张易
硕士生导师

职称：主治医师

学院：第一临床医学院
@qq.com







个人简介
张易，男，32岁，博士后，主治医师，讲师。
本人从事消化系统肿瘤发生发展的基础与临床研究，其中，非编码RNA以及RNA修饰与消化系统肿瘤发生发展分子机制研究一直是本人研究工作的重点，且在该领域与日本广岛大学、中南大学、广西医科大学保持着长期科研合作。近几年在该领域取得了以下工作成绩：证实m6a修饰介导的CBX8高表达能够调控结直肠癌的干性和耐药性。发现LINC01234通过与miR-642a-5p互补结合调控丝氨酸/甘氨酸代谢进而影响结肠癌增殖；发现Lnc-PDZD7能够通过miR-101-EZH2-ATOH8途径调控肝癌干细胞样特性；证实miR-875通过靶向结合DOR抑制EGFR/ERK通路，进而调控肝癌转移；证实miR-506通过EZH2和MDR1分别调控结直肠癌转移和化疗耐药。
截至目前以第一作者或通讯作者发表SCI收录论文10余篇，累计影响因子>60分，单篇影响因子最高15.3分。相关研究发表于《Mol Cancer》、《J Exp Clin Cancer Res》、《Cell Death & Disease》、《Cell proliferation》、《Oncotarget》学术期刊。主持国家自然科学基金2项，江苏省自然科学基金1项，博士后面上项目一等资助1项，徐州重点研发项目1项。并参与国家自然科学基金3项（其中2项为第1参与人）。

论文情况（近五年）
1) Fanchao Meng, Xin Liu, Changwei Lin, Lei Xu, Jinjin Liu, Pengbo Zhang, Xiuzhong Zhang, Jun Song, Yichao Yan, Zeqiang Ren, Yi Zhang*. SMYD2 suppresses APC2 expression to activate the Wnt/β-catenin pathway and promotes epithelial-mesenchymal transition in colorectal cancer. American Journal of Cancer Research.
2) Zhang Y, Kang M, Zhang B, Meng F, Song J, Kaneko H, Shimamoto F, Tang B. m6A modification-mediated CBX8 induction regulates stemness and chemosensitivity of colon cancer via upregulation of LGR5. Mol Cancer. 2019 Dec 18;18(1):185.
3) Zhang Y, Tang B, Song J, Yu S, Li Y, Su H, He S. Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression. J Exp Clin Cancer Res. 2019 Feb 20;38(1):92.
4) Lin C, Zhang Y , Chen Y, Bai Y, Zhang Y. Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer. Cell Death Dis. 2019 Feb 12;10(2):137.
5)Zhang Y, Wei Y, Li X, Liang X, Wang L, Song J, Zhang X, Zhang C, Niu J, Zhang P, Ren Z, Tang B. microRNA-874 suppresses tumor proliferation and metastasis in hepatocellular carcinoma by targeting the DOR/EGFR/ERK pathway. Cell Death Dis. 2018 Jan 26;9(2):130.
6) Zhou Hui, Lin Changwei, Zhang Yi*, Zhang Xiuzhong, Zhang Chong, Zhang Pengbo, Xie Xingwang, Ren Zeqiang*. miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression. Cell Prolif. 2017 Jun;50(3).
7) Chen Yifei#, Zhang Yi#, He Jianhuai, Fu Ying, Lin Changwei*, Li Xiarong*.MicroRNA-133b is regulated by TAp63 while no gene mutation is present in colorectal cancer. Oncol Rep. 2017 Mar;37(3):1646-1652.
8) Zhang Yi, Lin Changwei , Liao Guoqing*, Liu S, Ding J, Tang F, Wang Z, Liang X, Li B, Wei Y, Huang Q, Li X, Tang Bo*. MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2. Oncotarget. 2015;6(32):32586-601.
9) Lin C, Li X, Zhang Y, Guo Y, Zhou J, Gao K, Dai J, Hu G, Lv L, Du J, Zhang Y. The microRNA feedback regulation of p63 in cancer progression. Oncotarget. 2015 ;6(11):8434-53.








发表论文:
SMYD2 suppresses APC2 expression to activate the Wnt/β-catenin pathway and promotes epithelial-mesenchymal transition in colorectal cancer

---

m6A modification-mediated CBX8 induction regulates stemness and chemosensitivity of colon cancer via upregulation of LGR5

---

Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression

---

Long noncoding RNA LINC01234 promotes serine hydroxymethyltransferase 2 expression and proliferation by competitively binding miR-642a-5p in colon cancer

---

microRNA-874 suppresses tumor proliferation and metastasis in hepatocellular carcinoma by targeting the DOR/EGFR/ERK pathway

---

miR-506 enhances the sensitivity of human colorectal cancer cells to oxaliplatin by suppressing MDR1/P-gp expression

---

MicroRNA-133b is regulated by TAp63 while no gene mutation is present in colorectal cancer

---

MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2

---

The microRNA feedback regulation of p63 in cancer progression

---

Aberrant upregulation of 14-3-3σ and EZH2 expression serves as an inferior prognostic biomarker for hepatocellular carcinoma
教材专著:

科研项目:
miR-506通过BMP-4逆转结直肠癌干细胞干性研究

---

miR-506通过BMP-4逆转结直肠癌干细胞干性研究

---

miR-133b通过lncRNA-LUCAT1/EZH2复合体调控结直肠癌转移的作用机制研究
获奖成果: