徐州医科大学基础医学院导师教师师资介绍简介-高殿帅

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高殿帅
博士生导师

职称：教授

学院：基础医学院
gds@xzhmu.edu.cn

个人简介
高殿帅，博士，1965年4月出生，二级教授，博士生导师，博士后合作导师。神经生物学重点实验室主任，神经生物学研究中心主任，徐州医科大学基础医学院院长兼党委书记。江苏省“333高层次人才培养工程”首批中青年科学技术带头人；江苏省“六大人才高峰”项目资助对象；江苏省“优秀科技工作者”；中国解剖学会神经解剖学专业委员会委员；《神经解剖学杂志》编委；《Journal of Modern Neurology》主编；美国神经科学会会员；中国神经科学会会员；《Neuroscience Letter》等SCI收录杂志审稿人；国家自然科学基金项目评审专家、中国博士后基金项目评审专家；徐州医科大学学术委员会委员；徐州医科大学学位评定委员会委员。
主要从事胶质瘤和帕金森病发生发展相关机制的研究。先后获国家自然科学基金资助项目7项，江苏省自然科学基金项目1项，省教改课题2项；发表学术论文近百篇，其中最高影响因子10.198；已授权专利3项，省厅级科技成果研究奖二等奖2项，市级科技成果进步奖二等奖2项和三等奖1项。指导博士后、博士研究生、硕士研究生总计达百人，在读留学生4人。
承担研究生、本科生课程3门（细胞生物学、神经生物学、人体解剖学）；主编教材2部，参与撰写英文专著2部。

成果奖励（近五年）
1. 神经胶质母细胞瘤的发生发展机制探索；高殿帅，张宝乐，孙申，熊晔，李风；2018；江苏省教育厅，高校自然科学研究奖，二等奖；
2. 神经胶质瘤细胞中GDNF基因高表达的调控机制研究；高殿帅，虞正权，张宝乐，李亨，熊晔；2016；江苏省教育厅，高校科学技术研究奖，二等奖。

科研项目（近五年）
1. 国家自然科学基金面上项目，**，前额叶皮质GDNF含量降低致帕金森病伴工作记忆障碍的机制研究，55万元，2020/01-2023/12；
2. 国家自然科学基金面上项目，**，恶性胶质瘤细胞中GDNF基因启动子上特定顺式作用元件甲基化水平升高的分子机制研究，57万元，2018/01-2021/12；
3. 国家自然科学基金面上项目，**，神经钙粘素前体介导胶质瘤细胞迁移的机制研究，70万元，2014/01-2017/12。

论文情况（近五年）
1. Baole Zhang, Xiaohe Gu, Xiao Han, Qing Gao, Jie Liu, Tingwen Guo, Dianshuai Gao*, Crosstalk between DNA methylation and histone acetylation triggers GDNF high transcription in glioblastoma cells. Clinical Epigenetics, accept, 2020 (IF=5.496, JCR=2)
2. Ayanlaja AA,Ji GQ,Wang J,Gao Y,Cheng B,Kanwore K,Zhang L,Xiong Y,Kambey PA,Gao DS. Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression. Cell Commun Signal. 2020; 18(1):24. (IF=5.111, JCR=2)
3. Gao J, Kang XY, Sun S, Li L, Gao DS. MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling. J Mol Neurosci. 2020, 70(3):328-339. (IF=2.577, JCR=4)
4. Liu Y, Tong SY, Ding L, Liu N, Gao DS. Serum levels of glial cell line-derived neurotrophic factor and multiple neurotransmitters: In relation to cognitive performance in Parkinson's disease with mild cognitive impairment. Int J Geriatr Psychiatry. 2029, 35(2):153-162. (IF=3.141, JCR=3)
5. Tang CX, Wang Y, Zhang L, Wang J, Wang W, Han X, Mu CY. Gao DS. Identification of novel LncRNA targeting Smad2/PKCα signal pathway to negatively regulate malignant progression of glioblastoma. J Cell Physiol. 2020,235(4):3835-3848. (IF=4.522, JCR=2)
6. Gu XH, Li H, Zhang L, He T, Chai X, Wei H, Gao DS. Differential expression of glial cell line-derived neurotrophic factor splice variants in the mouse brain. Neural Regen Res. 2020; 15(2):270-276. (IF=2.472, JCR=4)
7. Li F, Jin D, Guan L, Zhang CC, Wu T, Wang YJ, Gao DS. CEP55 promoted the migration, invasion and neuroshpere formation of the glioma cell line U251. Neurosci Lett. 2019, 705:80-86. (IF=2.173, JCR=4)
8. Zhou F, Liu X, Gao L, Zhou X, Cao Q, Niu L, Wang J, Zuo D, Li X, Yang Y, Hu M, Yu Y, Tang R, Lee BH, Choi BW, Wang Y, Izumiya Y, Xue M, Zheng K, Gao D. HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways. J Neuroinflammation. 2019, 16: 71. (IF=5.7, JCR=2)
9. Tang C.X., L. Luan, L. Zhang, Y. Wang, X.F. Liu, J. Wang, Y. Xiong, D. Wang, L.Y. Huang, and D.S. Gao, Golgin-160 and GMAP210 play an important role in U251 cells migration and invasion initiated by GDNF. PloS one, 2019, 14(1): e**. (IF= 2.776, JCR=3)
10. Tang, C.X., W. Wang, M.Y. Shi, N. Zhang, X.Y. Zhou, X. Li, C.C Ma, G. Chen, J. Xiang, and D.S. Gao, Meta-analysis of the effects of the COMT Val158/108Met polymorphism on Parkinson‘s disease susceptibility and cognitive dysfunction. Frontiers in Genetics, 2019, 10: 644. (IF=3.517, JCR=2)
11. Ayanlaja, A.A., B.L. Zhang, G.Q. Ji, Y. Gao, J. Wang, K. Kanwore, and D.S Gao, The reversible effects of glial cell line-derived neurotrophic factor (GDNF) in the human brain. Semin Cancer Biol, 2018, 53: 212-222. (IF=10.198, JCR=1)
12. Sun, S., Y. Wang, Y. Wu, Y. Gao, Q. Li, A.A. Abdulrahman, X.F. Liu, G.Q. Ji, J. Gao, L. Li, F.P. Wan, Y.Q. Li, and D.S. Gao, Identification of COL1A1 as an invasionrelated gene in malignant astrocytoma. Int J Oncol, 2018. (IF= 3.33, JCR=3)
13. Wang, Y.Q., Y.X. Qin, T.W. Guo, C.X. Tang, L.Y. Liu, and D.S. Gao, High Concentration of Glial Cell Line-Derived Neurotrophic Factor Protects Primary Astrocytes from Apoptosis. Dev Neurosci, 2018. (IF=2.133, JCR=3)
14. Li, F., D. Jin, C.X. Tang, and D.S. Gao, CEP55 promotes cell proliferation and inhibits apoptosis via the PI3K/Akt/p21 signaling pathway in human glioma U251 cells. Oncol Lett, 2018. 15(4): p. 4789-4796. (IF=1.664, JCR=4)
15. Tang, C.X., Y.X. Gu, X.F. Liu, S.Y. Tong, A.A. Ayanlaja, Y. Gao, G.Q. Ji, Y. Xiong, L.Y. Huang, and D.S. Gao, Cross-link regulation of precursor N-cadherin and FGFR1 by GDNF increases U251MG cell viability. Oncol Rep, 2018. 40(1): p. 443-453. (IF=2.976, JCR=3)
16. Zhang, B.L., F.L. Dong, T.W. Guo, X.H. Gu, L.Y. Huang, and D.S. Gao, MiRNAs Mediate GDNF-Induced Proliferation and Migration of Glioma Cells. Cell Physiol Biochem, 2017. 44(5): p. 1923-1938. (IF=5.104，JCR=2)
17. Li, L., H.J. Song, P.P. Mu, M. Xu, C. Liu, Y. Wang, Y.X. Qin, S. Sun, J. Gao, T. Wang, and D.S. Gao, The Actin Cytoskeleton Is Involved in Glial Cell Line-Derived Neurotrophic Factor (GDNF)-Induced Ret Translocation into Lipid Rafts in Dopaminergic Neuronal Cells. Int J Mol Sci, 2017. 18(9). (IF=3.226，JCR=2)
18. Zhu, S., H. Liu, H. Sha, L. Qi, D.S. Gao, and W. Zhang, PERK and XBP1 differentially regulate CXCL10 and CCL2 production. Exp Eye Res, 2017. 155: p. 1-14. (IF=3.33，JCR=3)
19. Fan, H.B., L.X. Chen, X.B. Qu, C.L. Ren, X.X. Wu, F.X. Dong, B.L. Zhang, D.S. Gao, and R.Q. Yao, Transplanted miR-219-overexpressing oligodendrocyte precursor cells promoted remyelination and improved functional recovery in a chronic demyelinated model. Sci Rep, 2017. 7: p. 41407. (IF=4.26，JCR=3)
20. Chen, J., X.Y. Kang, C.X. Tang, and D.S. Gao, Impact of Pitx3 gene knockdown on glial cell line-derived neurotrophic factor transcriptional activity in dopaminergic neurons. Neural Regen Res, 2017. 12(8): p. 1347-1351. (IF=1.76，JCR=4)
21. Chen, J., T. Wang, X.Y. Zhou, C.X. Tang, and D.S. Gao, Glucose-6-phosphatase- α participates in dopaminergic differentiation. Neurological Research, 2017. 39(10): p. 869-876. (IF=1.376，JCR=4)
22. Ayanlaja, A. A., Y. Xiong, Y. Gao, G.Q. Ji, C.X. Tang, Z. Abdikani Abdullah, and D.S. Gao, Distinct Features of Doublecortin as a Marker of Neuronal Migration and Its Implications in Cancer Cell Mobility. Front Mol Neurosci, 2017. 10: p. 199. (IF=5.076，JCR=2)

指导研究生情况(近五年)
2016级
硕士研究生：顾笑赫、王月、李雪、刘娜、高成
博士研究生：
2017级
硕士研究生：史明语、周晓雨、王洁、韩笑
博士研究生：唐传喜
博士后：张娜、薛敏
2018级
硕士研究生：程博、陈刚、夏莹、郭肖肖、马成成、高擎
博士研究生：张琳
2019级
硕士研究生：吴姣、秦登利、曹媛媛、杜银贞、王潇雨、查威、洪晓亮
博士研究生：陈静
2020级
硕士研究生：徐伟、刘依放、刘文雅、刘业豪、周晗
博士研究生：史明语

主讲课程（近五年）
承担研究生、本科生课程3门（细胞生物学、神经生物学、人体解剖学）。

知识产权（近五年）
发明专利1项：
李亨，高殿帅，姚瑞琴，张宝乐，曲德伟，何涛，柴祥，用于检测GDNF剪接变异体1、3的实时荧光定量PCR专用引物，2016，中国，CN7.7

著作教材（近五年）
专著2部
1. Dian-shuaiGao, Jin Gao. Striatum: Anatomy, FunctionsandRole in Disease (ISBN: 978-1-61942-384-8), Striatum: Anatomy, FunctionsandRole in Disease (章节标题), 6793字, NOVA Science Publisher,2012；
2. Dianshuai Gao, Yi Liu, Shen Sun, Li LiandYe Xiong. etiology and pathophysiology of Parkinson’s disease (edited by Abdul Qayyum Rana, ISBN 978- 953-307-462-7), Actions of GDNF on Midbrain Dopaminergic Neurons: The Signaling Pathway(章节标题), 2.8万字, INTECH，2011。

发表论文:
Glial cell line-derived neurotrophic factor alters lipid composition and protein distribution in MPP+-injured differentiated SH-SY5Y cells

Possible role of glial cell line-derived neurotrophic factor for predicting cognitive impairment in Parkinson’s disease: a case-control study

Identification of novel LncRNA targeting Smad2/PKC alpha signal pathway to negatively regulate malignant progression of glioblastoma

Crosstalk between DNA methylation and histone acetylation triggers GDNF high transcription in glioblastoma cells

MES23.5 DA Immortalized Neuroblastoma Cells Self-protect Against Early Injury by Overexpressing Glial Cell-derived Neurotrophic Factor via Akt1/Eya1/Six2 Signaling

Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression

Serum levels of glial cell line-derived neurotrophic factor and multiple neurotransmitters: In relation to cognitive performance in Parkinson's disease with mild cognitive impairment

Differential expression of glial cell line-derived neurotrophic factor splice variants in the mouse brain

Meta-Analysis of the Effects of the Catechol-O-Methyltransferase Val158/108Met Polymorphism on Parkinson's Disease Susceptibility and Cognitive Dysfunction

CEP55 promoted the migration, invasion and neuroshpere formation of the glioma cell line U251
教材专著:
Striatum: Anatomy, Functions a

Etiology and pathophysiology o
科研项目:
神经胶质瘤细胞中GDNF基因高转录

CB介导的GDNF对多巴胺能神经元保

NCAM140介导GDNF对DA能神经细胞

GDNF与雌激素协同保护神经细胞的

大鼠中脑腹侧含钙结合蛋白的多巴

大鼠脑黑质内具有抗变性能力的多

神经钙粘素前体介导胶质瘤细胞迁
获奖成果:
淮海科学技术奖

江苏省优秀科技工作者

发明专利：用于检测小鼠GDNF剪接

江苏省教育厅科技成果进步奖

徐州市科技进步奖

江苏省“六大人才高峰” 项目资

帕金森病早期大鼠模型的建立及中