谷小珂
硕士生导师

职称：副教授

学院：药学院
gu_xk@xzhmu.edu.cn







个人简介
江苏省“六大人才高峰”和“333高层次人才培养工程”培养对象。2012年毕业于中国药科大学药物化学专业，获理学博士学位。同年进入徐州医科大学药学院任职。2020年在美国明尼苏达大学进行为期一年的访学研修。主要研究方向为抗肿瘤及糖尿病并发症药物分子的设计、合成及生物活性研究。近年来主持国家自然科学基金青年项目、江苏省自然科学基金面上项目、江苏省肿瘤生物治疗重点实验室开放课题、徐州市自然科学基金、徐州医科大学优秀人才科研启动基金等项目。以第一或通讯作者在Journal of Medicinal Chemistry、European Journal of Medicinal Chemistry、Bioorganic & Medicinal Chemistry、Bioorganic & Medicinal Chemistry Letters等药物化学权威杂志发表SCI论文18篇，申请专利4项（已授权2项）。作为合成项目负责人，完成企业横向课题2项。




发表论文:
Discovery of novel quinazolinone derivatives as potential anti-HBV and anti-HCC agents

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Synthesis and assessment of phenylacrylamide derivatives as potential anti-oxidant and anti-inflammatory agents

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Assessment of quinazolinone derivatives as novel non-nucleoside hepatitis B virus inhibitors

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Synthesis and biological evaluation of bifendate derivatives bearing acrylamide moiety as novel antioxidant agents

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Assessment of a bifendate derivative bearing a 6,7- dihydro-dibenzo?c,e]azepine scaffold as a potential anti-metastatic agent

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Synthesis and biological evaluation of bifendate derivatives bearing 6,7-dihydro-dibenzo[c,e]azepine scaffold as potential P-glycoprotein and tumor metastasis inhibitors

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Design, synthesis and evaluation of novel phenyl propionamide derivatives as non-nucleoside hepatitis B virus inhibitors

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Lasiokaurin derivatives: synthesis, antimicrobial and antitumor biological evaluation, and apoptosis-inducing effects

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Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivatives against Drug-Resistant K562/A02 Cells in Vitro and in Vivo

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Synthesis and Biological Evaluation of Matijin-Su Derivatives as Potential Antihepatitis B Virus and Anticancer Agents
教材专著:

科研项目:
具有多重作用机制的新型肿瘤MDR

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基于迈克尔受体的Nrf2激活剂的设

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新型P-gp抑制剂的设计、合成及逆

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新型肿瘤多药耐药逆转剂的设计、

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基于NO和附属敏感性的新型HDACs

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基于NO和附属敏感性的新型HDACs
获奖成果:
江苏省药理学会临床前药理专业委