江南大学药学院硕士研究生导师简介-许正宏
江南大学 免费考研网/2013-12-21
=【个人简&2=0171;】姓名=许正宏，<=/span>ZhenghongXU性别=男出生日期=1971.07职称=教授电话=0510－85918206传真=0510－85918206E-mail=zhenghxu@163.com，zhenghxu@jiangnan.edu.cn=URL=http://www.researcherid.com/rid/A-8124-2012【学术简&2=0171;】〖学习经&2=1382;〗：
2006.3-2009.3江南大学轻工&=#25216;术与工程专业，博&22=763;后2001.2-2005.3江南&2=2823;学发酵工程专业，&2403=7;学博士1993.9-1996.6山东&2=2823;学细胞生物学专业&6529=2;理学硕士1989.9-1993.6无锡&3=6731;工业学院发酵工程&1998=7;业，工学学士〖工作经&2=1382;〗：
2012.11-=江南大学药学&=#38498;=教授，博士生&=#23548;师2007.6-2012.10江南&2=2823;学医药学院教授，博&227=63;生导师2001.3-2007.6江南大学&299=83;物工程学院讲师、副&259=45;授、教授1996.7-2001.2无锡轻工&228=23;学生物工程学院，助=教、讲师1999.10-2000.9日本&2=2823;阪大学应用生物工&2339=8;专业，访问研究〖学术及社会兼职&=12311;：
中国&3=1185;学院天津工业生物&2521=6;术研究所特聘客座研&=#31350;员（2011.2-2016.2）=中国科学&384=98;天津工业生物技术研=究所学术委员会委员&6=5288;2010-2013）=国家固态&372=47;造工程技术研究中心=副主任，技术委员会&2=2996;员（2011.8-）=青藏高原&244=94;生物国家地方联合研=究中心主任（2012.3-）=中国生物&240=37;程学会糖生物工程专=业委员会委员（2002.12-）=中国微生&292=89;学会分子微生物学与=生物工程专业委员会&6=5288;2011.10-2016.10）【研究领&2=2495;】&nbs=p;发酵工程、生物制&=33647;（1）微生物代谢工程&=19982;生物催化：致力于&244=94;生物代谢育种及生物=催化平台技术的建立&1=2290;着重开展药用氨基&3724=0;、甾体药物新菌种资&=#28304;的开发，高产菌株&20=195;谢工程改造以及生&20135=;过程优化与放大技术&=30340;研究。（2）药用微生物资源&=30340;开发利用（药食用&304=95;菌生物技术）：着重=研究各类药食用真菌&3=0340;深层液体发酵技术&6529=2;建立各种药物筛选模&=#22411;，在此基础上进行&33=647;食用真菌生物活性&29289=;质的筛选、鉴定及相&=24212;的产品开发。（4）传统发酵食品工&=33402;机理解析与优化：&305=28;力建立传统多菌种混=合发酵工艺由“艺术&82=21;向“技术”转变的通&=36947;。采用系统微生物&233=98;、风味代谢组学等技=术手段，解析我国传&3=2479;发酵过程中微生物&3267=6;落生态特征与功能之&=#38388;的关系，进而进行&20=854;功能优化调控。【研究生&2=5307;生】每年招收博=士研究生1-3名&=#65292;硕士研究生4-6名&=#12290;博士专业：发酵工程=（生物工程学院）学术型硕士专&=#19994;：发酵工程（生物&24=037;程学院）、药学（&33647=;学院）专业型硕士专&=#19994;：制药工程【主要论&3=3879;】合作发表科研&=#35770;文1=40余篇：1.YanGeng,ZheHe,Zhen-MingLu,Hong-YuXu,Guo-HuaXu,Jin-SongShi,Zheng-HongXu*.Antro=diacamphorataATCC200183sporulatesasexuallyinsubmergedculture.ApplMicrobiolBiotechnol.(2013)DOI10.1007/s00253-012-4513-22.Jin-SongGong,HengLi,Xiao-YanZhu,Zhen-MingLu,YanWu,Jing-SongShi,Zheng-HongXu*.=FungalHis-taggednitrilasefromGibberellaintermedia:Genecloning,heterolo=gousexpressionandbiochemicalproperties.PLoSONE(2012),7(11):e50622.doi:10.1371/journal.pone.00506223.Yong-JianYu,Zhen-MingLu,Ning-HuaYu,WeiXu,Guo-QuanLi,J=ing-SongShi,Zheng-HongXu*.HS-SP=ME/GC-MSandchemometricsforvolatilecompositionofChinesetraditionalaromat=icvinegarintheZhenjiangregion.J.Inst.Brew.2012,118(1):133–141DOI:10.1002/jib.20<=/span>4.Jin-SongGong,Zhen-MingLu,HengLi,Jin-SongShi,Zhe-MinZho=u,Zheng-HongXu*.Nitrilasesinnitrilebiocatalysis:Recentprogressandforthcomingresearch.Microbi=alCellFactories2012,11:142doi:10.1186/1475-2859-11-1425.MeijuanXu,Zhimi=ngRao*,WenfangDou,JuanYang,JianJ=in,ZhenghongXu*.Site-directedmutagenesisandfeedback-resistantN-acetyl-L-glutamatekinase(NAGK)increaseCorynebacteriumcrenatumL-arginineproduction.AminoAcids(2=012),43(1):255-266DOI:1=0.1007/s00726-011-1069-x6.XuMJ,RaoZM*,Y=angJ,XiaHF,DouWF,JinJ,XuZH*.HeterologousandhomologousexpressionoftheargininebiosyntheticargCsimilartoHclusterfromCorynebacteriumcrenatumforimprovementofl-arginineproduction.JournalofIndustrialMicrobiology&Biotechnology(2012),39(3):495-5027.XuMJ,RaoZM*,D=ouWF,JinJ,XuZH*.Site-Direct=edMutagenesisStudiesonthel-Arginine-BindingSitesofFeedbackInhibit=ioninN-Acetyl-l-glutamateKinase(NAGK)fromCorynebacteriumglutamicum.=CurrentMicrobiology(2012),64(2):164-1728.LuZM,TaoWY,XuHY,LimJ,ZhangXM,WangLP,ChenJH,XuZH*.AnalysisofvolatilecompoundsofAntrodiacamphoratainsubmergedcultureusingheadspacesolid-phasemicroextraction.FoodChemistry(2011),127(2):662-668=9.LuZM,LeiJY,XuHY,ShiJS,XuZH*.OptimizationoffermentationmediumfortriterpenoidproductionfromAntrodiacamphorataATCC200183usingartificialintelligence-basedtechniques.AppliedMicrobiologyandBiotechnology(2011),92(2):371-3=7910.Jin-SongGong,Zhen-MingLu,Jing-SongShi,Wen-FangDou,Hong-=YuXu,Zhe-MinZhou,Zheng-HongX=u*.Isolation,Identification,andCultureOptimizationofaNovelGlycinonitrile-HydrolyzingFungus—FusariumoxysporumH3.ApplBio=chemBiotechnol(2011),165(3-4):963-97711.WenfangDou,MeijuanXu,DongmeiCai,XiaomeiZhang,ZhimingRaoandZhenghongXu*.Improve=mentofl-ArginineProductionbyOverexpressionofaBifunctionalOrnithineAcetyltransferaseinCorynebacteriumcrenatum.AppliedBiochemistryandBiotechnology(2011),165(3-4):845-85512.MeijuanXu,ZhimingRao*,HongXu,ChunyanLan,WenfangDou,XiaomeiZhang,HongyuXu,JianJin，ZhenghongXu*.EnhancedProductionofl-ArgininebyExpressionofVitreoscillaHemoglobinUsingaNovelExpressionSysteminCorynebacteriumcrenatum.AppliedBiochemistryandBiotechnology(2011),163(6):707-71913.ZhenmingLu,Zhenghong=Xu*.AntcinAContributstoanti-inflammatoryeffectofNiuchangchih(Antrod=iacamphorate).ActaPharmacologicaSinica(2011),32(8):981-98214.WeiXu,ZhiyongHuang,XiaojunZhang,QiLi,ZhenmingLu,Jinso=ngShi,ZhenghongXu*,Yanhe=Ma.MonitoringTheMicrobialCommunityDuringSolid-StateAceticAcidFermentationOfZhenjiangAromaticVinegar,FoodMicrobiology(2011),28(6):1175-118115.WeiXu,QingpingXu,JinghuaChen,ZhenmingLu,RongXia,Guoqu=anLi,ZhengHongXu*,YanHeM=a.LigustrazineformationinZhenjiangaromaticvinegar:changesduringfermentationandstoringprocess.JournaloftheScienceofFoodandAgriculture(2011),91(9):1612–161716.ZhenMingLu,WeiXu,NingHuaYu,TuZhou,GuoQuanLi,JinSongS=hi,ZhengHongXu*.Recoveryofar=omacompoundsfromZhenjiangaromaticvinegarbysupercriticalfluidextraction.InternationalJournalofFoodScienceandTechnology(2011),=46(7):1508-151417.YongfengLiu,ShulingZhang,YangchunYong,ZhixiaJi,XinMa,=ZhenghongXu*,ShouwenChen*,EfficientproductionofacetoinbythenewlyisolatedBacilluslicheniformisstrainMEL09,ProcessBiochemistry(2011),46:390-39418.Zhen-MingLu,Wen-YiTao,Hong-YuXu,Zong-HuaAo,Xiao-MeiZha=ng,Zheng-HongXu*.Furtherstudi=esonthehepatoprotectiveeffectof=Antrodiacamphoratainsubmergedcultureonethanol-inducedacuteliverinju=ryinrats.NaturalProductResearch(2011),25(7):684-69519.ZhangX,YangTW,LinQ,XuMJ,XiaHF,XuZH,LiHZ,RaoZM.Isolationandidentificationofanacetoinhighproductionbacteriumthatcanreversetransform2,3-butane=dioltoacetoinatthedeclinephaseoffermentation.WorldJournalofMicrobiology&Biotechnology(2011),279(12):2785-279020.YangTW,RaoZM,ZhangX,LinQ,XiaHF,XuZH,YangST.Productionof2,3-butanediolfromglucosebyGRASmicroorganismBacillusamyloliquefaciens.JournalofBasicMicrobiology(2011),51(6):650-65821.Hong-YuXu,Xiao-MingKong,Zong-HuaAo,Zhen-MingLu,Zheng-HongXu*.Inhibitoryef=fectofdrymatterofculturebrothofAntrodiacamphoratainsubmergedcultureonmiceHepatoma22.NatProdRes(=2010)22:411-41522.XinXu,ChongPang,ChengjianYang,YitongZheng,HongyuXu,ZhenmingLu,Zheng-HongXu*.AntihyperglycemicandAntilipidperoxidativeEffectsofPolysaccharidesExtractedfromMedicinalMushroomChaga,Inonotusobliquus(Pers.:Fr.)Pilát(Aphyllophoromycetideae)onAlloxan-DiabetesMice.Int.J.Med.Mushr.(2010)12:235-244.23.LuG,LingK,ZhaoP,=XuZ,DengC,ZhengH,HuangJ,ChenJ*.Anovelinsitu-formedhydrogelwounddressingbythephotocross-linkingofachitosanderivative.WoundRepa=irRegen.(2010)18(1):70-79.24.HongXu,Wen-FangDou,Hong-YuXu,Xiao-MeiZhang,Zhi-MingRao=,Zhong-PingShi,Zheng-HongXu*.Atwo=-stageoxygensupplystrategyforenhancedl-arginineproductionbyCorynebacteriumcrenatumbased=onmetabolicfluxesanalysis.BiochemEngJ(2009)43:41-51.25.Zong-HuaAo,Zheng-Hon=gXu*,Zhen-MingLu,Hong-YuXu,Xiao-MeiZhang,Wen-FangDou.Niuchangchih(Antrodiacamphorata)anditspotentialintreatingliverdiseases.JEthnopharmacol(2009)121:194-212.26.WangJ,XuX,ZhengH,LiJ,DengC,XuZ,ChenJ*.Structuralcharacterization,chainconformat=ion,andmorphologyofabeta-(1-->3)-D-glucanisolatedfromthefruitingbodyofDictyophoraindusiata.JAgricFoodChem.(2009)57(13):5918-24.=27.Jun-EnSun,Zong-HuaAo*,Zhen-MingLu,Hong-YuXu,Xiao-MeiZh=ang,Wen-FangDou,Zheng-HongXu*.AntihyperglycemicandantilipidperoxidativeeffectsofdrymatterofculturebrothofInonotusobliq=uusinsubmergedcultureonnormalandalloxan-diabetesmice.JEthnopharma=col(2008)118:7-13.28.Heng-FengMiao,Wen-YiTao*,Feng-JieCui,Zheng-HongXu,Zong-HuaAo.Kineticstudyofhumicacidozo=nationinaqueousmedia.Clean-soilairwater(2008)36:893-899.29.Yi-YuLu,Zong-HuaAo*,Zhen-MingLu,Hong-YuXu,Xiao-MeiZhan=g,Wen-FangDou,Zheng-HongXu*.Analgesicandanti-inflammatoryeffectsofthedrymatterofculturebr=othofTermitomycesalbuminosus=anditsextracts.JEthnopharmacol(2008)120:432-436.30.Wen-FangDou,Jian-YongLei,Lian-FenZhang,Zheng-HongXu,Yun=Chen,JianJin*.Expression,purification,andcharacterizationofrecombinanthumanserumalbuminfusionproteinwithtwohumanglucagon-likepeptide=-1mutantsinPichiapastoris.ProteinExpresPurif(2008)61:45-49.31.ZhouJing-Wen,ChangYa-Fei,XuZheng-Hong,YuZi-Niu,ChenShou-Wen*，2007，Productionofthuringiensinbyfed-=batchcultureofBacillusthuringiensissubsp.darmstadiensis032withanimprovedpH-controlglucosefeedingstrategy，ProcessBiochemistry,42(1),52-56<=o:p>32.Shan-ShanLin,Wen-FangDou,Hong-YuXu,Hua-ZhongLi,Zheng-HongXu*,Yan-HeMa.Optimizationofmediumcompositionfortheproductionofalkalineβ-mannanasebyalkaliphilicBacillussp.N16-5usingresponsesurfacemethodology.ApplMicrobiolBiot(2007)75:1015-102233.Xian-ChunJin,Gao-QiangLiu,Zheng-HongXu,Wen-YiTao*.Decol=orizationofadyeindustryeffluentbyA=spergillusfumigatusXC6.ApplMicrobiolBiot(2007)74:239-24334.Feng-JieCui,Wen-YiTao*,Zheng-HongXu,Wen-JieGuo,Hong-YuXu,Zong-HuaAo,JianJin,Yuan-QingWei.Structuralanalysisofanti-tumorheteropolysaccharideGFPS1bfromtheculturedmyceliaofGrifolafro=ndosaGF9801.BioresourceTechnol(2007)98:395-401.35.Wen-JieGuo,Guan-JunTao,Wen-YiTao*,Feng-JieCui,Xian-ChunJin,FangBi,Zheng-HongXu,Zong-HuaAo.AmyxobacteriumstrainSora=ngiumcellulosumAHB125producingepothiloneBandotheranticancersubstances.NatProdRes(2007)21:1256-1265.36.Feng-JieCui,YLi,Zh=eng-HongXu,Hong-YuXu,KeSun,Wen-YiTao*.Optimizationofthemediumcompositionforproductionofmycelialbiomassandexo-polymerbyGrifolafrondosaGF9801usingresponsesurfacemethodology.BioresourceTechnol(2006)97:1209-1216.=37.Zheng-HongXu,Yun-LingBai,XiaXu=,Jing-SongShi,Wen-YiTao*.Productionofalkali-tolerantcellulose-freexylanase=byPseudomonassp.WLUN024withw=heatbranasthemainsubstrate.WorldJMicrobiolBiot(2005)21:575-58138.Zhen=g-HongXu,LeiLi,Zhi-SongShen*.Treatmentofpraziquantelwastewaterusingtheintegratedproce=ssofcoagulationandgasmembraneabsorption.WaterRes(2005)39:2189-2=195.39.Yan-HeMa,Yan-FenXue,Yue-TanDou,Zheng-HongXu,Wen-YiTao*,Pei-JinZhou.Characterization=andgenecloningofanovelbeta-mannanasefromalkaliphilicBacillussp.N16-5.Extremophi=les(2004)8:447-454.主要著作：<=o:p>[=1]陶文沂,敖宗华=,=许泓瑜,许正宏=编著.药食用&30495=;菌生物技术.=化学工业出版社,=2007年.[=2]马延和编译.=生物炼制(卷1),化学工&19994=;出版社,=2007年.(主要参&19982=;)=【科研项&3=0446;】[1]甾体化&2151=2;物的生物转化技术（<=/span>2011AA02A211）&65=292;863重&22=823;项目课题（2011-2015）[2]基于元&2252=2;因组分析的镇江香醋&=#39118;味合成途径构建（31271922）&65=292;国家自然科学基金&35838=;题（2013-2016）[3]基于元&2252=2;因组分析的国窖酿造&=#24494;生物群落功能解析&21=450;优化（2011B2211）&65=292;国家固态酿造工程&25216=;术研究中心开放课题&=65288;2011-2013）[4]L-丝氨酸&2998=3;产菌的代谢工程育种&=#21450;中试发酵研究（2012B091000083<=spanstyle=3D'mso-bidi-font-size:10.5pt;font-family:SimSun;mso-ascii-font-fa=mily:"TimesNewRoman";mso-hansi-font-family:"TimesNewRoman"'>）&65=292;广东省教育部产学&30740=;项目（2012-2013）[5]低值贝&3186=7;资源高值化健康食品&=#30340;研发和产业化示范&65=288;201305007），国&23=478;海洋局海洋公益性&34892=;业科研专项课题（2013-2016）[6]其&23=427;企业合作项目，主&35201=;集中在生物催化产品&=12289;药食用真菌药物及&244=94;生态制剂等方面【科&=#30740;成果及奖励】2005年&20=043;前主持或主要参与&27743=;苏省、国家“十五”&31=185;技攻关等项目10余&39=033;，完成鉴定或验收&31185=;研项目10余&39=033;，获得多项荣誉称&21495=;。[1]江&33=487;省“九&20=116;”产&23=398;研联合先进个人，=2000年[2]教&32=946;部新世纪人才支持&35745=;划获得者，2007年[3]江&33=487;省新长征突击手，=2009年[4]药&29=992;真蕈深层液态发酵&20851=;键技术及其生物活性&=29289;质开发，中国商业&328=52;合会科技进步一等奖=（排名第一）【所&=#33719;专利】申请国家发明专利<=spanlang=3DEN-USstyle=3D'mso-bidi-font-size:10.5pt;line-height:125%;color:=black;mso-font-kerning:0pt'>40余项，主要发明专利=如下：[1]陶文沂，许正宏等，=“高纯度低聚木糖的酶=法制备”，中国发明专利（<=spanlang=3DEN-USstyle=3D'mso-bidi-font-size:10.5pt;line-height:125%;color:=black;mso-font-kerning:0pt'>ZL00109788.1）[2]陶文沂，许正宏等，=“一种生产L-精氨酸的菌株及其诱=变方法与利用该菌株&2=9983;产L-精氨酸的方法”，中国发明专利（<=spanlang=3DEN-USstyle=3D'mso-bidi-font-size:10.5pt;line-height:125%;color:=black;mso-font-kerning:0pt'>ZL03112896.3）[3]许正宏等，“一株产L-丝氨酸的菌株及用该=菌株生产L-丝氨酸的方法”，中国发明专利（申=请号：200610097730.3）[4]许正宏等.一株&=#39640;产3-羟基丁酮的地衣芽&=32990;杆菌MEL09的筛选及应用.中国发明专利（201010166969.8）=[5]许正宏等.一株&=#30701;小芽孢杆菌及其应&29=992;.中国发明专利（201010297112.X）=[6]许正宏等.一株&=#26543;草芽孢杆菌及其应&29=992;.中国发明专利（201010297131.2）=[7]许正宏等.一种&=#20445;健食醋的酿造方法.中国发明专利（200910026025）=
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