侯悦，女，1977年出生，博士，教授。2000年毕业于沈阳药科大学日语药学专业获得学士学位，2005年毕业于沈阳药科大学获得药理学博士学位。主要研究方向为神经生物学及肿瘤生物学。作为负责人主持国家自然基金、中国博士后科学基金、教育部高等学校博士学科点专项科研基金、辽宁省教育厅科学技术研究项目等多项课题，作为课题副组长参加国家科技重大专项课题3项，作为主要成员参加国家科技重大专项课题、辽宁省科学技术计划重大重点项目、教育部重点实验室基金项目、辽宁省自然基金等。曾获得2006年辽宁省优秀博士学位论文、2007年辽宁省自然科学学术成果二等奖、2007年沈阳市科技进步一等奖、2010年辽宁省自然科学学术成果三等奖及2014年辽宁省自然科学学术成果三等奖。目前，在国际学术期刊上发表SCI收载文章28篇，其中第一作者或通讯作者12 篇。



科研方向

主要研究方向为神经生物学及肿瘤生物学。



基金项目

1. 国家自然科学基金面上项目：以抑制小胶质细胞活化为靶标探索龙血竭抗阿尔茨海默病的物质基础及作用机制，项目负责人

2.国家自然科学基金青年基金：小胶质细胞-MAPK-PIC在精神分裂症中的作用机制研究，项目负责人

3.教育部基本科研业务费创新团队建设项目：BAP31在重大疾病中的作用研究，项目负责人

4.中国博士后科学基金：天然药物中肿瘤多药耐药逆转剂与抗癌药的复方筛选及作用机制研究，项目负责人

5.辽宁省科学技术基金项目：基于高通量筛选的抗老年痴呆活性样品发现及其作用研究，项目负责人

6.辽宁省教育厅创新团队项目：抗老年痴呆新药—白藜芦醇衍生物RV的研究与开发，项目负责人

7.国家科技重大专项课题：动物实验和药效学评价试验技术子平台，项目副组长

8.国家科技重大专项课题：抗老年痴呆一类新药BQGY-8的研究开发，项目副组长

9.国家科技重大专项课题：临床前WF-210的研究开发，项目副组长



代表性论文

1.Hou Y, Xie G, Miao F, Ding L, Mou Y, Wang L, Su G, Chen G, Yang J, Wu C. Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2014;54:92-102.

2.Hou Y, Zhang H, Xie G, Cao X, Zhao Y, Liu Y, Mao Z, Yang J, Wu C. Neuronal injury, but not microglia activation, is associated with ketamine-induced experimental schizophrenic model in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2013;45:107-16.

3.Li N, Ma Z, Li M, Xing Y, Hou Y. Natural potential therapeutic agents of neurodegenerative diseases from the traditional herbal medicine Chinese dragon’s blood. J Ethnopharmacol. 2014 Mar 28;152(3):508-21.（通讯作者）

4.Hou Y, Wu CF, Yang JY, Guo T. Differential effects of haloperidol, clozapine and olanzapine on learning and memory functions in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30:1486-1495.

5.Hou Y, Wu CF, Yang JY, He X, Bi XL, Yu L, Guo T. Effects of clozapine, olanzapine and haloperidol on nitric oxide production by lipopolysaccharide-activated N9 cells. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30:1523-1528.

6.Hou Y, Yang JY, Wu CF, Huang M. Effects of clozapine, olanzapine and haloperidol on ethanol-induced ascorbic acid release in mouse striatum. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:83-89.

7.Hou Y, Wu CF, Yang JY, Tu L, Gu PF, Bi XL. Differential effects of clozapine on ethanol-induced ascorbic acid release in mouse and rat striatum. Neurosci Lett. 2005;380:83-87.

8.Hou Y, Wu CF, Yang JY, He X, Guo T. Ethanol similarly induces ascorbic acid release in the prefrontal cortex and striatum of freely moving mice. Yakugaku Zasshi. 2006;126:671-675.

9.Hou Y, Guo T, Wu C, He X, Zhao M. Effect of shikonin on human breast cancer cells proliferation and apoptosis in vitro. Yakugaku Zasshi. 2006;126:1383-1386.

10.Hou Y, Wu CF, Yang JY, Gu PF, Bi XL, Dai F. Similar effects of clozapine and olanzapine on ethanol-induced ascorbic acid release in the prefrontal cortex of freely moving mice. Pharmazie. 2007;62:158-160.

11.Hou Y, Guo T, Wu C, He X. Effect of tetrandrine combined with epirubicin on the growth of human breast carcinoma multidrug resistance cell line. Yakugaku Zasshi. 2008;128:663-666.

12.Dai F, Yang JY, Gu PF, Hou Y, Wu CF. Effect of drug-induced ascorbic acid release in the striatum and the nucleus accumbens in hippocampus-lesioned rats. Brain Res. 2006;1125(1):163-170.

13.Gu PF, Wu CF, Yang JY, Shang Y, Hou Y, Bi XL, Dai F. Differential effects of drug-induced ascorbic acid release in the striatum and nucleus accumbens of freely moving rats. Neurosci Lett. 2006;399(1-2):79-84.

14.Zhao M, Guo T, Wang M, Zhao Q, Liu Y, Sun X, Wang H, Hou Y. The course of uncarinic acid E-induced apoptosis of HepG2 cells from damage to DNA and p53 activation to mitochondrial release of cytochrome c. Biol Pharm Bull. 2006;29(8):1639-1644.

15.Gu P, Li Y, Shang Y, Hou Y, Zhao S. Proliferation changes in dentate gyrus of hippocampus during the first week following kainic acid-induced seizures. Yakugaku Zasshi. 2010;130(12):1751-1754.

16.Sun JY, Yang JY, Wang F, Hou Y, Dong YX, Wu CF. GABAA receptors in VTA mediate the morphine-induced release of ascorbic acid in rat nucleus accumbens. Brain Res. 2011;1368:52-58.

17.Mou YH, Yang JY, Cui N, Wang JM, Hou Y, Song S, Wu CF. Effects of cobalt chloride on nitric oxide and cytokines/chemokines production in microglia. Int Immunopharmacol. 2012 Apr 1;13(1):120-125.

18.Yang J, Wang Q, Zhao R, Sun B, Wang L, Hou Y, Li X, Wu C. Identification of oligomer proanthocyanidins (F2) isolated from grape seeds as a formyl peptide receptor 1 partial agonist. Int Immunopharmacol. 2013 Apr;15(4):756-63.

19.Wang LH, Yang JY, Yang SN, Li Y, Ping GF, Hou Y, Cui W, Wang ZZ, Xiao W, Wu CF. Suppression of NF-κB signaling and P-glycoprotein Function by Gambogic Acid Synergistically Potentiates Adriamycin -induced Apoptosis in Lung Cancer. Curr Cancer Drug Targets. 2014 Jan;14(1):91-103.

20.Xia X, Bi X, Wu W, Mou Y, Hou Y, Zhang K, Zhao Y. Inhibition of β-Catenin Signaling Involved in the Biological Activities of a Lignan E2S Isolated from Carya cathayensis Fruits. Planta Med. 2013 Nov;79(17):1648-52. doi: 10.1055/s-**.

21.Su GY, Yang JY, Wang F, Xiong ZL, Hou Y, Zhang K, Song C, Ma J, Song SJ, Teng HF, Wu CF. Xiaochaihutang prevents depressive-like behaviour in rodents by enhancing the serotonergic system. J Pharm Pharmacol. 2013 Dec 22. doi: 10.1111/jphp.12201. [Epub ahead of print]

22.Wang JY, Yang JY, Wang F, Fu SY, Hou Y, Jiang B, Ma J, Song C, Wu CF. Neuroprotective effect of pseudoginsenoside-f11 on a rat model of Parkinson’s disease induced by 6-hydroxydopamine. Evid Based Complement Alternat Med. 2013;2013:152798. doi: 10.1155/2013/152798. Epub 2013 Dec 10.1.722

23.Chu Y, Wang H, Chen J, Hou Y. New Sesquiterpene and Polymethoxy- Flavonoids from Artemisia annua L. Pharmacogn Mag. 2014 Jul;10(39):213-6. doi: 10.4103/0973-1296.137359.

24.Bi X, Xia X, Mou T, Jiang B, Fan D, Wang P, Liu Y, Hou Y, Zhao Y. Anti-tumor activity of three ginsenoside derivatives in lung cancer is associated with Wnt/β-catenin signaling inhibition. Eur J Pharmacol. 2014 Sep 6. pii: S0014-2999(14)00637-2. doi: 10.1016/j.ejphar.2014.08.032. [Epub ahead of print]

25.Wang LH, Li Y, Yang SN, Wang FY, Hou Y, Cui W, Chen K, Cao Q, Wang S, Zhang TY, Wang ZZ, Xiao W, Yang JY, Wu CF. Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling. Br J Cancer. 2014 Jan 21;110(2):341-52. doi: 10.1038/bjc.2013.752.

26.Zheng HL, Yang J, Hou Y, Sun B, Zhang Q, Mou Y, Wand L, Wu C. Oligomer procyanidins (F2) isolated from grape seeds inhibits tumor angiogenesis and cell invasion by targeting HIF-1α in vitro. Int J Oncol. 2014 Nov 10. doi: 10.3892/ijo.2014.2744. [Epub ahead of print]

27.Bi X, Liu W, Xia X, Chen L, Mu T, Liu J, Hou Y, Zhao Y. Effects of Callistephus chinensis flower polyphones on improving metabolic disorders in high-fat diet-induced mice. Food Funct. 2014 Nov 4. [Epub ahead of print]



联系方式

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E-mail: houy**@163.com