王小明 副教授 硕士生导师





办公电话：
邮政编码： 210023

联系地址：
电子邮件： wangxm07@nju.edu.cn








个人简介
研究方向
科研成果





个人简介


学术兼职
中国化学会会员
中国药学会高级会员






研究方向
天然药物化学

化学生物学






获奖情况


科研成果
论文：
一、王小明已经发表的部分研究成果：(*通讯作者)
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1．Lin Hong-Yan, Li Zi-Kang, Bai Li-Fei, Baloch Karim Shahla, Wang Fang, Qiu Han-Yue, Wang Xue, Jin-Liang Qi, Rong-Wu Yang, Wang Xiao-Ming * and Yang Yong-Hua. Synthesis of phenyl thiazole acyl shikonin ester derivatives as anti-cancer agents through microtubule stabilization. Biochemical Pharmacology. 2015, 96(2), 93-106.

2．Qiu Han-Yue, Wang Peng-Fei, Li Zhen, Ma Jun-Ting, Wang Xiao-Ming, * Yang Yong-Hua, Zhu Hai-Liang. Synthesis of dihydropyrazole sulphonamide derivatives that act as anti-cancer agents through COX-2 inhibition. Pharmacological Research. 2016, 104: 86-96.

3．Qiu Han-Yue, Zhu Xiang, Luo Yue-Lin, Lin Hong-Yan, Tang Cheng-Yi, Qi Jin-Liang, Pang Yan-Jun, Yang Rong-Wu, Lu Gui-Hua, Wang Xiao-Ming,* Yang Yong-Hua. Shikonin Derivatives Targeting STAT3 SH2 Domain Induce Antitumor Effects. Scientific Reports 2017, 7, 2863.

4．Hu Yang, Li Cui-Yun, Wang Xiao-Ming, Yang Yong-Hua, Zhu Hai-Liang. 1, 3, 4-Thiadiazole: synthesis, reactions and applications in medicinal, agricultural, materials chemistry. Chemical Reviews. 2014, 114(10): 5572-5610.

5．Sun Wen-Xue, Ji Ya-Jing, Wan Yun, Han Hong-Wei, Lin Hong-Yan, Lu Gui-Hua, Qi Jin-Liang*, Wang Xiao-Ming*, Yang Yong-Hua*. Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents. Bioorganic & Medicinal Chemistry Letters 2017, 27 4066–4074.

6．Zhang Ya-Han, Han Hong-Wei, Qiu Han-Yue, Lin Hong-Yan, Yu Lu-Gang, Zhu Wan-Zhan, Qi Jin-Liang, Yang Rong-Wu, Pang Yan-Jun, Wang Xiao-Ming, * Lu Gui-Hua, and Yang Yong-Hua. Antiviral activity of a synthesized Shikonin ester against influenza A (H1N1)virus and its insights into its mechanism. Biomedicine & Pharmacotherapy 2017,93:636-645.

7．Zhang Ya-Han, Han Hong-Wei, Qiu Han-Yue, Lin Hong-Yan, Yu Lu-Gang, Zhu Wan-Zhan, Qi Jin-Liang, Yang Rong-Wu, Pang Yan-Jun, Wang Xiao-Ming, * Lu Gui-Hua, and Yang Yong-Hua. Antiviral activity of shikonin ester derivative PMM-034 against enterovirus 71 in vitro. Brazilian Journal of Medical and Biological Research 2017,50(10): e6586.

8．Qiu Han-Yue, Wang Fang, Wang Xue, Sun Wen-Xue, Qi Jin-Liang, Pang Yan-Jun, Yang Rong-Wu, Lu Gui-Hua, Wang Xiao-Ming,* Yang Yong-Hua. Design, synthesis, and biological evaluation of chalcone-containing shikonin derivatives as inhibitors of tubulin polymerization.ChemMedChem 2017,12(5):399-406.

9．Wang Zi-Zhen, Sun Wen-Xue, Wang Xue, Zhang Ya-Han, Qiu Han-Yue, Qi Jin-Liang, Pang Yan-Jun, Lu Gui-Hua, Wang Xiao-Ming,* Yu Fu-Gen, Yang Yong-Hua. Design, Synthesis, Biological evaluation and 3D-QSAR Analysis of podophyllotoxin-dioxazole combination as tubulin targeting anticancer agents. Chemical Biology & Drug Design 2017，90:236-243.

10．Qiu Han-Yue, Wang Peng-Fei, Wang Zi-Zhen, Luo Yue-Lin, Hu Dong-Qing, Qi Jin-Liang, Lu Gui-Hua, Pang Yan-Jun, Yang Rong-Wu, Zhu Hai-Liang, Wang Xiao-Ming*, Yang Yong-Hua*. Shikonin derivatives as inhibitors of tyrosyl-tRNA synthetase: Design, synthesis and biological evaluation. RSC Advances, 2016, 6, 83003-83010.

11．Han Hong-Wei, Qiu Han-Yue, Hu Cui, Sun Wen-Xue, Yang Rong-Wu, Qi Jin-Liang, Wang Xiao-Ming,* Lu Gui-Hua and Yang Yong-Hua. Design, synthesis and anti-cancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs. Bioorganic & Medicinal Chemistry Letters 2016,26(14),3237-3242.

12．Baloch Karim Shahla, Ma Lin, Wang Xue-Liang, Shi Jing, Zhu Yu, Wu Feng-Yao, Pang Yan-Jun, Lu Gui-Hua, Qi Jin-Liang, Wang Xiao-Ming,* Gu Hong-We and Yang Yong-Hua. Design, Synthesis and Mechanism of Novel Shikonin Derivatives as Potent Anticancer Agents. RSC Advances, 2015, 5(40), 31759-31767.

13．Lin Hong-Yan, Li Zi-Kang, Han Hong-Wei, Qiu Han-Yue, Gu Hong-Wei, Yang Yong-Hua, Wang Xiao-Ming.* Synthesis of novel aryl dithian valeryl podophyllotoxin ester derivatives as potential anti-tubulin agents RSC Advances, 2015, 5(59),47511-47521.

14．Lin Hong-Yan, Bai Li-Fei, Wang Fang, Wu Xun, Han Lu-Jing, Baloch Karim Shahla, Yang Yong-Hua, Wang Xiao-Ming.* Semi-synthesis and anti-lung cancer activity evaluation of aryl thiazol acyl podophyllotoxin ester derivatives. RSC Advances 2015, 5(35), 27775 - 27784.

15．Baloch Karim Shahla, Ma Lin, Xu Guo-Hua, Bai Li-Fei, Zhao Hua, Tang Cheng-Yi, Pang Yan-Jun, Yang Rong-Wu, Wang Xiao-Ming,* Lu Gui-Hua, Yang Yong-Hua. A Potent Anticancer Agent of Shikonin Derivative Targeting Tubulin, Chirality 2015, 27：274-280.

16．Lin Hong-Yan, Han Hong-Wei, Bai Li-Fei, Qiu Han-Yue, Yin De-Zheng, Qi Jin-Liang, Wang Xiao-Ming,* Gu Hong-Wei and Yang Yong-Hua. Design, Synthesis and Biological Evaluation of Shikonin Thio-glycoside Derivatives: New Anti-Tubulin Agents. RSC Advances 2014,4(91)，49796-49805.

17．Qiu Han-Yue, Wang Zhong-Chang, Wang Peng-Fei, Yan Xiao-Qiang, Wang Xiao-Ming*, Yang Yong-Hua, Zhu Hai-Liang. Design, Synthesis, Evaluation and 3D-QSAR Analysis of Benzosulfonamide Benzenesulfonates as Potent and Selective Inhibitors of MMP-2. RSC Advances 2014, 4(74), 39214−39225.

18．Baloch Karim Shahla, Ling Li-Jun, Qiu Han-Yue, Ma Lin, Lin Hong-Yan, Huang Shou-Cheng, Qi Jin-Liang, Wang Xiao-Ming,* Lu Gui-Hua, Yang Yong-Hua. Synthesis and biological evaluation of novel shikonin ester derivatives as potential anti-cancer agents. RSC Advances 2014, 4(67), 35588−35596.

19．Guo Jing, Chen Xiao-Feng, Liu Jing, Lin Hong-Yan, Han Hong-Wei, Liu Hong-Chang, Huang Shou-Cheng, Baloch Karim Shahla, Andrew Kulek, Qi Jin-Liang,Wang Xiao-Ming, * Ling Li-Jun,* and Yang Yong-Hua. Novel Shikonin Derivatives Targeting Tubulin as Anti-cancer Agents. Chemical Biology & Drug Design 2014, 84(5), 603−615.

20．Wang Xiao-Ming, Lin Hong-Yan, Kong Wen-Yao, Guo Jing, Shi Jing, Huang Shou-Cheng, Qi Jin-Liang, Yang Rong-Wu, Gu Hong-Wei and Yang Yong-Hua.* Synthesis and Biological Evaluation of Heterocyclic Carboxylic Acyl Shikonin Derivatives. Chemical Biology & Drug Design 2014, 83(3):331-343.

21．Dong Jing-Jun, Li Qing-Shan, Liu Zhi-Peng, Wang Shu-Fu, Zhao Meng-Yue, Yang Yong-Hua, Wang Xiao-Ming*, Zhu Hai-Liang. Synthesis, Biological Evaluation and Molecular Docking Studies of Flavone and Isoflavone Derivatives as a Novel Class of KSP (Kinesin Spindle Protein) Inhibitors. European Journal of Medicinal Chemistry 2013, 70, 427-433.

22．Kong Wen-Yao, Chen Xiao-Feng, Shi Jing, Baloch Karim Shahla, Qi Jin-Liang, Zhu Hai-Liang, Wang Xiao-Ming* and Yang Yong-Hua. Design and Synthesis of Fluoroacylshikonin as Anticancer Agents. Chirality 2013, 25, 757-762.

23．Zhang Hao, Zheng Yu-Qiong, Guo Jing, Wang Xiao-Ming*, and Yang Yong-Hu. Synthesis, Docking and Biological Evaluations of Isoquinolonic Acid Derivatives. Chemical Research in Chinese Universities. 2013, 29(6): 1110-1114.

24．Li Yao, Zhao Chang-Po, Ma Hua-Ping, Zhao Meng-Yue, Xue Ya-Rong, Wang Xiao-Ming*, Zhu Hai-Liang. Design, Synthesis and Antimicrobial Activities Evaluation of Schiff Base Derived from Secnidazole Derivatives as Potential FabH Inhibitors. Bioorganic & Medicinal Chemistry. 2013, 21(11): 3120-3126.

25．Sun Juan, Li Ming-Hui, Qian Shao-Song, Guo Feng-Jiao, Dang Xiao-Fang, Wang Xiao-Ming*, Xue Ya-Rong, Zhu Hai-Liang. Synthesis and Antitumor Activity of 1, 3, 4-oxadiazole Possessing 1, 4-benzodioxan Moiety as a Novel Class of Potent Methionine Aminopeptidase type II Inhibitors. Bioorganic & Medicinal Chemistry Letters. 2013, 23(10): 2876-2879.

26．Lin Hong-Yan, Chen Wei, Shi Jing, Kong Wen-Yao, Qi Jin-Liang, Wang Xiao-Ming * and Yang Yong-Hua. Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives. Chemical Biology & Drug Design. 2013, 81(2), 275-283.

27．Luo Yin, Zhang Li-Rong, Hu Yang, Zhang Shuai, Fu Jie, Wang Xiao-Ming*, and Zhu Hai-Liang. Synthesis and Antimicrobial Activities of Oximes Derived from O-Benzyl hydroxylamine as FabH Inhibitors. ChemMedChem. 2012, 7(9), 1587-1593.

28．Yang Xian-Hui, Lu Xiang, Li Xi, Zhao Ting-Ting, Zhang Hui, Zhou Wen-Ping, Wang Xiao- Ming*, Gong Hai-Bin, Zhu Hai-Liang. Synthesis, biological evaluation, and molecular docking studies of 1, 3, 4-thiadiazol-2-amide derivatives as novel anticancer agents. Bioorganic & Medicinal Chemistry. 2012, 20(9): 2789-2795.

29．Qiu Ke-Ming, Wang Hai-Hong, Wang Li-Ming, Luo Yin, Yang Xian-Hui, Wang Xiao-Ming*, Zhu Hai-Liang. Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors. Bioorganic & Medicinal Chemistry. 2012, 20(6): 2010-2018.

30．Zhang Hui, Lu Xiang, Zhang Li-Rong, Liu Jia-Jia, Yang Xian-Hui, Wang Xiao-Ming*, Zhu Hai-Liang. Design, synthesis and biological evaluation of N-phenylsulfonylnicotinamide derivatives as novel antitumor inhibitors. Bioorganic & Medicinal Chemistry. 2012, 20(4): 1411-1416.

31． Zhang Hong-Jia, Qin Xuan, Liu Kai, Zhu Di-Di, Wang Xiao-Ming*, Zhu Hai-Liang. Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N0-phenyl-thiourea. Bioorganic & Medicinal Chemistry. 2011, 19(18): 5708-5715.

32．Sun Juan, Cao Ning, Zhang Xiao-Min, Yang Yu-Shun, Zhang Yan-Bin, Wang Xiao-Ming*, Zhu Hai-Liang. Oxadiazole derivatives containing 1, 4-benzodioxan as potential Immuno -suppressive agents against RAW264.7 cells. Bioorganic & Medicinal Chemistry. 2011, 19(16): 4895-4902.

33．Wang Xiao-Ming, Zhang Suo-Qin, Zhu Ling, Wang Si-Si, Li Xin-Yuan, Fang Qian-Rong, Yin Ya-Le, Liu Hao-Yan, Li Yao-Xian, Jia Gao-Feng, Pang Yan-Jun, Qi Jin-Liang, Wang Xiu-Qiang, Yang Yong-Hua*. Synthesis and Crystal Structure of N3-(dimethylpyrimidine) -N4-(tri-O-acetyl-xylosyl) thiourea. Chinese Journal of Structural Chemistry. 2008. 27(3): 321-325.

34．Wang Xiao-Ming, Li Yao-Xian, Liu Hao Yan, Li Xin-Yuan, Yang Yong-Hua, Jia Gao-Feng, Zhang Suo-Qin*. “Synthesis and Characterization of Novel N-glucoside”. Acta Chimica Sinica. 2008, 66(4): 492-495.

35．Wang Xiao-Ming, Zhu Tao, Zheng Liang-Yu, Li Yao-Xian, Zhang Suo-Qin, Bai Jie. “Synthesis of β-D-Glucopyranosyl Thiourea and Biological Activity”. Chinese Journal of Organic Chemistry. 2006, 26(5): 660-666.

36．Zheng Ji-Fu, Li Yao-Xian, Zhang Suo-Qin, Yang Song-Tao, Wang Xiao-Ming, Wang Yong- Zhi, Bai Jie, Liu Fu-An. New N-terminal prolyl-dipeptide derivatives as organocatalysts for direct asymmetric aldol reaction. Tetrahedron Letters. 2006, 47: 7793-7796.

37．Zheng Ji-Fu, Li Yao-Xian, Zhang Suo-Qin, Wang Xiao-Ming, Yang Song-Tao, Bai Jie, Wang Fang, Zhang Guang-Liang, Liu Fu-An. Studies on Synthesis of Novel Chiral Organocatalysts and Its Evaluations for Asymmetric Direct Aldol Reactions. Acta Chimica Sinica. 2007, 65(6): 553-556.

38．Yang Song-Tao, Zhang Suo-Qin, Zhang Guang-Liang, Wang Xiao-Ming and Li Yao-Xian. Novel Catalytic Method for Synthesis of Glycosyl Esters by Combining PTC with DMAP. Chemical Research in Chinese Universities 2007, 23(4): 426-429.

二、王小明已经发表的会议文章列表：
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1.Lin Hong-Yan, Li Zi-Kang, Bai Li-Fei, Baloch Karim Shahla, Wang Fang, Qiu Han-Yue, Wang Xue, Qi Jin-Liang, Yang Rong-Wu, Wang Xiao-Ming*, Yang Yong-Hua *. Synthesis of Phenyl Thiazole Acyl Shikonin Ester Derivatives as Anti-cancer Agents through Microtubule Stabilization. Drug Discovery & Therapy World Congress 2015, Boston, USA （2015. 7.22-26）

2.Han Hong-Wei, Qiu Han-Yue, Wang Xiao-Ming,* Yang Yong-Hua.* Synthesis and Biological Evaluation of Podophyllotoxin Derivatives as Potent Anticancer Agents.2015第九届有机化学会议，长春，东北师范大学（2015）（邀请报告）

3.Han Hong-Wei, Han Lu-jing, Wang Xiao-Ming*, Yang Yong-Hua*. A novel shikonin derivative induces the cervical cancer cell line Hela cells via mitochondria-mediated pathway. 2015年长三角药物化学会议，南京，中医药大学药学院（2015.11.13-14）

4.Li Deng-Chao, Shi Jing, Wang Xiao-Ming*, Yang Yong-Hua*. Synthesize and anticancer mechanism of a novel shikonin derivative as an EGFR Inhibitor. 2015年长三角药物化学会议，南京，中医药大学药学院（2015.11.13-14）

5.Qiu Han-Yue, Wang Zi-Zhen, Luo Yue-Lin, Wang Xiao-Ming*, Yang Yong-Hua*. Synthesis and evaluation of novel shikonin derivatives as potent antitumor agents. 2015年长三角药物化学会议，南京，中医药大学药学院（2015.11.13-14）（口头报告）

6.Han Hong-Wei, Han Lu-Jing, Wang Xiao-Ming,* and Yang Yong-Hua.* A novel shikonin derivative induces the cervical cancer cell line Hela cells via mitochondria-mediated pathway. 2015年长三角药物化学会议，墙报，南京，中医药大学药学院（2015.11.13-14）

7.Li Deng-Chao, Shi Jing, Wang Xiao-Ming,* and Yang Yong-Hua. * Synthesize and anticancer mechanism of a novel shikonin derivative as an EGFR Inhibitor. 2015年长三角药物化学会议，墙报，南京，中医药大学药学院（2015.11.13-14）

8.Qiu Han-Yue, Wang Zi-Zhen, Luo Yue-Lin, Wang Xiao-Ming,* Yang Yong-Hua.* Synthesis and evaluation of novel shikonin derivatives as potent antitumor agents. 2015年长三角药物化学会议，墙报，南京，中医药大学药学院（2015.11.13-14）

9.王小明,* 孔文尧, 郑雨琼, 杨永华.* 2011. 异喹啉酸衍生物的合成，中国化学会第七届有机化学学术会议论文集, No.3-8, P1195. 南京，2011.11.12-15

10.浩日沁巴图, 林红燕, 王小明,* 杨永华.* 新法合成2, 3-二氨基吡啶，中国化学会第七届有机化学学术会议论文集, No.3-3, P1190. 南京，2011.11.12-15
11.Liu Hong-Chang, Shi Jing, Wang Xiao-Ming,* Yang Yong-Hua.* synthesis of Novel 5, 8- Dihydroxy-1, 4-Naphthoquinone Derivatives, 中国化学会第七届有机化学学术会议论文集, No.3-4, P1191. 南京，2011.11.12-15

12.王小明, 刘昊琰，张靖靖，杨永华. * 邻苯二甲酰肼取代二硝基苯胺的合成，2009年，中国化学会第六届有机化学学术会议论文集; P545. 西安，2009.8.17-20

13.王小明, 李鑫源，袁文，贺斐，杨永华. * 2007 “新型Topo I异构酶抑制剂的设计与合成”.年. 中国化学会第五届有机化学学术会议论文集，P374, 郑州，2007. 8. 1-4.

14.王小明, 庞延军，刘少华，杨永华，张锁秦，李耀先. 2006. “基于生物安全新型糖酯除草化合物的设计合成” 中国农业生物技术学会生物安全分会成立会论文集，P44, 南京，2006.12.1-3.




专著：
石明旺主编，王小明第一副主编. 新编常用农药安全使用指南. 北京：化学工业出版社（2010.12）




专利：
1．王小明，缪律，张浩，杨永华，浩日沁巴图，刘昊琰，杨晓亮，石明旺，田壮，郑雨琼，乙酰化糖基硫脲衍生物制备及其在异喹啉酸合成中的应用，授权号：ZL6.9

2．王小明，杨永华，刘洪昌，石婧，孔文尧，郭靖，黄守程，刘静，孔令如，张培培. 紫草宁苯氧羧酸酯类衍生物及其合成方法和应用.授权号：ZL6.X，

3．王小明，刘业好，刘根林，杨永华，刘昊琰，顾宏伟，王玲玲，朱思梅，陈静，萘茜糖类衍生物及其制备方法和应用，公开号：CN A

4．王小明，杨永华，邱寒月，陆桂华，林红燕，韩洪苇. 紫草宁衍生物及其合成方法和应用，申请号：4.5

5．王小明，杨永华，邱寒月，林红燕，韩洪苇. 一种羟肟酸类化合物及其制备方法与应用， 公开号：CNA

6．王小明，杨永华，石婧. 一类新颖结构紫草宁酯作为表皮生长因子受体抑制剂的应用，申请号：.9

7．杨永华, 王小明, 刘少华, 李鑫源, 刘昊琰, 赵卫国, 杨建文, 殷晶晶, 袁文勇, 圣丙刚. 紫草宁糖类衍生物及其合成方法和应用.授权号：ZL9.8

8．杨永华, 王小明, 浩日沁巴图, 刘洪昌, 戚金亮, 林红燕, 石婧, 孔文尧. 紫草宁含氟羧酸酯类衍生物及其合成方法和应用，公开号：CNA

9．杨永华，王小明，浩日沁巴图，韩秋敏，刘洪昌，林红燕，石婧，孔文尧. 二取代和三取代糖基紫草宁衍生物及其制备方法和应用，公开号：CNA

10．杨永华，王小明，林红燕，石婧，刘洪昌，孔文尧，浩日沁巴图，黄守程，紫草宁肉桂酸酯类衍生物及其合成方法和应用，公开号：CNA

11．杨永华，孔文尧，石婧，王小明，张培培，刘洪昌，林红燕，孔令如，刘静，郭靖. 一类紫草宁酯类衍生物的合成方法及应用，公开号：CNA

12．杨永华，夏红梅，戚金亮，王小明，杨荣武，刘洪昌，浩日沁巴图，张靖靖，孔文 尧.紫草宁及其衍生物或修饰物的脂质体的制备方法和应用， 公开号：CNA