卫伟
化学与化工学院
联系电话：** 办公时间：
传 真： 主页网址：
办公地点：新化学材料楼 501 电子邮箱：weiw@seu.edu.cn
通讯地址：












研究方向


分析化学



招收博士研究生、学术型硕士研究生！


特别需要专业硕士研究生，从事烟草相关研究！



1.环境、食品中农药残留、重金属等有害物质的灵敏检测方法研究
2.与疾病相关的DNA、RNA、蛋白质、细胞等生物标志物检测。
3.新型纳米材料的合成及其在分析化学（光谱及电化学）研究中的应用。





荣誉奖励


研究简历

? 2001年-2004年，南京大学，化学与化工学院，分析化学博士研究生/博士，师从鞠熀先教授。
? 2001年-2004年，在南京大学攻读博士学位，研究药物和蛋白质的分离分析方法。主要研究毛细管柱的修饰方法，减少药物和蛋白质在毛细管管壁的吸附，提高其分离检测的灵敏度和重现性。
? 2004年-2010年，在东南大学公共卫生学院，主要从事药物与蛋白质、DNA的相互作用；研究食品及其它环境、生物样品中的有效或有害成份检测。利用毛细管电泳、荧光、电致化学发光等技术建立了蜂王浆、血液中的胆碱和乙酰胆碱的检测新方法，研究了不同农产品中氨基糖苷类抗生素残留的检测方法。
? 2010年-至今，在东南大学化学化工学院，主要是利用纳米材料作探针，设计新型的分子信标，利用电化学、电致化学发光及紫外、荧光等光谱等信号转导性质，并研究其在与癌症相关的DNA、RNA、蛋白质、酶等不同生物标志物检测中的应用。






学术成果






作为项目负责人，先后主持包括国家自然科学基金、江苏省自然科学基金等项目：
（1）国家自然科学基金（面上项目):聚ADP核糖酶的高通量检测及其在生物医学中的应用研究， 2018.12.21.12，主持。65万
（2）国家自然科学基金（面上项目）：DNA功能化组装及其在肺癌检测和治疗中的应用研究，2015.1-2018.12，主持。85万
（3）国家自然科学基金（青年基金）：基于纳米探针的DNA损伤检测新方法及其在化学品基因毒性评价中的应用，2013.1-2015.1，主持。25万
（4）江苏省自然科学基金：基于DNA损伤检测的化学品基因毒性评价与筛查新方法，2012.9-2014.12，主持。10万
（5）东南大学-南京医科大学合作项目（重点项目）：基于血清淀粉蛋白A纳米抗体的肺癌早期检测新方法研究。2018-2020，主持。30 万
（6）南京医科大学现代毒理学教育部重点实验室开放基金。主持。5万，2018-2020。
（7）东南大学基本科研业务费（高水平论文及奖励）：23万。主持
（8）南京大学生命分析化学国家重点实验室开放课题，5万，2017-2018。主持
（9）苏州创新培育计划：水产品中氨基糖苷类抗生素残留的检测，主持。
（10）江苏省自然科学基金：纳米纤维在环境污染物高效采样富集器件中的应用技术研究。参与
（11）江苏省自然科学基金：复合二氧化钛纳米管阵列的制备及其氢传感应用研究。参与
（12）国家级自然（社会）科学基金一般项目：食品安全培训与宣传展示。参与
学生培养：
2018年，刘叙获得东南大学优秀硕士论文。
2018年，吴霜霜获得国家奖学金。
2017年，徐晓林获得国家奖学金。
2016年，刘元建、刘叙、吕冰婧获得国家奖学金。
2014年，高春燕获得国家奖学金。
近几年发表论文情况：

2020
1. Ye Lu^＃,Min Wei^＃, Chenchen Wang, Wei Wei^*,Yong Liu^*.Enhancinghydrogels-based long-lasting chemiluminescence by platinum-metal organicframework and its application in array detection of pesticides and D-aminoacids. Nanoscale, …
2019
1.Haitang Yang, Fangjia Fu, WeiLi, Wei Wei*, Yuanjian Zhang, SongqinLiu*. Telomerase and poly(ADP-ribose) polymerase-1 activity sensing based onhigh fluorescence selectivity and sensitivity of TOTO-1 towards G bases insingle strand DNA and poly(ADP-ribose). Chemical Science, 2019, 10, 3706 – 3714.
2.Haitang Yang, Peng Li,Dingzhong Wang, Yong Liu, Wei Wei*, Yuanjian Zhang, SongqinLiu. Quartz Crystal Microbalance Detection of Poly(ADP-ribose)Polymerase-1 Based on GNRs Signal Amplification. Anal. Chem., 2019, 91, 17, 11038-11044.
3.Haitang Yang,Ying Li, Dingzhong Wang, Yong Liu, Wei Wei *,Yuanjian Zhang, Songqin Liu, Peng Li*.Quartz crystal microbalance for telomerase sensing based on goldnanoparticles induced signal amplification. Chem Commun. 2019，55,5994-5997.
4.Xiaoyuan Zhou¹, Chenchen Wang¹, ZhuangWang, Haitang Yang, Wei Wei^,*, Yong Liu^*, Songqin Liu. Renewable electrochemical sensor for PARP-1 activity detectionbased on host-guest recognition. Biosensor. Bioelectron., 2020, 148，111810.
5.Tiantian Yao, Anran Liu^a, Yong Liu^b,*, Min Wei^c, WeiWei^a,*, Songqin Liu^a RatiometricFluorescence Sensor for Organophosphorus Pesticide Detection Based on OppositeResponses of two Fluorescence Reagents to MnO2 Nanosheets. Biosensor. Bioelectron., 2019,145, 111705
6.Chenchen Wang^＃, Ying Li^＃, Ensheng Xu, Qing Zhou,Jin Chen, Wei Wei^*, Yong Liu, Songqin Liu. ALabel-free PFP-based Photoelectrochemical Biosensor for Highly SensitiveDetection of PARP-1 Activity. Biosensor.Bioelectron．2019, 138,111308-111314.
7.Shuang Shuang Wu, MinWei^*, WeiWei^*,YongLiu, SongqinLiu. Electrochemical aptasensor for aflatoxin B1 based on smarthost-guest recognition of β-cyclodextrin polymer. Biosensor. Bioelectron．2019, 129, 58-63.
8.Zhuang Wang, Ensheng Xu, Chenchen Wang, Wei Wei*, Yong Liu,Songqin Liu. High specificity and efficiency electrochemical detection of poly(ADP-ribose)polymerase-1 activity based on versatile peptide-templated coppernanoparticlesand detection array. Anal. Chim. Acta,2019,1091，95-102.
9.Ye Lu, Yong Liu, Chenchen Wang, Shuangshuang Wu, Wei Wei^*. Fluorometric enzymaticdetermination of D-alanine usingpoly[9,9-bis(6-N,N,N-trimethylammonium)-hexyl]fluorenylene phenylene and MnO₂nanosheets, Microchim Acta, 2019,186(7), 460
10.Ensheng Xu^#,Haitang Yang^#, Lina Wu^*, Jin Chen, Wei Wei*, Yong Liu,Songqin Liu. Label-free poly(ADP-ribose) polymerase-1 activity assay based onperpendicular orientated mesoporous silica films". Sensors & Actuators: B. Chemical, 2019,294,185-191.
11.Chao Xu, Fen Zhang, KanWang, Ensheng Xu, Wei Wei*, Yong Liu, Songqin Liu。 A three-dimensional DNAzyme motorfor sensitive imaging of telomerase activity in living cells. Sensors Actuator B,2019,298,126930.
12.Min Wei,Chunlei Wang, Ensheng Xu, Jin Chen^*,Xiaolin Xu, Wei Wei^*, Songqin Liu. A simple and sensitiveelectrochemiluminescence aptasensor for determination of ochratoxin A based ona nicking endonuclease-powered DNA walking machine. Food Chemistry. 2019,282, 141-146.
2018
1.Peixin Li, Min Wei, Fen Zhang, juanSu, Wei Wei^*, Yuanjian Zhang, Songqin Liu. A NovelFluorescence Switch for MicroRNA Imaging in Living Cells based on DNAzymeAmplification Strategy. AcsAppl. Mater. Inter., 2018, 10 (50), pp 43405–43410。http://dx.doi.org/10.1021/acsami.8b15330 IF = 8.1
2.Wei Wei^*, Min Wei, Lihong Yin, Yuepu Pu, SongqinLiu. Improving the Fluorometric Determination of the Cancer Biomarker8-hydroxy-2'-deoxyguanosine by using a 3D DNA Nanomachine. Microchim Acta(2018) 185: 494. DOI: 10.1007/s00604-018-3036-7
3.Shuangshuang Wu, Min Wei, Haitang Yang, Jiahui Fan, Wei Wei*,Yuanjian Zhang, Songqin Liu. Counterions-mediated gold nanorods-based sensorfor label-free detection of poly(ADP-ribose) polymerase-1 activity and itsinhibitor. Sensors Actuator B, 2018, 259, 565-572. IF = 5.4　（已报）
4.Shuangshuang Wu, Changhui Chen, Haitang Yang, Wei Wei^*,Min Wei^* Yuanjian Zhang, Songqin Liu. A sensitive fluorescence"turn-off-on" biosensor for poly(ADP-ribose) polymerase-1 detectionbased on cationic conjugated polymer-MnO2 nanosheets.Sensors Actuator B, 2018, 273, 1047-1053. IF = 5.4 （已报）
5.Chunlei Wang, Haitang Yang, Shuangshuang Wu,Yuanjian Liu, Wei Wei*, Yuanjian Zhang, Min Wei*,Songqin Liu. Manifold methods for telomerase activity detection based on variousunique probes. Trends in AnalyticalChemistry, 2018, 105, 404- 412.IF= 7.6（已报）
6.Yong Liu, Bingjing Lv, Anran Liu,Geyu Liang, Lihong Yin, Yuepu Pu, Wei Wei*Songqin Liu. Multicolor sensor fororganophosphorus pesticides determination based on the bi-enzyme catalyticetching of gold nanorods. SensorsActuator B, 2018, 265, 675-681.IF = 5.4
7.Yong Liu, Jiahui Fan, Haitang Yang, Enshen Xu, Wei Wei*,Yuanjian Zhang, Songqin Liu. Detection of PARP-1 activity based onhyperbranched-poly (ADP-ribose) polymers responsive current in artificialnanochannels. 2018, Biosensors andBioelectronics 2018, 113, 136–141. IF = 8.3 https://doi.org/10.1016/j.bios.2018.05.005
8.Yong Liu, Jiahui Fan, Li Shangguan, Yuanjian Liu, YuanqingWei, Wei Wei*, Songqin Liu. Ultrasensitive electrochemical detection of poly(ADP-ribose) polymerase-1 via polyaniline deposition. Talanta, 2018 , 180,127-132. IF= 4.3
9.Yong Liu, Xiaolin Xu, Haitang Yang, Ensheng Xu, ShuangshuangWu, Wei Wei*, Jin Chen*. Analysis of poly(ADP-ribose) polymerase-1 byenzyme-initiated auto-PARylation controlled aggregation of hemin-graphenenanocomposites. Analyst, 2018, 143, 2501 - 2507. 封面论文IF = 3.8

2017
9.Xu Liu, Min Wei,EnshengXu,Haitang Yang,Wei Wei,^* Yuanjian Zhang,Songqin Liu. A Sensitive, Label-free ElectrochemicalDetection of Telomerase Activity withoutModification or Immobilization. Biosensors andBioelectronics，2017, 91，347-353。IF = 8.3
10.Xiaolin Xu, Yuanjian Liu, Xu Liu,Wei Wei,*Yuanjian Zhang, Songqin Liu. A simple, fast, label-free colorimetricmethod for detection of telomerase activity in urine by using hemin-grapheneconjugates. Biosensors and Bioelectronics，2017, 87, 600-606. IF = 8.3
11.YuanjianLiu, Min Wei, Ying Li, Anran Liu, Wei Wei, ^*Yuanjian Zhang, Songqin Liu. Application of spectral crosstalk correction forimproving multiplexed microRNA detection using a single excitation wavelength. Anal.Chem., 2017, 89, 3430–3436。IF = 6.2
12.Changhui Chen，Min Wei，Yuanjian Liu，Ensheng Xu，Wei Wei，Yuanjian Zhang，Songqin Liu. Visualand fluorometric determination of telomerase activity by using a cationic conjugatedpolymer and fluorescence resonance energy transfer. MicrochimicaActa, 2017, 184, 3453-3460. IF = 5.4
13.Haitang Yang,^#Anran Liu,^# Min Wei, Yuanjian Liu, Bingjing Lv, Wei Wei,* YuanjianZhang, Songqin Liu*. A visual, label-free telomerase activity monitor viaenzymatic etching of gold nanorods. Anal. Chem.2017, 89, 12094-12100.IF = 6.2
2016
14.Yuanjian Liu, Min Wei, XuLiu, Wei Wei, Hongyu Zhao, Yuanjian Zhang andSongqin Liu. Label-free ultrasensitive detection of telomerase activityvia multiple telomeric hemin/G-quadruplexes triggered polyaniline depositionand DNA tetrahedron-structure regulated signal. Chem. Commun., 2016, 52,1796 - 1799. IF=7.4封面论文
15.Xuehong Zhang, Min Wei,Bingjing Lv, Yuanjian Liu, Xu Liu, and Wei Wei*. Sensitive colorimetricdetection of glucose and cholesterol by using Au@Ag core-shell nanoparticles. RSCAdvances, 2016, 6, 35001 - 35007.
16.Linqun Zhang,^#Yuanjian Liua,^# Ying Li, Yuewu Zhao, Wei Wei,* Songqin Liu,*Sensitive electrochemical assaying of DNA methyltransferase activity based onmimic-hybridization chain reaction amplified strategy.Anal. Chim. Acta, 2016, 933,75-81. IF=5.3
17.Yuanjian Liu, Min Wei,Linqun Zhang, Yuanjian Zhang, Wei Wei*, Lihong Yin, Yuepu Pu, Songqin Liu. Chiroplasmonicassemblies of gold nanoparticles for ultrasensitive detection of8-hydroxy-2’-deoxyguanosine in human serum sample. Anal. Chem. 2016, 88,6509-6514.IF=6.2
18.Jingjing Ji, Yuanjian Liu, Wei Wei, Yuanjian Zhang, SongqinLiu. Quantitation of DNA methyltransferase activity via chronocoulometry incombination with rolling chain amplification. Biosensors and Bioelectronics, 2016, 85, 25-31. IF=8.3
19.Bingjing Lv, Min Wei*,Yuanjian Liu, Xu Liu, Wei Wei*, Songqin Liu. Ultrasensitive photometric andvisual determination of organophosphorus pesticides based on the inhibition ofenzyme-triggered formation of core-shell gold-silver nanoparticles. MicrochimicActa. 2016.183, 2941–2948. DOI:10.1007/s00604-016-1939-8。IF=5.2
20.Liu, Xu; Wei, Min; Liu, Yuanjian; Lv, Bingjing; Wei, Wei;Zhang, Yuanjian; Liu, Songqin. Label-free detection of telomerase activity inurine using telomerase-responsive porous anodic alumina nanochannels.Anal. Chem. 2016, 88,8107-8114.IF=6.2
21.JiahuiFan^#, Yuanjian Liu^#, Ensheng Xu, Yuanjian Zhang, WeiWei*, Lihong Yin, Yuepu Pu, Songqin Liu. A label-free ultrasensitive assay of8-hydroxy-2’- deoxyguanosine in human serum and urine samples via polyanilinedeposition and tetrahedral DNA nanostructure. Anal. Chim. Acta. 2016,946, 48-55. IF=5.2
2015
22.Yuanjian Liu, Linqun Zhang, Wei Wei,* Hongyu Zhao, Zhenxian Zhou,Yuanjian Zhang and Songqin Liu. Colorimetric detection of influenza A virususing antibody-functionalized gold nanoparticles, Analyst, 2015, 140, 3989–3995.
23.Linqun Zhang, Min Wei,Chunyan Gao, Wei Wei^*,Yuanjian Zhang, Songqin Liu.Label-freeElectrochemical Detection of Methyltransferase Activity and Inhibitor Screeningbased on Endonuclease HpaII and the Deposition of Polyaniline. Biosens. Bioelectron. 2015,73,188-194. IF=8.3
24.Yuanjian Liu, Min Wei,Linqun Zhang, Wei Wei*, Yuanjian Zhang, Songqin Liu. Evaluation of DNAMethyltransferase Activity and Inhibition via Chiroplasmonic Assemblies of GoldNanoparticles. Chem. Commun. 2015, 51, 76, 14350-14353. IF=7.4
25.Wei Wei, Chunyan Gao, Yanxiang Xiong, Lihong Yin, Yuepu Pu*,Songqin Liu*. A fluorescence method for detection of DNA andDNA methylation based on graphene oxide and endonuclease HpaII. Talanta,131(2015)342–347。
专利申请及授权：
1.卫伟，高春燕，刘松琴。限制性内切酶和核酸外切酶III的无标记荧光检测DNA和DNA甲基化转移酶活性的检测方法。授权号：CNA；申请号：0.8.2015.11.24
2.卫伟，康学军，邓慧华，陆祖宏。蜂王浆中乙酰胆碱的检测方法。授权号：CN B，授权公告日，2012.04.25,
3.卫伟，熊艳翔，刘松琴。基于氧化石墨烯和限制性内切酶的DNA甲基化检测方法及其试剂盒。授理号：4.8授权号CN A2016
4.卫伟，倪蔷薇，刘松琴。一种电化学DNA生物传感器及其制备方法与应用。授理号：授权号CNA2016
5.卫伟，康学军，邓慧华，陆祖宏。壮观霉素的毛细管电泳-电致化学发光检测方法。授理号：8
6.卫伟，刘元建，刘松琴。一种金纳米粒子探针比色法检测甲型流感病毒H3N2的方法。授理。 2.3。授权号20**050
7.卫敏，刘叙，卫伟。基于纳米传感和电化学传感定量检测端粒酶活性的方法。授理号：8.8.
8.卫伟，徐晓林，范佳惠，陈昌慧，刘松琴。基于Hemin-石墨烯复合材料的端粒酶活性检测方法。授理号：2.x.
9.卫伟，刘叙，刘松琴。利用亚甲基蓝与G-四链体的结合检测端粒酶活性检测方法。授理号：3.4.
10.卫伟，陈昌慧，刘松琴。基于阳离子水溶性聚合物的荧光可视化定量检测端粒酶活性的检测方法。授理号：9.1.
11.卫伟，范佳慧，张雪红，徐晓林，陈昌慧，刘松琴。基于苯胺沉积的电化学传感定量检测8-OHdG的方法。授理号：4.9.
12.卫伟，刘元建，刘松琴。一种通过荧光法同时检测多种miRNA的方法。授理号：20**
13.卫伟，吴霜霜，刘松琴。一种基于金纳米棒比色法检测多聚腺苷二磷酸核糖聚合酶-1的新方法。授理号：1.9，授理日2017.8.8
14.刘勇，范佳慧，卫伟，基于聚苯胺沉积的定量检测多聚腺苷二磷酸核糖聚合酶-1活性的方法，0.1,2017.08.24
15.刘勇，徐晓林，卫伟，基于hemin-石墨烯复合材料分析检测PARP活性的方法，4.5，2017-07-31