南京大学医学院博（硕）士研究生导师简介
姓名
金 磊
研究方向：
生物材料、骨组织工程、肿瘤放、化疗患者口腔健康维护


联系方式
电话：/**
Email: Ljin@nju.edu.cn

学术兼职：
中华口腔医学会口腔修复专委会常务委员
中华口腔医学会口腔颌面修复学专业委员会常务委员
第三届江苏省口腔医学会口腔修复专委会主任委员

个人简介

1、工作简历
2017/07-至今，南京大学，博士研究生导师
2015/12-至今，南京大学，教授
2014/04-至今，南方医科大学，教授，博士研究生导师
2013/04-至今，南京大学、南京医科大学，硕士研究生导师
2013/12-至今，南京大学医学院附属金陵医院，主任医师
2014/07-2017/07, Head & Neck Surgery Department, MD Anderson Medical Center, Visiting Scholar
2012/02-2014/01， Head & Neck Surgery Department, MD Anderson Medical Center, Visiting Associate Professor
2010/04-2014/03，南方医科大学，副教授，硕士研究生导师
2、科研情况简介
从事口腔医学临床专业工作20余年，现任南京大学医学院附属金陵医院口腔科主任医师、教授、博士研究生导师。技术专长为牙体牙髓、牙周病、牙缺失等口腔常见病、多发病的诊治及美容修复、微创修复、种植修复和颌面缺损赝复等。担任医学研究生学报编委、Journal of dental research 等近十个杂志同行评议人。2012年2月至2014年2月为美国MD Anderson Medical Center客座副教授。2014年7月至2017年7月为美国MD Anderson Medical Center访问****。
已发表60余篇论文，其中第一、通讯作者SCI论文24篇，SCI累计影响因子80余分。2011年，获得Frechette世界口腔修复新研究奖； 获江苏省科技厅第十三届江苏省青年科技奖。以第一负责人身份主持国家自然科学基金项目4项， 江苏省“333工程”科研项目2项， 2014年获得江苏省自然科学基金-****基金项目资助。江苏省“333”、 江苏省“六大人才高峰”等高层次人才培养工程培养对象及江苏省医学重点人才；南京医科大学优秀研究生导师团队。
3、研究兴趣
主要研究方向是口腔生物材料与组织工程；头颈部放化疗患者的口腔健康维护：研究采用水基电泳成型技术，克服纳米粉体表面比大、易团聚问题，成功成型氧化锆修复体，在提高材料机械性能的同时大幅降低了制作成本，具有临床应用价值；制备了微观形态与人骨松质相近的三维联通纳米氧化锆多孔支架，支架孔径和孔隙率皆为可控，骨髓间充质干细胞在支架上附着及生长情况俱佳，成骨分化表达良好，为进一步的临床应用转化奠定了基础；基于对放化疗患者的口腔健康普查得出的结果，结合美国MD Anderson Cancer Center放、化疗患者口腔健康检查维护方法与防护措施，制定符合我国放化疗患者的口腔健康检查、防护、治疗方法，编写放化疗患者口腔健康指导手册，预防和治疗癌症患者因放化疗引起的口颌系统不适和并发症，以期提高放化疗患者口颌系统健康水平。?

代表性论文

Shuai Yi#*, Bingyao Liu, Guilong Zhou, Liang Rong, Chunzi Niu, Lei Jin *.Oral manifestations related to malaria: A systematic review.Oral Diseases. 2020;00:1–5. (accepted) (IF=2.625)
Shuai Yi#*, Wang Junlan#, Jianghui Juan#, Yu Yang, Lei Jin *. Oral-maxillofacial adverse events related to antimalarials. Oral Dis. 2020. (accepted) (IF=2.625)
Yi Shuai, Zhang Zhang, Tao Guo, Rui Yang, Lei Jin*, Wenjia Liu* Postmenopausal Osteoporosis: A Mini Review European Medical Journal. EMJ EUROPEAN MEDICAL JOURNAL . RHEUMATOLOGY ? July 2019:90-100
Shuai Yi#, Yang Rui#, Mu Rui#, Yu Yang, Rong Liang, Lei Jin*. MiR-199a-3p Mediates the Adipogenic Di?erentiation of Bone Marrow-Derived Mesenchymal Stem Cells by Regulating KDM6A/WNT Signaling. LIF=e Sci. 2019; 220(\):84-91( IF=3.448)
Shengqi Zang, Rui Mu, Feng Chen, Xiaocui We, Lei Zhu, Biyao Han, Hongchuan Yu, Bo Bi,Bo Chen, Qintao Wang, Lei Jin*, Injectable chitosan/β-glycerophosphate hydrogels with sustained release of BMP-7 and ornidazole in periodontal wound healing of class III furcation defects. Materials Science & Engineering C 99 (2019) 919–928 (IF=4.959)
Lei Zhu, Juan Ma, Rui Mu, Ruiqiao Zhu, Feng Chen, Xiaocui Wei, Xiaolei Shi, Shengqi Zang, Lei Jin*. Bone morphogenetic protein 7 promotes odontogenic dIF=ferentiation of dental pulp stem cells in vitro. LIF=e Sciences. June 2018, 202(1) 175-181 (IF=2.93)
Rui Yang, Yurong Tao, Chao Wang, Yi Shuai, Lei Jin*, Circulating microRNA panel as a novel biomarker to diagnose bisphosphonate-related osteonecrosis of the jaw . International Journal of Medical Science. 2018; 15(14): 1694-1701(IF=2.333)
Wang,Lei;Asempah,Isaac;Li,Xu;Zang,Shengqi;Zhou,Yanfei;Ding,Jie;LeiJin*.Indentation size effect in aqueous electrophoretic deposition zirconia dental ceramic. Journal of materials research.dol:10.1557/jmr. 2018.464 (IF=1.982)
Shengqi Zang*,Lei Zhu*, Kefu Luo,Rui Mu,Feng Chen, Xiaocui Wei, Xiaodong Yan,Biyao Han,Xiaolei Shi,Qintao Wang, LeiJin*.Chitosan composite scaffold combined with bone marrowderived mesenchymal stem cells for bone regeneration: in vitro and in vivo evaluation. Oncotarget 2017. 8 :110890-110903(IF=5.168)
Wang, Lei*, Isaac Asempah, Song-Tao Dong, Pian-Pian Yin, Lei Jin*, Quantitative studies of electric field intensity on atom dIF=fusion of Cu/Ta/Si stacks during annealing, Surface Science,2017,399,215–219 (IF=4.439)
Shengqi Zang#, Lei Jin#, Shuai Kang, Xin Hu, Meng Wang, Jinjin Wang, Bo Chen, Bo Peng and Qintao Wang*. Periodontal Wound Healing by Transplantation of Jaw Bone Marrow-Derived Mesenchymal Stem Cells in Chitosan/Anorganic Bovine Bone Carrier into One-Wall Infrabony Defects in Beagles. Journal of Periodontology, 2016, 87(8):971-81(IF=3.030)
Yinglan Zhu,Ruiqiao Zhu,Juan Ma,Zhiqiang Weng,Yang Wang,Xiaolei Shi,Yicai Li,Xiaodong Yan,Zhen Dong,Jinke Xu,Chengzhong Tang and Lei Jin*. In vitro cell proliferation evaluation of porous nano-zirconia scaffolds with dIF=ferent porosity for bone tissue engineering.Biomed Mater,2015.10(5):055009. (IF=3.361)
Kun Yuan#, Fu Wang#, Jing Gao, Xiang Sun, Zai-Xi Deng, Hui Wang, Lei Jin*, Ji-Hua Chen*, Effect of zircon-based tricolor pigments on the color, microstructure, flexural strength and translucency of a novel dental lithium disilicate glass-ceramic. J Biomed Mater Res Part B 2013. 2014;102(1):98-107 (IF=2.759)
Lei Jin#, Erich M. Sturgis, Yang Zhang#, Zhigang Huang, Peng Wei, Wei Guo, Zhongqiu Wang, Qingyi Wei, Xicheng Song, and Guojun Li*,Genetic variants in p53-related genes confer susceptibility to second primary malignancy in patients with index squamous cell carcinoma of head and neck. Carcinogenesis, 2013,34(7):1551-1557. (IF=5.266)
Lei Jin#, Erich M. Sturgis, Xiaolin Cao#, Xicheng Song, Taufiq Salahuddin, Qingyi Wei, and Guojun Li*,Interleukin-10 promoter variants predict HPV-positive tumors and survival of squamous cell carcinoma of the oropharynx. The FASEB Journal,2013.27(6):2496-2503(IF=5.48)
Lei Jin#, Erich M Sturgis, Yang Zhang#, Zhigang Huang#, Xicheng Song, Chao Li, Qingyi Wei, and Guojun Li*, Association of tumor necrosis factor-alpha promoter variants with risk of HPV-associated oral squamous cell carcinoma. Molecular Cancer. 2013.12:80(IF=5.397)
Xicheng Song#, Lei Jin#, Erich M. Sturgis, Zhongqiu Wang, Qingyi Wei, Guojun Li*, Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx. International Journal of Cancer. 2013.133(3):695-704(IF=5.007)
Wei Bao#, Lei Jin#, Hai-jing Fu#, Yong-nian Shen, Gui-Xia Lu, Huan Mei, Xin-zhi Cao, Hong-sheng Wang*, Interleukin-22 Mediates Early Host Defense against Rhizomucor pusilluscan Pathogens. PloS One. 2013.6.17,8(6)(IF=3.534)
Weiwei Nie#, Lei Jin#, Yanru Wang, Zexing Wang, Xiaoxiang Guan*. The Bioinformatics Analysis of miRNAs Signatures DIF=ferentially Expressed in HER2(+) Versus HER2(-) Breast Cancers. Cancer Biother Radiopharm. 2013.28(1):71-76(IF=1.738)
Qianli Ma#, Wei Wang#, Paul K Chu, Shenglin Mei, Kun Ji, Lei Jin*, Yumei hang*, Concentration- and time-dependent response of human gingival fibroblasts to fibroblast growth factor 2 immobilized on titanium dental implants. International Journal of Nanomedicine. 2012.7:1965-1976 (IF=3.463)
Lei Jin#, Li Xu, Xicheng Song#, Qingyi Wei, Erich M. Sturgis, Guojun Li*, Genetic variation in MDM2 and p14ARF and susceptibility to salivary gland carcinoma, PLoS One. 2012.09.01,7(11)(IF=3.73)
Lei Jin #, Wang SH,Wang ZY*,Chen LL, Wang XH*, Fabrication of nanosized 3Y-TZP ceramic dental restoration frameworks on gypsum models by aqueous electrophoretic deposition,Advances in Applied Ceramics,2008.2.01,107(1):34-36 (IF=0.871)
Lei Jin#, Zhongyi Wang, Liangliang Chen, Jun Jia, Xiaohui Wang*,Aqueous electrophretic deposition fabricate allceramic dental crown,Journal of US-China Medical Science,2007.04.01,04(01):17-20
Lei Jin #, Wang Zhongyi, Chen Liangliang, Jia Jun,Wang Xiaohui*, Fabrication of in-ceram dental restoration by aqueous electrophoretic deposition, Rare Metal Materials and Engineering,2007.9.0136:191-194

承担科研项目

1. 头颈部放化疗患者口颌系统健康维护研究，江苏省医学重点人才培养类别A，100万，课题编号：ZDRCA**
2.可诱导表达三维联通纳米骨组织工程支架系统的建立优化及修复颌面缺损应用研究，江苏省****基金，100万，课题编号：BK**
3. 基于钠米氧化锆/羟基磷灰石复合支架的RU486嵌合反式激活表达系统在颌骨修复中作用的基础研究，国家自然科学基金面上项目，65万，课题编号：**
4. 颌面部骨组织缺损体外纳米复合材料支架的构建及性能研究，国家自然科学基金面上项目，28万，课题编号：**
5.基于纳米二氧化锆氧化石墨烯复合HIF-1α/LMP-1双基因转染的牙髓干细胞支架修复颌骨缺损的研究，国家自然科学基金面上项目，25万，课题编号：**
6. 水基EPD近型成型高强度纳米Y-TZP义齿修复生物陶瓷，国家自然科学基金面上项目，8万，课题编号：**
7.癌症放化疗对颌面部、口腔的影响及防护方案的研究，江苏省第五期“333高层次人才培养工程”第二层次培养对象，15万，课题编号：BK**
12.牙科全瓷修复，江苏省“333”科研项目资助，6万，课题编号：BRA**