朱作斌
硕士生导师

职称：副教授
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学院：生命科学学院
zhuzuobin@xzhmu.edu.cn







个人简介
衰老和死亡是人类永恒的挑战。随着人口老龄化的加剧，老年病的发病率逐年增加。衰老是百病之源，发掘抗衰老物质并理清其抗衰老机制对人类健康及老年病的预防和治疗具有重要的应用价值。
本课题组依托徐州市医学遗传与转化工程中心及徐州医科大学形态实验中心，以秀丽隐杆线虫、果蝇和小鼠为动物模型进行衰老及相关疾病（如阿尔兹海默病、帕金森病等神经退行性疾病）的遗传机制研究及抗衰老药物的研发。
主持国家自然科学基金、江苏省自然科学基金、徐州市基础研发计划和徐州医科大学优秀人才科研启动资金各一项，参与国家重点基础研究发展计划项目1项，国家自然科学基金面上项目2项。近五年以第一作者或通讯作者发表SCI论文10余篇。 承担研究生和本科生的教学工作。讲授《高级医学遗传学》、《遗传与进化》及《系统生物学》等课程。






发表论文:
Characterization of glycogen molecular structure in the worm Caenorhabditis elegans

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piRNAs Regulated by Mitochondria Variation Linked with Reproduction and Aging in Caenorhabditis elegans

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Comparative genome analysis of 12 Shigella sonnei strains: virulence, resistance, and their interactions

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The whole transcriptome regulation as a function of mitochondrial polymorphisms and aging in Caenorhabditis elegans

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Teasaponin suppresses Candida albicans filamentation by reducing the level of intracellular cAMP.

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Anticandidal Activity of Kalopanaxsaponin A: Effect on Proliferation, Cell Morphology, and Key Virulence Attributes of Candida albicans

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Identification of Specific Nuclear Genetic Loci and Genes That Interact With the Mitochondrial Genome and Contribute to Fecundity in Caenorhabditis elegans

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The inhibition of trans-cinnamaldehyde on the virulence of Candida albicans via enhancing farnesol secretion with low potential for the development of resistance

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Identification of ROBO1/2 and SCEL as candidate genes in Kallmann syndrome with emerging bioinformatic analysis

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Close genetic relationships between a spousal pair with autism-affected children and high minor allele content in cases in autism-associated SNPs
教材专著:

科研项目:
核基因组与线粒体基因组相互作用与衰老关系的研究

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线粒体-核基因组相互作用与线虫生殖关系的研究

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衰老基因调控网络的探究及相关基

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核基因组-线粒体基因组相互作用
获奖成果: