个人信息
陈坚
学习工作经历

1999-2003 北京大学生命科学学院 理学学士学位 克隆SARS细胞表面受体，筛选抗SARS小分子和多肽

2004-2011 UTsouthwestern medical Center at Dallas 发育与遗传系 博士，博士后 从事神经干细胞，胶质脑细胞瘤肿瘤干细胞的研究

2012-2014 OriGene Technologies 高级科学家，研发总监 从事肿瘤病理诊断抗体的研发和筛选

2014-现在 苏州大学功能纳米与软物质研究院 教授
下载CV
科学研究
90
小鼠模型

小鼠是我们研究肿瘤和其他疾病的研究对象
80
干细胞

研究肿瘤干细胞和普通干细胞的干性及其分化机理
50
生物技术

应用纳米技术进行肿瘤的诊断、示踪和治疗
1. 使用小鼠模型研究肿瘤（胶质脑细胞瘤和胃肠道肿瘤）的发生，维系以及肿瘤治疗
2. 研究正常成年干细胞以及肿瘤干细胞“干性”的分子机理
3. 免疫检测以及肿瘤的免疫治疗
4. 使用纳米材料检测、示踪、靶向治疗肿瘤
教学招生
实验室成员
现有硕士研究生2人,本科生2人
陆明敏

研一
翟侠

研一
易玉兰

大四
招生：
招收生物医学、化学及材料背景的硕士和博士候选人。 欢迎对科研有激情且有执行力的同学加入团队。有兴趣的同学请回答问卷并将答案邮寄到chenjian2014{at}suda.edu.cn

招聘：
根据课题组发展需要，招收生物医学方向的副教授或者CO-PI以及生物纳米方向的博士后。有意者请发送简历至chenjian2014{at}suda.edu.cn

科研成果

What I have done in my academic career
主要成果和贡献:

利用小鼠胶质脑细胞瘤模型研究肿瘤的细胞起源以及肿瘤干细胞的概念。目前在《Nature》《Cell》《Cancer Cell》《Genes&Development》等杂志发表文章17篇，引用次数超过1900次（Google Scholar），其中多篇文章被Faculty of 1000推荐。2012年发表在《Nature》的文章被NPR、BBC等450多家媒体报道，入选 2012年全球年度自然科学十大突破。
获得奖励:

2013年，江苏省“双创”科技人才

2013年，入选江苏省“创新团队”核心成员（OriGene Technologies）

2009年，American Association for Cancer Research Bristol-Myers Squibb Scholar-in-Training Award
发表论文:

1. Efrain Sanchez-Ortiz, Woosung Cho, Inga Nazarenko, Wei Mo, Jian Chen#, and Luis F. Parada# (2014) NF1 regulation of RAS/ERK signaling is required for appropriate granule neuron progenitor expansion and migration in cerebellar development.Genes Dev.28 (21) (Cover article；#,corresponding author)

2. Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, McKay RM, Lev D, Le LQ, Parada LF (2013). CXCR4/CXCL12 Mediate Autocrine Cell- Cycle Progression in NF1-Associated Malignant Peripheral Nerve Sheath Tumors. Cell. 152(5):1077-90

3. Chen J, Li Y, Yu TS, McKay RM, Burns DK, Kernie SG, Parada LF (2012). A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 488(7412):522-6. (Selected by Faculty of 1000; the discovery was reported by BBC, NPR, China Daily and more than 150 other media globally; it was selected as one of the world’s top10 annual scientific breakthrough by Chinese Academic of Sciences http://news.sciencenet.cn/htmlnews/2013/1/274159.shtm)

4. Chen J, Mckay RM, Parada LF (2012). Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell. 30;149(1):36-47.

5. Blaiss CA, Yu TS, Zhang G, Chen J, Dimchev G, Parada LF, Powell CM, Kernie SG (2011). Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury. J Neurosci. 31(13):4906-16.

6. Alcantara Llaguno S*, Chen J*, Kwon CH*, Jackson EL, Li Y, Burns DK, Alvarez-Buylla A, Parada LF (2009). Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell. 15:45-56. (*, Authorship equally shared)(Selected by Faculty of 1000)

7. Chen J*, Kwon CH*, Lin L, Li Y, Parada LF (2009). Inducible site-specific recombination in neural stem/progenitor cells. Genesis. 47(2):122-31. (*, Authorship equally shared)

8. Alcantara Llaguno SR, Chen J, Parada LF (2009). Signaling in malignant astrocytomas: role of neural stem cells and its therapeutic implications. Clin Cancer Res 1;15(23):7124-9.

9. Lin L, Chen J, Richardson, Parada LF (2009). Mice lacking neurofibromin develop gastric hyperplasia. Am J physiol Gastriointest Liver Physiol. 297: G751-G761

10. Llaguno SA, Chen J, Kwon CH, Parada LF (2008). Neural and Cancer Stem Cells in Tumor Suppressor Mouse Models of Malignant Astrocytoma. Cold Spring Harb Symp Quant Biol. 73:421-6.

11. Li Y, Luikart BW, Birnbaum S, Chen J, Kwon CH, Kernie SG, Bassel-Duby R, Parada LF (2008). TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron. 59:399-412.(Selected by Faculty of 1000)

12. Kwon CH, Zhao D, Chen J, Alcantara S, Li Y, Burns DK, Mason RP, Lee EY, Wu H, Parada LF (2008). Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 68:3286-94.

13. Lush ME, Li Y, Kwon CH, Chen J, Parada LF (2008). Neurofibromin is required for barrel formation in the mouse somatosensory cortex. J Neurosci. 28:1580-7.

14. Wang P*, Chen J*, Zheng A*, Nie Y, Shi X, Wang W, Wang G, Luo M, Liu H, Tan L, Song X, Wang Z, Yin X, Qu X, Wang X, Qing T, Ding M, Deng H (2004). Expression cloning of functional receptor used by SARS coronavirus. Biochem Biophys Res Commun. 315:439-44. (*,Authorship equally shared)

15. Yi L, Li Z, Yuan K, Qu X, Chen J, Wang G, Zhang H, Luo H, Zhu L, Jiang P, Chen L, Shen Y, Luo M, Zuo G, Hu J, Duan D, Nie Y, Shi X, Wang W, Han Y, Li T, Liu Y, Ding M, Deng H, Xu X (2004). Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. J Virol. 78:11334-9.

16. Nie Y, Wang P, Shi X, Wang G, Chen J, Zheng A, Wang W, Wang Z, Qu X, Luo M, Tan L, Song X, Yin X, Chen J, Ding M, Deng H (2004). Highly infectious SARS-CoV pseudotyped virus reveals the cell tropism and its correlation with receptor expression. Biochem Biophys Res Commun. 321:994-1000.

17. Yuan K, Yi L, Chen J, Qu X, Qing T, Rao X, Jiang P, Hu J, Xiong Z, Nie Y, Shi X, Wang W, Ling C, Yin X, Fan K, Lai L, Ding M, Deng H (2004). Suppression of SARS-CoV entry by peptides corresponding to heptad regions on spike glycoprotein. Biochem Biophys Res Commun. 319:746-52.