines》
（SCI），编委
f. 中国植物学会植物化学和资源学专业委员会委员（2014-）
g. 《Mongolian Journal of Chemistry》，编委（2015-）
社会兼职
a.四川省知识分子联谊会，副会长（2015-）
b.四川省欧美同学会×四川留学人员联谊会，常务理事（2015-）
c.四川省科青联第四届常务理事（2013-）
d.四川省政协委员（2015-）

研究领域
植物和微生物次生代谢产物的分析、活性、功能、转化以及基于天然产物的化学生物学研究。专业领域：药物化学/天然产物化学/有机化学；化学生物学/药理学。

科研项目
1.负责人，中科院****，抗肿瘤天然药物研究，1998-2001，30+90万元
2.负责人，四川省****基金，针对PPARg的抗糖尿病药物研究，2002.01-2004.12，15万元
3.负责人，四川省攻关/基础研究，一种抗微管植物的有效成分研究，2002.01-2004.12，40万元
4.负责人，四川省攻关/应用研究，黄栀子的质量标准和不同栽培条件下的质量可控性研究，2002.09-2004.12，20万元
5.负责人，四川省科技厅/基础研究，具有免疫调节活性川牛膝多糖的研究（2006Q14-039），5万元，2006-2008
6.负责人，四川省科技厅/应用研究，促雌激素E2合成的天然药物开发（2006Z08-084），15万元，2006.01-2008.12
7.负责人，N-手性季铵盐的合成（**），国家自然科学基金，2007.01-2009.12，28万元
8.负责人，化学小分子激活干扰素JAK/STAT信号途径研究（重大研究计划，**），国家自然科学基金委，2008.01-2010.12，60万元
9.课题负责人，具有雌激素作用中药复方物质基础及作用机理研究——“通骨络”药效成分构效关系及作用机理研究（KSCX2-YW-R-078），中国科学院，2008.01-2010.12， 40万元
10.课题负责人，确有疗效的有毒中药科学应用关键问题的基础研究——有毒中药毒效物质基础研究（国家重点基础研究计划，973计划，2009CB522804），科技部，2009.01-2013.12， 200万元
11.负责人，调控雌激素合成与代谢的天然产物研究（重点项目，**），国家自然科学基金委，2009.01-2013.12，200万元
12.负责人，天然产物库的构建，新药创制重大专项，科技部，2008-2010，2009ZX**-002，200万元
13.负责人，天然产物库的构建，中国科学院，2011-2014，150万元
14.负责人，淫羊藿苷类似物的合成及构效关系（**），国家自然科学基金委，2012.01.01-2015.12，65万元
15.课题负责人，新药创制重大专项，"中药化学成分库"（2011ZX09307-002-02）科技部，223.0275万元，2011.01-2013.12
16. 负责人，苯并呋喃：基于分子内脱羧、C-O键形成的合成与芳香化酶抑制活性，**/ B020602，国家自然科学基金委，90万元，2014.01-2017.12
17.课题负责人，基于小分子探针的细胞命运决定的分子机制研究，**，国家自然科学基金委，81万元（总1200万元），2013/1/1-2015/12/31，
18. 负责人，治疗老年性疾病的天然产物药物发现研究，，国家自然科学基金委，300万元，2015.10-2018.9（2015年度国家自然科学基金委员会与泰国研究基金会合作研究项目）

发表论文
已发表研究论文250余篇（其中SCI收录刊物100余篇）。近五年发表的主要论文如下：
1.Zhijun Wu, Dongming Sun, Jianzhong Chen, Xiaozhen Chen, Dongmei Fang, Na Li, Ping Cheng，Guolin Zhang*, Analysis of cipadesin limonoids from Cipadessa cinerascensusing electrospray ionization quadrupole time-of-flight tandem mass spectrometry and quantum chemical calculations, RapidCommnications in Mass Spectrometry, 2012, 26:563–571
2.Guobo Xu, Limei Li, Dongmei Fang, Guoyou Li, Guolin Zhang, Zhijun Wu^*. Electrospray tandem mass spectrometry of chaetoglobosins, RapidCommnications in Mass Spectrometry,2012, 26,2115-2122.
3.Zhengfu Tai, Guolin Zhang, Fei Wang. Identification of small molecule activators of the Janus kinase/signal transducer and activator of transcription pathway using a cell-based screening. Biological & Pharmaceutical Bulletin, 2012, 35:65-71
4.Yinggang Luo, Min Zhou, Qi Ye, Guolin Zhang*, Dihydroagarofurna derivatives from dried roots of Tripterygium wilfordii, Journal ofNaturalProducts,2012, 75: 98-102
5.Qianfeng Chen, Xiaozhen Chen, Guoyou Li, Chun Wang, Guolin Zhang*, Two new 2-phenylbenzofurans from the bark of Styrax perkinsiae, Chinese Journal of Natural Medicine, 2012, 10(2): 92-97
6.Xiaoqing Wu, Xiaozhen Chen, Qingchun Huang, Dongmei Fang, Guoyou Li, Guolin Zhang*, Toxicity of raw and processed roots of Polygonum multiflorum, Fitoterapia, 2012, 83: 469-475
7.DanfengLu,LijuanYang,FeiWang,GuolinZhang, Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19),Journal of Agricultural and Food Chemistry, 2012, 60(34): 8411-18.
8.Danfeng Lu,Lijuan Yang, Qilin Li, Xiaoping Gao, Fei Wang*, Guolin Zhang*, EgonolgentiobiosideandegonolgentiotriosidefromStyraxperkinsiaepromotethebiosynthesis ofestrogen by aromatase, European Journal of Pharmacology, 2012, 691:275–282
9.Guobo Xu, Limei Li,Tao Yang, Guolin Zhang*, Guoyou Li*,Chaetoconvosins A and B, Alkaloids with new skeleton from fungus Chaetomium convolutum, Organic Letters, 2012, 14(23): 6052–6055
10.GuangzhouLi, DumaaMishig, XiangPu, JinhaiYi, GuolinZhang，YinggangLuo, Chemical Components of Aerial Parts ofLagochilus ilicifolius(冬青叶兔唇花),Chin J Appl Environ Biol,2012，18 ( 6) : 924~927
11.Qianfeng Chen, Lijuan Yang, Guolin Zhang*,Fei Wang*,Bioactivity-guided isolation of antiosteoporotic compounds from Ligustrum lucidum, PhytotherapyResearch,2013, 27:973-979.
12.Lijuan Yang, Danfeng Lu, Jiajia Guo, Xianli Meng, Guolin Zhang, Fei Wang，IcariinfromEpimediumbrevicornumMaximpromotesthebiosynthesisofestrogenbyaromatase(CYP19)，JournalofEthnopharmacology, 2013, 145: 715-721.
13.鲁丹枫，Azimova Bahtigul Jovliqizi，张国林，王飞*，采用磁微粒分离酶联免疫法构建基于KGN细胞的雌激素生物合成筛选模型，天然产物研究与开发，2013, 25: 27-30,67
14.Puzhao Zhang, Fei Wang, Lijuan Yang, Guolin Zhang*, Pregnane alkaloids from Sarcococca hookeriana vardigyna(双蕊野扇花), Fitoterapia, 2013, 89:143-148
15.Yuan Lin, Fei Wang, Lijuan Yang, Ze Chun, Jinku Bao, Guolin Zhang*, Anti-inflammatory phenanthrene derivatives from stems of Dendrobiumdenneanum（迭鞘石斛）, Phytochemistry, 2013, 95: 242-251
16.Xiang Pu, Xixing Qu, Fei Chen, Jinku Bao, Guolin Zhang*, Yinggang Luo*, Endophytic fungus Trichoderma atrovirideLY357: Isolation, identification, and camptothecin production, Applied Microbiology and Biotechnology, 2013, 97:9365–9375
17.Wei Yang, Dongmei Fang, Hongping He, Xiaojiang Hao, Zhijun Wu*, Guolin Zhang, Analysis of mexicanolide- and phragmalin-type limonoids fromHeynea trijugausing high-performance liquid chromatography/electrospray tandem mass spectrometry,Rapid Commun. Mass Spectrom. 2013, 27:1203–1212
18.Jie Ren, Guoyou Li, Lan Shen, Guolin Zhang*, Laurance A. Nafie, Huajie Zhu*，Challenges in the assignment of relative and absolute configurationsof complex molecules: computation can resolve conflicts betweentheory and experiment, Tetrahedron, 2013, 69(48): 10351-10356
19.Xiang Pu, Guangzhou Li, Tao Yang, Guoyou Li, Jinhai Yi, Guolin Zhang, Yinggang Luo*, A new cyclododeca[d]oxazole derivative from Streptomyces spp. CIBYL1, Natural Product Research, 2013,27 (7):603-608
20.蒲祥,李光州,肖青,易进海,田永强,张国林,赵立兴,罗应刚*,产喜树碱的喜树内生真菌Aspergillus sp. LY013的分离、退化及退化后的次级代谢产物,Chin J Appl Environ Biol 2013，19 ( 5 ) : 787-793
21.Zhijun Wu*, Jianhua Wang, Dongmei Fang, Guolin Zhang, Analysis of iridoid glucosides from Paederia scandens using HPLC–ESI-MS/MS, Journal of Chromatography B, 2013, 923–924: 54–64
22.Wenchen Pu,Guanmin Mu,Guolin Zhang*, Chun Wang*,Copper-Catalyzed Decarboxylative intramolecular C-O coupling: Synthesis of 2-arylbenzofuran from 3-arylcoumarin, RSC Advances, 2014, 4:903–906
23.Zhengfu Tai, Yujiao He, Yuan Lin, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang*,Fei Wang*,Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway through PKA-mediated inhibition of SHP-2 in cancer cells, Cell Signaling, 2014, 26:619-628
24.GuoyongLuo, Min Zhou, Yan Liu, Qi Ye, Jian Gu, Tianfang Huang, Guolin Zhang, Yinggang Luo*，3-Formyl-2-arylbenzofurans from the aerial parts of Itea ilicifolia（冬青叶鼠刺），Phytochemistry Letters, 2014, 10: 19–22
25.Yuan Lin, FeiWang,GuolinZhang*,Natural products and their derivatives regulatingthe Janus kinase/signal transducer and activator of transcription pathway, Journal of Asian Natural Products, 2014, 16(7)：800-812
26.Guoyong Luo, Yun Yang, Min Zhou, Qi Ye, Yan Liu, Jian Gu, Guolin Zhang, Yinggang Luo*, Novel 2-arylbenzofuran dimers and polyisoprenylated flavanones from Sophora tonkinensis（山豆根）, Fitoterapia, 2014, 99 : 21-27
27.Jiajia Guo, Yun Yuan, Danfeng Lu, Liang Xiong, Jiangong Shi, Lijuan Yang, Xiaohong Yuan, Guolin Zhang*, Fei Wang*, Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol,inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19), Toxicology and Applied Pharmacology, 2014, 279(1):23-32(AUG 15 2014)
28.Yinggang Luo,Xiang Pu,Guoyong Luo,Min Zhou, Huayi Qi, Qi Ye,Yan Liu, Guolin Zhang*, Nitrogen-containing dihydro-β-agarofuran derivatives mined from the dried roots ofTripterygium wilfordii,Journal of Natural Products, 2014,77(7):1650-1657(JUL 2014)
29.Wenchen Pu, Yuan Lin, Jianshuo Zhang, Fei Wang, Chun Wang, Guolin Zhang*, 3-Arylcoumarins: Synthesis and potent anti-inflammatory activity, Bioorganic & Medicinal Chemistry Letters, 2014, 24: 5432-5434
30.Munkhgerel Lodonjav,罗国勇,周敏,Regdel Duger,张国林,罗应刚*,食用林地菇的化学成分,Chin J Appl Environ Biol，2014，20 (4) : 629-632
31.Xuewen Fu,Wenchen Pu,Chun Wang, GuolinZhang, SynthesisofsalicylaldehydesfromphenolsviaCopper-mediatedDuffReaction, ResearchonChemicalIntermediates,2015, 41: 8147-8158
32.Guoyong Luo, Yinggang Luo,Min Zhou, Jian Gu, Qi Ye, Rong Zhou, Ya Dai, Guolin Zhang*, Antioxidant compounds from ethanol extracts of bamboo (Neosinocalamus affinis) leaves，Journal of Asian Natural Products Research，2015, 17 (3): 248-255. DOI: 10.1080/**.2014.981164
33.Qinggang Mei, Chun Wang, Weicheng Yuan,Guolin Zhang*,Selective methylation of kaempferol via benzylation and deacetylation of kaempferol acetates,Beilstein Journal of Organic Chemistry, 2015, 11:288–293. doi:10.3762/bjoc.11.33
34.Puzhao Zhang, Jian Gu, GuolinZhang*, NovelStilbenesfrom Artocarpusnanchuanensis（南川木菠萝）, Journal of Asian Natural Products Research，2015, 17 (3): 217-223 10.1080/**.2015.**
35.Guitao Luo, Yunping Li, An Wang, Qiang Lin, Guolin Zhang, Chun Wang*，Dummy molecularly imprinted mesoporous silicates for selective adsorption of 2-naphthol，Open Chem., 2015,13: 756–762
36.Tian Cai, Yinggang Luo, Min Zhou, Zhijun Wu*, Dongmei Fang, Guolin Zhang∗,Analysis of sesquiterpene pyridine alkaloids using ESI–MS/MS: The product ion at m/z 310 formed by an ion–dipole intermediate，International Journal of Mass Spectrometry, 2015, 376: 54-57
37.Tian Cai, Yinggang Luo, Min Zhou, Dan Wang, Zhijun Wu*, Dongmei Fang, and Guolin Zhang*. Untargeted analysis of sesquiterpene pyridine alkaloids from the dried roots of Tripterygium wilfordii using high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Communications in Mass Spectrometry,2015, 29:965-972.
38.Qinggang Mei, Chun Wang, Zhigang Zhao, Weicheng Yuan,Guolin Zhang*, Synthesis of icariin from kaempferol through regioselective methylation and para-Claisen-Cope rearrangement, Beilstein Journal of Organic Chemistry, 2015, 11:1220–1225.doi:10.3762/bjoc.11.135
39.Guobo Xu, Gu He, Huanhuan Bai, Tao Yang, Guolin Zhang, Linwei Wu, Guoyou Li*, Indole Alkaloids from Chaetomium globosum, Journal of Natural Products, 2015, 78:1479−1485，2015, DOI: 10.1021/np**
40.Nilubon Sornkaew, Yuan Lin, Fei Wang, Guolin Zhang, Ratchanaporn Chokchaisiri, Ailian Zhang,Kanjana Wongkrajang, Parichat Suebsakwong, Pawinee Piyachaturawat, Apichart Suksamrarn*, Diarylheptanoids of Curcuma comosa with inhibitory effects onNitric Oxide production in Macrophage RAW 264.7 Cells, Natural Product Research, 2015, 10 (1):89-93
41.Guoyong Luo, Min Zhou, Qi Ye, Jun Mi, Dongmei Fang, Guolin Zhang*, Yinggang Luo*, Phenolic derivatives from Hypericum japonicum, Natural Product Communications, 2015, 10 (12): 2109-2112
42.Xiang Pu, Fei Chen, Yun Yang, Xixing Qu, Guolin Zhang, Yinggang Luo*. Isolation and characterization of Paenibacillus polymyxaLY214, a camptothecin-producing endophytic bacterium from Camptotheca acuminata. Journal of Industrial Microbiology & Biotechnology,2015, 42:1197-1202.
43.Xixing Qu, Xiang Pu, Fei Chen, Yun Yang, Lixia Yang, Guolin Zhang, Yinggang Luo*. Molecular cloning, heterologous expression, and functional characterization of an NADPH-cytochrome P450 reductase gene from Camptotheca acuminata, a camptothecin-producing plant. PLoS ONE,2015, 10(8):e**. Doi: 10.1371/journal.pone.**.
44.Yujiao He, Junmei Huang, Ping Wang, Xiaofei Shen, Sheng Li, Lijuan Yang, Wanli Liu, Apichart Suksamrarn, Guolin Zhang*, Fei Wang*, Emodin potentiates the antiproliferative effect of interferon a/bby activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome, Oncotarget, 2016, 7 (4): 4664-4679.
45.Puzhao Zhang, Yamei Zhang, Jian Gu, GuolinZhang*, Two new alkaloids from Melodinus hemsleyanus（川山橙）, Natural Product Research, 2016,30 (2):162-167.
46.Guoyong Luo, Qi Ye, Baowen Du, Fei Wang, Guolin Zhang*, Luo Yinggang*, Iridoid glucosides and diterpenoids from Caryopteris glutinosa, Journal of Natural Products,2016, 79: 886-893
47.Yunping Li, Wei Xiong, Chun Wang*, Bo Song, Guolin Zhang, Synthesis of hexagonal mesoporous silicates with amino groups functionalized on the pore channels by a co-condensation approach, RSC Advances, 2016,6:53991-54000.
48.Fei Chen, Wei Li, Liangzhen Jiang, Xiang Pu, Yun Yang, Guolin Zhang, Yinggang Luo*, Functional characterization of a geraniol synthase-encoding gene from Camptotheca acuminataand its application in production of geraniol in Escherichia coli, ,Journal of Industrial Microbiology & Biotechnology, 2016, 43:1281–1292.
49.Lianqi Chen, Xiaofei Shen, Boyang Hu, Yuan Lin, Ighodaro Igbe,Chenggang Zhang, Guolin Zhang, Xiaohong Yuan*, Fei Wang*, Evaluation of synthesizedphenanthrene analogues in the suppression of lipopolysaccharide-stimulated inflammatory responsesin murine macrophage RAW264.7 cells，Bioorganic & Medicinal Chemistry Letters,2016, 26: 2521–2525
50.Lin Zhang, Yeming Yang, Shujin Li, Zhengfu Tai, Lulin Huang, Yuqing Liu, Xiong Zhu, Yanan Di, Chao Qu, Zhilin Jiang, Yuanfeng Li, Guolin Zhang, Ramasamy Kim, Periasamy Sundaresan, Zhenglin Yang*, Xianjun Zhu, Whole-Exome Sequencing Analysis Identifies Mutations in LRP5 in Indian Families with Familial Exudative Vitreoretinopathy, Genetic Testing and Molecular Biomarkers, 2016, 20(7):346-351
51.Wenchen Pu, Yun Yuan, Danfeng Lu, Xin Wang, Chun Wang, Fei Wang, Guolin Zhang*, 2-Phenylbenzo[b]furans: synthesis and promoting activity on estrogen biosynthesis，Bioorganic & Medicinal Chemistry Letters,2016, 26: 5497-5500.
52.Wei Li, Lixia Yang, Liangzhen Jiang, Guolin Zhang, and Yinggang Luo*. Molecular cloning and functional characterization of a cinnamate 4-hydroxylase-encoding gene from Camptotheca acuminata. Acta Physiol Plant,2016, 38 (11): 256-.
53.Yun Yang, Xiang Pu, Xixing Qu, Fei Chen, Guolin Zhang, Yinggang Luo*, Enhanced production of camptothecin and biological preparation of N¹-acetylkynuramine in Camptotheca acuminatacell suspension cultures, Applied Microbiology and Biotechnology, 2017, 101:4053–4062
54.Lixia Yang, Liangzhen Jiang, Wei Li, Yun Yang, Guolin Zhang, Yinggang Luo*. A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial application in geraniol production in Escherichia coli. Journal of Industrial Microbiology & Biotechnology 2017, 44 (10), 1431-1441
55.Xianyan Shen, Qiang Zhou, Wei Xiong, Wenchen Pu, Guolin Zhang^*, Chun Wang^*,Synthesis of 5-subsituted flavonols via Algar-Flynn-Oyamada(AFO) reaction: the mechanistic implication, Tetrahedron,2017, 73: 4822-4829
56.Orawan Wonganan, Yujiao He, Xiaofei Shen, Kanjana Wongkrajang, Apichart Suksamrarn, Guolin Zhang*, Fei Wang*, 6-Hydroxy-3-O-methyl-kaempferol 6-O-glucopyranoside potentiatesthe antiproliferative effect of interferon α/β by promoting the activation of JAK/STAT signaling through the inhibition of SOCS3in hepatocellular carcinoma cells, Toxicology and Applied Pharmacology,2017,336:31-39

科研创新
至今申报发明专利约50件，获得授权发明专利25件

教学活动
主要进行如下课程的教学及相关讲座
1. 天然药物化学
2. 药理学
3. 科技写作（论文、专利、项目申报书等）
4. 有机分析

指导学生情况
至今指导毕业硕士研究生40余名，博士研究生30余名。

我的团队
目前团队主要骨干
1. 研究员4名
2. 副研究员2名