肖诚
博士生导师

职称：教授


学院：麻醉学院
xchengxj@xzhmu.edu.cn







个人简介
肖诚，博士，教授，博士生导师，江苏省****。先后毕业于新疆医科大学、四川大学华西医学中心和中国疾病预防控制中心，获医学学士、硕士和博士学位。2006-2012年，在美国加州理工学院做博士后，2012-2016年在加州理工学院任高级研究****，2016年全职回国到麻醉学重点实验室工作，担任麻醉与神经调控课题组长。主要研究方向为神经系统疾病疼痛、运动、情绪改变的神经环路机制；麻醉觉醒的神经环路机制；术后认知功能损伤的修复策略。研究手段有脑片膜片钳、透明脑、光遗传学、神经示踪、光纤成像、在体电生理、组织形态学、动物行为追踪和检测等技术。主持国家自然科学基金3项、美国MichaelJ.Fox基金、其它省部级课题多项，在Neuron、PNAS、JNeurosci、Neuropsychopharmacology等期刊杂志上发表SCI论文共50余篇，论文总引用2500次以上。论文中以通讯作者或第一作者发表的SCI论文17篇(包括JCR一区杂志8篇)。应邀为多个SCI期刊审稿。
近5年研究成果：
1. Luan Y^#, Tang D^#, Wu H^#, Gu W, Wu Y, Cao J*, Xiao C*, Zhou C*. Reversal of hyperactive subthalamic circuits differentially mitigates pain hypersensitivity phenotypes in parkinsonian mice. PNAS. 2020, 117(18) 10045-10054. https://doi.org/10.1073/pnas.. Faculty1000推荐阅读文章. 并列通讯作者
2. Tang D, Luan Y, Zhou C*, Xiao C*. D2 receptor activation relieves pain hypersensitivity by inhibiting superficial dorsal horn neurons in parkinsonian mice. Acta Pharm Sin 2020, https://doi.org/10.1038/s41401-020-0433-3. 并列通讯作者
3. Wu H^#, Yan X^#, Tang D^#, Gu W, Luan Y, Cai H, Zhou C*, Xiao C*. Internal states influence representation and modulation of food intake by subthalamic neurons. Neurosci Bull. 2020. https://doi.org/10.1007/s12264-020-00533-3. 并列通讯作者
4. Xiao C*, Zhou C*, Jiang JH, Yin C. Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence. Acta Pharm Sin. 2020. 41(1): p. 1-9. 并列通讯作者
5. Zhou C, Gu W, Wu H, Yan X, Deshpande P, Xiao C?, Lester HA*. Bidirectional dopamine modulation of excitatory and inhibitory synaptic inputs to subthalamic neuron subsets containing α4β2 or α7 nAChRs. Neuropharmacology 148 (2019) 220–228. 并列通讯作者
6. Wang T, Zhu H, Hou Y, Gu W, Wu H, Luan Y, Xiao C*, Zhou C*. Galantamine reversed early postoperative cognitive deficit via alleviating inflammation and enhancing synaptic transmission in mouse hippocampus. Eur J Pharmacol. 2019, 846:63-7. 并列通讯作者
7. Cho JR, Treweek JB, Robinson JE, Xiao C, Bremner LR, Greenbaum A, Gradinaru V*. Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimulation. Neuron 2017, 94, 1–15.
8. Xiao C, Cho R, Zhou C, Treweek J, McKinney S, Yang B, Chan K, Gradinaru V*. Cholinergic Mesopontine signals govern locomotion and reward through dissociable midbrain pathways. Neuron 2016; 90:333-347. 被期刊编委选为该期的特色文章(featured article).
9. Zuo W, Xiao C, Gao M, Hopf F, Krnjecvic K, McIntosh M, Fu R, Wu J, Bekker A, Ye JH*. Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms. Sci Rep. 2016; 6: 32937.
10. Xiao C, Miwa JM, Henderson B, Wang Y, Deshpande P, McKinney S, Henry A. Lester*. Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus. J Neurosci 2015; 35(9): 3734-46. 被期刊编委选为该期的特色文章(featured article)，并受到该刊Journal club专栏的特别评论 (J Neurosci (35(30): 10645-10646).





发表论文:
Neural circuits and nicotinic acetylcholine receptors mediate the cholinergic regulation of midbrain dopaminergic neurons and nicotine dependence

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Bidirectional dopamine modulation of excitatory and inhibitory synaptic inputs to subthalamic neuron subsets containing α4β2 or α7 nAChRs

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Galantamine reversed early postoperative cognitive deficit via alleviating inflammation and enhancing synaptic transmission in mouse hippocampus

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Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli

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Cholinergic Mesopontine signals govern locomotion and reward through dissociable midbrain pathways.

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Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus.

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Nicotine regulates activity of lateral habenula neurons via presynaptic and postsynaptic mechanisms

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Whole-Body Tissue Stabilization and Selective Extractions via Tissue-Hydrogel Hybrids for High Resolution Intact Circuit Mapping and Phenotyping.
教材专著:

科研项目:
基于光遗传学技术的帕金森氏病运

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丘脑底核在帕金森氏病疼痛治疗中

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江苏特聘教授-特别资助

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江苏省高等学校自然科学研究重大

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国家自然科学面上项目

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徐州医科大学优秀人才启动基金

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江苏特聘教授
获奖成果: