通讯地址：成都市人民南路三段17号四川大学华西药学院（邮编610041）
电子邮箱：
dpli@scu.edu.cn
dpli_dapengli@hotmail.com




教育工作经历：
2021.03-至今，四川大学，华西药学院，药物分析系，特聘副研究员
2018.07-2020.12，香港浸会大学，化学系，博士后
2017.02-2017-03，美国斯坦福大学/太平洋大学，访学
2015.07-2015.08，香港大学，李嘉诚医学院，访学
2013.9-2018.6，中国药科大学，中药学院，博士
2009.9-2013.6，中国药科大学，中药学院，学士


研究方向：
1. 蛋白组学/修饰组学及药物作用机制和靶点发现
2. 功能纳米化学临床生物分子的诊断监测分析
3. 药物/天然药物质量控制及分析新技术新方法


科研项目：
1. 基于蛋白组学的药物性胆汁淤积肝损伤的作用机制研究，四川大学引进人才经费，2021.3-2024.3，负责人
2. 基于修饰组学的药物作用机制及靶点的发现研究，专项四川省配套经费，2021.3-2024.3，负责人


发表论文：
(1) Li, D.; Jiang, L.; Hong, Y.; Cai, Z.* Multilayered Glycoproteomic Analysis Reveals the Hepatotoxic Mechanism in Perfluorooctane Sulfonate (PFOS) Exposure Mice. Environmental Pollution 2021, 268, 115774.
(2) Li, D.; Zhang, J.; Xie, G.; Ji, F.; Shao, X.; Zhu, L.; Cai, Z.* A Dual-Zwitterion Functionalized Ultra-Hydrophilic Metal–Organic Framework with Ingenious Synergy for Enhanced Enrichment of Glycopeptides. Chemical Communications 2019, 55 (93), 13967–13970.
(3) Li, D.; Xu, L.; Qi, J.; Yu, B.* Screening and Analysis of Cyclooxygenase-2 Inhibitors from the Complex Matrix: A Case Study to Illustrate the Important Effect of Immobilized Enzyme Activity in Magnetic Ligand Fishing. Journal of Pharmaceutical and Biomedical Analysis 2019, 175, 112795.
(4) Yang, C.; Zhu, L.; Kang, Q.; Lee, H. K.; Li, D.; Chung, A. C. K.; Cai, Z.* Chronic Exposure to Tetrabromodiphenyl Ether (BDE-47) Aggravates Hepatic Steatosis and Liver Fibrosis in Diet-Induced Obese Mice. Journal of Hazardous Materials 2019, 378, 120766.
(5) Yi, R.; Fu, R.; Li, D.; Qi, J.*; Liu, H. Identification of Ligands from Natural Products as Inhibitors of Glutathione S-Transferases Using Enzyme Immobilized Mesoporous Magnetic Beads with High-Performance Liquid Chromatography plus Quadrupole Time-of-Flight Mass Spectrometry and Molecular Docking. Journal of Separation Science 2019, 42 (24), 3611–3620.
(6) Li, D.; Yi, R.; Tian, J.; Li, J.; Yu, B.*; Qi, J.* Rational Synthesis of Hierarchical Magnetic Mesoporous Silica Microspheres with Tunable Mesochannels for Enhanced Enzyme Immobilization. Chemical Communications 2017, 53 (63), 8902–8905.
(7) Wang, T.; Li, D.#; Yu, B.*; Qi, J.* Screening Inhibitors of Xanthine Oxidase from Natural Products Using Enzyme Immobilized Magnetic Beads by High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry. Journal of Separation Science 2017, 40 (9), 1877–1886.
(8) Wang, Y.; Hong, F.; Li, D.; Qi, J.*; Liu, X. A Novel Strategy for Evaluation of Natural Products Acting on the Myeloperoxidase/Hypochlorous Acid System by Combining High-Performance Liquid Chromatography-Photodiode Array Detection-Chemiluminescence and Ultrafiltration-Mass Spectrometry Techniques. Journal of Separation Science 2018, 41 (22), 4222–4232.
(9) Li, D.; Wang, T.; Guo, Y.; Hu, Y.; Yu, B.*; Qi, J.* Online Screening of Nitric Oxide Scavengers in Natural Products Using High Performance Liquid Chromatography Coupled with Tandem Diode Array and Fluorescence Detection. Journal of Chromatography A 2015, 1425, 106–115.
(10) Li, F.; Tan, Y.-S.; Chen, H.-L.; Yan, Y.; Zhai, K.-F.; Li, D.-P.; Kou, J.-P.*; Yu, B.-Y.* Identification of Schisandrin as a Vascular Endothelium Protective Component in YiQiFuMai Powder Injection Using HUVECs Binding and HPLC-DAD-Q-TOF-MS/MS Analysis. Journal of Pharmacological Sciences 2015, 129 (1), 1–8.
(11) 李大鹏; 谢光珊; 谢佩斯; 朱林; 蔡宗苇*. 两性离子双功能化超亲水金属有机框架纳米复合材料的制备及其用于糖肽的选择性富集. 色谱 2020, 1–6.
(12) 毕素侠; 王莹; 李大鹏; 戚进; 余伯阳*. 中药活性成分筛选方法研究进展. 海峡药学 2018, 30 (11), 43–46.