董咸池 教授 博士生导师





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电子邮件： xianchidong@nju.edu.cn








个人简介
研究方向
科研成果





个人简介
本科 南京大学生命科学学院
博士 中国科学院 上海生命科学研究院
博士后 哈佛大学 医学院
讲师 哈佛大学 医学院
教授 南京大学 生命科学学院


学术兼职



研究方向
免疫与凝血系统中重要蛋白质与蛋白质复合物的研究


获奖情况


科研成果
Dong X.,SpringerT.A. (2020)Disulfide Exchange in Multimerization of von Willebrand factor and Gel-forming Mucins.Blood.
Dong X., LeksaN.C., ChhabraE.S., ArndtJ.W., Lu Q., KnockenhauerK.E., Peter R., SpringerT.A. (2019) The von Willebrand Factor D’D3 Assembly and Structural Principles for Factor VIII binding and Concatemer Biogenesis. Blood. 133, 14, 1523-1533
Feng J.*, Dong X.*, Pinello J.F.*,Zhang J.*, Lu C., Iacob R.E., Engen J.R., Snell W.J., Springer T.A. (2018) Fusion surface structure, function, and dynamics of gamete fusogen HAP2. Elife. 2018, 7, e39772
Dong X.*, Zhao B.*, Lin F. Lu C., Roger B.N., Springer T.A. (2018) High integrin αVβ6 affinity reached by hybrid domain deletion slows ligand-binding on-rate.Proc Natl Acad Sci115(7), E1429-E1436
Dong X.*, Zhao B.*, Iacob R.E., Zhu J., Koksal A.C., Lu C., Engen J.R., Springer T.A. (2017) Force Interacts with Macromolecular Structure in Activation of TGF-b. Nature542, 55-59
Kotecha A., Wang Q., Dong X., Ilca S., Ondiviela M., Rao Z., Seago J., Charleston B., Fry E., Abrescia N., Springer A. *, Huiskonen J. *, Stuart D.*Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus. Nature communication. 2017
Wang J, Dong X., Zhao B., Li J., Lu C., Springer T.A.* Atypical Interactions of Integrin αvβ8 with pro-TGF-β1, Proc Natl Acad Sci, 2017,
Dong X., Hudson N., Lu C., Springer T.A. (2014)Structural determinants of integrin β-subunit specificity for latent TGF-β. Nat. Struct. & Mol. Biol.21 (12), 1091-1096
Blenner M.A., Dong X., Springer T.A. (2014) Towards the structural basis of regulation by force of von Willebrand factor binding to Glycoprotein Ib. J. Biol. Chem.289, 5565-5579
Dong X.,Mi L., Zhu J., Wang W., Hu P., Luo B. H., Springer T.A. (2012) αVβ3 Integrin crystal structures and their functional implications. Biochemistry51, 8814-8828
Wang R., Zhu J., Dong X., Shi M., Lu C., Springer T.A. (2012) GARP regulates the bioavailability and activation of TGF-β. Mol. Biol. Cell.23, 1129-1139
Chen H., Dong X., Zhou M., Shi H., Luo X. (2011) Docking-based virtual screening of potential human P2Y12 receptor antagonists. Acta. Biochim. Biophys. Sin.43, 400-408.
Zhou M.*, Dong X.*, Baldauf C., Chen H., Zhou Y., Springer T.A., Lu X., Zhong, C., Grater, F., Ding, J. (2011) A novel calcium-binding site of von Willebrand factor A2 domainregulates its cleavage by ADAMTS13. Blood.117, 4623-4631.
Zhou B., Wang S., Xu L.X., Meng F.L., Xuan Y.J., Duan Y.M., Wang J.Y., Hu H., Dong X., Ding J., Zhou J.Q. (2010) SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation. Mol. Cell. Biol.30, 2391-2400.
Zhou M.*, Dong X.*, Shen N., Zhong C., Ding J. (2010) Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design. Nucleic Acids Res.38, 3399-3413.
Dong X.*, Zhou M.*, Zhong C., Yang B., Shen N., Ding J. (2010) Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase. Nucleic Acids Res.38, 1401-1412. (Cover Story & Featured Article)
Dong X.*, Yang B.*, Li Y., Zhong C., Ding J. (2009) Molecular basis of the acceleration of the GDP-GTP exchange of human Ras homolog enriched in brain by human translationally controlled tumor protein. J. Biol. Chem.284, 23754-23764.