单位：四川大学华西医院中药药理实验室
通讯地址：成都市高新区高朋大道科园4路1号华西科技园
电话/传真：(028) **
E-mail: huangwen@scu.edu.cn

简历
学习工作经历：
1999–2002，四川大学，博士
2002–2004，北京大学，博士后
2004–2006，北京中医药大学，药学院
2006–2009，四川大学，生物治疗国家重点实验室
2009–至今，四川大学，华西医院中药药理实验室主任

社会职务：
四川省学术带头人；联合国人居署“SCP” 项目中方专家；中国—欧盟“EMCP”国际合作项目中方专家；国家中医药管理局项目评委；国家自然科学基金项目评审专家。
研究方向：
天然药物和传统药物药理学，天然药物及中药新药临床前研究与评价
主要研究课题及成果：
1. Bcl-xL调控mtDNA/P选择素在糖尿病血瘀证发病中的作用及薯蓣皂苷的干预机制（国家自然科学基金，2017-2020，负责人）
2. 环戊烷并多氢菲类化合物抗新生血管新药临床前基础研究与评价（企业合作项目，2015-2020，负责人）
3. 环境有害化合物毒理及其生物降解研究（国家“十二五”科技支撑，2011-2015，负责人）
4. 一种新型高效单宁酰基水解酶的晶体结构及其催化机制（国家自然科学基金，2010-2012，负责人）
5. 靶向治疗心血管疾病的薯蓣皂苷纳米脂质载药体系制备技术研究（四川省科技支撑，2008-2010，负责人）
6. 黄姜资源高值产品的开发和利用技术研究（国家“十一五”科技支撑，2006-2009，负责人）
7. 食品添加剂叔丁基对苯二酚（TBHQ）体内代谢及其检测技术研究（国家“十五”科技攻关，2003-2005，负责人）
代表论著：
1.pH-Responsive nanoparticles based on ibuprofen prodrug as drug carriers for inhibition of primary tumor growth and metastasis. J Mat Chem B 2017, 5(33): 6860-6868.(IF 4.543，通讯作者)
2.Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release. Free Radic Biol Med 2017, 108: 247-257. (IF 5.6059，通讯作者)
3.Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway. Scientific reports 2017, 7: 12. (IF 4.2589，通讯作者)
4.Synthesis, characterization, and biological studies of diosgenyl analogs. Journal of Asian Natural Products Research 2017, 19(3): 272-298. (通讯作者)
5.Preventive effect of a novel diosgenin derivative on arterial and venous thrombosis in vivo. Bioorganic & Medicinal Chemistry Letters 2016, 26(14): 3364-3369. (通讯作者)
6.One compound of saponins from Disocorea zingiberensis protected against experimental acute pancreatitis by preventing mitochondria-mediated necrosis. Scientific reports 2016, 6: 35965. (IF 4.2589，通讯作者)
7.Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release. Scientific reports 2016, 6: 36222. (通讯作者)
8.Synthesis, characterization, and biological studies of diosgenyl analogs. J Asian Nat Prod Res 2016: 1-27. (通讯作者)
9.9,10-Dihydrophenanthrene derivatives and one 1,4-anthraquinone firstly isolated from Dioscorea zingiberensis C. H. Wright and their biological activities. Fitoterapia 2016, 109: 20-24. (通讯作者)
10.Novel polyacetylenes from Coreopsis tinctoria Nutt. Journal of Asian Natural Products Research 2015, 17(7): 744-749. (通讯作者)
11.Reference Intervals for Hemoglobin and Age- and Gender-Related Trends in the Population of Southwest China. Clinical Laboratory 2015, 61(12): 1831-1836. (通讯作者)
12.Haloemodin as Novel Antibacterial Agent Inhibiting DNA Gyrase and Bacterial Topoisomerase I. Journal of Medicinal Chemistry 2014, 57(9): 3707-3714. (IF 6.2589，通讯作者)
13.Micro-flowers changing to nano-bundle aggregates by translocation of the sugar moiety in Janus TA nucleosides. Chemical Communications 2013, 49(36): 3742-3744. (IF6.3189，通讯作者)
14.Anti-thrombosis effect of diosgenyl saponins in vitro and in vivo. Steroids 2013, 78(11): 1064-1070. (通讯作者)
15.Synthesis of Diosgenin-Ibuprofen Derivatives and Their Activities against Insulin-Dependent Diabetes Mellitus. Chemical & Pharmaceutical Bulletin 2013, 61(5): 532-538. (通讯作者)
16.Determination of deltonin in rat plasma by using HPLC-MS/MS and the application of this method in pharmacokinetic studies. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2013, 931: 1-5. (通讯作者)
17.Cytotoxicity and apoptosis-inducing effect of steroidal saponins from Dioscorea zingiberensis Wright against cancer cells. Steroids 2012, 77(12): 1219-1227. (通讯作者)
18.Ultrasonic and fermented pretreatment technology for diosgenin production from Diosorea zingiberensis CH Wright. Chemical Engineering Research & Design 2011, 89(2A): 239-247. (通讯作者)
19.Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis CH Wright in vitro and in vivo. Phytomedicine 2011, 18(6): 458-463. (通讯作者)
20.Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright. Fitoterapia 2010, 81(8): 1147-1156. (通讯作者)
21.Robinetinidol-(4beta-->8)-epigallocatechin 3-O-gallate, a galloyl dimer prorobinetinidin from Acacia mearnsii De Wild, effectively protects human neuroblastoma SH-SY5Y cells against acrolein-induced oxidative damage. J Alzheimers Dis 2010, 21(2): 493-506.（第一作者）
22.Rutin inhibits hydrogen peroxide-induced apoptosis through regulating reactive oxygen species mediated mitochondrial dysfunction pathway in human umbilical vein endothelial cells. Eur J Pharmacol 2010, 628(1-3): 27-35. (通讯作者)
23.Optimised ultrasonic-assisted extraction of flavonoids from Folium eucommiae and evaluation of antioxidant activity in multi-test systems in vitro. Food Chemistry 2009, 114: 1147-1154.（第一作者）
24.The best utilization of D. zingiberensis C.H. Wright by an eco-friendly process. Bioresource Technology 2008, 99(15): 7407-7411.（第一作者）
25.Ellagic acid from acorn fringe by enzymatic hydrolysis and combined effects of operational variables and enzymes on yield of the production. Bioresource Technology 2008, 99(6): 1518-1525.（第一作者）
26.Optimization of ellagic acid production from ellagitannins by co-culture and correlation between its yield and activities of relevant enzymes. Bioresource Technology 2008, 99(4): 769-775.（第一作者）
27.Bioactivity of Solanesol Extracted from Tobacco Leaves with Carbon Dioxide-Ethanol Fluids. Biochemical Engineering Journal 2008, 42: 92-96.（第一作者）
28.Utilization of acorn fringe for ellagic acid production by Aspergillus oryzae and Endomyces fibuliger. Bioresource Technology 2008, 99(9): 3552-3558.（第一作者）
29.Optimization of operating parameters of supercritical carbon dioxide extraction for lycopene production and extract antioxidant activity by response surface methodology. Journal of Food Engineering 2008, 89: 298-302.（第一作者）
30.Effect of ellagitanin acyl hydrolase, xylanase and cellulase on ellagic acid production from cups extract of valonia acorns. Process Biochemistry 2007, 42: 1291-1295.（第一作者）


编辑：四川大学华西药学院