博士研究生导师简介
姓名
李维勤
研究方向：
重症医学


联系方式


学术兼职：
全军重症医学专业委员会主任委员
中国医师协会胰腺病分会副主任委员
中华医学会重症医学分会常委
江苏省医学会重症医学分会副主任委员
江苏省医学会胰腺病分会副主任委员

个人简介

东部战区总医院重症医学科主任，重症胰腺炎中心主任，南京大学医学院教授、博士生导师，********。
带领团队对重症救治技术进行系统的研究，在重症急性胰腺炎的ICU治疗、早期肠内营养、微创治疗，以及腹腔高压、腹腔感染、腹腔出血和门静脉血栓等并发症处理方面积累了丰富经验，所在的重症胰腺炎中心是目前全国收治转诊病人最多、疗效最好的治疗中心之一。以第一作者或通讯作者发表SCI文章90余篇。有关科研成果以第一完成人先后获得教育部高校科技进步奖二等奖1项、江苏省科技进步一等奖1项、江苏省科技进步二等奖1项、军队医疗成果二等奖1项和军队科技进步二等奖1项。

代表性论文[近2年通讯作者或第一作者]

1.Shi XL, Yang Q, Pu N, Li XY, Chen WW, Zhou J, Li G, Tong ZH, Ferec C, Cooper DN et al: Identification and functional characterization of a novel heterozygous missense variant in the LPL associated with recurrent hypertriglyceridemia-induced acute pancreatitis in pregnancy. Molecular genetics & genomic medicine 2020, 8(3):e1048.
2.Li XY, Pu N, Chen WW, Shi XL, Zhang GF, Ke L, Ye B, Tong ZH, Wang YH, Liu G et al: Identification of a novel LPL nonsense variant and further insights into the complex etiology and expression of hypertriglyceridemia-induced acute pancreatitis. Lipids in health and disease 2020, 19(1):63.
3.Xie X, Yuan C, Yin L, Zhu Q, Ma N, Chen W, Ding Y, Xiao W, Gong W, Lu G et al: NQDI-1 protects against acinar cell necrosis in three experimental mouse models of acute pancreatitis. Biochemical and biophysical research communications 2019, 520(1):211-217.
4.Wu J, Ma X, Chen W, Yang N, Gao L, Mao W, Yang J, Yang Q, Dong J, Tong Z et al: Protective effects of HTD4010, a Reg3alpha/PAP-derived peptide, in mouse model of acute pancreatitis via toll-like receptor 4 pathway. Biochemical and biophysical research communications 2019, 512(4):670-677.
5.Mao W, Wu J, Zhang H, Zhou J, Ye B, Li G, Gao L, Li X, Ke L, Tong Z et al: Increase in serum chloride and chloride exposure are associated with acute kidney injury in moderately severe and severe acute pancreatitis patients. Pancreatology : official journal of the International Association of Pancreatology (IAP) [et al] 2019, 19(1):136-142.
6.Li G, Ke L, Tong Z, Li W, Ouyang X, Chen C: Is it necessary for all patients to use prokinetic agents to place a trans-pyloric tube? Intensive care medicine 2019.
7.Li G, Gao L, Zhou J, Ye B, Zhang J, Qu C, Ke L, Tong Z, Li W: Management of Splenic Abscess after Splenic Arterial Embolization in Severe Acute Pancreatitis: A 5-Year Single-Center Experience. Gastroenterology research and practice 2019, 2019:**.
8.Ke L, Mao W, Zhou J, Ye B, Li G, Zhang J, Wang P, Tong Z, Windsor J, Li W: Stent-Assisted Percutaneous Endoscopic Necrosectomy for Infected Pancreatic Necrosis: Technical Report and a Pilot Study. World journal of surgery 2019, 43(4):1121-1128.
9.Gao L, Ke L, Li WQ: Accurate and Dynamic Monitoring of Pancreatic Endocrine Function Is Required in Discharged Patients With Necrotizing Pancreatitis. Gastroenterology 2019, 157(3):892.
10.Fei Y, Li WQ: APnet, an innovative multidisciplinary medical information platform for acute pancreatitis. Revista da Associacao Medica Brasileira (1992) 2019, 65(2):118-122.
11.Chen WW, Yang Q, Li XY, Shi XL, Pu N, Lu GT, Tong ZH, Chen JM, Li WQ: Identification of a novel and heterozygous LMF1 nonsense mutation in an acute pancreatitis patient with severe hypertriglyceridemia, severe obesity and heavy smoking. Lipids in health and disease 2019, 18(1):68.
12.Yong Li YP, 1 Lin Gao,1 Jingzhu Zhang ,1 Xiaochun Xie,1 Zhihui Tong ,1, Baiqiang Li GL, 1 Guotao Lu ,1,2 and Weiqin Li 1: Corrigendum to "Naringenin Protects against Acute Pancreatitis in Two Experimental Models in Mice by NLRP3 and Nrf2/HO-1 Pathways". 2018, 2018:**.
13.Ye B, Mao W, Chen Y, Tong Z, Li G, Zhou J, Ke L, Li W: Aggressive Resuscitation Is Associated with the Development of Acute Kidney Injury in Acute Pancreatitis. Digestive diseases and sciences 2018.
14.Yang N, Li B, Pan Y, Tu J, Liu G, Lu G, Li W: Hypertriglyceridaemia delays pancreatic regeneration after acute pancreatitis in mice and patients. Gut 2018, 68(2):378-380.
15.Yang N, Ke L, Tong Z, Li W: The effect of thymosin alpha1 for prevention of infection in patients with severe acute pancreatitis. Mediators of inflammation 2018, 18(sup1):53-60.
16.Xing J, Zhang Z, Ke L, Zhou J, Qin B, Liang H, Chen X, Liu W, Liu Z, Ai Y et al: Enteral nutrition feeding in Chinese intensive care units: a cross-sectional study involving 116 hospitals. Critical care (London, England) 2018, 22(1):229.
17.Tu J, Yang Y, Zhang J, Yang Q, Lu G, Li B, Tong Z, Ke L, Li W, Li J: Effect of the disease severity on the risk of developing new-onset diabetes after acute pancreatitis. Medicine (Baltimore) 2018, 97(22):e10713.
18.Liu J, Zou GJ, Yang L, Rong S, Li BQ, Tong ZH, Li WQ, Li JS: Early Prediction of Persistent Organ Failure by Circulating Endothelial Progenitor Cells in Patients With Acute Pancreatitis. Shock (Augusta, Ga) 2018, 50(3):265-272.
19.Li Y, Pan Y, Gao L, Zhang J, Xie X, Tong Z, Li B, Li G, Lu G: Naringenin Protects against Acute Pancreatitis in Two Experimental Models in Mice by NLRP3 and Nrf2/HO-1 Pathways. Mediators of inflammation 2018, 2018:**.
20.Li Y, Pan Y, Gao L, Lu G, Zhang J, Xie X, Tong Z, Li B, Li G, Li W: Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression. Biochemical and biophysical research communications 2018, 495(4):2439-2447.
21.Li X, Yang Q, Shi X, Chen W, Pu N, Li W, Li J: Compound but non-linked heterozygous p.W14X and p.L279 V LPL gene mutations in a Chinese patient with long-term severe hypertriglyceridemia and recurrent acute pancreatitis. BMC gastroenterology 2018, 17(1):144.
22.Li X, Ke L, Dong J, Ye B, Meng L, Mao W, Yang Q, Li W: Significantly different clinical features between hypertriglyceridemia and biliary acute pancreatitis: a retrospective study of 730 patients from a tertiary center. BMC gastroenterology 2018, 18(1):89.
23.Li B, Yang N, Li C, Li C, Gao K, Xie X, Dong X, Yang J, Yang Q, Tong Z et al: INT-777, a bile acid receptor agonist, extenuates pancreatic acinar cells necrosis in a mouse model of acute pancreatitis. Biochemical and biophysical research communications 2018:1-7.
24.Ke L, Mao W, Li X, Zhou J, Li G, Ye B, Tong Z, Li W: The Pancreatitis Activity Scoring System in Predicting Infection of Pancreatic Necrosis. The American journal of gastroenterology 2018.
25.Gao L, Zhang J: Air Medical Transportation for Severe Acute Pancreatitis Patients over an Extra Long Distance: Is It Safe Enough? 2018, 2018:**.
26.Gao L, Lu GT, Lu YY, Xiao WM, Mao WJ, Tong ZH, Yang N, Li BQ, Yang Q, Ding YB et al: Diabetes aggravates acute pancreatitis possibly via activation of NLRP3 inflammasome in db/db mice. American journal of translational research 2018, 10(7):2015-2025.
27.Fei Y, Liu XQ, Gao K, Xue CB, Tang L, Tu JF, Wang W, Li WQ: Analysis of influencing factors of severity in acute pancreatitis using big data mining. 2018, 64(5):454-461.
28.Fei Y, Hu J, Gao K, Tu J, Wang W, Li WQ: Risk Prediction for Portal Vein Thrombosis in Acute Pancreatitis Using Radial Basis Function.Ann Vasc Surg. Annals of vascular surgery 2018, 47:78-84.
29.Fei Y, Gao K, Tu J, Wang W, Zong GQ, Li WQ: Predicting and evaluation the severity in acute pancreatitis using a new modeling built on body mass index and intra-abdominal pressure. American journal of surgery 2018, 216(2):304-309.
30.Fei Y, Gao K, Li WQ: Artificial neural network algorithm model as powerful tool to predict acute lung injury following to severe acute pancreatitis. Revista da Associacao Medica Brasileira (1992) 2018, 18(8):892-899.
31.Fei Y, Gao K, Li WQ: Prediction and evaluation of the severity of acute respiratory distress syndrome following severe acute pancreatitis using an artificial neural network algorithm model. HPB : the official journal of the International Hepato Pancreato Biliary Association 2018.


承担科研项目[项目负责人]

2019-2022 “战时危重伤员重要脏器功能的快速检测和救治关键技术研究”
全军后勤科研重大项目
2018-2020 “全军急重症救治研究重点实验室”军队后勤科研条件实验室项目
2018-2020 “现代战争条件下战伤救治技术集成研究”全军十三五重大项目子课题
2019-2021 “肝脏特异性表达人LPLS447X预防LPL基因缺陷型高甘油三酯血症急性胰腺炎的实验室研究”国家自然基金面上项目

获奖情况

2018．10 “基于人工智能的急性胰腺炎数据挖掘及其并发症辅助诊断的应用”
苏省医学新技术引进一等奖（第一完成人）
2017.2 “重症急性胰腺炎救治关键技术的创新与应用”
教育部高校科学技术进步奖二等奖（第一完成人）
2013．10 “创伤感染的代谢改变和特殊营养支持”
获军队科技进步奖二等奖（第一完成人）
2009.1 “重症急性胰腺炎的实验和临床研究”
获江苏省科技进步奖一等奖（第一完成人）
2006.2 “重症急性胰腺炎的综合治疗进步”
军队医疗成果奖二等奖（第一完成人）
2000.10 “严重腹腔感染病人低蛋白血症的分子机理和防治研究”
获江苏省科技进步奖二等奖（第一完成人）