魏炜 副教授 博士生导师





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邮政编码：

联系地址：
电子邮件： weiwei@nju.edu.cn








个人简介
研究方向
科研成果





个人简介


学术兼职



研究方向
1，生物体内微量金属元素和无机多聚物的代谢机制及调控功能：
微量金属元素和无机多聚物在生命过程中有着一系列其他物质所不能替代的特殊作用。这些物质在体内的代谢水平紊乱，会导致多种疾病,包括癌症、神经退行性疾病、中风、脑出血、创伤性脑损伤等。为了研究其在生物体内的代谢机制及调控功能，我们将运用化学生物学，生物无机化学，微生物学，合成生物学和蛋白质组学等多学科交叉的研究方法，相关的主要课题包括：
（1）细胞铁死亡相关金属蛋白的作用机制；
（2）多聚磷酸盐在原核及真核系统中的生物学功能。

2，基于光电驱动的新型半人工光合作用：
半人工光合作用系统是通过将具有光电催化功能的材料与具有生物活性的酶/微生物细胞复合构建的杂化系统，是合成生物学，化学生物学和材料科学等学科国际****共同关注的热点。设计开发新型的半人工光合系统并应用到医药和生物技术研究中将具有重要的科研价值和巨大的社会效益。相关的主要课题包括：
（1）光电驱动的微生物“非天然”生物合成。

3，无机二维材料和金属介导的免疫调控与干预。


获奖情况
南京大学“仲英青年****”
2019年度南京大学魅力导师奖
2018年度南京大学本科教学实践优秀教师
国际基因工程机器大赛金牌（2015,2016,2018,2019）
国际基因工程机器大赛最佳能源项目单项奖（2016）



科研成果
代表性论文、论著：
Wang, Xiuxiu#; Hu, Yi#; Mo, Jianbin#; Zhang, Jingyi; Wang, Zhenzhen;Wei, Wei; Li, Huanlin; Xu, Yun; Ma, Jing; Zhao, Jing*; Jin, Zhong*; Guo, Zijian*; Arsenene: A Potential Therapeutic Agent for Acute Promyelocytic Leukaemia Cells by Acting on Nuclear Proteins, Angewandte Chemie International Edition, 2020, 59(7): 5151-5158.
Mo, Jianbin#; Xu, Yun#; Wang, Xiuxiu#; Wei, Wei*; Zhao, Jing*; Exploiting the protein corona: coating of black phosphorus nanosheets enables macrophage polarization via calcium influx, Nanoscale, 2020, 12(3): 1742-1748.
Wang, Xiuxiu#; Chen, Feng#; Zhang, Jingyi; Sun, Jianxuan; Zhao, Xinyang; Zhu, Yuelu; Wei, Wei*; Zhao, Jing*; Guo, Zijian*; A ferroptosis-inducing iridium(III) complex, Science China Chemistry, 2020, 63(1): 65-72.
Wang, Xin; Shi, Chenke; Mo, Jianbin; Xu, Yun; Wei, Wei*; Zhao, Jing*; An Inorganic Biopolymer Polyphosphate Controls Positively Charged Protein Phase Transitions, Angewandte Chemie International Edition, 2020, 59(7): 2679-2683.
Wang, Xiuxiu; Zhang, Jingyi; Zhao, Xinyang; Wei, Wei*; Zhao, Jing*; Imaging and proteomic study of a clickable iridium complex, Metallomics, 2019, 11(8): 1344-1352.

W. Wei(#); P. Sun; Z. Li; K. Song; W. Su; B. Wang; Y. Liu; J. Zhao(*), A surface-display biohybrid approach to light-driven hydrogen production in air, Science Advances, 2018.2.21, 4(2) IF：12.804
Mo Jianbin(#); Xie Qingyun; W. Wei(*); Zhao Jing(*), Revealing the immune perturbation of black phosphorus nanomaterials to macrophages by understanding the protein corona, Nature Communications, 2018.06.26, 9(1): 2480IF：11.878
Yan Li(#); Sun Peiqing; Xu Yun; Xu Yun; W.Wei(*); Zhao Jing(*), Integration of a Gold-Specific Whole E. coli Cell Sensing and Adsorption Based on BioBrick, International Journal of Molecular Sciences, 2018, 19(12)IF：4.183
X. Wang(#); M. Zhu; F. Gao; W. Wei; Y. Qian; H.-K. Liu(*); J. Zhao(*), Imaging of a clickable anticancer iridium catalyst, Journal of Inorganic Biochemistry, 2017.12.29, 180: 179~185IF：3.224
X. Wang(#); X. Wang; K. Hui; W. Wei; W. Zhang; A. Miao; L. Xiao; L. Yang, Highly Effective Polyphosphate Synthesis, Phosphate Removal, and Concentration Using Engineered Environmental Bacteria Based on a Simple Solo Medium-Copy Plasmid Strategy, Environmental Science & Technology, 2017, 52(1): 214~222IF：7.149
S. Cai(#); Y. Shen; Y. Zou; P. Sun;W. Wei(*); J. Zhao(*); C. Zhang(*), Engineering highly sensitive whole-cell mercury biosensors based on positive feedback loops from quorum-sensing systems, Analyst, 2017.12.11, 143(3): 630~634IF：4.019
F. Xiong(#); L. Lu; T.-Y. Sun; Q. Wu; D. Yan; Y. Chen; X. Zhang; W. Wei; Y. Lu; W.-Y. Sun; J. J. Li; J. Zhao(*), A bioinspired and biocompatible ortho-sulfiliminyl phenol synthesis, Nature Communications, 2017.1.19, 8IF：11.878
Q. Wu(#); D. Yan(#); Y. Chen(#); T. Wang; F. Xiong; W. Wei; Y. Lu; W.-Y. Sun; J. J. Li; J. Zhao(*), A redox-neutral catechol synthesis, Nature Communications, 2017.1.27, 8: 14227~14227IF：11.878
W. Wei(#); Y. Sun(#); M. Zhu; X. Liu; P. Sun; F. Wang; Q. Gui; W. Meng; Y. Cao(*); J. Zhao(*), Structural Insights and the Surprisingly Low Mechanical Stability of the Au–S Bond in the Gold-Specific Protein GolB, Journal of the American Chemical Society, 2015, 137(49): 15358~15361IF：14.695
Wei, Wei(#); Liu, Xiangzhi; Sun, Peiqing; Wang, Xin; Zhu, Hong; Hong, Mei; Mao, Zong-Wan(*); Zhao, Jing(*), Simple Whole-Cell Biodetection and Bioremediation of Heavy Metals Based on an Engineered Lead-Specific Operon, Environmental Science & Technology, 2014.3.18, 48(6): 3363~3371IF：7.149
Yang, Maiyun(#); Jalloh, Abubakar S.; Wei, Wei; Zhao, Jing(*); Wu, Peng(*); Chen, Peng R.(*), Biocompatible click chemistry enabled compartment-specific pH measurement inside E-coli, Nature Communications, 2014.9, 5: 4981IF：11.878
Wang, Dongqi(#); Cai, Sheng; Ben, Rong; Zhou, Yang; Li, Xingwei; Zhao, Jing; Wei, Wei(*); Qian, Yong(*), Direct Access to Isoindolinone Derivatives by Palladium-Catalyzed C-H Activation and Isocyanide Insertion by Using Molecular Oxygen as the Sole Oxidant, Synthesis, 2014.8, 46(15): 2045~2050IF：2.867
Yan, Li(#); Yan, Yiyong; Pei, Lei; Wei, Wei(*); Zhao, Jing(*), A G-quadruplex DNA-based, Label-Free and Ultrasensitive Strategy for microRNA Detection., Scientific Reports, 2014, 4: 7400~7400IF：4.011
Yang, Hualin(#); Cui, Hanli; Wang, Longgang; Yan, Li; Qian, Yong; Zheng, Xi Emily; Wei, Wei(*); Zhao, Jing(*), A label-free G-quadruplex DNA-based fluorescence method for highly sensitive, direct detection of cisplatin, Sensors and Actuators B: Chemical, 2014.10, 202: 714~720IF：6.393
Wei, Wei(#); Zhu, Tianze; Wang, Yue; Yang, Hualin; Hao, Ziyang; Chen, Peng R.(*); Zhao, Jing(*), Engineering a gold-specific regulon for cell-based visual detection and recovery of gold, Chemical Science, 2012, 3(6): 1780~1784IF：9.556
Wei, Wei(#); Yang, Chun; Luo, Jun; Lu, Changmei; Wu, Yajun; Yuan, Sheng(*), Synergism between cucumber alpha-expansin, fungal endoglucanase and pectin lyase, Journal of Plant Physiology, 2010, 167(14): 1204~1210IF：2.825