高北

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电子邮箱：003375@nuist.edu.cn
所在单位：海洋科学学院
学历：博士研究生毕业
性别：女
职称：讲师（高校）

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姓名: 高北
性别: 女
最高学历: 博士
工作单位: 南京信息工程大学海洋科学学院
所属系部: 海洋科学系
毕业院校: 美国佐治亚大学（University of Georgia）
研究方向: 海洋污染物的健康风险评估；海洋微生物资源的开发与利用；代谢组学；脂质组学；稳定性同位素追踪；肠道微生物

工作经历：
2020.10- 南京信息工程大学，海洋科学学院，校聘教授，龙山****
2019.01- 2020.09 美国加州大学圣地亚哥分校（University of California, San diego），博士后
2017.01-2018.12 美国加州大学戴维斯分校 (University of California, Davis)，西海岸代谢组学中心 (West Coast Metabolomics Center)，博士后
2016.08-2016.12 美国北卡罗莱纳大学教堂山分校，访问****

近期发表期刊论文:
Gao B, Friedman E, Regunathan R, Shrivastava A, Barrows I, Amdur R, Andrews S, Barrows E, Raj D. Gut Microbiota and Host Co-metabolism are Altered by Patiromer Induced Changes in Serum and Stool Potassium. Kidney International reports.2020 Dec. 28; doi: 10.1016/j.ekir.2020.12.026.IF 3.374 (二区)
Gao B, Bian X, Mahbub R, Lu K. Sex-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions. Environ Health Perspect. 2017 Feb;125(2):198-206. doi: 10.1289/EHP202. Selected as Papers of the Month by the NIEHS. IF 8.382 (一区)
Lang S^#, Fairfied B^#, Gao B^# (Co-first author), Duan Y, Zhang X, Fouts D, Schnabl B. Changes in the fecal bacterial microbiota associated with disease severity in alcoholic hepatitis patients. Gut Microbes. 2020, July 20; doi:10.1080/**.2020.**. IF 7.74 (一区)
Gao B, Emami A, Nath S, Schnabl B. Microbial products and metabolites contributing to alcohol-related liver disease. Mol. Nutr. Food Res. 2020, June 24; doi: 10.1002/mnfr.. IF 5.309 (二区)
Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Lu J, Loomba R, Brenner D, Starkel P, Schnabl B. Functional microbial responses to alcohol abstinence in patients with alcohol use disorder. Front. physiol. 2020; doi: 10.3389/fphys.2020.00370. IF 3.367 (二区)
Gao B, Chi L, Tu P, Gao N, Lu K. The Carbamate Aldicarb Altered the Gut Microbiome, Metabolome, and Lipidome of C57BL/6J Mice. Chem Res Toxicol. 2019 Jan 22;32(1):67-79. doi: 10.1021/acs.chemrestox.8b00179 IF 3.184 (二区)
Gao B^#, Gallagher T^# (Co-first author), Zhang Y, Elbadawi-Sidhu M, Lai Z, Fiehn O, Whiteson KL. Tracking Polymicrobial Metabolism in Cystic Fibrosis Airways: Pseudomonas aeruginosa Metabolism and Physiology Are Influenced by Rothia mucilaginosa-Derived Metabolites. mSphere. 2018 Apr 25;3(2). doi: 10.1128/mSphere.00151-18. IF 4.282 (二区)
Gao B, Chi L, Tu P, Bian X, Thomas J, Ru H, Lu K. The organophosphate malathion disturbs gut microbiome development and the quorum-Sensing system. Toxicol Lett. 2018 Feb;283:52-57. doi: 10.1016/j.toxlet.2017.10.023. IF 3.569 (二区)
Gao B, Bian X, Chi L, Tu P, Ru H, Lu K. Editor's Highlight: Organophosphate Diazinon Altered Quorum Sensing, Cell Motility, Stress Response, and Carbohydrate Metabolism of Gut Microbiome. Toxicol Sci. 2017 Jun 1;157(2):354-364. doi: 10.1093/toxsci/kfx053. Selected as Editor’s Highlight. IF 3.703 (二区)
Gao B, Chi L, Mahbub R, Bian X, Tu P, Ru H, Lu K. Multi-Omics Reveals that Lead Exposure Disturbs Gut Microbiome Development, Key Metabolites, and Metabolic Pathways. Chem Res Toxicol. 2017 Apr 17;30(4):996-1005. doi: 10.1021/acs.chemrestox.6b00401. IF 3.184 (二区)
Gao B^#, Duan Y^# (Co-first author), Lang S, Barrupal D, Wu T, Valdiviez L, Roberts B, Choy Y, Shen T, Byram G, Zhang Y, Fan S, Wancewicz B, Shao Y, Vervier K, Wang Y, Zhou R, Jiang L, Nath S, Looma R, Abraldes J, Bataller R, Tu X, Starkel P, Lawley T, Fiehn O, Schnabl B. Functional microbiomics reveals alterations of the gut microbiome and host co-metabolismin alcoholic hepatitis patients. Hepatol. Commun. 2020 June; https://doi.org/10.1002/hep4.1537.
Gao B, Alonzo-Palma N, Brooks B, Jose A, Barupal D, Jagadeesan M, Nobakht, E, Collins A, Ramezani A, Omar B, Amdur R, Raj D. A Pilot Study On the Effect of Prebiotic on Host-Microbial Co-metabolism in Peritoneal Dialysis Patients. KI reports. 2020 June; doi:10.1016/j.ekir.2020.05.023.IF 3.374 (二区)

Gao B, Lang S, Duan Y, Wang Y, Shawcross DL, Louvet A, Mathurin P, Ho SB, St?rkel P, Schnabl B. Serum and Fecal Oxylipins in Patients with Alcohol-Related Liver Disease. Dig Dis Sci. 2019 Jul;64(7):1878-1892. doi: 10.1007/s10620-019-05638-y.IF 2.751
Barupal DK^#, Gao B^# (Co-first author), Budczies J, Phinney BS, Perroud B, Denkert C, Fiehn O. Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining. Oncotarget. 2019 Jun 11;10(39):3894-3909. doi: 10.18632/oncotarget.26995
Gao B, Lue HW, Podolak J, Fan S, Zhang Y, Serawat A, Alumkal JJ, Fiehn O, Thomas GV. Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma. Metabolites. 2019 Apr 26;9(5). doi: 10.3390/metabo**. Selected as Journal Issue Cover.IF 4.079 (二区)

Gao B^#, Tu P^# (Co-first author), Bian X, Chi L, Ru H, Lu K. Profound perturbation induced by triclosan exposure in mouse gut microbiome: a less resilient microbial community with elevated antibiotic and metal resistomes. BMC Pharmacol Toxicol. 2017 Jun 12;18(1):46. doi: 10.1186/s40360-017-0150-9. Selected as BMC Pharmacology and Toxicology 2017 Highlight.IF 1.771

Duan Y, Llorente C, Lang S, Brandl K, Chu H, Jiang L, White R, Clarke T, Nguyen K, Torralba M, Shao Y, Liu J, Hernandez-Morales A, Lessor L, Rahman I, Miyamoto Y, Ly M, Gao B, Sun W, Kiesel R, Hutmacher F, Lee S, Ventura-Cots M, Bosques-Padilla F, Verna E, Abraldes J, Brown Jr R, Vargas V, Altamirano J, Caballería J, Shawcross D, Ho S, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Bataller R, Tu X, Eckmann L, Donk W, Young R, Lawley T, St?rkel P, Pride D, Fouts D, Schnabl B. Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature. 2019; doi:10.1038/s41586-019-1742-x. Comment in Microbial clues to a liver disease by Clokie MRJ; Manipulating the gut microbiota to combat alcoholic hepatitis by Ray K; Phages fight alcoholic hepatitis by Crunkhorn S; Bacteriophage prevents alcoholic liver disease by Colakoglu M Xue J and Trajkovski M.IF 42.778
Cai D, Wang J, Gao B, Li J, Wu F, Zou J, Xu J, Jiang Y, Zou H, Huang Z, Borowsky A, Bold R, Lara P, Li J, Chen X, Lam K, To K, Kung H, Fiehn O, Zhao R, Evans R, Chen H. RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nat. Commun. 2019; 10:4621. doi: 10.1038/s41467-019-12529-3.IF 12.121
Jiang L, Lang S, Duan Y, Zhang X, Gao B, Chopyk J, Schwanemann L, Ventura-Cots M, Bataller R, Bosques-Padilla F, Verna E, Abraldes J, Brown R, Vargas V, Altamirano J, Caballeria J, Shawcross D, Ho S, Louvet A, Lucey M, Mathurin P, Garcia-Tsao G, Kisseleva T, Brenner D, Tu X, Starkel P, Pride S, Pride D, Fouts D, Schnabl B. Intestinal virome in patients with alcoholic hepatitis. Hepatology. 2020, July 12; doi:10.1002/hep.31459.IF 14.971
Lang S, D Münevver, Martin A, Jiang L, Zhang X, Duan Y, Gao B, Wisplinghoff H, Kasper P, Roderburg C, Tacke F, Steffen H, Goeser T, Abraldes J, Tu X, Loomba R, Pride D, Fouts D, Schnabl B. Intestinal virome signature associated with non-alcoholic steatohepatitis and fibrosis. Gastroenterology. 2020; doi: 10.1053/j.gastro.2020.07.005 IF 17.373
Hendrikx T, Duan Y, Wang Y, Oh JH, Alexander LM, Huang W, St?rkel P, Ho SB, Gao B, Fiehn O, Emond P, Sokol H, van Pijkeren JP, Schnabl B. Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice. Gut. 2019 Aug;68(8):1504-1515. doi: 10.1136/gutjnl-2018-317232.IF 19.819
Zhang Y, Gao B, Valdiviez L, Zhu C, Gallagher T, Whiteson K, Fiehn O. Comparing stable isotope enrichment by gas chromatography with time-of-flight, quadrupole time-of-light and quadrupole mass spectrometry. Analytical Chemistry.2021, Jan 12; doi: 10.1021/acs.analchem.0c04013.
Zhou R, Llorente C, Cao J, Gao B, Duan Y, Jiang L, Wang Y, Vipin K, Peter S, Lars B, Fan X, Schnabl B. Deficiency of intestinal α1-2-fucosylation exacerbates ethanol-induced liver disease in mice. Alcoholism: Clinical and Experimental Research. 2020, July 6; doi: 10.1111/acer.14405
Maccioni L, Gao B, Leclercq S, Pirlot B, Horsmans Y, Timary P, Leclercq I, Fouts D, Schnabl B, St?rkel P. Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans. Gut Microbes. 2020, June 26; doi: 10.1080/**.2020.**
Jiang L, Chu H, Gao B, Lang S, Wang Y, Duan Y, Schnabl B. Transcriptomic profiling identifies novel hepatic and intestinal genes following chronic plus binge ethanol feeding in mice. Dig Dis Sci. 2020. doi: 10.1007/s10620-020-06461-6.
Chu H, Jiang L, Gao B, Gautam N, Alamoudi J, Lang S, Wang Y, Duan Y, Alnouti Y, Cable E, Schnabl B. The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice. Transl Res. 2020; doi.org/10.1016/j.trsl.2020.06.006.
Tu P, Chi L, Bodnar W, Zhang Z, Gao B, Bian X, Stewart J, Fry R,Lu K. Gut Microbiome Toxicity: Connecting the Environment and Gut Microbiome-associated Diseases. Toxics 2020, 8(1), 19; doi:10.3390/toxics**. Selected as Journal Issue Cover.
Tu P, Bian X, Chi L, Xue J, Gao B, Lai Y, Ru H, Lu K. Metabolite profiling of the gut microbiome in mice with dietary administration of black raspberries. ACS Omega. 2020; doi:10.1021/acsomega.9b00237.
Glenn T, Pierson T, Bayona-Vásquez N, Kieran T, Hoffberg S, Thomas J, Lefever D, Finger J, Gao B, Bian X, Louha S, Kohli R, Bentley K, Rushmore J, Wong K, Shaw T, Rothrock M, Mckee A, Guo T, Mauricio R, Molina M, Cummings B, Lash L, Lu K, Gilbert G, Hubbell S, Faircloth B. Adapterama II: Universal amplicon sequencing on illumina platforms (TaggiMatrix). PeerJ. 2019; 7:e7786 doi:10.7717/peerj.7786.
Tu P, Xue J, Bian X, Chi L, Gao B, Leng J, Ru H, Knobloch TJ, Weghorst CM, Lu K. Dietary administration of black raspberries modulates arsenic biotransformation and reduces urinary 8-oxo-2'-deoxyguanosine in mice. Toxicol Appl Pharmacol. 2019 Aug 15;377:114633. doi: 10.1016/j.taap.2019.114633.
Xia Y, Ye B, Ding J, Yu Y, Alptekin A, Thangaraju M, Prasad PD, Ding ZC, Park EJ, Choi JH, Gao B, Fiehn O, Yan C, Dong Z, Zha Y, Ding HF. Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway. Cancer Res. 2019 Aug 1;79(15):3837-3850. doi: 10.1158/0008-5472.CAN-18-3541. Commented by Aida Rodriguez Garcia and Marie Arsenian-Henriksson in Cancer Research Highlight Article.
Tu P, Gao B, Chi L, Lai Y, Bian X, Ru H, Lu K. Subchronic low-dose 2,4-D exposure changed plasma acylcarnitine levels and induced gut microbiome perturbations in mice. Sci Rep. 2019 Mar 13;9(1):4363. doi: 10.1038/s41598-019-40776-3.
Lai Y, Xue J, Liu CW, Gao B, Chi L, Tu P, Lu K, Ru H. Serum Metabolomics Identifies Altered Bioenergetics, Signaling Cascades in Parallel with Exposome Markers in Crohn's Disease. Molecules. 2019 Jan 27;24(3). doi: 10.3390/molecules**.
Tu P, Bian X, Chi L, Gao B, Ru H, Knobloch TJ, Weghorst CM, Lu K. Characterization of the Functional Changes in Mouse Gut Microbiome Associated with Increased Akkermansia muciniphila Population Modulated by Dietary Black Raspberries. ACS Omega. 2018 Sep 30;3(9):10927-10937. doi: 10.1021/acsomega.8b00064.
Nusbaum DJ, Sun F, Ren J, Zhu Z, Ramsy N, Pervolarakis N, Kunde S, England W, Gao B, Fiehn O, Michail S, Whiteson K. Gut microbial and metabolomic profiles after fecal microbiota transplantation in pediatric ulcerative colitis patients. FEMS Microbiol Ecol. 2018 Sep 1;94(9). doi: 10.1093/femsec/fiy133. Selected as Editor’s Choice.
Shan J, Peng L, Qian W, Xie T, Kang A, Gao B, Di L. Integrated Serum and Fecal Metabolomics Study of Collagen-Induced Arthritis Rats and the Therapeutic Effects of the Zushima Tablet. Front Pharmacol. 2018;9:891. doi: 10.3389/fphar.2018.00891.
Chi L, Gao B, Tu P, Liu CW, Xue J, Lai Y, Ru H, Lu K. Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome. Mamm Genome. 2018 Feb;29(1-2):63-79. doi: 10.1007/s00335-018-9736-9.
Chi L, Bian X, Gao B, Tu P, Lai Y, Ru H, Lu K. Effects of the Artificial Sweetener Neotame on the Gut Microbiome and Fecal Metabolites in Mice. Molecules. 2018 Feb 9;23(2). doi: 10.3390/molecules**
Chi L, Mahbub R, Gao B, Bian X, Tu P, Ru H, Lu K. Nicotine Alters the Gut Microbiome and Metabolites of Gut-Brain Interactions in a Sex-Specific Manner. Chem Res Toxicol. 2017 Dec 18;30(12):2110-2119. doi: 10.1021/acs.chemrestox.7b00162. Featured by the American Chemical Society press release. Recommended in F1000Prime.
Chi L, Bian X, Gao B, Tu P, Ru H, Lu K. The Effects of an Environmentally Relevant Level of Arsenic on the Gut Microbiome and Its Functional Metagenome. Toxicol Sci. 2017 Dec 1;160(2):193-204. doi: 10.1093/toxsci/kfx174.
Chi L, Gao B, Bian X, Tu P, Ru H, Lu K. Manganese-induced sex-specific gut microbiome perturbations in C57BL/6 mice. Toxicol Appl Pharmacol. 2017 Sep 15;331:142-153. doi: 10.1016/j.taap.2017.06.008.
Bian X, Tu P, Chi L, Gao B, Ru H, Lu K. Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions. Food Chem Toxicol. 2017 Sep;107(Pt B):530-539. doi: 10.1016/j.fct.2017.04.045.
Bian X, Chi L, Gao B, Tu P, Ru H, Lu K. Gut Microbiome Response to Sucralose and Its Potential Role in Inducing Liver Inflammation in Mice. Front Physiol. 2017;8:487. doi: 10.3389/fphys.2017.00487.
Bian X, Chi L, Gao B, Tu P, Ru H, Lu K. The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice. PLoS One. 2017;12(6):e**. doi: 10.1371/journal.pone.**.
Chi L, Bian X, Gao B, Ru H, Tu P, Lu K. Sex-Specific Effects of Arsenic Exposure on the Trajectory and Function of the Gut Microbiome. Chem Res Toxicol. 2016 Jun 20;29(6):949-51. doi: 10.1021/acs.chemrestox.6b00066.

高北, 陶妍. 斑点叉尾鮰BPI抗菌肽的cDNA克隆及原核表达载体的构建. 生物技术通报, 2012(12): 131-138.
高北, 陶妍. 斑点叉尾鮰（Ictalurus punctatus）LEAP2成熟太在大肠杆菌中的融合表达.生物技术通报, 2014(2): 130-135.
孙立人，陶妍, 高北. 斑点叉尾鮰LEAP-2成熟肽在毕赤酵母中的表达及其抑菌活性.上海海洋大学学报,2017,26(1):23-28.

SCI收录会议论文：
Gao, Bei, Xiaoming Bian, Liang Chi, Pengcheng Tu, and Kun Lu. 2016. “Metatranscriptomics Reveals Functional Effects of Diazinon Exposure on Gut Microbiome.” Abstracts of Papers of the American Chemical Society 252 (August).

Bian, Xiaoming, Bei Gao, Kun Lu, Liang Chi, and Pengcheng Tu. 2016. “Gut Microbiome and Metabolome Response to Artificial Sweeteners.” Abstracts of Papers of the American Chemical Society 252 (August).
Fairfield, Bradley S., Sonja Lang, Bei Gao, Derrick E. Fouts, and Bernd Schnabl. 2020. “CHANGES IN GUT MICROBIOME IN PATIENTS WITH ALCOHOLIC HEPATITIS: HOW DISEASE SEVERITY CORRELATES WITH REDUCED MICROBIOTA DIVERSITY.” Gastroenterology 158 (6): S1351–S1351.
Gallagher, T., Bei. Gao, J. Phan, A. Dvomikov, O. Fiehn, M. Digman, and K. Whiteson. 2018. “TRACKING METABOLIC INTERACTIONS BETWEEN THE CYSTIC FIBROSIS PATHOGEN, PSEUDOMONAS AERUGINOSA AND THE ORAL MICROBE, ROTHIA MUCILAGINOSA.” Pediatric Pulmonology 53 (September): 320–320.
Llorente, Cristina, Rongrong Zhou, Jinling Cao, Livia S. Zaramela, Suling Zeng, Bei Gao, Shang-Zhen Li, et al. 2020. “INTESTINAL Alpha 1-2-FUCOSYLATION CONTRIBUTES TO OBESITY AND STEATOHEPATITIS IN MICE.” Hepatology 72 (November): 336A-337A.
Raj, Dominic, Bei Gao, Elizabeth Barrows, Muralidharan Jagadeesan, Richard Amdur, Ashte Collins, Renu Regunathan-Shenk, Danielle Kincaid, Badryah Omar, and Muhammad Siddiqi. 2020. “REGULATION OF GUT MICROBIOTA AND HOST CO-METABOLISM BY POTASSIUM HOMEOSTASIS IN PATIENTS ON HEMODIALYSIS.” Nephrology Dialysis Transplantation 35 (June): 51–51.
Tu, Pengcheng, Ridwan Mahbub, Xiaoming Bian, Bei Gao, Liang Chi, and Kun Lu. 2016. “Effects of Nicotine on the Gut Microbiome and Its Metabolic Functions.” Abstracts of Papers of the American Chemical Society 252 (August).














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