梁昌镛，博士，教授。南昌大学微生物专业学士学位，中国科学院武汉病毒研究所微生物专业博士学位。2003-2008年在中国科学院武汉病毒研究所从事研究工作， 2006-2007年在荷兰Wageningen大学病毒学实验室从事合作研究。2008年调动到扬州大学。目前从事病毒分子生物学和病毒基因工程的研究，研究重点为病毒基因与基因组的结构与功能、病毒与宿主的相互作用、病毒表达载体以及用于基因治疗的病毒载体的构建等。目前已主持国家自然科学基金课题三项、作为研究骨干参加两项973课题，另外，主持中国科学院院长奖资助基金，病毒灭活实验横向课题等在研课题。曾获中国科学院院长优秀奖。从2002年至今已发表的与本研究相关的论文40余篇，其中SCI源22篇。
通讯地址：通讯地址: 扬州大学生物科学与技术学院生物化学与分子生物学教研室 江苏省扬州市文汇东路12号
邮政编码: 225009
电 话： (办公室)
传 真：
E-mail: cyliang@yzu.edu.cn
一、 研究方向：
1、 病毒与宿主相互作用
2、 病毒基因的结构与功能
3、 病毒基因工程
二、 承担的科研项目：
1. 杆状病毒pk-1基因调控病毒极晚期转录的分子机制 国家自然科学基金（**） 30.0万 项目负责人
2. 乙型肝炎重症化临床监测及防治的基础研究 国家重点基础研究发展规划项目（“973”项目）(2007CB512901) 50.0万 研究骨干
3. 昆虫病毒感染关键步骤的分子机理研究 国家重点基础发展规划项目（973项目）子课题 （2009CB118903）15万，研究骨干
4. AcMNPV 凋亡抑制基因iap的结构与功能研究 国家自然科学基金（**） 30.0万 项目负责人
5. 杆状病毒HaSNPV作为靶向性基因治疗载体的研究 国家自然科学基金（**）。20.0万 项目负责人
三、发表的主要论文：
1. Zhao S, He G, Yang Y, Liang C. Nucleocapsid assembly of baculoviruses. Viruses. 2019; 11: 595
2. Zhao S, Xu G, He G, Peng Y, Liang C. Characterization of an endonuclease in rice stripe tenuivirus Pc1 in vitro. Virus Res. 2019; 260: 33-37
3. Liang C, Su X, Xu G, Dai X, Zhao S. Autographa californica multiple nucleopolyhedrovirus PK1 is a factor that regulates high-level expression of very late genes in viral infection. Virology. 2017;512: 56-65
4. Zhao SL, Hao JH, Xue YN, Liang CY. Mapping of the regions involved in self-interaction of rice stripe virus P3 protein. Acta virologica. 2016; 60: 94-99
5. Zhao SL, Hao JH, Xue YN, Liang CY (2015). Intracellular localization of rice stripe virus RNA-dependent RNA polymerase. Virus Genes. 51: 423-429.
6. Zhao SL, Xue YN, Hao JH, Liang CY (2015). The RNA-binding properties and domain of rice stripe virus nucleocapsid protein. Virus Genes. 51: 276-282.
7. Liang C, Lan D, Zhao S, Liu L, Xue Y, Zhang Y, Wang Y, Chen X. The Ac124 is not essential for the propagation of AcMNPV, but it is a viral pathogenicity factor. Archives of Virology. 2015; 160: 275-284
8. Liang C, Li M, Dai X, Zhao S, Hou Y, Zhang Y, Lan D, Wang Y, Chen X. Autographa californica multiple nucleopolyhedrovirus PK-1 is essential for nucleocapsid assembly. Virology. 2013; 443(2): 349-57.
9. Zhao S, Zhang G, Dai X, Hou Y, Li M, Liang J, Liang C*. Processing and intracellular localization of rice stripe virus Pc2 protein in insect cells. Virology. 2012, 429(2):148-54.
10. Zhao SL, Dai XJ, Liang JS, Liang CY*. Surface display of rice stripe virus NSvc2 and analysis of its membrane fusion activity. Virol Sin. 2012, 27(2):100-8.
11. Liang C., Lange J., Chen X., van Oers M., Vlak J., Westenberg M. Functional analysis of two inhibitor of apoptosis (iap) orthologs from Helicoverpa armigera nucleopolyhedrovirus. Virus Reasearch. (2012) 165：107-111
12. Wang Y., Wang Q., Liang C.Y., Song J.H., Li N, Shi H., Chen X.W. Autographa californica multiple nucleopolyhedrovirus nucleocapsid protein BV/ODV-C42 mediates the nuclear entry of P78/83. Journal of Virology. (2008) 82: 4554-61.
13. Wang Q., Wang Y., Liang C.Y., Song J.H., Chen X.W. Identification of a hydrophibic domain of HA2 essential to morphogenesis of Helicoverpa armigera nucleopolyhedrovirus. Journal of Virology. (2008) 82: 4072-81.
14. Liang C.Y., Chen X.W. 2007 Baculoviruses as vectors in mammalian cells Viriologica Sinica VIROLOGICA SINICA Vol.22 No.2 P.148-157
15. Liang, C., Song, J, Chen, X. Group I but not Group II NPV Induces Antiviral Effects in Mammalian Cells. Science inChina(Series C). (2006) 2006, 49: 467-72.
16. Liang, C, Song, J., Chen, X. The GP64 protein of Autographa californica multiple nucleopolyhedrovirus rescues Helicoverpa armigera nucleopolyhedrovirus transduction in mammalian cells. J. Gen. Virol. (2005) 86: 1629-35.
17. Liang, C., Wang, H, Li, T., Hu, Z., Chen, X. High efficiency gene transfer into mammalian kidney cells using baculovirus vectors. Archives of Virology. (2004) 149: 51-60.
18. Liang, C.Y., Hu, Z.H. and Chen, X.W. The development of baculoviruses as novel gene therapy vector. Prog. Biochem. Biophys. (2002). 29: 860-862.
19. Wang Q, Liang C, Song J, Chen X. HA2 from the Helicoverpa armigera nucleopolyhedrovirus: a WASP-related protein that activiates Arp2/3-induced actin filament formation. Virus Research. (2007) 127(1):81-87.
20. Song J, Liang C, Chen X. Transduction of avian cells with recombinant baculovirus. J Virol Methods. (2006) 135(2):157-62.
21. Mao H., Song J., Liang C., Yu Z., Chen X. Construction of eukaryotic surface display based on the baculoviral F protein BioTechniques (2006). 41: 266-72.
22. Nie Y, Wang Q, Liang C, Fang M, Yu Z, Chen X. Characterization of ORF2 and its encoded protein of the Helicoverpa armigera nucleopolyhedrovirus. Virus Research. (2006) 116:129-35.
23. Liu X, Li K, Song J, Liang C, Wang X, Chen X. Efficient and stable gene expression in rabbit intervertebral disc cells transduced with a recombinant baculovirus vector. Spine. (2006) 31:732-5.
24. Li X, Song J, Jiang T, Liang C, Chen X. 2007. Autographa californica multiple nucleopolyhedrovirus pif-3 N-terminal hydrophobic sequence is essential for oral infection, Archives of Virology 152(10):1851-1858
25. S.L.Zhao, Liang C.Y., J.J.Hong, H.Y.Peng. Genomic sequence analyses of segments 1 to 6 of Dendrolimus punctatus cytoplasmic polyhedrosis virus. Archives of Virology. (2003) 148:1357-1368
26. S.L.Zhao, Liang C.Y., J.J.Hong, H.G.Xiu, H.Y.Peng. Molecular characterization of segments 7 to 10 of Dendrolimus punctatus cytoplasmic polyhedrosis virus provides the complete genome. Virus Research. (2003) 94:17-23
五、授权专利
1. 带折通管添加MB药物的新型病毒灭活输血滤器 实用新型专利 ZL2.5 2013.9.25 2/6
2. 超声波氧气浓度连续检测显示装置 实用新型专利 ZL7.X 2014.6.4 3/5
3. 冷沉淀凝血因子制备仪用蠕动泵及蠕动泵模块 实用新型专利 ZL2.2 2014.9.24 2/6
4. 具有新式活塞的医用注射器 实用新型专利 ZL6.9 2014.10.22 4/5