周爱华教授性别:男
职称:教授（药物化学）
通信地址:江苏大学药学院，江苏镇江市学府路301号，212013
电话:18796002400
E-mail:ahzujs.edu.cn学习和工作简历:2010-至今江苏大学药学院2008-2010美国威斯康星大学药学院(UniversityofWisconsin,Madison),助理研究员.（从事抗癌药物的合成，筛选，酶催化的天然产物的糖苷化反应，糖化学研究）2006-2008美国堪萨斯大学(UniversityofKansas)CMLD药物发现中心,博士后.(从事药用化合物的设计，合成及高通量筛选)2005美国密西西比州立大学化学系,博士后(有机合成方法学)1999-2004美国密西西比州立大学(MississippiStateUniversity)，获有机化学博士学位(同时还修完该校化工系博士毕业所需的所有化工理论课和工程数学课).1995-1999中国石化仪征化纤公司化工厂对苯二甲酸装置工作。1991-1995中国石油辽阳化纤公司化工一厂和芳烃厂工作。1988-1991大连理工大学化工学院化学系，应用化学硕士学位1984-1988大连理工大学化工学院化学工程系，化学工程，工学学士学位.本人曾在多套石化装置工作多年，不少时间在一线工作，对连续催化重整再生(ＵOP工艺)，芳烃抽提，歧化及异构化,二甲苯分离(旋转吸附分子筛分离)，裂解汽油加氢，丙烷／丁烷制氢，PTA精对苯二甲酸装置（BP-AMOCO工艺)有非常丰富的开车，停车，正常操作及事故处理经验。除工艺外,对多种催化剂，对各种自动化仪表，自动化操作及连锁控制等也有相当的了解。在美国11年期间，作为首要研究者实施和完成多项美国卫生署（NIH）和美国自然科学基金资助的项目(NIHAI52218，NIHP50GM069663，NIHP41GM076302和NSF,EPS012618)，项目资助额超过500多万美元。2010年回国后，获得4项发明专利，帮助国内药企开发抗癌药物的合成工艺和质量标准的制定一项，帮助国内化工企业完成二个C9芳烃催化剂的研制和工艺路线设计的等科研项目。并发表（和待发）了高影响因子的国际一流的专业期刊的研究论文多篇。研究领域1)药物发现,活性天然产物的修饰,糖化学，酶催化。2)有机合成方法学研究,活性化合物合成，不对称合成，过渡金属催化3)天然化合物的合成、修饰和筛选。4)组合化学，多样化合成，固/液相合成,固/液相化试剂合成5)有机化工，新药、仿制药的合成工艺开发，放大和质量标准的制定，药物申报材料的撰写。主要代表论文发表在国外著名核心期刊共27篇来江苏大学后发表（和即将发表）的文章：(1)SelectiveSynthesisofSeven-andEight-MemberedRingSultamsviaTwoTandemReactionProtocolsfromOneStartingMaterial
MinWang,YanjieWang,XueyongQi,GuohuaXia,KunTong,JinchangTu,CharlesU.Pittman,Jr.,andAihuaZhou*Org.Lett.,2012,14(14),3700–3703.(影响因子：5.86,通讯作者)(2)SynthesesofFive-andSeven-memberedRingSultamDerivativesviaMichaelAdditionandBaylis-HillmanReactions
KunTong,^?JinchangTu,^?XueyongQi,^?MinWang,^?YanjieWang,^?HaizhenFu,^?CharlesU.Pittman,Jr.,^?andAihuaZhou*^?Tetrahedron,2013,69,2369-2375.(影响因子：3.06,通讯作者)(3)SynthesesofEight-memberedRingSultamsviaTwoCascadeReactionsInWater
MinWang,YanjieWang,XueyongQi,KunTong,JinchangTu,CharlesU.Pittman,Jr.,andAihuaZhou*(RSCAdvances(inpress),通讯作者)(4)FacileSynthesesofSeven-andEight-memberedRingg-Sultams
MinWang,YanjieWang,XueyongQi,KunTong,JinchangTu,CharlesU.Pittman,Jr.,andAihuaZhou*(ManuscriptsubmittedtoTetrahedron,通讯作者)(5)UnexpectedResultsWhenReactingVinylSulfonamidewithH₂O₂/NaOHinWater
MinWang,YanjieWang,XueyongQi,KunTong,JinchangTu,CharlesU.Pittman,Jr.,andAihuaZhou*(ManuscriptPrepared,通讯作者)(6)Preparationof64Eight-memberedRingSultamLibrarybyaTandemReactionProtocolandSimplePurificationProcess
YanjieWang,LeiXu,MinWang,XueyongQi,KunTong,JinchangTu,CharlesU.Pittman,Jr.,andAihuaZhou*(ManuscriptsubmittedtoACSCombinatorialChem.,通讯作者)在美国期间发表的文章:(7)AutomatedSynthesisofa184-MemberLibraryofThiadiazepan-1,1-dioxide-4-ones
ErikFenster,TobyR.Long,QinZang,DavidHill,BenjaminNeuenswander,GeraldH.Lushington,AihuaZhou,ConradSantini,andPaulR.Hanson,ACSComb.Sci.2011,13,244-250.(影响因子：3.45)(8)Reactionsof2-Methyl-and1,2-Dimethyl-1,4,5,6-tetrahydropyrimidinewithAroylChlorides:DiverseReactivitiesofCyclicKeteneN,N-AcetalsGeneratedinsitu
GuozhongYe,SabonieChatterjee,AihuaZhou,BobbyLloydBarker,etal,CharlesU.Pittman,Synthesis2010,7,1209-1216.(影响因子：2.67)(9)TandemReactionsof2-Methylimidazolineand1,2-DimethylimidazolinewithVariousBenzoylChlorides
GuozhongYe,ChunlongChen，SabornieChatterjee,Collier,WillardE.,ZhouAihua,YingquanSong,DebbieJ.Beard,CharlesU.Pittman,Synthesis2010,1,141-152.(影响因子：2.67)(10)Push–pullalkenesfromcyclicketene-N,N’-acetals:awidespanofdoublebondlengthsandtwistangles
GuozhongYe,SabornieChatterjee,MinLi,AihuaZhou,YingquanSong,BobbyLloydBarker,ChunlongChen,DebbieJ.Beard,WilliamP.Henry,CharlesU.Pittman,Tetrahedron2010,66,2919-2927.(影响因子：3.06)(11)“Click,Click,Cyclize”:ADOSApproachtoSultamsUtilizingVinylSulfonamideLinchipins
AihuaZhou,PaulR.Hanson,Org.Lett.2009,11,531-534.(影响因子：5.860)(12)Push-pullAlkenesbyReactingN,N-dimethylCyclicKeteneN,N-AcetalsWithIsocyanates:Synthesis,StructuresandReactivities
GuozhongYe,WilliamP.Henry,ChunlongChen,AihuaZhou,CharlesU.Pittman,TetrahedronLett.2009,50,2135-2139.(影响因子：2.660)(13)a-Haloarylsulfonamides:MultipleCyclizationPathwaystoSkeleallyDiverseBenzofusedSultams
DineshKumarRayabarapu,AihuaZhou,KyuOkjeon,ThiwankaSamarakoon,AlanRolfe,HinaSiddiquiandPaulR.Hanson,Tetrahedron,应邀文章,2009,65,3180-3188.(影响因子：3.06)(14)SynthesisofSultamScaffoldsviaIntramolecularOxa-MichaelandDiastereoselectiveBaylis-HillmanReaction
AihuaZhou,PaulR.Hanson,Org.Lett.2008,10,2951-2954.(影响因子：5.862)(15)1,8-NaphthyridinetetraonesfromOne-potReactionsof2-Methyllimidazolineor2-Methyl-1,4,5,6-Tetrahydropyrimidinewith1,3-DiacidChlorides
GuozhongYe,AihuaZhou,WilliamP.Henry,YingquanSong,SabornieChatterjee,DebbieJ.Beard,CharlesU.Pittman,J.Org.Chem.2008,73,5170-5172.(影响因子：4.50)(16)StereoselectiveRadicalCyclizationsofN-(2-Halobenzoyl)-CyclicKetene-N,X(X=O,S)-Acetals”
AihuaZhou,MosesN.Njogu,CharlesU.Pittman,Tetrahedron2006,62,4093-4102.(影响因子:3.06).(17)“Push-Pull”andSpirobicyclicStructuresbyReactingN-MethylCyclicKetene-N,X(X=S,O)-acetalswithIsocyanatesandIsothiocyanates
AihuaZhou,CharlesU.Pittman,Tetrahedron2006,62,4188-4200.(影响因子：3.06)(18)GenerationofCyclicKetene-N,X-Acetals(X=O,S)from2-Alkyl-1,3-oxazolinesand2-Alkyl-1,3-thiazolines.ReactionswithAcidChlorides,1,3-DiacidChloridesandN-(Chlorocarbonyl)Isocyanate
AihuaZhou,CharlesU.Pittman,Synthesis2006,1,37-48.(影响因子：2.47)(19)ReactionsofCyclicKetene-N,S-acetalswithIsocyanates,IsothiocyanateandVinylisocyanates
AihuaZhou,LiweiCao,HaiqingLi,ZhuqingLiu,CharlesU.Pittman,Synlett.2006,2,201-206.(影响因子：2.71)(20)Ring-openingReactionsofCyclicKetene-N,X-acetals(X=O,S)withCarboxylicAcids,PhenolsandThiols
AihuaZhou,CharlesU.Pittman,J.Comb.Chem.2006,8,262-267.(影响因子：3.450)(21)CyclizationReactionsofOxazolinesandThiazolineswithDiacidChlorides”
AihuaZhou,CharlesU.Pittman,TetrahedronLett.2005,46,2045-2048.(影响因子：2.660)(22)SynthesisofLibraryof1,5,2-Dithiazepine-1,1-Dioxide.Part1:AOne-Potulfonylation/Thia-Michaelprotocol.
Zang,Q.;Zhou,A.;Javed,S.;Maity,P.K.;Knudtson,C.A.;Bi.D.;Hastings,J.J.;Basha,F.Z.;Hanson,P.R.Heterocycles.2012,86,1661-1674.(23)ArylRadicalCyclizationofN-2-HalobenzoylCyclicKetene-N,S-acetals
AihuaZhou,CharlesU.Pittman,TetrahedronLett.2005,46,3801-3805.(影响因子：2.660).(24)Reactionsof2-MethylthiazolinesandN-MethylCyclicKetene-N,S-acetalswithAcidChlorides
AihuaZhou,CharlesU.Pittman,TetrahedronLett.2004,45,8899-8903(影响因子：2.660)(25)MultiCapillaryFlowReactor:Synthesisof1,2,5-thiadiazepane1,1-dioxideLibraryUtilizingOne-PotEliminationandInter-/IntramolecularDoubleaza-MichaelAdditionViaMicrowave-Assisted,ContinuousFlowOrganicSynthesis(MACOS).
Ullah,F.;Zang,Q.;Javed,S.;Zhou,A.;Knudtson,C.A.;Bi.D.;Hanson,P.R.;Organ,M.G.J.FlowChem.2012,2,118-123.(26)ApplicationofaDoubleAza-MichaelReactionina‘Click,Click,Cy-Click’Strategy:FromBenchtoFlow
QinZang,SalimJaved,FarmanUllah,AihuaZhou,ChristopherA.Knudtson,DanseBi,FatimaZ.Basha,MichaelG.Organ,PaulR.Hanson,Synthesis2011,17,2743–2750.(影响因子：2.67)(27)SynthesisofLibraryof1,5,2-Dithiazepine1,1-Dioxide.Part2:RoutestobicyclicSultams.
Zang,Q.;Javed,S.;Zhou,A.;Maity,P.K.;Knudtson,C.A.;Bi.D.;Hastings,J.J.;Basha,F.Z.;Hanson,P.R.Heterocycles.2012,86,1675-1688.教授过的课程：（1）药物化学
（2）药物设计和研发过程
（3）药物化学工程和技术
（4）化工原理其他:1.美国化工学会会员(MemberofAmericanChemicalSociety).2.四面体(Tetrahedron),四面体通讯(TetrahedronLett.)有机化学杂志审稿人.