叶利明
四川大学华西药学院分析测试中心 主任，硕士生导师


简历
1984年 毕业于华西医科大学药学院，药物化学本科
1997年 毕业于华西医科大学药学院，获硕士学位
2008年 毕业于四川大学华西药学院，获博士学位
1984年～至今 四川大学华西药学院 任助教、讲师、副教授、研究员（教授）
1991年 西藏自治区卫生学校自愿援藏教师
研究方向
1.药物“定量保留-活性关系”预测模型及细胞色谱研究
2.药动学及药物代谢产物研究
3.NIR&Raman在线测定系统方法学及应用研究
4.中药、中药材及化学药质量标准研究
主要研究课题及成果
1.靶向释药系统与新制剂技术平台的建设。国家重大新药创制科技重大专项课题（No.：2009ZX09310-002），2009—2010，参研
2.中药绵马贯众饮片炮制规范化研究中的质量标准研究（子课题）（“十五”国家科技攻关，No.**BA701A11），子课题负责人
3.国家科技支撑计划课题（多糖类功能食品有效成分检测和鉴伪技术的研究-降压类功能食品中违禁添加成分的HPLC和LC-MS检测方法研究，No.2006BAD27B02）子课题负责人
4.中药成分受体的肝胞内靶向给药系统的研究（国家自然科学基金，No.**），第一主研
5.槟榔炒制过程中物质基础与生物效应动态变化规律研究（国家自然科学基金No.**）。子课题负责人
6.川产法定挥发性药材指纹图谱研究（四川省中医药管理局课题，No.H0020），负责人
7.新型纤溶活性物质枯激酶的应用研究（四川省科技攻关项目，No.36001），第一主研
8.“十二五”国家科技支撑计划子课题-三七三醇皂苷及三七通舒胶囊生产过程在线近红外质量检测与监控技术开发（13H0965）
9.槟榔炒焦”长于消食导滞”的物质基础与作用机理（国家自然科学基金No. **）。子课题负责人
10.国家一类新药KB药学研究质量标准项目，负责人。


主要科研和教学情况
完成和参与国家自然科学基金项目2项，国家“十一五”重大科技专项“重大新药创制”单元平台项目项，国家“十二五”重大科技项目1项，国家科技支撑计划课题项目2项，四川省重点项目2项，其他横向课题约50项。发表论文90余篇，其中SCI、EI收录50余篇。申请发明专利3项。获四川省科技进步奖三等奖1项，获得成都市科学技术奖励二等奖2项。担任以下学术期刊：《华西药学杂志》,《四川大学学报》,《Journal of Pharmaceutical Analysis》, 《Asian Journal of Chemistry》, 《Biomedical Chromatography》, 《Environmental Technology》,《Infrared Physics and Technology》and 《Journal of Medicinal Plant Research》.审稿人。为博士、硕士研究生课堂讲授《分析化学》，《现代仪器分析》（红外，紫外，薄层扫描，质谱章节），《药物研究新技术与新方法》（质谱新技术章节），《食品药品分析仪器联用技术选论》，《药物分析学选论》和《药物分析专业英语》课程。
指导博士3名；培养毕业硕士36余名。
培养硕士研究生1名获2009年度宝钢国家奖。
指导本科2014级大学生创新团队“黄嘌呤水平检测对无高尿酸血症高排泄型痛风的诊断意义探讨”项目获国家级资助


代表论著
张志荣, 胡清学, 叶利明. 《现代仪器联用分析》 成都科技大学出版社，1989，第一版
发表论文（英文2007年以来）：


1．Shurong Wang, Yu Cheng, Zhaoxia Gao, Meijin Xiong, Zhirong Zhang, Liming Ye*. Gas chromatographic-mass spectrometric analysis of d-limonene in human plasma. Journal of Pharmaceutical and Biomedical Analysis. 2007, 44: 1095 - 1099
2．Qiang Zheng, Liming Ye, Rong Gao, Jing Han, Meijin Xiong, Dong Zhao, Tao Gong．Kinetic release of triptolide after injection of renal-targeting 14-succinyl triptolide-lysozyme in a rat kidney　study by liquid chromatography / mass spectrometry. Biomedical Chromatography. 2007, 21: 724–729.
3．Shu-Rong Wang, Yu Chen, Li-Ping Wu, Wen-Juan Miao, Mei-Jin Xiong, Cong Chen, Zhi-Rong Zhong and Li-Ming Ye*. Development of predictive quantitative retention-activity relationship models of HMG-CoA reductase inhibitors by biopartitioning micellar chromatography. Journal of Pharmaceutical and Biomedical Analysis. 2008, (2): 243-249
4．Li-Ping Wu, Yu Chen, Shu-Rong Wang, Cong Chen, Li-Ming Ye*. Quantitative retention-activity relationship models for quinolones using biopartitioning micellar chromatography. Biomedical Chromatography. 2008, 22(1):106-114
5．Li-ping Wu, Li-ming Ye, Cong Chen, Jia-qi Wu, Yu Chen. Biopartitioning micellar chromatography separation methods: modelling quantitative retention-activity relationships of cephalosporins. Biomedical Chromatography. 2008, 22: 606-615.
6．Li-ping Wu, Yan Cui, Mei-jin Xiong, Shu-rong Wang, Cong Chen and Li-ming Ye *. Mixed micellar chromatography methods: modelling quantitative retention–activity relationships of angiotensin converting enzyme inhibitors. Biomedical Chromatography. 2008, 22(11):1243-1251
7．Ke Lan, Xuehua Jiang, Yunxia Li, Ling Wang, Jing Zhou, Qian Jiang and Limin Ye. Quantitative determination of rosuvastatin in human plasma by ion pair liquid–liquid extraction using liquid chromatography with electrospray ionization tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2007, 44: 540-546.
8. Shu-Rong Wang, Cong Chen, Mei-Jin Xiong, Li-Ping Wu, Li-Ming Ye*, Cong Chen. Quantitative retention-activity relationship models of angiotensin enzyme inhibitors using biopartitioning micellar chromatography. Journal of Chromatographic Science. 2010, 48 (2): 134-138
9. Yu Chen, Li-Ping Wu, Li-Ming Ye* Cong Chen. Development of predictive quantitative retention-activity relationship models of alkaloids by mixed micellar liquid chromatography. Biomedical Chromatography. 2010, 24(2):195-201
10.Yan Cui , HaiLinYin , Xu Bao , MeiJin Xiong , Cong Chen and LiMing
Ye *. Determination of penehyclidine hydrochloride in beagle dog plasma by liquid chromatography electro spray ionization mass spectrometry and the pharmacokinetic study. Journal of Chinese Pharmaceutical Sciences. 2008, 17：32-38
11.Jian Zhong Wang*, Li Ming Ye, Xiao Bing Chen. A new C27-steroidal glycoside from Ophiogon japonicus. Chinese Chemical Letters. 2008, 19 (1): 82-84
12. Zhang Z, Sun W, Luo P, Wu L, Ye L, Zhang H. Simultaneous determination of five main active constituents of Erigeron multiradiatus by HPLC-DAD-MS. Journal of Pharmaceutical and Biomedical Analysis. 2008, 48 (3): 980-985.
13. Xiao-Juan Ren , Shu-Rong Wang, Yu-Jie Liu, Li-Ping Wu, Cong Chen,Li-Ming Ye*. Effect of acidity of drugs on the prediction for human oral absorption by biopartitioning micellar chromatography. AJXJU(Academic Journal of Xi’an Jiaotong University).2010.229(4):233～240
14. Jintao Xue , Chunjie Wu, Leilei Wang, Su Jiang , Guo Huang , Jiliang Zhang , Silan Wen, Liming Ye*.Dynamic prediction models for alkaloid content using NIR technology for the study and online analysis of parching in Areca Seed. Food Chemistry.2011 (126): 725～730
15. Si-Lan Wen, Yu-Jie Liu, Hai-Lin Yin , Liu Zhang, Jin Xiao, Hong-Yuan Zhu , Jin-Tao Xue* and Li-Ming Ye*.Effect of Acupuncture on Rats with Acute Gouty Arthritis Inflammation: A Metabonomic Method for Profiling of both Urine and Plasma Metabolic Perturbation. AJCM(The American Journal of Chinese Medicine). 2011.39 (2) : 287～300
16. Intra-herb pharmacokinetics interaction between quercetin and isorhamentinLan, K., He, J.-L., ian, Y., Tan, F., Jiang, X.-H., Wang, L., Ye, L.-M. Acta Pharmacologica Sinica， 2008 （29）11：1376 - 1382
17. Jintao Xue , Chunjie Wu, Leilei Wang, Su Jiang , Guo Huang , Jiliang Zhang , Silan Wen, Liming Ye*.Rapid and Automated Analytical Method for Identification of the Types of Parched Areca Seed by Near Infrared Spectroscopy. Asian Journal of Chemistry; 2011 (22) 12:6543
18. Yan Liang, Xiao Juan Ren, Jin Tao Xue,Si Lan Wen ,Cong Chen ,Li Ming Ye* Development of QSAR/QRAR methods by biopartioning micellar chromatography and application in prediction of oral absorption of bioactive ingredients in Traditional Chinese Medicines. Asian Journal of Chemistry. 2013 (25) 3: 1525-1530
19. Yan Liang, Zong-Ling Yin, Jing-Jing Zhang, Qi-Bing Zhang, Zhong-Xia Wang, Xiao –Juan Ren, Jian Chen, Li –Ming Ye* Release test of alliin /alliinase double-layer tablet by HPLC. Journal of Pharmaceutical Analysis 2012 ( 4 ) 4 : 1234
20. Han Chen, Yan Liang, Xiao Juan Ren, Dong Mei Xiong, Shu Rong Wang, Li Ping Wu, Cong Chen, Li Ming Ye* . Studies effect of acid-base property in conjunction with molecular descriptors for chemical drugs and bioactive ingredients of Traditional Chinese Medicine on prediction of oral absorption by biopartioning micellar chromatography. Asian Journal of Chemistry; 2013 (25)15:8431-8443
21. Xue Jintao, Chen Han, Xiong Dongmei, Huang Guo, Ai Hong, Liang Yan, Yan Xinyu, Gan Yuan, Chen Cong, Chao Ruobing. Ye Liming *. Noninvasive Measurement of Glucose in Artificial Plasma with Near-Infrared (NIR) and Raman Spectroscopy Applied. Spectroscopy.2014 (68)04:08
22．D.M.XIONG, Z. LIU, H. CHEN, J.T. XUE, Y. YANG, C. CHEN, L.M.YE* . Profiling the dynamics of Abscisic acid and ABA-glucose ester after using the glucosyltransferase UGT71C5 to mediate abscisic acid homeostasis in Arabidopsis thaliana by HPLC-ESI-MS/MS .Journal of Pharmaceutical Analysis. 2014 4（3）：190-196
23. D.M.XIONG, S.L.WEN,? H.CHEN, X.BAO*, and L.M.YE*. Determination of Leuprolide in Beagle Dogs’ serum by High Performance Liquid Chromatography-mass Spectrometry and Study on Bioequivalence. Asian Journal of Chemistry; 2013 (25)18:15826-15831
24. Yuan Gan, Yan Liang, Han Chen,Jin Tao Xue,Yu Xin Yan,Mei Dong Xiong,
Cong Chen, Ming Li Ye*,, Ting Xu, Yu Chen. Prediction and Screening of Biologically Active Compounds In Honeysuckle (Lonicera japonica) by Biopartitioning Micellar Chromatography. Asian Journal of Chemistry; 2015 (27)
25.Jia –Yu Ding, Xiu-Xiu Liu, Dong-Mei Xiong, Li-Ming Ye, Rou-Bing Chao. Simultaneous Determination of Thirteen Aminoalcohl-Diterpenoid Alkaloid in the Lateral Roots of Aconitum carmichaeli by Solid-Phase Extraction-Chromatography-Tandem Mass Spectrometry. Planta Med 2014,80:723-731 DOI 10.1055/s-
26. Liu Z, Yan JP, Li DK, Luo Q, Yan Q, Liu ZB, Ye LM, Wang JM, Li XF, Yang Y.UDP-glucosyltransferase71c5, a major glucosyltransferase, mediates abscisic acid homeostasis in Arabidopsis. Plant Physiol. 2015 Apr;167(4):1659-70. doi: 10.1104/pp.15.00053. Epub 2015 Feb 20.
27．Shuping Shuai, Shanlan Yue, Junyi Yang, Liming Ye et al. Preparation, characterization and in vitro/vivo evaluation of tectorigenin solid dispersion with improved dissolution and bioavailability. European journal of drug metabolism and pharmacokinetics. Fist online: 11 February 2015, pp 1-10.
28. L. WANG, H.R. YANG, J.T. XUE, L.M. YE, D.S. LIN and X.P. XU. Simultaneous Determination of Ginsenosides, Ginsenosides, Notoginsenosides and Panaxtrol Saponin of Panax notoginseng by Near Infrared Spectroscopy. Asian Journal of Chemistry; Vol. 27, No. 2 (2015), 555-557
29. Xue Jintao, Ye Liming *. Noninvasive and Fast Measurement of Blood Glucose in vivo by Near Infrared (NIR) Spectroscopy .Spectrochimica Acta Part A: Molecular and Biomolecular SpectroscopySaa, doi: 10.1016/j.saa.2017.02.032
30. Kaiyue Li, Weiying Wang, Yanping Liu, Su Jiang, Guo Huang, Liming Ye*. NIR Spectroscopy as a Process Analytical Technology Tool for Monitoring the Parching Process of Traditional Chinese Medicine based on Two Kinds of Representative Chemical Values. Pharmacognosy Magazine.2017 pm_416_16R4
31. Dan Hu, Tian Cai, Wei-Ying Wang, Li-Ming Ye,* and Zhi-Jun Wu,* .Unexpected hydrated ions in the detection of sodium adduct coumarins using electrospray tandem mass spectrometry. European Journal of Mass Spectrometry.2017 Vol. 23(3) 122–126
32. Yanping LIU, Min LIANG, Jintao XUE, Jianzhong WANG1, Kaiyue LI & Liming YE*. Simultaneous determination of five isosteroidalalkaloidsinSiberian Fritillary Bulbin rat plasma andits application in pharmacokinetic studyby HPLC-MS/MS.Latin American Journal of Pharmacy(Lat. Am. J. Pharm). 2017.36 (5):1024
33. Weiying Wang, Jintao Xue, *Kaiyue Li, Dan Hu, Guo Huang, Liming Ye*. Dynamic Predictive Models of Five Alkaloids during theProcess of Stir-frying with Wine inCoptisUsing Near-infrared Spectroscopy. International Journal of Food Properties. 2017, VOL. 20, NO. S1, S644–S653
34. J. LIU, S. Y. DAI, L. M. YE AND C. M. FU. Study on the Chemical Profiling of Fangfeng Tongsheng Pills by HPLC. Indian Journal of Pharmaceutical Sciences. May - June 2016
35. D. Hu, X. Xu, T. Cai, W.-y. Wang, C.-j. Wu and L.-m. Ye*. Simultaneous determination of isopyrazam and azoxystrobin in cucumbers by Liquid Chromatography-Tandem Mass Spectrometry" . Journal of Food Protection Decision for Manuscript Vol. 80, No. 12, 2017, Pages 2112–2118
36. Binge Deng,Yuan Gan,Kaiyue Li,MengZhang,Liming Ye,* Study on chromatographic behavior of different water-soluble drugs via dynamic cell membrane chromatography online coupled with HPLC. Analytical Letters. 2018, VOL. 51, NO. 8, 1109–1121
37. Yinghui Wen,Li He , Rui Peng,, Yonghong Lin, Lina Zhao, Xiaoxiao Li , Liming Ye, Junyi Yang,?A novel strategy to evaluate the quality of herbal products based on the chemical profiling, efficacy evaluation and pharmacokinetics. Journal of Pharmaceutical and Biomedical Analysis 161 (2018) 326–335
38.Xue Jintao,Shi Yongli ,Ye Liming *, Yang Quanwei ,Li Chunyan , Chen Xingyi , Jing Yun . Near-infrared spectroscopy for rapid and simultaneous determination of five main active components in rhubarb of different geographical origins and processing.Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 205 (2018) 419–427.
39. Binge Deng , Xia Luo , Meng Zhang, Liming Ye* , Yu Chen*. Quantitative detection of acyclovir by surface enhanced Raman spectroscopy using a portable Raman spectrometer coupled with multivariate data analysis. Colloids and Surfaces B: Biointerfaces 173 (2019) 286–294.
40. Yu Wang,Miao Deng,Binge Deng, Liming Ye*,Xiaofan Fei*,Zhigang Huang. Study on the diagnosis of gout with xanthine and hypoxanthine. J Clin Lab Anal. 2019;e22868. 1 of 7 https://doi.org/10.1002/jcla.22868
41. Meng Zhang , Xia Luo , Binge Deng, Bihua Ma1 and Liming Ye *.Evaluating the effect of Ganoderma lucidum polysaccharides on five cytochrome P450 isozymes with cocktail probe drugs in rats by LC–MS/MS. J Pharmaceut Res, 2019. Volume 4 | Issue 1 | 2 of 9
42. Xingyi Chen , Jintao Xue , Weiying Wang , Bihua Ma , Guo Huang , Yu Chen, Liming Ye*. Rapid and Simultaneous Analysis of Five Free Anthraquinone Contents in Rhubarb during the Stir-Frying with Rice Wine Process by Near Infrared Reflectance Spectroscopy . Pharmacognosy Magazine, Volume 15, Issue 63, July-September **-486
43. Bihua Ma,Meng Zhang,Dan Hu,Xingyi Chen,Yu Chen*,Liming Ye*.Pharmacokinetic Study of Azoxystrobin and Isopyrazam in Rat by LC-MS/MS and
Evaluation of Its Toxicity. International Journal of Biopharmaceutical Sciences. 2020.Volume: 3.1:1-7
44. Qinyan Zhang, Dongguo Li, Bihua Ma, Xueyan Wang , Junyi Yang, Donglin
Chen,*, Liming Ye*. Pharmacokinetics and Tissue Distribution Study in Rats of Hupehenenine, A Novel Isosteroid Alkaloid Isolated from Bulbs Hupehensis Fritillariae. Biomedical Chromatography.2021(printing)
45. Dongguo Li, Qinyan Zhang, Bing Deng, Yu Chen, Liming Ye*. Rapid, sensitive detection of ganciclovir, penciclovir and valacyclovir?hydrochloride by artificial neural network and partial least squares combined with surface enhanced Raman spectroscopy. Applied Surface Science.539(2021).148224.
46. Peng Qin, Binhua Hu, Guohua Zhang, Binhua Hu,Jie Wu, Weilan Chen, Zhijie Ren, Yulan Liu, Jing Xie,Hua Yuan, Bin Tu, Bingtian Ma, Yuping Wang, Limin Ye, Legong Li, Chengbin Xiang*, Shigui Li*. Leaf-derived ABA regulates rice seed development via a transporter-mediated and temperature-sensitive mechanism. Science Advances.2021;7:eabc8873 15 January 2021