施恒亮
硕士生导师

职称：副教授

学院：第一临床医学院
shl@xzhmu.edu.cn







个人简介
施恒亮，1982年7月生，博士，现为徐州医科大学副教授，硕士研究生导师。南京医科大学博士后，美国西北大学访问****，江苏省“青蓝工程”中青年学术带头人、江苏省“科教强卫”青年医学重点人才。近年来，发表SCI论文24篇，累计影响因子100余分；主持国家自然科学基金项目3项和江苏省自然科学基金面上项目等省部级、市厅级课题7项，校级课题1项目，累计科研经费263万元。曾获吉林省科技进步一等奖1项、江苏省教育教学与研究成果三等奖1项。现担任国家自然科学基金评审专家，中国医师协会脑胶质瘤专业委员会分子诊疗学组委员、江苏省抗癌协会神经肿瘤专业委员会青年委员、欧美同学会中国留学人员联谊会会员、J Exp & Clin Cancer Res等SCI杂志审稿人。




发表论文:
TSG101 promotes the proliferation, migration and invasion of hepatocellular carcinoma cells by regulating the PEG10

---

Jab1 promotes glioma cell proliferation by regulating Siah1/β-catenin pathway

---

Loss of SH3GL2 promotes the migration and invasion behaviours of glioblastoma cells through activating the STAT3/MMP2 signalling

---

PHAP1 promotes glioma cell proliferation by regulating the Akt/p27/stathmin pathway

---

CacyBP/SIP inhibits Doxourbicin-induced apoptosis of glioma cells due to activation of ERK1/2

---

Nrdp1S, short variant of Nrdp1, inhibits human glioma progression by increasing Nrdp1-mediated ErbB3 ubiquitination

---

The Ubiquitin Ligase COP1 Promotes Glioma Cell Proliferation by Preferentially Downregulating Tumor Suppressor p53

---

Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1

---

Hepatitis B virus X protein reduces the stability of Nrdp1 to up-regulate ErbB3 in hepatocellular carcinoma cells

---

Nrdp1-mediated ErbB3 degradation inhibits glioma cell migration and invasion by reducing cytoplasmic localization of p27(Kip1)
教材专著:

科研项目:
肝癌和结直肠癌的发病机制研究

---

COP1通过PCDH9调控STAT3/Cyclin D1信号通路促进胶质瘤增殖的机制研究

---

江苏省“青蓝工程”中青年学术带头人

---

COP1调控ZBRK1/HMGA2信号通路促进胶质瘤增殖的机制研究

---

COP1通过调控ZBRK1介导的HMGA2转录促进胶质瘤增殖的机制研究

---

COP1 调控 ZBRK1/MMP9信号促进胶质瘤浸润性生长的机制研究

---

COP1调控ZBRK1/HMGA2通路促进胶质瘤增殖的机制研究

---

NIP调控Nrdp1介导的胶质瘤细胞凋亡的机制研究

---

Nrdp1在巨噬细胞抗结核感染中的作用及分子机制研究
获奖成果:
胶质瘤分子靶标的应用基础研究

---

脑胶质瘤分子病理机制研究

---

细胞骨架蛋白与胞内外信号转导分