学术学位博导
--> 职称：教授
**
单位：病原生物学系
hkbi@njmu.edu.cn
专业：微生物学
个人简介
毕洪凯，男，博士，现任南京医科大学病原生物学系教授，博士生导师。2009年毕业于日本千叶大学，获医药学博士学位。2009年至2015年在美国伊利诺伊大学做博士后和研究科学家，研究方向为细菌脂肪酸生物合成及其调控机制的多样性研究。现为美国微生物学会、生化与分子生物学会会员，担任专业期刊如PLOS ONE、Microbiology(SGM)、FEMS Microbiology Letters、Research in Microbiology、Current Microbiology、Annals of Microbiology和Journal of Basic microbiology等多种SCI期刊审稿专家人。2015年受聘于南京医科大学，致力于病原细菌与宿主相互作用和幽门螺杆菌生理代谢等方面的研究工作。现主持国家自然基金面上项目1项，并作为主要参与者参加美国国立卫生研究院（NIH）项目两项。代表性论文1. Bi H*, Zhu L, Jia J, Zeng L, Cronan JE*. Unsaturated Fatty Acid Synthesis in the Gastric Pathogen Helicobacter pylori Proceeds via a Backtracking Mechanism. Cell Chem Biol. 2016,23(12):1480-14892. Bi H*, Zhu L, Jia J, Cronan JE*. A Biotin Biosynthesis Gene Restricted to Helicobacter.Sci Rep. 2016, 12;6:211623. Bi H, Yu Y, Dong H, Wang H, Cronan JE. Xanthomonas campestris RpfB is a fatty acyl-CoA ligase required to counteract the thioesterase activity of the RpfF diffusible signal factor (DSF) synthase. Molecular Microbiology. 2014,93(2):262-275 4. Bi H*, Zhang C. Integration host factor is required for the induction of acid resistance in Escherichia coli. Current Microbiology. 2014, 69(2):218-224 (*corresponding author)5. Bi H, Zhu L, Wang H, Cronan JE. Inefficient Translation Renders the Enterococcus faecalis fabK Enoyl-ACP Reductase Phenotypically Cryptic. Journal of Bacteriology. 2014, 196(1):170-179 6. Zhu L†, Bi H†, Ma J, Hu Z, Zhang W, Cronan JE, Wang H.. The two functional enoyl-acyl carrier protein reductases of Enterococcus faecalis do not mediate triclosan resistance. mBio. 2013, 4(5):e00613-13 (†equal contribution) 7. Bi H, Wang H, Cronan JE. FabQ, a dual-function dehydratase/isomerase, circumvents the last step of the classical fatty acid synthesis cycle. Chemistry & Biology. 2013, 20(9):1157-1167 8. Bi H, Christensen QH, Feng Y, Wang H, Cronan JE. The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities. Molecular Microbiology. 2012, 83(4):840-855 9. Bi H, Sun L, Fukamachi T, Saito H, Kobayashi H. HU participates in expression of a specific set of genes required for growth and survival at acidic pH in Escherichia coli. Current Microbiology. 2009, 58(5):443-448.
发表论文:
Unsaturated Fatty Acid Synthesis in the Gastric Pathogen Helicobacter pylori Proceeds via a Backtracking Mechanism.
Integration host factor is required for the induction of acid resistance in Escherichia coli.
The Burkholderia cenocepacia BDSF quorum sensing fatty acid is synthesized by a bifunctional crotonase homologue having both dehydratase and thioesterase activities.
HU participates in expression of a specific set of genes required for growth and survival at acidic pH in Escherichia coli.
Inefficient Translation Renders the Enterococcus faecalis fabK Enoyl-ACP Reductase Phenotypically Cryptic
The two functional enoyl-acyl carrier protein reductases of Enterococcus faecalis do not mediate triclosan resistance
FabQ, a dual-function dehydratase/isomerase, circumvents the last step of the classical fatty acid synthesis cycle
A Biotin Biosynthesis Gene Restricted to Helicobacter.
Comparative Genomics of H. pylori and Non-Pylori Helicobacter Species to Identify New Regions Associated with Its Pathogenicity and Adaptability
Xanthomonas campestris RpfB is a fatty acyl-CoA ligase required to counteract the thioesterase activity of the RpfF diffusible signal factor (DSF) synthase
教材专著:
科研成果:
幽门螺杆菌感染的基础和个人化诊治研究及其推广应用
目前承担的科研项目:
幽门螺杆菌不饱和脂肪酸生物合成新途径研究（31570053）
南京医科大学引进人才启动基金（2015RC01）
高通量新靶点抗细菌、癌症耐药先导物的筛选与评价
一条全新的细菌生物素前体的生物合成途径研究
江苏特聘教授
江苏特聘医学专家
已经完成的科研项目:
