石小东
硕士生导师

职称：副教授

学院：麻醉学院
xiaodongs01@163.com







个人简介
石小东，博士，副教授，硕士生导师，江苏省“青蓝工程”优秀青年骨干教师，北京大学生物化学与分子生物学博士，美国贝勒医学院访问****。长期从事蛋白质结构功能及相互作用研究，主持国家自然科学基金青年项目1项（**，已结题），江苏省自然科学基金青年项目1项（BK**，已结题），徐州医科大学优秀人才科研启动基金1项（已结题），国家自然科学基金面上项目1项（**，在研）。目前从事感染的基础研究，主要采用冷冻断层三维重构技术、生物化学及分子生物学等手段对革兰氏阴性菌膜蛋白复合物在耐药、感染宿主等方面发挥功能的机制进行研究。
以第一作者或者通讯作者在Nature Communications、Journal of Neuroscience、Journal of Biological Chemistry、FEBS Letters、Biochemical and Biophysical Research Communications等SCI收录期刊发表论文9篇，累计影响因子38，其中单篇最高影响因子12.121。






发表论文:
IbpB-bound substrate release in living cells as revealed by unnatural amino acid-mediated photo-crosslinking

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鼠伤寒沙门菌小分子热休克蛋白AgsA的N与C末端在溶液中暴露比较

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Blocking the interaction between EphB2 and ADDLs by a small peptide rescues impaired synaptic plasticity and memory deficits in a mouse model of Alzheimer’s disease

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The function of Ile-X-Ile motif in the oligomerization and chaperone-like activity of small heat shock protein AgsA at room temperature

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Toxicological differences between NMDA receptor antagonists and cholinesterase inhibitors

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Differential degradation for small heat shock proteins IbpA and IbpB is synchronized in Escherichia coli: implications for their functional cooperation in substrate refolding

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In vivo substrate diversity and preference of small heat shock protein IbpB as revealed by using a genetically incorporated photo-cross-linker

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Small heat shock protein IbpB acts as a robust chaperone in living cells by hierarchically activating its multi-type substrate-binding residues

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In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
教材专著:

科研项目:
大肠杆菌多药外排泵MacAB-TolC的原位结构和组装机制研究
获奖成果: