许家林博士,生化与分子生物学研究所副教授。2009年7月在中国医学科学院/北京协和医学院获得博士学位。2009年至2013年,在美国罗德岛大学(University of Rhode Island)进行博士后研究工作。2013年8月回国工作。在SCI收录期刊发表论文12篇。
学术兼职
Journal of Biochemical and Molecular Toxicology, British Journal of Nutrition, Clinical Nutrition, BMC Pharmacology and Toxicology, PLoS ONE, and Toxicology and Applied Pharmacology 等杂志专业审稿人。
科研方向
1. 转录因子Nuclear factor-E2 related-factor 2(Nrf2)以及其他相关核受体(FXR,LXR,AhR等)对脂肪前体细胞分化进程影响的相关研究。2. 研究转录因子Nrf2对肝脏脂质代谢影响的相关研究。3. 研究环境化合物(双酚A
1. Jialin Xu, Supriya R. Kulkarni, Ajay C. Donepudi, Vijay R. More, and Angela L. Slitt. Enhanced Nrf2 activity aggravates insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice. Diabetes. 61:3208–3218, 2012.
2. Jialin Xu, Supriya Kulkarni, Liya Li and Angela L. Slitt. UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis. Drug Metabolism and Disposition. 40 (2):259-66, 2012.
3. Supriya R. Kulkarni, Ajay C Donepudi, Jialin Xu, Wei Wei, Qiuqiong C. Cheng, Maureen Varina Driscoll, Jeffrey A. Johnson, and Angela L. Slitt. Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in Mouse and Human. Antioxidants & Redox Signaling. 2013 [Epub ahead of print]
4. Vijay More, Jialin Xu, Prajakta Shimpi, Clyde Belgrave, James Luyendyk, Masayuki Yamamoto, Angela Slitt. Keap1 Knockdown increases markers of metabolic syndrome after long-term high fat diet feeding. Free Radical Biology and Medicine. 61:85–94, 2013.
5. Lauren M. Aleksunes, Jialin Xu, Eugenia Lin, Xia Wen, Michael J. Goedken and Angela L. Slitt. Pregnancy Represses Induction of Efflux Transporters in Livers of Diabetic Mice. Pharmaceutical Research . DOI 10.1007/s11095-013-0981-z, 2013.
6. Laura E. Armstrong, Maureen V. Driscoll, Ajay C. Donepudi, Jialin Xu, Angela A. Baker,Lauren Aleksunes, Jason R. Richardson, and Angela L. Slitt. Metabolic Effects of Perinatal Deltamethrin Exposure in White Adipose Tissue of Mice. Journal of Biochemical and Molecular Toxicology. 2013 Volume 27, Number 2, 2013.
7. Yao Song, Jialin Xu, Yanfeng Li, Chunshi Jia, Xiaowei Ma, Lei Zhang, Xiaojie Xie, Yong Zhang, Xiang Gao, Youyi Zhang, Dahai Zhu. Cardiac ankyrin repeat protein attenuates cardiac hypertrophy by inhibition of ERK1/2 and TGF-b signaling pathways (Co-first author). PloS ONE. 7(12): e50436, 2012.
8. Tao Yuan, Yuanqing Ding, Chunpeng Wan, Liya Li, Jialin Xu, Ke Liu, Angela Slitt, Daneel Ferreira, Ikhlas A. Khan, Navindra P. Seeram. Unprecedented Antidiabetic Ellagitannins from Pomegranate Flowers: Inhibition of??-Glucosidase and Lipogenic Gene Induction. Organic Letters. 14 (20):5358–5361, 2012.
9. Seeram Navindra, Jialin Xu, Liya Li, Angela Slitt. Pharmacy research at URI: mining red maple (Acer rubrum) trees for novel therapeutics to manage diabetes. Med Health R I. 2012 Sep;95(9):283-4.
10. Jianwei Ye, Yong Zhang, Jialin Xu, Qiang Zhang, Dahai Zhu. FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy. Gene. 404: 53–60, 2007.
联系方式
地址:沈阳市沈河区文化东路89号,东北大学生命科学与健康学院生化与分子生物学研究所邮编:110015E-mail:jialinxu.xu@gmail.com