崔京南
院系：精细化工国家重点实验室
办公电话：**
电子信箱：jncui@dlut.edu.cn
更新时间：2015-8-25
其他专业：应用化学



个人简介
1978-1982年：毕业于东北电力学院、电厂化学专业，学士学位；
1992-1995年：毕业于日本冈山大学、应用化学专业，硕士学位；
1995-1998年：毕业于日本冈山大学、合成有机化学专业，博士学位；
1999-2006年：大连理工大学、精细化工国家重点实验室，副教授；
2006-2007年：瑞典皇家工学院，化学系，访问学者；
2007年--至今：大连理工大学、精细化工国家重点实验室，教授，博士生导师


社会兼职
（1）J. Org. Chem.; （2）Tetrahedron Lett.; （3）Bioorg. Med. Chem.; （4）Int. J. Mol. Sci. 等学术期刊审稿人。

研究领域（研究课题）
1）芳香杂环化学和光化学；
2）生物酶催化合成有机化学



硕博研究方向
1）功能染料设计、合成及应用：荧光分子探针、荧光化学传感器；
2）酶催化合成手性化合物；


出版著作和论文
(31) A highly selective fluorescent ESIPT probe for the detection of human carboxylesterase 2 and its biological applications,
Lei Feng, Zhao-ming Liu, Guang-bo Ge, Xia Lv, Jie Hou, Jing Ning, Jing-nan Cui, Ling Yang.
Biosensors and Bioelectronics, 2015, 65, 9-15.
(30) A ratiometric fluorescent sensor for highly selective detection of human carboxylesterase 2 and its application in living cells.
Zhao-ming Liu, Lei Feng, Jie Hou, Xia Lv, Jing Ning, Guang-bo Ge, Ke-wei Wang, Jing-nan Cui, Ling Yang.
Sensors and Actuators B: Chemical. 2014, 205: 151–157.
(29) A highly selective long-wavelength fluorescent probe for human carboxylesterase 2 and its biomedical applications,
Lei Feng, Zhao-ming Liu, Guang-bo Ge, Liang Xu, Xia Lv, Jing Ning, Jie Hou, Jing-nan Cui, Ling Yang.
Chem. Commun., 2014, 50, 14519-14522.
(28) Quantitatively Mapping Cellular Viscosity with Detailed Organelle Information via a Designed PET Fluorescent Probe,
Tianyu Liu, Xiaogang Liu, David R. Spring, Xuhong Qian, Jingnan Cui, Zhaochao Xu,
Scientific Reports, 2014, DOI: 10.1038/srep05418.
(27) A highly selective ratiometric fluorescent probe for invitro monitoring and cellular imaging of human carboxylesterase1,
Liu ZM, Feng L, Ge GB, Lv X, Hou J, Cao YF, Cui JN, Yang L.
Biosensors and Bioelectronics, 2014, 57, 30–35.
(26) A red emission fluorescent probe for hydrogen sulfide and its application in living cells imaging，
Tao Chen, Yi Zheng, Zhaochao Xu*, Miao Zhao, Yongnan Xu, Jingnan Cui*，
Tetrahedron Letter，2013, 54, 2980-2982
(25) A Lysosome-Targetable Fluorescent Probe for Imaging Hydrogen Sulfide in Living Cells,
Tianyu Liu, Zhaochao Xu,* David R. Spring,* Jingnan Cui*,
Org. Lett., 2013, 15, 2310-2313.
(24) A two-photon fluorescent probe for imaging hydrogen sulfide in living cells,
Tianyu Liu, Xinfu Zhang, Qinglong Qiao, Chunyan Zou, Lei Feng, Jingnan Cui,* Zhaochao Xu,*
Dyes and Pigments, 2013, 99, 537-542.
(23) Rational design of fluorescent viscosity sensors by the principle of photoinduced electron transfer,
Zhiyong Wu, Jingnan Cui*, Xuhong Qian*,
Tetrahedron Lett., 2013, 54, 2575–2578.
(22) A fluorescent and colorimetric chemosensor for nitric oxide based on 1,8-naphthalimide,
Min Wang, Zhaochao Xu,* Xu Wang, Jingnan Cui,*
Dye and Pigments, 2013, 96, 333-337.
(21) A 4-aminonaphthalimide based environmentally sensitive fluorescence probe,
Zhi-Yong Wu, Jing-Nan Cui, Xu-Hong Qian, Tian-Yu Liu,
Chinese Chemical Letters. 2013, 24(5), 359-361.
(20) Novel acenaphthopyrazine derivatives as antitumor agents against MCF-7 cells: Molecular synthesis, optical properties, and DNA-binding studies,
Junling Xing, Jingnan Cui,* Shuang Wang, Jin Gao, Zhichao Zhang,
Monatsh Chem, 2012, 143, 243-250.
(19) A ratiometric and exclusively selective Cu-II fluorescent probe based on internal charge transfer (ICT),
Xiufu Chen, Jingyun Wang, Jingnan Cui,* Zhaochao Xu, Xiaojun Peng,*
?Tetrahedron, 2011, 67,?4869-4873.
(18) Zn2+-Triggered Amide Tautomerization Produces a Highly Zn2+-Selective, Cell-Permeable, and Ratiometric Fluorescent Sensor
Zhaochao Xu,* Kyung-Hwa Baek, Ha Na Kim, Jingnan Cui, Xuhong Qian, David R. Spring, Injae Shin,* ,Juyoung Yoon*
J. Am. Chem. Soc. 2010, 132, 601.
(17) A new class of organic dyes based on acenaphthopyrazine for dye-sensitized solar cells, Z. Kong, H. Zhou, J. Cui, T. Ma, X. Yang, L. Sun,
J. Photochem. Photobio. A: Chem. 2010, 213, 152-157.
(16) Preparation of chiral trans-5-substituted-acenaphthene-1,2-diols by baker’s yeast-mediated reduction of 5-substituted-acenaphthylene-1,2-diones,
L. Wang, X. Wang, J. Cui, W. Ren, N. Meng, X. Qian,
Tetrahedron: Asymmetry, 2010, 21, 825-830.
(15) Design, Synthesis and Bioactivity of Vinylnitro-cyano Neonicotinoids as Potential Insecticides,
K. Wang, X. Qian, J. Cui,
Monatsh. Chem. 2010, 141, 1117.
(14) One step from nitro to oxime: a convenient preparation of unsaturated oximes by the reduction of the corresponding vinylnitro compounds
Kewei Wang, Jingnan Cui, Xuhong Qian,*
Tetrahedron, 2009, 65, 10377.
(13) Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: synthesis, cytotoxicity, DNA-binding and cell cycle evaluation,
Lijuan Xie, Yi Xiao, Fang Wang, Yufang Xu, Xuhong Qian,* Rong Zhang, Jingnan Cui,* Jianwen Liu*
Bioorg. Med. Chem. 2009, 17, 7615.
(12) Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies,
Lijuan Xie, Yufang Xu, Fang Wang, Jianwen Liu, Xuhong Qian,* Jingnan Cui *
Bioorg. Med. Chem. 2009, 17, 804.
(11) Novel Angular Furoquinolinones Bearing Flexible Chains as Antitumor Agents: Synthesis, Cytotoxic Evaluation and DNA-Binding Studies,
Lijuan Xie, Xuhong Qian,* Jingnan Cui,* Yi Xiao, Kewei Wang, Peichun Wu, Liying Cong
Bioorg. Med. Chem. 2008, 16, 8713.
(10) A Ratiometric and Highly Selective Fluorescent Sensor for Cadmium under Physiological pH Range: a New Strategy to Discriminate Cadmium from Zinc,
Chunliang Lu, Zhaochao Xu, Jingnan Cui,* Rong Zhang, Xuhong Qian;*
J. Org. Chem. 2007, 72，3554-3557.
(9) Molecular design, chemical synthesis, and biological evaluation of ‘4-1’ pentacyclic arylimidazonaphthalimides,
Feng Li, Jingnan Cui,* Lianying Guo, Xuhong Qian,*Weimin Ren, Kewei Wang, Fengyu Liu,
Boorg. Med. Chem. 2007, 15, 5114-51221.
(8) Baker’s yeast-mediated enantioselective reduction of substituted fluorenones,
Feng Li, Jingnan Cui,* Xuhong Qian,* Weimin Ren, Xingyong Wang
Chem. Commun., 2006, 865-867.
(7) Exploiting the deprotonation mechanism for the design of ratiometric and colorimetric Zn2+ fluorescent chemosensor with a large red-shift in emission,
Zhaochao Xu, Xuhong Qian,* Jingnan Cui,* Rong Zhang
Tetrahedron, 2006, 62, 100117-10122.
(6) Detecting Hg2+ ions with an ICT fluorescent sensor molecule: Remarkable emission spectra shift and unique selectivity,
Jiaobing Wang, Xuhong Qian,* Jingnan Cui
J. Org. Chem. 2006, 71, 4308-4311.
(5) Highly chemoselective reduction of aromatic nitro compounds to the corresponding hydroxylamines catalysed by plant cells from grape (Vitis vinifera L.),
Feng Li, Jingnan Cui,* Xuhong Qian,* Rong Zhang, Yi Xiao,
Chem. Commun., 2005, 1901-1903.
(4) A Colorimetric and Ratiometric Fluorescent Chemosensor With a Large Red-shift in Emission: Cu(II)-Only Sensing by Deprotonation of Secondary Amines as Receptor Conjugated to Naphthalimide Fluorophore,
Zhaochao Xu, Xuhong Qian,* Jingnan Cui,*
Org. Lett. 2005, 3029-3032.
(3) A Ratiometric and Selective Fluorescent Sensor for CuII Based on Internal Charge Transfer (ICT) ,
Zhaochao Xu, Yi Xiao, Xuhong Qian,* Jingnan Cui,* Dawei Cui,
Org. Lett. 2005, 889-892.
(2)A New Class of Long-Wavelength Fluorophores: Strong Red Fluorescence, Convenient Synthesis and Easy Derivation，
Yi Xiao, Fengyu Liu, Xuhong Qian,* Jingnan Cui,
Chem. Commun. 2005, 239-241.
(1) A novel strategy for the preparation of arylhydroxylamines: chemoselective reduction of aromatic nitro compounds using bakers’ yeast，
Feng Li, Jingnan Cui,* Xuhong Qian,*Rong Zhang,
Chem. Commun., 2004, 2338-2339.

工作成果（奖励、专利等）
奖励：
（1）国家技术发明二等奖，2006年，大幅面数码喷墨染料及其应用，彭孝军、崔京南、张蓉、王力成、樊江丽、王力军；
（2）上海市自然科学一等奖，2008年，生物功能色素及荧光分子传感器，钱旭红、肖义、崔京南、徐玉芳；
专利：
（9）一种染料型中性墨水及其制备方法，ZL**5.5；
（8）一种以苊并吡嗪为母体的高灵敏性荧光探针、制备及应用，**1.7；
（7）一类邻二氰基苊并吡嗪化合物及其抗肿瘤应用，ZL**8.2。
（6）手性2-羟基苊酮类化合物的制备方法，ZL**5.2；
（5）芳杂环基咪唑并萘酰亚胺类化合物及其应用，ZL**7.5；
（4）提高喷头使用寿命的喷墨染料,ZL**5.X；
（3）4,5-双取代-1,8-萘酰亚胺类化合物及其应用，ZL**5.3；
（2）水基喷墨染料，ZL**.9；
（1）一种萘酰亚胺荧光染料及其制备和应用，ZL**1.8;



在读学生人数
9

毕业学生人数
15