宋远见
硕士生导师

职称：副教授

学院：生命科学学院
@qq.com







个人简介
宋远见，博士，副教授，硕士生导师。徐州医科大学遗传学学科负责人，徐州市医学遗传与转化工程研究中心常务副主任，基础医学院副院长。
江苏省“333工程”第三层次培养对象，江苏省“六大人才高峰”高层次人才培养对象，江苏省“青蓝工程”中青年学术带头人，江苏省“青蓝工程”优秀青年骨干教师，徐州医科大学“优秀青年科技工作者”，徐州医科大学“振兴计划”优秀青年骨干教师。国家自然科学基金项目评审专家。
研究方向：神经损伤的分子遗传学机制、脑靶向基因纳米载体的研发与应用。近年来，主持国家自然科学基金项目3项，省厅级基金项目4项，校级基金项目2项；发表学术论文30余篇，其中以第一作者和通讯作者在Mol Neurobiol、Aging和Behav Brain Res等国际学术期刊上发表SCI收录论文20余篇；获批专利2项，徐州市科技进步二等奖1项。已指导9名研究生完成毕业论文并获得硕士学位。
承担研究生、本科生和留学生的遗传学教学工作。讲授专业课《医学遗传学》《遗传与优生》《遗传与进化》；积极开展CBL、双语和翻转课堂等教学改革；副主编教材《医学遗传学》和《细胞生物学与医学遗传学实验教程》各1部，参编《医学生物学实验》1部；主持校教育教学改革项目1项；指导大学生创新计划项目1项。
欢迎同学们报考或调剂遗传学专业，如感兴趣，可以直接将简历发到@qq.com或直接加我QQ：。


【主持课题】
1.江苏省“六大人才高峰”高层次人才培养对象项目，WSN-089，10万，2019-2021，主持，在研。
2.国家自然科学基金面上项目，**，ASK1-MKK4-JNK信号模块与Cdc42作用位点的筛选及其在缺血性脑损伤中的作用机制，57万，2017-2020，主持，已结题。
3.国家自然科学基金面上项目，**，MLK3-MKK7-JNK3信号模块与HO-1的作用位点在缺血性脑中风中的作用机制，70万，2014-2017，主持，已结题。
4.国家自然科学基金青年项目，**，缺血性脑损伤中血红素加氧酶-1/一氧化碳系统对JNK信号通路调控的分子机制，20万，2008-2012，主持，已结题。
5.江苏省脑病生物信息重点实验室，Jsbl1102，非病毒PLGA载药纳米粒的构建及靶向治疗缺血性脑中风的实验研究，2万，2009-2012，主持，已结题。
6.江苏省高校自然科学基金面上项目，09KJB310016，Akt信号通路介导的热休克在缺血性脑损伤中作用机制的研究，3万，2009-2012，主持，已结题。
7.江苏省“青蓝工程” 中青年学术带头人项目，10万，2014-2017，主持，在研。
8.江苏省“青蓝工程” 优秀青年骨干教师项目，0.3万，2010-2013，主持，已结题。
9.徐州医科大学“振兴计划” 优秀青年骨干教师项目，0.2万，2010-2013，主持，已结题。
10.徐州医科大学院长专项人才科研基金项目，2012KJZ06，JNK3介导的胱硫醚β-合酶/硫化氢在缺血性脑中风中的作用，3万，2012-2015，主持，已结题。
【代表性论文】（*为通讯作者）
1.LiuTJ, SongYJ*,HuAK*. Neuroprotective mechanisms of mangiferin in neurodegenerative diseases. Drug Dev Res. 2021, 17.
2.GaoYT, CuiMM, ZhongSJ, FengCY, Alexander Kenechukwu Nwobodo, ChenB, SongYJ*, WangYL*. Dihydroartemisinin ameliorates LPS-induced neuroinflammation by inhibiting the PI3K/AKT pathway. Metab Brain Dis. 2020, 35(4):661-672.
3.Song YJ, Shi Y, Cui MM, Li M, Wen XR, Zhou XY, Lou HQ, Wang YL, Qi DS, Tang M, Zhang XB.H₂S attenuates injury after ischemic stroke by diminishing the assembly of CaMKII with ASK1-MKK3-p38 signaling module.Behav Brain Res. 2020, 384:112520.
4.Song YJ, Wang YC, Li Y, Wang L, Zhang WD, Cheng J, Zhu Y, Zhang HY, Zhang Q, Niu HC, Zheng YW, Liang MY, Deng MQ, Shi H, Wang H, Zhang F, Zhu ZB. The whole transcriptome regulation as a function of mitochondrial polymorphisms and aging in Caenorhabditis elegans.Aging (Albany NY). 2020, 12(3):2453-2470.
5.Song YJ,Dai CX, Li M, Cui MM, Ding X, Zhao XF, Wang CL, Li ZL, Guo MY, Fu YY, Wen XR, Qi DS, Wang YL. The potential role of HO-1 in regulating the MLK3-MKK7-JNK3 module scaffolded by JIP1 during cerebral ischemia/reperfusion in rats. Behav Brain Res,2019, 359:528-535.
6.Song YJ,Qin L, Yang RL, Yang F, Kenechukwu NA, Zhao XF, Zhou XY, Wen XR, Li L. Inhibition of HDAC6 alleviating lipopolysaccharide-induced p38MAPK phosphorylation and neuroinflammation in mice. Pharm Biol,2019, 57(1):263-268.
7.Song YJ,Zhao XF, Wang D, Zheng Y, Dai CX, Guo MY, Qin L, Wen XR, Zhou XY, Liu ZA. Inhibition of LPS-induced brain injury by NR2B antagonists through reducing assembly of NR2B-CaMKII-PSD95 signal module. Immunopharmacol Immunotoxicol,2019, 3:1-9.
8.Song YJ, Zhang F, Ying CJ, Kumar KA, Zhou XY. Inhibition of NF-κB activity by aminoguanidine alleviates neuroinflammation induced by hyperglycemia. Metab Brain Dis,2017, 32(5):1627-1637.
9.Zhou XY, Zhang F, Ying CJ, Chen J, Chen L, Dong J, Shi Y, Tang M, Hu XT, Pan ZH, Xu NN, Zheng KY, Tang RX,Song YJ*. Inhibition of iNOS alleviates cognitive deficits and depression in diabetic mice through downregulating the NO/sGC/cGMP/PKG signal pathway. Behav Brain Res,2017, 322(Pt A):70-82.
10.Zhou XY, Zhang F, Hu XT, Chen J, Tang RX, Zheng KY, Song YJ*. Depression can be prevented by astaxanthin through inhibition of hippocampal inflammation in diabetic mice.Brain Res,2017 Feb 15;1657:262-268.
11.Wen XR, Fu YY, Liu HZ, Wu J, Shao XP, Zhang XB, Ma K, Zhang F, Wang YW, Tang H, Han D, Zhang P, Wang SL, Xu Z, Song YJ*. Neuroprotection of sevoflurane against ischemia/reperfusion-induced brain injury through inhibiting JNK3/Caspase-3 by enhancing Akt signaling pathway. Mol Neurobiol, 2016, 53(3):1661-1671.
12.Zhang F, Fu YY, Zhou XY, Pan W, Shi Y, Wang M, Zhang XB, Qi DS,Li L,Ma K, Tang RX, Zheng KY, Song YJ*. Depression-like behaviors and heme oxygenase-1 are regulated by Lycopene in lipopolysaccharide-induced neuroinflammation. J Neuroimmunol, 2016, 298, 1-8.
13.Wen XR, Tang M, Qi DS, Huang XJ, Liu HZ, Zhang F, Wu J, Wang YW, Zhang XB, Guo JQ, Wang SL, Liu Y, Wang YL, Song YJ*. Butylphthalide suppresses neuronal cells apoptosis through inhibiting JNK-Caspase3 signaling pathway after brain ischemia/reperfusion in rats. Cell Mol Neurobiol, 2016, 36(7)1087-1095.
14.Wang M, Qi DS, Zhou C, Han D, Li PP, Zhang F, Zhou XY, Han M, Di JH, Ye JS, Yu HM, Song YJ*, Zhang GY. Ischemic preconditioning protects the brain against injury via inhibiting CaMKII-nNOS signaling pathway. Brain Res,2016, 1634:140-149.
15.Zhou XY, Zhang F, Hu X, Chen J, Wen XR, Sun Y, Liu Y, Tang RX, Zheng KY, Song YJ*. Inhibition of inflammation by astaxanthin alleviates cognition deficits in diabetic mice. Physiol Behav, 2015, 151, 412-420.
16.Fu YY, Liu HZ, Song CJ, Zhang F, Liu Y, Wu J, Wen XR, Liang C, Ma K, Li L, Zhang XB, Shao XP, Sun Y, Du Y, Song YJ*. Mangiferin regulates cognitive deficits and heme oxygenase-1 induced by lipopolysaccharide in mice. Int Immunopharmacol, 2015, 29(2), 950-956.
17.Ying CJ, Zhang F, Zhou XY, Hu XT, Chen J, Wen XR, Sun Y, Zheng KY, Tang RX, Song YJ*. Anti-inflammatory Effect of Astaxanthin on the Sickness Behavior Induced by Diabetes Mellitus. Cell Mol Neurobiol, 2015, 35(7), 1027-1037.
18.Wen XR, Qi DS, Sun Y, Huang XJ, Zhang F, Wu J, Fu YY, Ma K, Du Y, Dong HY, Liu Y, Liu HZ, Song YJ*. H₂S attenuates cognitive deficits through Akt1/JNK3 signaling pathway in ischemic stroke, Behav Brain Res, 2014, 269, 6-14.
19.Wen XR, Wang K, Zhao Z, Zhang Y, Sun T, Zhang F, Wu J, Fu YY, Du Y, Zhang L, Sun Y, Liu Y, Ma K, Liu HZ, Song YJ*. Brain-targeted delivery of trans-activating transcriptor-conjugated magnetic PLGA/lipid Nanoparticles. Plos One, 2014, 9(9):e106652.
20.Fu YY, Zhang F, Zhang L, Liu HZ, Zhao ZM, Wen XR, Wu J, Qi DS, Sun Y, Du Y, Dong HY, Liu YH, Song YJ*Mangiferin regulates interleukin-6 and cystathionine-b-synthase in lipopolysaccharide-induced brain injury, Cell Mol Neurobiol, 2014, 34(5), 651-657.
21.Qi DS, Liu HZ, Niu J, Fan X, Wen XR, Du Y, Mou J, Pei DS, Liu ZA, Zong ZM, Wei XY, Song YJ*. Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia, J Neurol Sci, 2012, 317(1-2), 123–129.
22.Song YJ, Zong ZM, Liu HZ, Mukasa R, Pei DS, Mou J, Wen XR, Liu ZA, Wei XY. Heme oxygenase-1 regulates the JNK signaling pathway through the MLK3-MKK7-JNK3 signaling module in brain ischemia injury, Brain Res, 2012, 1429, 1-8.
【专利】
1.宋远见、苏晓、杜银贞、胡嘉怡、杨欢, 一种适用于缺血性脑卒中实验用大鼠的鼠笼, 2019.2.19-2029.2.19, 中国, ZL 2018 2 **.8 (专利)
2.温相如、李灵芝、宋远见、杨婷琳、李甜甜, 一种新型灌注针, 2016.9.8-2026.9.8, 中国, ZL8.0 (专利)
【科技成果】
1.腺病毒载体介导GluR6羧基肽段对脑中风神经元的保护作用，宋远见，2011，徐州市科技进步二等奖，2010-2-35-R5







发表论文:
Comparative Analysis of the Complete Mitochondrial Genomes for Development Application

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Ischemic preconditioning protects the brain against injury via inhibiting CaMKII-nNOS signaling pathway

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Depression-like behaviors and heme oxygenase-1 are regulated by Lycopene in lipopolysaccharide-induced neuroinflammation

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Neuroprotection of sevoflurane against ischemia/reperfusion-induced brain injury through inhibiting JNK3/Caspase-3 by enhancing Akt signaling pathway

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Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia

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Mangiferin regulates interleukin-6 and cystathionine-b-synthase in lipopolysaccharide-induced brain injury

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Brain-targeted delivery of trans-activating transcriptor-conjugated magnetic PLGA/lipid nanoparticles

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H2S attenuates cognitive deficits through Akt1/JNK3 signaling pathway in ischemic stroke

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Anti-inflammatory Effect of Astaxanthin on the Sickness Behavior Induced by Diabetes Mellitus

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Inhibition of inflammation by astaxanthin alleviates cognition deficits in diabetic mice
教材专著:
《医学遗传学》

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《细胞生物学与医学遗传学实验教
科研项目:
JNK3介导的胱硫醚β-合酶/硫化氢

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江苏省“六大人才高峰”高层次人

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ASK1-MKK4-JNK信号模块与Cdc42作

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MLK3-MKK7-JNK3信号模块与HO-1的

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江苏省“青蓝工程”中青年学术带
获奖成果:
徐州市科学技术进步二等奖

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徐州医科大学“优秀青年科技工作