张国林职 务:副所长职 称:研究员学 历:博士研究生电 话:**传 真:**通讯地址:四川省成都市人民南路四段九号，中科院成都生物所
邮政编码:610041电子邮件:zhanggl@cib.ac.cn
个人简历 1980.09-1984.07?? 四川大学化学系，获理学学士学位
1984.09-1987.07?? 兰州大学化学系有机合成专业，获理学硕士学位。
1990.09-1993.09?? 波恩大学数学——自然科学学院药物研究所，获理学博士学位。
1987.07-1990.09?? 中国科学院成都生物研究所，助研（1989.07）
1993.09-1994.12?? 波恩大学，从事抗肿瘤活性天然产物的研究
1995.01-1996.11?? 北京大学化学与分子工程学院有机化学研究所，博士后
1996.11-???????? 中国科学院成都生物研究所从事天然药物化学的研究，研究员（1998）、博士生导师（1999）、副所长（2008）
研究方向 天然药物化学
代表论著 近五年发表的主要论文:?
1.???????? Zhijun Wu, Guoyou Li, Dongmei Fang, Huayi Qi, Weijian Ren, Guolin Zhang, Analysis of epipolythiodioxopiperazines in fungus Chaetomium cochliodes using HPLC-ESI-MS/MS/MS, Analytical Chemistry, 2008, 80 (1): 217-226?
2.???????? Guoyou Li, Bogang Li, Tao Yang, Guangye Liu, Guolin Zhang, Secondary metabolites from the fungus Chaetomium brasiliense, Helvetica Chimica Acta, 2008, 91: 124-129?
3.???????? Xiaoyu Hu, Yinggang Luo, Xiaozhen Chen, Le Zhou, Guolin Zhang, Chemical constituents of Nouelia insignis Franch, Journal of Asian Natural Products Research, 2008, 10 (2): 125-131?
4.???????? Qilin Li, Bogang Li, Yan Zhang, Xiaoping Gao, Chongqian Li, Guolin Zhang, Three angiotensin-converting enzyme inhibitors from Rabdosia coetsa, Phytomedicine, 2008, 15: 386-388?
5.???????? Yipeng Xie, Bogang Li, Guolin Zhang, Preparation of two diastereomeric decalins synthons and (-)-ambrox, Helvetica Chimica Acta, 2008, 91: 734-740?
6.???????? Xiaozhen Chen, Huafang Wu, Guoyou Li, Shengming Lu, Bogang Li, Dongmei Fang, ?Guolin Zhang, Iridoids from Viburnum cylindricum, Helvetica Chimica Acta, 2008, 91: 1072-1076?
7.???????? Qingchun Huang, Bogang Li, Yipeng Xie, Kaibei Yu, Guolin Zhang. (3aS,7S,9aS,9bR)-3a,6,6,9a-Tetramethyl-2-oxoperhydronaphtho[2,1-b]furan-7-yl acetate, Acta Crystallographica, Section E, 2008, E64, o1765?
8.???????? Huafang Wu, Yinggang Luo, Kaibei Yu, Guolin Zhang, Xinfu Pan, (2S,NS)-N-Allyl-N-benzyl-1-hydroxy-3-(4-hydroxyphenyl)-N-methylpropan-2-aminium bromide, Acta Crystallographica, Section E, 2008, E64, o1621?
9.??? Shengming Lu, Guolin Zhang, Alkaloids from Gendarussa vulgaris Nees, Natural Products Research, 2008, 22 (18): 1610-1613?
10.???? Ling Qin, Bogang Li, Jiafa Guan, Guolin Zhang, In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus, Natural Products Research, 2009, 23 (4): 309-318?
11.?Zhijun Wu, Xiaoli Ma, Dongmei Fang, Huayi Qi, Weijian Ren, Guolin Zhang, Analysis of caffeic acid derivatives from Osmanthus yunnanesis using electrospray ionization quadrupole time-of-flight mass spectrometry, Eur. J. Mass Spectrom, 2009, 15: 415-429?
12.?Guoyou Li, Tao Yang, Yinggang Luo, Xiaozhen Chen, Dongmei Fang, Guolin Zhang, Brevianamide J, a new indole alkaloid dimer from fungus Aspergillus versicolor, Organic Letters, 2009, 11 (16): 3714-3717?
13.????? Feiyan Tao, Yinggang Luo, Qingchun Huang, Yan Liu, Bogang Li, Guolin Zhang. Facile syntheses of l-β-haloalanine derivatives from l-cysteine or l-cystine. Amino Acids, 2009, 37 (4): 603-607?
14.???? Huafang Wu,Wenbin Lin, Lizi Xia, Yinggang Luo, Xiaozhen Chen, Guoyou Li, Guolin Zhang, Xinfu Pan, N-Stereogenic quaternary ammonium salts from L-amino acids: Synthesis, separation, and absolute configuration, Helvetica Chimica Acta, 2009, 92: 677-688?
15.??? Zhijun Wu, Xiaozhen Chen, Dongmei Fang, Huayi Qi, Weijian Ren, Guolin Zhang, Analysis of phenolic glycosides from Ilex litseaefolia using electrospray ionization quadrupole time-of-flight mass spectrometry, Rapid Commnications in Mass Spectrometry, 2009, 23: 3881–3885?
16.???? Zhijun Wu, Jianxin Pu, Limei Li, Dongmei Fang, Huayi Qi, Guoyou Li, Jianzhong Chen, Handong Sun, Guolin Zhang, Electrospray tandem mass spectrometry of longipedlactone triterpenoids, J. Mass Spectrom. 2010, 45: 451-455.?
17.???? Zhijun Wu, Dan Han, Xiaozhen Chen, Dongmei Fang, Huayi Qi, Guolin Zhang, Analysis of benzofuran derivatives using electrospray ionization ion trap and electrospray ionization quadrupole time-of-flight mass spectrometry, Rapid Commnications in Mass Spectrometry. 2010, 24: 1211-1215.?
18.???? Lizi Xia, Min Zhou, Yanhua Xiao, Guoyou Li, Xiaozhen Chen, Guolin Zhang, Chemical Constituents from Helwingia japonica, 中国天然药物(Chinese Journal of Natural Medicine), 2010, 8 (1): 16-20?
19.???? Hongwei Yu, Bogang Li, Xiaozhen Chen, Changsong Li, Guolin Zhang, Chemical Study on Evodia vestita, Chin J Appl Biol, 2010, 16 (1): 72-75?
20.???? Xiaozhen Chen, Guoyou Li, Xiaoqing Wu, Qingchun Huang, Guolin Zhang, Chemical Study on Sambucus adnata Wall, Chin J Appl Biol, 2010, 16 (1): 197-201?
21.???? Guoyou Li, Limei Li, Tao Yang, Xiaozhen Chen, Dongmei Fang, Guolin Zhang, Four New Alkaloids, Brevianamides O–R, from the fungus Aspergillus versicolor, Helvetica Chimica Acta, 2010, 93 (10): 2075-2080?
22.???? Changsong Li, Hongwei Yu, Guoyou Li, Guolin Zhang, Chemical constituents from the roots of Dysoxylum densiflorum, Chinese Journal of Natural Medicine, 2010, 8 (4): 270-273?
23.???? Zhijun Wu, Dongmei Fang, Dan Han, Guoyou Li, Xiaozhen Chen, Huayi Qi, Guolin Zhang, Analysis of sesterterpenoids from Aspergillus terreus using ESI-QTOF and ESI-IT, Phytochemical Analysis, 2010, 21 (4): 374-383?
24.???? Chun Feng, Bogang Li, Xiaoping Gao, Huayi Qi, Guolin Zhang, A new triterpene and an antiarrhythmic liriodendrin from Pittosporum brevicalyx, Archives of Pharmacal Research，2010, 33 (12): 1927-1932?
25.???? Changsong Li, Hongwei Yu, Xiaozhen Chen, Xiaoqing Wu, Guoyou Li, Guolin Zhang, Three new eudesmanolides from Camchaya loloana, Helvetica Chimica Acta, 2011, 94 (1): 105-110?
26.???? Lijuan Yang, Qianfeng Chen, Fei Wang, Guolin Zhang，Antiosteoporotic compounds from seeds of Cuscuta chinensis, Journal of Ethnopharmacology, 2011, 135: 553–560 ?
27.???? Jianyu Zhao, Min Zhou, Yan Liu, Guolin Zhang, Yinggang Luo, Chromones and coumarins from the dried fructus of Cnidium monnieri, Fitoterapia, 2011, 82: 767–771?
28.???? 王星, 吕广颖, 杨利娟, 王飞, 王淳, 7-羟基异黄酮及其衍生物的合成与选择性雌激素受体结合的构效关系研究, 有机化学, 2011, 31 (8): 1245-1251.?
29.???? Zhijun Wu, Dongming Sun, Jianzhong Chen, Xiaozhen Chen, Dongmei Fang, Na Li, Ping Cheng，Guolin Zhang, Analysis of cipadesin limonoids from Cipadessa cinerascens using electrospray ionization quadrupole time-of-flight tandem mass spectrometry and quantum chemical calculations, Rapid Commnications in Mass Spectrometry, 2012, 26: 563–571?
30.??? Guobo Xu, Limei Li, Dongmei Fang, Guoyou Li, Guolin Zhang, Zhijun Wu*. Electrospray tandem mass spectrometry of chaetoglobosins, Rapid Commun. Mass Spectrom. 2012, 26, 2115-2122.?
31.???? Zhengfu Tai, Guolin Zhang, Fei Wang. Identification of small molecule activators of the Janus kinase/signal transducer and activator of transcription pathway using a cell-based screening. Biological & Pharmaceutical Bulletin, 2012, 35: 65-71?
32.???? Yinggang Luo, Min Zhou, Qi Ye, Guolin Zhang, Dihydroagarofurna derivatives from dried roots of Tripterygium wilfordii, Journal of Natural Products, 2012, 75: 98-102?
33.???? Qianfeng Chen, Xiaozhen Chen, Guoyou Li, Chun Wang, Guolin Zhang, Two new 2-phenylbenzofurans from the bark of Styrax perkinsiae, Chinese Journal of Natural Medicine, 2012, 10 (2): 92-97?
34.???? Xiaoqing Wu, Xiaozhen Chen, Qingchun Huang, Dongmei Fang, Guoyou Li, Guolin Zhang, Toxicity of raw and processed roots of Polygonum multiflorum, Fitoterapia, 2012, 83: 469-475?
35.???? Danfeng Lu, Lijuan Yang, Fei Wang, Guolin Zhang, Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19), ?Journal of Agricultural and Food Chemistry, 2012, 60 (34): 8411-18. ?
36.????? Danfeng Lu, Lijuan Yang, Qilin Li, Xiaoping Gao, Fei Wang, Guolin Zhang, Egonol?gentiobioside?and?egonol?gentiotrioside?from?Styrax?perkinsiae?promote?the??biosynthesis of estrogen by aromatase, European Journal of Pharmacology, 2012, 691: 275–282?
37.???? Guobo Xu, Limei Li, Tao Yang, Guolin Zhang, Guoyou Li, Chaetoconvosins A and B, Alkaloids with new skeleton from fungus Chaetomium convolutum, Organic Letters, 2012, 14 (23): 6052–6055?
38.???? Qianfeng Chen, Lijuan Yang, Guolin Zhang, Fei Wang, Bioactivity-guided isolation of antiosteoporotic compounds from Ligustrum lucidum, Phytotherapy Research, 2013, 27: 973-979.?
39.???? Lijuan Yang, Danfeng Lu, Jiajia Guo, Xianli Meng, Guolin Zhang, Fei Wang，Icariin?from?Epimedium?brevicornum?Maxim?promotes?the?biosynthesis?of?estrogen?by?aromatase?(CYP19)，Journal?of?Ethnopharmacology, 2013, 145: 715-721. ?
40.???? 鲁丹枫，Azimova Bahtigul Jovliqizi，张国林，王飞*，采用磁微粒分离酶联免疫法构建基于KGN细胞的雌激素生物合成筛选模型，天然产物研究与开发，2013, 25: 27-30,67 ?
41.???? Puzhao Zhang, Fei Wang, Lijuan Yang, Guolin Zhang*, Pregnane alkaloids from Sarcococca hookeriana var digyna, Fitoterapia, 2013, 89:143-148 ?
42.???? Yuan Lin, Fei Wang, Lijuan Yang, Ze Chun, Jinku Bao, Guolin Zhang*, Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum, Phytochemistry, 2013, 95: 242-251 ?
43.???? Xiang Pu, Xixing Qu, Fei Chen, Jinku Bao, Guolin Zhang*, Yinggang Luo*, Endophytic fungus Trichoderma atroviride LY357: Isolation, identification, and camptothecin production, Applied Microbiology and Biotechnology, 2013, 97: 9365–9375?
44.???? Wei Yang, Dongmei Fang, Hongping He, Xiaojiang Hao, Zhijun Wu*, Guolin Zhang, Analysis of mexicanolide- and phragmalin-type limonoids from Heynea trijuga using high-performance liquid chromatography/electrospray tandem mass spectrometry, Rapid Commun. Mass Spectrom. 2013, 27: 1203–1212?
45.???? Jie Ren, Guoyou Li, Lan Shen, Guolin Zhang*, Laurance A. Nafie, Huajie Zhu*，Challenges in the assignment of relative and absolute configurations of complex molecules: computation can resolve conflicts between theory and experiment, Tetrahedron, 2013, 69 (48): 10351-10356?
46.???? Wenchen Pu, Guanmin Mu, Guolin Zhang*, Chun Wang*, Copper-Catalyzed Decarboxylative Intramolecular C-O Coupling: Synthesis of 2-Arylbenzofuran from 3-Arylcoumarin, RSC Advances, 2014, 4: 903–906?
47.???? ?Zhengfu Tai, Yujiao He, Yuan Lin, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang*, ?Fei Wang*, Luteolin Sensitizes the Antiproliferative Effect of Interferon α/β by Activation of JAK/STAT Pathway through PKA-Mediated Inhibition of SHP-2 in cancer cells, Cell Signaling, 2014, 26: 619-628?
48.???? Guoyong Luo, Min Zhou, Yan Liu, Qi Ye, Jian Gu, Tianfang Huang, Guolin Zhang, Yinggang Luo，3-Formyl-2-arylbenzofurans from the aerial parts of Itea ilicifolia，Phytochemistry Letters, 2014, 10: 19–22?
49.???? Yuan Lin, Fei Wang, Guolin Zhang*, Natural products and their derivatives regulating the Janus kinase/signal transducer and activator of transcription pathway, Journal of Asian Natural Products, 2014, 16 (7)：800-812?
50.???? Guoyong Luo, Yun Yang, Min Zhou, Qi Ye, Yan Liu, Jian Gu, Guolin Zhang, Yinggang Luo, Novel 2-arylbenzofuran dimers and polyisoprenylated flavanones from Sophora tonkinensis, Fitoterapia, 2014, 99 : 21-27?
51.???? Jiajia Guo, Yun Yuan, Danfeng Lu, Liang Xiong, Jiangong Shi, Lijuan Yang, Xiaohong Yuan, Guolin Zhang*, Fei Wang*, Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19), Toxicology and Applied Pharmacology, 2014,? 279?(1):?23-32 (AUG 15 2014)?
52.???? Yinggang Luo, Xiang Pu, Guoyong Luo, Min Zhou, Huayi Qi, Qi Ye, Yan Liu, Guolin Zhang*, Nitrogen-containing dihydro-β-agarofuran derivatives mined from the dried roots of Tripterygium wilfordii, Journal of Natural Products, 2014,??77?(7):?1650-1657?(?JUL 2014)?
53.???? Wenchen Pu, Yuan Lin, Jianshuo Zhang, Fei Wang, Chun Wang, Guolin Zhang*, 3-Arylcoumarins: Synthesis and potent anti-inflammatory activity, Bioorganic & Medicinal Chemistry Letters, 2014, 24: 5432-5434?
54.???? Guoyong Luo, Yinggang Luo, Min Zhou, Jian Gu, Qi Ye, Rong Zhou, Ya Dai, Guolin Zhang , Antioxidant compounds from ethanol extracts of bamboo (Neosinocalamus affinis) leaves，Journal of Asian Natural Products Research，DOI: 10.1080/**.2014.981164?
承担科研项目情况1. 国家自然科学基金, 2008-2010, 化学小分子激活干扰素JAK/STAT信号途径研究
2. 中国科学院重要方向, 2008-2010, 具有雌激素作用中药复方物质基础及作用机理研究——“通骨络”药效成分构效关系及作用机理研究
3. 国家重点基础研究发展计划, 2009-2013,确有疗效的有毒中药科学应用关键问题的基础研究——有毒中药毒效物质基础研究
获奖及荣誉 1997 入选中国科学院“百人计划” ?
1999 入选“百千万人才工程”（人事部等部委） ?
2001 中国科学院青年科学家奖 ?
2003 入选“四川省学术技术带头人” ?
2004 第七届四川省青年科技奖 ?
2006 中国科学院优秀教师 ?
2006 四川省优秀回国人员 ?
2006 国务院政府津贴。?
代表论著 近五年发表的主要论文:?
1.???????? Zhijun Wu, Guoyou Li, Dongmei Fang, Huayi Qi, Weijian Ren, Guolin Zhang, Analysis of epipolythiodioxopiperazines in fungus Chaetomium cochliodes using HPLC-ESI-MS/MS/MS, Analytical Chemistry, 2008, 80 (1): 217-226?
2.???????? Guoyou Li, Bogang Li, Tao Yang, Guangye Liu, Guolin Zhang, Secondary metabolites from the fungus Chaetomium brasiliense, Helvetica Chimica Acta, 2008, 91: 124-129?
3.???????? Xiaoyu Hu, Yinggang Luo, Xiaozhen Chen, Le Zhou, Guolin Zhang, Chemical constituents of Nouelia insignis Franch, Journal of Asian Natural Products Research, 2008, 10 (2): 125-131?
4.???????? Qilin Li, Bogang Li, Yan Zhang, Xiaoping Gao, Chongqian Li, Guolin Zhang, Three angiotensin-converting enzyme inhibitors from Rabdosia coetsa, Phytomedicine, 2008, 15: 386-388?
5.???????? Yipeng Xie, Bogang Li, Guolin Zhang, Preparation of two diastereomeric decalins synthons and (-)-ambrox, Helvetica Chimica Acta, 2008, 91: 734-740?
6.???????? Xiaozhen Chen, Huafang Wu, Guoyou Li, Shengming Lu, Bogang Li, Dongmei Fang, ?Guolin Zhang, Iridoids from Viburnum cylindricum, Helvetica Chimica Acta, 2008, 91: 1072-1076?
7.???????? Qingchun Huang, Bogang Li, Yipeng Xie, Kaibei Yu, Guolin Zhang. (3aS,7S,9aS,9bR)-3a,6,6,9a-Tetramethyl-2-oxoperhydronaphtho[2,1-b]furan-7-yl acetate, Acta Crystallographica, Section E, 2008, E64, o1765?
8.???????? Huafang Wu, Yinggang Luo, Kaibei Yu, Guolin Zhang, Xinfu Pan, (2S,NS)-N-Allyl-N-benzyl-1-hydroxy-3-(4-hydroxyphenyl)-N-methylpropan-2-aminium bromide, Acta Crystallographica, Section E, 2008, E64, o1621?
9.??? Shengming Lu, Guolin Zhang, Alkaloids from Gendarussa vulgaris Nees, Natural Products Research, 2008, 22 (18): 1610-1613?
10.???? Ling Qin, Bogang Li, Jiafa Guan, Guolin Zhang, In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus, Natural Products Research, 2009, 23 (4): 309-318?
11.?Zhijun Wu, Xiaoli Ma, Dongmei Fang, Huayi Qi, Weijian Ren, Guolin Zhang, Analysis of caffeic acid derivatives from Osmanthus yunnanesis using electrospray ionization quadrupole time-of-flight mass spectrometry, Eur. J. Mass Spectrom, 2009, 15: 415-429?
12.?Guoyou Li, Tao Yang, Yinggang Luo, Xiaozhen Chen, Dongmei Fang, Guolin Zhang, Brevianamide J, a new indole alkaloid dimer from fungus Aspergillus versicolor, Organic Letters, 2009, 11 (16): 3714-3717?
13.????? Feiyan Tao, Yinggang Luo, Qingchun Huang, Yan Liu, Bogang Li, Guolin Zhang. Facile syntheses of l-β-haloalanine derivatives from l-cysteine or l-cystine. Amino Acids, 2009, 37 (4): 603-607?
14.???? Huafang Wu,Wenbin Lin, Lizi Xia, Yinggang Luo, Xiaozhen Chen, Guoyou Li, Guolin Zhang, Xinfu Pan, N-Stereogenic quaternary ammonium salts from L-amino acids: Synthesis, separation, and absolute configuration, Helvetica Chimica Acta, 2009, 92: 677-688?
15.??? Zhijun Wu, Xiaozhen Chen, Dongmei Fang, Huayi Qi, Weijian Ren, Guolin Zhang, Analysis of phenolic glycosides from Ilex litseaefolia using electrospray ionization quadrupole time-of-flight mass spectrometry, Rapid Commnications in Mass Spectrometry, 2009, 23: 3881–3885?
16.???? Zhijun Wu, Jianxin Pu, Limei Li, Dongmei Fang, Huayi Qi, Guoyou Li, Jianzhong Chen, Handong Sun, Guolin Zhang, Electrospray tandem mass spectrometry of longipedlactone triterpenoids, J. Mass Spectrom. 2010, 45: 451-455.?
17.???? Zhijun Wu, Dan Han, Xiaozhen Chen, Dongmei Fang, Huayi Qi, Guolin Zhang, Analysis of benzofuran derivatives using electrospray ionization ion trap and electrospray ionization quadrupole time-of-flight mass spectrometry, Rapid Commnications in Mass Spectrometry. 2010, 24: 1211-1215.?
18.???? Lizi Xia, Min Zhou, Yanhua Xiao, Guoyou Li, Xiaozhen Chen, Guolin Zhang, Chemical Constituents from Helwingia japonica, 中国天然药物(Chinese Journal of Natural Medicine), 2010, 8 (1): 16-20?
19.???? Hongwei Yu, Bogang Li, Xiaozhen Chen, Changsong Li, Guolin Zhang, Chemical Study on Evodia vestita, Chin J Appl Biol, 2010, 16 (1): 72-75?
20.???? Xiaozhen Chen, Guoyou Li, Xiaoqing Wu, Qingchun Huang, Guolin Zhang, Chemical Study on Sambucus adnata Wall, Chin J Appl Biol, 2010, 16 (1): 197-201?
21.???? Guoyou Li, Limei Li, Tao Yang, Xiaozhen Chen, Dongmei Fang, Guolin Zhang, Four New Alkaloids, Brevianamides O–R, from the fungus Aspergillus versicolor, Helvetica Chimica Acta, 2010, 93 (10): 2075-2080?
22.???? Changsong Li, Hongwei Yu, Guoyou Li, Guolin Zhang, Chemical constituents from the roots of Dysoxylum densiflorum, Chinese Journal of Natural Medicine, 2010, 8 (4): 270-273?
23.???? Zhijun Wu, Dongmei Fang, Dan Han, Guoyou Li, Xiaozhen Chen, Huayi Qi, Guolin Zhang, Analysis of sesterterpenoids from Aspergillus terreus using ESI-QTOF and ESI-IT, Phytochemical Analysis, 2010, 21 (4): 374-383?
24.???? Chun Feng, Bogang Li, Xiaoping Gao, Huayi Qi, Guolin Zhang, A new triterpene and an antiarrhythmic liriodendrin from Pittosporum brevicalyx, Archives of Pharmacal Research，2010, 33 (12): 1927-1932?
25.???? Changsong Li, Hongwei Yu, Xiaozhen Chen, Xiaoqing Wu, Guoyou Li, Guolin Zhang, Three new eudesmanolides from Camchaya loloana, Helvetica Chimica Acta, 2011, 94 (1): 105-110?
26.???? Lijuan Yang, Qianfeng Chen, Fei Wang, Guolin Zhang，Antiosteoporotic compounds from seeds of Cuscuta chinensis, Journal of Ethnopharmacology, 2011, 135: 553–560 ?
27.???? Jianyu Zhao, Min Zhou, Yan Liu, Guolin Zhang, Yinggang Luo, Chromones and coumarins from the dried fructus of Cnidium monnieri, Fitoterapia, 2011, 82: 767–771?
28.???? 王星, 吕广颖, 杨利娟, 王飞, 王淳, 7-羟基异黄酮及其衍生物的合成与选择性雌激素受体结合的构效关系研究, 有机化学, 2011, 31 (8): 1245-1251.?
29.???? Zhijun Wu, Dongming Sun, Jianzhong Chen, Xiaozhen Chen, Dongmei Fang, Na Li, Ping Cheng，Guolin Zhang, Analysis of cipadesin limonoids from Cipadessa cinerascens using electrospray ionization quadrupole time-of-flight tandem mass spectrometry and quantum chemical calculations, Rapid Commnications in Mass Spectrometry, 2012, 26: 563–571?
30.??? Guobo Xu, Limei Li, Dongmei Fang, Guoyou Li, Guolin Zhang, Zhijun Wu*. Electrospray tandem mass spectrometry of chaetoglobosins, Rapid Commun. Mass Spectrom. 2012, 26, 2115-2122.?
31.???? Zhengfu Tai, Guolin Zhang, Fei Wang. Identification of small molecule activators of the Janus kinase/signal transducer and activator of transcription pathway using a cell-based screening. Biological & Pharmaceutical Bulletin, 2012, 35: 65-71?
32.???? Yinggang Luo, Min Zhou, Qi Ye, Guolin Zhang, Dihydroagarofurna derivatives from dried roots of Tripterygium wilfordii, Journal of Natural Products, 2012, 75: 98-102?
33.???? Qianfeng Chen, Xiaozhen Chen, Guoyou Li, Chun Wang, Guolin Zhang, Two new 2-phenylbenzofurans from the bark of Styrax perkinsiae, Chinese Journal of Natural Medicine, 2012, 10 (2): 92-97?
34.???? Xiaoqing Wu, Xiaozhen Chen, Qingchun Huang, Dongmei Fang, Guoyou Li, Guolin Zhang, Toxicity of raw and processed roots of Polygonum multiflorum, Fitoterapia, 2012, 83: 469-475?
35.???? Danfeng Lu, Lijuan Yang, Fei Wang, Guolin Zhang, Inhibitory effect of luteolin on estrogen biosynthesis in human ovarian granulosa cells by suppression of aromatase (CYP19), ?Journal of Agricultural and Food Chemistry, 2012, 60 (34): 8411-18. ?
36.????? Danfeng Lu, Lijuan Yang, Qilin Li, Xiaoping Gao, Fei Wang, Guolin Zhang, Egonol?gentiobioside?and?egonol?gentiotrioside?from?Styrax?perkinsiae?promote?the??biosynthesis of estrogen by aromatase, European Journal of Pharmacology, 2012, 691: 275–282?
37.???? Guobo Xu, Limei Li, Tao Yang, Guolin Zhang, Guoyou Li, Chaetoconvosins A and B, Alkaloids with new skeleton from fungus Chaetomium convolutum, Organic Letters, 2012, 14 (23): 6052–6055?
38.???? Qianfeng Chen, Lijuan Yang, Guolin Zhang, Fei Wang, Bioactivity-guided isolation of antiosteoporotic compounds from Ligustrum lucidum, Phytotherapy Research, 2013, 27: 973-979.?
39.???? Lijuan Yang, Danfeng Lu, Jiajia Guo, Xianli Meng, Guolin Zhang, Fei Wang，Icariin?from?Epimedium?brevicornum?Maxim?promotes?the?biosynthesis?of?estrogen?by?aromatase?(CYP19)，Journal?of?Ethnopharmacology, 2013, 145: 715-721. ?
40.???? 鲁丹枫，Azimova Bahtigul Jovliqizi，张国林，王飞*，采用磁微粒分离酶联免疫法构建基于KGN细胞的雌激素生物合成筛选模型，天然产物研究与开发，2013, 25: 27-30,67 ?
41.???? Puzhao Zhang, Fei Wang, Lijuan Yang, Guolin Zhang*, Pregnane alkaloids from Sarcococca hookeriana var digyna, Fitoterapia, 2013, 89:143-148 ?
42.???? Yuan Lin, Fei Wang, Lijuan Yang, Ze Chun, Jinku Bao, Guolin Zhang*, Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum, Phytochemistry, 2013, 95: 242-251 ?
43.???? Xiang Pu, Xixing Qu, Fei Chen, Jinku Bao, Guolin Zhang*, Yinggang Luo*, Endophytic fungus Trichoderma atroviride LY357: Isolation, identification, and camptothecin production, Applied Microbiology and Biotechnology, 2013, 97: 9365–9375?
44.???? Wei Yang, Dongmei Fang, Hongping He, Xiaojiang Hao, Zhijun Wu*, Guolin Zhang, Analysis of mexicanolide- and phragmalin-type limonoids from Heynea trijuga using high-performance liquid chromatography/electrospray tandem mass spectrometry, Rapid Commun. Mass Spectrom. 2013, 27: 1203–1212?
45.???? Jie Ren, Guoyou Li, Lan Shen, Guolin Zhang*, Laurance A. Nafie, Huajie Zhu*，Challenges in the assignment of relative and absolute configurations of complex molecules: computation can resolve conflicts between theory and experiment, Tetrahedron, 2013, 69 (48): 10351-10356?
46.???? Wenchen Pu, Guanmin Mu, Guolin Zhang*, Chun Wang*, Copper-Catalyzed Decarboxylative Intramolecular C-O Coupling: Synthesis of 2-Arylbenzofuran from 3-Arylcoumarin, RSC Advances, 2014, 4: 903–906?
47.???? ?Zhengfu Tai, Yujiao He, Yuan Lin, Junmei Huang, Jiajia Guo, Lijuan Yang, Guolin Zhang*, ?Fei Wang*, Luteolin Sensitizes the Antiproliferative Effect of Interferon α/β by Activation of JAK/STAT Pathway through PKA-Mediated Inhibition of SHP-2 in cancer cells, Cell Signaling, 2014, 26: 619-628?
48.???? Guoyong Luo, Min Zhou, Yan Liu, Qi Ye, Jian Gu, Tianfang Huang, Guolin Zhang, Yinggang Luo，3-Formyl-2-arylbenzofurans from the aerial parts of Itea ilicifolia，Phytochemistry Letters, 2014, 10: 19–22?
49.???? Yuan Lin, Fei Wang, Guolin Zhang*, Natural products and their derivatives regulating the Janus kinase/signal transducer and activator of transcription pathway, Journal of Asian Natural Products, 2014, 16 (7)：800-812?
50.???? Guoyong Luo, Yun Yang, Min Zhou, Qi Ye, Yan Liu, Jian Gu, Guolin Zhang, Yinggang Luo, Novel 2-arylbenzofuran dimers and polyisoprenylated flavanones from Sophora tonkinensis, Fitoterapia, 2014, 99 : 21-27?
51.???? Jiajia Guo, Yun Yuan, Danfeng Lu, Liang Xiong, Jiangong Shi, Lijuan Yang, Xiaohong Yuan, Guolin Zhang*, Fei Wang*, Two natural products, trans-phytol and (22E)-ergosta-6,9,22-triene-3β,5α,8α-triol, inhibit the biosynthesis of estrogen in human ovarian granulosa cells by aromatase (CYP19), Toxicology and Applied Pharmacology, 2014,? 279?(1):?23-32 (AUG 15 2014)?
52.???? Yinggang Luo, Xiang Pu, Guoyong Luo, Min Zhou, Huayi Qi, Qi Ye, Yan Liu, Guolin Zhang*, Nitrogen-containing dihydro-β-agarofuran derivatives mined from the dried roots of Tripterygium wilfordii, Journal of Natural Products, 2014,??77?(7):?1650-1657?(?JUL 2014)?
53.???? Wenchen Pu, Yuan Lin, Jianshuo Zhang, Fei Wang, Chun Wang, Guolin Zhang*, 3-Arylcoumarins: Synthesis and potent anti-inflammatory activity, Bioorganic & Medicinal Chemistry Letters, 2014, 24: 5432-5434?
54.???? Guoyong Luo, Yinggang Luo, Min Zhou, Jian Gu, Qi Ye, Rong Zhou, Ya Dai, Guolin Zhang , Antioxidant compounds from ethanol extracts of bamboo (Neosinocalamus affinis) leaves，Journal of Asian Natural Products Research，DOI: 10.1080/**.2014.981164?
承担科研项目情况1. 国家自然科学基金, 2008-2010, 化学小分子激活干扰素JAK/STAT信号途径研究
2. 中国科学院重要方向, 2008-2010, 具有雌激素作用中药复方物质基础及作用机理研究——“通骨络”药效成分构效关系及作用机理研究
3. 国家重点基础研究发展计划, 2009-2013,确有疗效的有毒中药科学应用关键问题的基础研究——有毒中药毒效物质基础研究
获奖及荣誉 1997 入选中国科学院“百人计划” ?
1999 入选“百千万人才工程”（人事部等部委） ?
2001 中国科学院青年科学家奖 ?
2003 入选“四川省学术技术带头人” ?
2004 第七届四川省青年科技奖 ?
2006 中国科学院优秀教师 ?
2006 四川省优秀回国人员 ?
2006 国务院政府津贴。?
2. 中国科学院重要方向, 2008-2010, 具有雌激素作用中药复方物质基础及作用机理研究——“通骨络”药效成分构效关系及作用机理研究
3. 国家重点基础研究发展计划, 2009-2013,确有疗效的有毒中药科学应用关键问题的基础研究——有毒中药毒效物质基础研究
