关水
院系：化工学院
办公电话：
电子信箱：guanshui@dlut.edu.cn
更新时间：2013-1-28
其他专业：无



个人简介
学习经历：
2011.02-2012.03英国牛津大学国家公派访问学者
（导师：Prof. Zhanfeng Cui）
2009.09 韩国首尔大学 Academic visitor
2007.09 英国牛津大学，帝国理工大学，巴斯大学 Academic visitor
2001.09-2006.06　大连理工大学环境与生命学院生物化工专业　工学博士学位
（导师：安利佳教授）
1994.09-1998.07辽宁大学生物系微生物专业理学学士学位

工作经历：
2012.12-至今 大连理工大学化工学院化学工程系副教授
2006.06-2012.12 大连理工大学化工学院化学工程系讲师
1998.07-2001.09 大连天龙科技发展有限公司技术员助理工程师

社会兼职
1. Planta Medica、European Journal of Pharmacology、Journal of Pharmacy and Pharmacology等国外学术期刊审稿人；
2. 化工学院化学工程教研室副主任；
2. 化工学院化学工程系工会组长；
3. 化工学院化学工程系党支部副书记；
4. 化工学院化学工程系化学工程与工艺专业12级07班的班主任。


研究领域（研究课题）
1. 神经组织工程研究：结合体外组织工程技术，采用胶原水凝胶、胶原-壳聚糖、胶原-透明质酸以及壳聚糖-明胶-透明质酸-硫酸肝素等复合支架材料构建神经干细胞的三维培养模型并实现有功能的神经元网络，从而为神经干细胞的进一步临床应用提供新的途径和细胞来源；
2. 中药分子药理学研究：构建新的药理模型、干细胞分化诱导抑制等方向对发现的强活性先导化合物进行分子药理学方向的研究，对中药现代化之药理研究建立中药分子药理学平台；
3. 中药与天然产物化学研究：采用活性追踪的方法从传统中草药中筛选具有抗肿瘤、抗老年性痴呆及治疗帕金森病的先导化合物。

硕博研究方向
1. 新型可降解导电嵌段共聚物支架的制备及调控神经干细胞分化的研究（中央高校基本科研业务费（生命+X）专项基金，2012.01-2013.12，负责人）
2. 原儿茶酸在帕金森病中的神经保护作用及对PHOX-ROS和TLR4信号通路的调控机制研究（国家自然科学基金，No.**，2012.01-2014.12，我校（合作单位）负责人）
3. 体外多巴胺能神经元网络的三维构建及原儿茶酸的调节作用研究（国家自然科学基金，No.**，2009.01-2011.12，负责人）
4. 原儿茶酸调节神经干细胞分化的作用及机制研究（高等学校博士学科点专项科研基金，No.**，2008.01-2009.12，负责人）
5. 中药影响干细胞增殖及分化的机理研究（校引进人才启动基金2007-2010，负责人）
6. 神经干细胞三维培养体系的构建及药物筛选技术（****讲座教授配套科研基金，负责人）
7. 脐带血干/祖细胞体外共培养模式与培养效果的机理研究（国家自然科学基金项目，2007-2009，No.**，主要参加人）
8. 神经干细胞移植治疗神经退行性疾病和神经再生及功能重建的神经营养素和细胞分化剂的应用研究（大连市干细胞与组织工程研发中心启动基金，2005-2007，主要参加人）




出版著作和论文
期刊论文
（1）Shui Guan*, Xiu-Li Zhang, Xiao-Min Lin, Tian-Qing Liu, Xue-Hu Ma, Zhan-Feng Cui. Chitosan/gelatin porous scaffolds containing hyaluronic acid and heparan sulfate for neural tissue engineering. Journal of Biomaterials Science, Polymer Edition, 2012. DOI: 10.1080/**.2012.731374. (SCI, IF=1.842)
（2）Shui Guan*, Xiu-Li Zhang, Dan Ge, Tian-Qing Liu, Xue-Hu Ma, Zhan-Feng Cui. Protocatechuic acid promotes the neuronal differentiation and facilitates survival of phenotypes differentiated from cultured neural stem and progenitor cells. European Journal of Pharmacology, 2011, 670 (2-3): 471-478. (SCI, 2.737, cited: 1, 他引1次)
（3）Shui Guan*. Development of in Vitro Neural Models for Drug Discovery and Toxicity Screening. In: Murray Moo-Young (Ed.), Comprehensive Biotechnology, 2e, 2011. Publisher: Elsevier, Amsterdam, Netherlands, pp. 565-572. (SCI)
（4）Xiu-li Zhang, Gui-Fang Shi, Xiu-zhen Liu, Li-jia An, Shui Guan*. Anti-aging effects of protocatechuic acid from Alpinia on spleen and liver antioxidative system of senescent mice. Cell Biochemistry and Function, 2011, 29 (4): 342-347. (SCI, 1.651, cited: 4, 他引3次)
（5）Han Wang, Tianqing Liu, Jihui Wang, Yanli Qi, Dan Ge, Shui Guan. Isomer-specific effects of conjugated linoleic acid on proliferative activity of cultured neural progenitor cells. Molecular and Cellular Biochemistry, 2011, 358 (1-2): 13-20. (SCI, 2.168)
（6）Shui Guan*, Xiaomin Lin, Dan Ge, Tian-qing Liu, Xue-hu Ma, Zhan-fang Cui. Growth of cultured neural stem/progenitor cells in chitosan-alginate-hyaluronate-heparan scaffolds. Cell Biological International, 2010, 34(8), s37. (SCI, 1.747)
（7）Shui Guan*, Dan Ge, Tian-qing Liu, Xue-hu Ma, Zhan-fang Cui. Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells. Toxicology in Vitro, 2009, 23(2), 201-208. (SCI, 2.546, cited:13, 他引11次)
（8）Shui Guan*, Tian-Qing Liu, Rui-Xin Lu, Dan Ge, Xue-Hu Ma, Zhan-Feng Cui. Growth and Differentiation of Neural Stem/Progenitor Cell in Three-Dimensional Collagen-Chitosan Scaffolds. Tissue Engineering and Regenerative Medicine, 2009 6(12), s248. (SCI-E)
（9）Yiqun Yin, Shui Guan, Kedong Song,Tianqing Liu. Ex Vivo Expansion of Hematopoietic Stem Cells and Mesenchymal Stem Cells Derived from Umbilical Cord Blood with Human Autoserum. Tissue Engineering and Regenerative Medicine, 2009 6(12), s72. (SCI-E)
（10）Lu R.X., Liu T.Q., Guan S., Ge D. Neural Stem Cells Culture in Collagen-Chitosan Polymeric Scaffolds. Tissue Engineering and Regenerative Medicine, 2009 6(12), s173. (SCI-E)
（11）Wang H, Liu TQ, Zhu YX, Guan S, Ma XH, Cui ZF. Effect of protocatechuic acid from Alpinia oxyphylla on proliferation of human adipose tissue-derived stromal cells in vitro. Molecular and Cellular Biochemistry, 2009 330 (1-2), 47-53. (SCI, 2.168)
（12）Ge Dan, Liu Tianqing, Guan Shui, Ma Xuehu, Cui Zhanfeng. Three-dimensional Culture of Neural Stem Cells in Extracellular Matrix Scaffolds. Tissue Engineering and Regenerative Medicine, 2009 6(12), s277. (SCI-E)
（13）Shui Guan*, Dan Ge, Tianqing Liu, Xuehu Ma, Zhanfang Cui. Neuroprotection by protocatechuic acid against MPP+-induced cytotoxicity in cultured neural stem/progenitor cells. Journal of Biotechnology, 2008, 136 (S1), 127-127. (SCI, 2.970)
（14）Guan S*; Ge D; Liu TQ, Ma XH, Cui ZF. Pretreatment with protocatechuic acid increases neurons from cultured neural stem/progenitor cells. Tissue Engineering Part A, 2008, 14 (5), 899-899. (SCI, IF=4.636)
（15）Jianqiang Xu, Shui Guan, Qing Yang, Jun Yang, Jan-Christer Janson. Identification of a soluble recombinant thrombin-like enzyme from Gloydius shedaoensis and its neurotoxicity in cultured PC12 cells. Journal of Biotechnology, 2008, 136 (S1), 210-211. (SCI, 2.970)
（16）Han Wang, Tian-Qing Liu, Shui Guan, Yan-Xia Zhu, Zhan-Feng Cui. Protocatechuic acid from Alpinia oxyphylla promotes migration of human adipose tissue-derived stromal cells in vitro. European Journal of Pharmacology, 2008, 599(1-3), 24-31. (SCI, 2.737)
（17）Guan S*, Ge D, Liu TQ, Li XQ, Song KD, Bao CY, Ma XH, Cui ZF. Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells. Tissue Engineering, 2007, 13 (7), 1748-1749. (SCI, 4.636)
（18）Ge D, Liu TQ, Cui ZF, Guan S, Ma XH. Cell shape regulates the proliferation of neural precursor cells. Tissue Engineering, 2007, 13 (7), 1649-1649. (SCI, 4.636)
（19）Li XQ, Liu TQ, Song KD, Zhu L, Ge D, Guan S, Ma XH, Cui ZF. Culture and Expansion of Mesenchymal Stem Cells in Air-Lift Loop Hollow-Fiber Membrane Bioreactor. Tissue Engineering, 2007, 13(7): 1663-1663. (SCI, 4.636)
（20）Li XQ, Liu TQ, Song KD, Guan S, Zhu LL, Ge D, Cui ZF. Effect of neural stem cells on apoptosis of PC12 cells induced by serum deprivation. Biotechnology Progress, 2007, 23 (4): 952-957. (SCI, 2.178)
（21）Guan S, Jiang B, Bao YM, An LJ. Protocatechuic acid suppresses MPP+-induced mitochondrial dysfunction and apoptotic cell death in PC12 cells. Food and Chemical Toxicology, 2006, 44 (10): 1659-1666. (SCI, 2.602, cited:14, 他引12次)
（22）Guan S, Bao YM, Jiang B, An LJ. Protective effect of protocatechuic acid from Alpinia oxyphylla on hydrogen peroxide-induced oxidative PC12 cell death. European Journal of Pharmacology, 2006, 538 (1-3): 73-79. (SCI, 2.737, cited:32, 他引26次)
（23）An LJ, Guan S, Shi GF, Bao YM, Duan YL, Jiang B. Protocatechuic acid from Alpinia oxyphylla against MPP+-induced neurotoxicity in PC12 cells. Food and Chemical Toxicology, 2006, 44 (3): 436-443. (SCI, 2.602, cited:35, 他引25次)
（24）Shi GF, An LJ, Jiang B, Guan S, Bao YM. Alpinia protocatechuic acid protects against oxidative damage in vitro and reduces oxidative stress in vivo. Neuroscience Letters, 2006, 403 (3): 206-210. (SCI, 2.055, cited:41, 他引39次)
（25）林小敏，关水*，葛丹，刘天庆，马学虎，崔占峰．壳聚糖-明胶-透明质酸-硫酸肝素复合支架的制备及性能评价．高校化学工程学报，2012，26（2）：265-271．（EI）
（26）关水*，李海华，葛丹，刘天庆，马学虎．原儿茶酸调节神经干/祖细胞分化的作用研究．中国药理学通报，2012，28（9）：1218-1223．（核心期刊）
（27）关水*，刘天庆，葛丹，陆瑞欣，马学虎，崔占峰．胶原-壳聚糖复合支架体外三维培养神经干细胞．大连理工大学学报，2011，51（5）：737-743．（EI）
（28）关水*，葛丹，陆瑞欣，刘天庆，马学虎，崔占峰．神经干细胞体外三维药物筛选模型的构建．《中国科技论文在线》学报，2011，6（3）：181-186．（核心期刊）
（29）王晗，刘天庆，关水，朱艳霞，马学虎，崔占峰．原儿茶酸促进人脂肪干细胞体外迁移研究．大连理工大学学报，2009，49（3）：327-332．（EI）
（30）关水*，刘天庆，葛丹，马学虎，崔占峰．原儿茶酸对体外培养的神经干/祖细胞增殖及凋亡的影响．中国药理学通报，2009，25（4）：448-452．（核心期刊）
（31）关水*，陆瑞欣，刘天庆，马学虎，崔占峰．体外神经干细胞三维药物筛选模型的构建．中国药理通讯，2009，26 （2）：71．
（32）王晗，刘天庆，朱艳霞，关水，马学虎，崔占峰．原儿茶酸促进人脂肪干细胞体外增殖的研究．生物化学与生物物理进展，2008，35（10）：1168-1174．(SCI, 0.211)
（33）于放，张冬艳，关水，白凤武，安利佳．反相高效液相色谱法制备喜树细胞内生物碱单体．分析化学，2005，33（4）：501-504．(SCI, 0.633)
（34）关水，安利佳．喜树碱生物合成途径及其代谢调控的研究进展．高技术通讯，2004，14（5）：106-110．（EI）
会议论文：
（35）Shui Guan, Xiaomin Lin, Dan Ge, Tian-Qing Liu, Xue-Hu Ma, Zhan-Feng Cui. Growth of cultured neural stem/progenitor cells in chitosan-alginate-hyaluronate- heparan scaffolds. Eighth International Symposium on Frontiers in Life Sciences ——New Advances and Challenges in Multidisciplinary Research, Aug.25-28, 2010, Yinchuan, CHINA(ISTP)
（36）Shui Guan, Dan Ge, Tian-Qing Liu, Xue-Hu Ma, Zhan-Feng Cui. Protocatechuic acid combined with BDNF increase in production of rat dopaminergic neurons from cultured mesencephalic neural stem/progenitor cells. Tissue Engineering & Regenerative Medicine International Society 2010 Asia Pacific Meeting, Sep.15-17, 2010, Sydney, AUSTRALIA. (ISTP)
（37）Xiaomin Lin, Shui Guan, Dan Ge, Tian-Qing Liu, Xue-Hu Ma, Zhan-Feng Cui. Fabrication of Chitasan-alginate- hyaluronate-heparan Scaffolds for neural stem/progenitor cell culture. Tissue Engineering & Regenerative Medicine International Society 2010 Asia Pacific Meeting, Sep.15-17, 2010, Sydney, AUSTRALIA. (ISTP)
（38）Shui Guan, Tian-Qing Liu, Rui-Xin Lu, Dan Ge, Xue-Hu Ma, Zhan-Feng Cui. Growth and Differentiation of Neural Stem/Progenitor Cell in Three-Dimensional Collagen-Chitosan Scaffolds. 2nd TERMIS World Congress in conjunction with 2009 Seoul Stem Cell Symposium, Aug.31-Sep.3, 2009, Seoul, Republic of Korea. (ISTP)
（39）Yiqun Yin, Shui Guan, Kedong Song,Tianqing Liu. Ex Vivo Expansion of Hematopoietic Stem Cells and Mesenchymal Stem Cells Derived from Umbilical Cord Blood with Human Autoserum. 2nd TERMIS World Congress in conjunction with 2009 Seoul Stem Cell Symposium, Aug.31-Sep.3, 2009, Seoul, Republic of Korea. (ISTP)
（40）Lu R.X., Liu T.Q., Guan S., Ge D. Neural Stem Cells Culture in Collagen-Chitosan Polymeric Scaffolds. 2nd TERMIS World Congress in conjunction with 2009 Seoul Stem Cell Symposium, Aug.31-Sep.3, 2009, Seoul, Republic of Korea. (ISTP)
（41）Ge Dan, Liu Tianqing, Guan Shui, Ma Xuehu, Cui Zhanfeng. Three-dimensional Culture of Neural Stem Cells in Extracellular Matrix Scaffolds. 2nd TERMIS World Congress in conjunction with 2009 Seoul Stem Cell Symposium, Aug.31-Sep.3, 2009, Seoul, Republic of Korea. (ISTP)
（42）Shui Guan, Dan Ge, Tianqing Liu, Xuehu Ma, Zhanfang Cui. Neuroprotection by protocatechuic acid against MPP+-induced cytotoxicity in cultured neural stem/progenitor cells. 13th International Biotechnology Symposium, Oct. 12-16, 2008, Dalian CHINA. (ISTP)
（43）Guan S; Ge D; Liu TQ, Ma XH, Cui ZF. Pretreatment with protocatechuic acid increases neurons from cultured neural stem/progenitor cells. TERMIS-EU, JUN 2008, Porto PORTUGAL. (ISTP)
（44）Jianqiang Xu, Shui Guan, Qing Yang, Jun Yang, Jan-Christer Janson. Identification of a soluble recombinant thrombin-like enzyme from Gloydius shedaoensis and its neurotoxicity in cultured PC12 cells. 13th International Biotechnology Symposium, Oct. 12-16, 2008, Dalian CHINA. (ISTP)
（45）Guan S, Ge D, Liu TQ, Li XQ, Song KD, Bao CY, Ma XH, Cui ZF. Protocatechuic acid promotes cell proliferation and reduces basal apoptosis in cultured neural stem cells. TERMIS-EU, Sep. 04-07, 2007, London, ENGLAND. (ISTP)
（46）Ge D, Liu TQ, Cui ZF, Guan S, Ma XH. Cell shape regulates the proliferation of neural precursor cells. TERMIS-EU, Sep. 04-07, 2007, London, ENGLAND. (ISTP)
（47）Li XQ, Liu TQ, Song KD, Zhu L, Ge D, Guan S, Ma XH, Cui ZF. Culture and Expansion of Mesenchymal Stem Cells in Air-Lift Loop Hollow-Fiber Membrane Bioreactor. TERMIS-EU, Sep. 04-07, 2007, London, ENGLAND. (ISTP)
（48）关水，陆瑞欣，刘天庆，马学虎，崔占峰．体外神经干细胞三维药物筛选模型的构建．第十一届全国生化与分子药理学学术会议．Apr. 18-21, 2009, 河南郑州．
（49）关水，陆瑞欣，刘天庆，马学虎，崔占峰．体外构建神经干细胞三维药物筛选模型．第11届中国细胞生物学学术大会暨2009西安细胞生物学国际会议．Jul. 5-7, 2009, 陕西西安．
（50）关水，刘天庆，葛丹，马学虎，崔占峰．原儿茶酸对体外培养神经干细胞作用的研究．第四届全国化学工程与生物化工年会．Nov. 26-29, 2007, 浙江杭州．
（51）李香琴，刘天庆，宋克东，葛丹，关水，马学虎，崔占峰. 气升式环流中空纤维膜生物反应器内骨髓间充质干细胞的培养与扩增. 第四届全国化学工程与生物化工年会．Nov. 26-29, 2007, 浙江杭州．

工作成果（奖励、专利等）
专利：
1.关水，林小敏，刘天庆，马学虎，崔占峰. 一种明胶-壳聚糖-透明质酸-硫酸肝素复合三维支架及其制备方法. 授权公告日：2012.12.11．专利号：ZL**1.7，国家发明专利，中国．
2.关水，刘天庆，李香琴，马学虎，崔占峰. 原儿茶酸在促进神经干细胞体外增殖及诱导分化方面的用途．授权公告日：2009.11.18．专利号：ZL**0.2，国家发明专利，中国．
3.安利佳，张冬艳，包永明，白凤武，于放，关水．喜树细胞中抗癌活性物质的制备及用于抑制癌细胞的方法．授权公告日：2006-07-19．专利申请号：CN**.x，授权公告号：CN**C，国家发明专利，中国．
4.刘天庆，姜波，关水，张文，宋克东，葛丹，李香琴，马学虎，陆瑞欣．一种可注射壳聚糖/甘油磷酸钠/胶原水凝胶的制备方法．国家发明专利申请号：**5.4．申请日：2009.03.05．公开号：CN**．
5.刘天庆，殷轶群，关水，鲍春雨，葛丹，李香琴，崔占峰，马学虎．一种可注射壳聚糖/甘油磷酸钠/胶原水凝胶的制备方法．国家发明专利申请号：**8.6．申请日：2009.04.15．公开号：CN**．

在读学生人数
4

毕业学生人数
6（其中协助指导博士生1人，硕士生2人）