高剑
硕士生导师

职称：副教授


学院：药学院
gaojian@xzhmu.edu.cn







个人简介
中国科学院大学化学生物学博士(2013年)，副教授，硕士生导师，药物化学学科后备带头人。江苏省“青蓝工程”优秀青年骨干教师，江苏省“六大人才高峰”高层次人才。
致力于糖尿病、肿瘤等重大疾病防治药物的计算机辅助药物设计，靶向药物开发，合成与生物活性评价。目前主持国家自然科学基金和江苏省自然科学基金面上项目各1项。已结题江苏省自然科学基金青年项目，徐州市科技计划项目，徐州医科大学优秀人才科研启动基金各1项。主持徐州医科大学江苏高校品牌专业建设专项教改课题和徐州医科大学药学院一流专业教改课题重点项目各1项。指导江苏省大学生创新创业项目的重点项目2项。以唯一指导教师身份指导本科生获得第十六届“挑战杯”大学生课外学术科技作品竞赛江苏省选拔赛二等奖1项，第十一届全国大学生药苑论坛创新成果奖一等奖1项。
近年来，以第一作者或者通讯作者，在Nanoscale; Eur. J. Med. Chem.;Int. J. Mol. Sci.; J. Comput.-Aided Mol. Des.; Molecules等SCI收录期刊发表论文20篇，其中单篇最高影响因子7.394，IF > 3的9篇。申请国家发明专利7项，授权4项。


论文情况（近五年）
Yao RS, Xie Y, Sun XY, Zhang MH, Zhou J, Liu LL, Gao J*, Xu KL*, Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma. Drug Des Dev Ther 2020, 14:3983-3993.

Gao, Jian*; Wang, Yan; Chen, Qingqing; Yao, Ruosi*, Integrating Molecular Dynamics Simulation and Molecular Mechanics/Generalized Born Surface Area Calculation into Pharmacophore Modelling: A Case Study on the Proviral Integration Site for Moloney Murine Leukaemia Virus (Pim)-1 Kinase Inhibitors, Journal of Biomolecular Structure and Dynamics 2020, 38(2):581-588.
An Yiqiang, Meng Chen, Chen Qingqing, Gao Jian*, Discovery of Small Molecule Sirt1 Activator Using High-Throughput Virtual Screening, Molecular Dynamics Simulation, Molecular Mechanics Generalized Born/Surface Area (Mm/Gbsa) Calculation, and Biological Evaluation. Medicinal Chemistry Research 2020, 29(2):255-261.
Chen Qingqing, Wang Yan, Shi Shanshan, Li Kaihang, Zhang Ling, Gao, Jian*, Insights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors Pim447 and Azd1208: A Molecular Dynamics Simulation and Mm/Gbsa Calculation Study. International Journal of Molecular Sciences 2019, 20(21):5410.
Qiu, Jingying; Chen, Wang; Zhang, Yinpeng; Zhou, Qingqing; Chen, Jing; Yang, Lihua; Gao, Jian*; Gu, Xiaoke*; Tang, Daoquan*, Assessment of Quinazolinone Derivatives as Novel Non-Nucleoside Hepatitis B Virus Inhibitors, European Journal of Medicinal Chemistry 2019, 176, 41-49.
Liu, Linlin; Kai, Xiaoning; Chen, Qingqing; Zhang, Ling; Yao, Ruosi*; Gao, Jian*, Identification of Protein Arginine Methyltransferase 7 (Prmt7) Inhibitor by Virtual Screening and Biological Evaluation in Vitro, Medicinal Chemistry Research 2019, 28, 125-132.
Gao, Jian*; Zhang, Yiran; Chen, Han; Chen, Qingqing; Feng, Dingding; Zhang, Ling; Li, Chenglin*, Computational Insights into the Interaction Mechanism of Transcription Cofactor Vestigial-Like Protein 4 Binding to Tea Domain Transcription Factor 4 by Molecular Dynamics Simulation and Molecular Mechanics Generalized Born/Surface Area) Calculation, Journal of Biomolecular Structure and Dynamics 2019, 37, 2538-2545.
Chen, Han; Wang, Yan; Gao, Zheng; Yang, Wen; Gao, Jian*, Assessing the Performance of Three Resveratrol in Binding with Sirt1 by Molecular Dynamics Simulation and Mm/Gbsa Methods: The Weakest Binding of Resveratrol 3 to Sirt1 Triggers a Possibility of Dissociation from Its Binding Site, Journal of Computer-Aided Molecular Design 2019, 33, 437-446.
Yao, Ruosi; Sun, Xiaoyang; Xie, Yu; Sun, Xiaoshen; Yao, Yao; Li, Hujun; Li, Zhenyu; Gao, Jian*; Xu, Kailin*, Identification of a Novel C-Myc Inhibitor with Anti-Tumor Effects on Multiple Myeloma Cells, Bioscience Reports 2018, BSR**.
Shi, Xi; Zhang, Yan; Qiu, Shiwei; Zhuang, Wei; Yuan, Na; Sun, Tiantian; Gao, Jian*; Qiao, Yuehua*; Liu, Ke*, A Novel Gjb2 Compound Heterozygous Mutation C.257c>G (P.T86r)/C.176del16 (P.G59a Fs*18) Causes Sensorineural Hearing Loss in a Chinese Family, Journal of Clinical Laboratory Analysis 2018, 32, e22444.
Li, Liang; Qianqian, Zhou; Zhixiang, Hao; Fanfan, Wang; Yasheng, Zhu; Qisi, Lin; Jian, Gao*, The Discovery of Antibacterial Natural Compound Based on Peptide Deformylase, Combinatorial Chemistry & High Throughput Screening 2018, 21, 292-297.
Jian, Gao; Shengzhi, Qiu; Li, Liang; Zhixiang, Hao; Qianqian, Zhou; Fanfan, Wang; Jie, Mou*; Qisi, Lin*, Design, Synthesis, and Biological Evaluation of Vanillin Hydroxamic Acid Derivatives as Novel Peptide Deformylase Inhibitors, Current Computer-Aided Drug Design 2018, 14, 95-101.
Gao, Jian*; Liang, Li; Chen, Qingqing; Zhang, Ling; Huang, Tonghui*, Insight into the Molecular Mechanism of Yeast Acetyl-Coenzyme a Carboxylase Mutants F510i, N485g, I69e, E477r, and K73r Resistant to Soraphen A, Journal of Computer-Aided Molecular Design 2018, 32, 547-557.
Gao, Jian; Sun, Jie; Wang, Tao; Sheng, Shen; Huang, Tonghui*, Combined 3d-Qsar Modeling and Molecular Docking Study on Spiro-Derivatives as Inhibitors of Acetyl-Coa Carboxylase, Medicinal Chemistry Research 2017, 26, 361-371.
Gao, Jian*; Wang, Tao; Qiu, Shengzhi; Zhu, Yasheng; Liang, Li; Zheng, Youguang, Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer, Molecules 2016, 21, 396.
Gao, Jian*; Liang, Li; Zhu, Yasheng; Qiu, Shengzhi; Wang, Tao; Zhang, Ling, Ligand and Structure-Based Approaches for the Identification of Peptide Deformylase Inhibitors as Antibacterial Drugs, International Journal of Molecular Sciences 2016, 17, 1141.





发表论文:
Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma

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Discovery of small molecule sirt1 activator using high-throughput virtual screening, molecular dynamics simulation, molecular mechanics generalized born/surface area (MM/GBSA) calculation, and biological evaluation

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Insights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors PIM447 and AZD1208: A Molecular Dynamics Simulation and

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Assessment of Quinazolinone Derivatives as Novel Non-Nucleoside Hepatitis B Virus Inhibitors

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Assessing the Performance of Three Resveratrol in Binding with Sirt1 by Molecular Dynamics Simulation and Mm/Gbsa Methods: The Weakest Binding of Resveratrol 3 to Sirt1 Triggers a Possibility of Disso

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Identification of Protein Arginine Methyltransferase 7 (Prmt7) Inhibitor by Virtual Screening and Biological Evaluation in Vitro

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Identification of a Novel C-Myc Inhibitor with Anti-Tumor Effects on Multiple Myeloma Cells

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A Novel Gjb2 Compound Heterozygous Mutation C.257c>G (P.T86r)/C.176del16 (P.G59a Fs*18) Causes Sensorineural Hearing Loss in a Chinese Family

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Insight into the Molecular Mechanism of Yeast Acetyl-Coenzyme a Carboxylase Mutants F510i, N485g, I69e, E477r, and K73r Resistant to Soraphen A

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The Discovery of Antibacterial Natural Compound Based on Peptide Deformylase
教材专著:

科研项目:
2-甲基萘并[1,2-b]呋喃类Sirt1激动剂的设计、合成及其抗糖尿病肾病活性评价

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江苏省“六大人才高峰”高层次人才

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江苏省“青蓝工程”优秀青年骨干教师

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基于Sirt1激动机制的全新激动剂发现及其在糖尿病肾病药物防治中的应用

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基于人肽脱甲酰基酶的新型抗肿瘤药物设计

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基于人PDF的新型抗肿瘤药物设计

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靶向人肽脱甲酰基酶的新型抗肿瘤药物设计
获奖成果: