李林，教授，博士生导师
祖籍江苏徐州，生于安徽寿县


联系方式
地址：南京市新模范马路5号, 南京工业大学丁家桥校区(210009)
Email: iamlli@njtech.edu.cn
个人简历
2014至今, 南京工业大学，先进材料研究院，教授
2009-2014，新加坡国立大学，化学系，博士后（YAO Shao Q.教授）
2004-2009，安徽大学，化学化工学院，博士（田玉鹏、杨家祥教授）
2000-2004，安徽大学，化学化工学院，学士
研究方向
（1）有机/生物医学光子学
（2）线粒体特异性检测与调控
主要学术成绩
课题组主要关注“合成小分子生物功能调节的生物医学光子学”研究，涵盖生物光子学/有机化学/药物化学/蛋白质工程，专注线粒体特异性的病理学生物体系显影新方法在早期诊疗和转化新药开发中的应用。研究成果在活体层面上分别揭示了小分子荧光探针在检测和调控蛋白质活性中的作用，同时在基因水平上阐述了该类合成小分子生物功能调节剂在疾病诊断、信号转导和药物开发等生物医学领域巨大的应用前景。迄今为止，在Journal of the American Chemical Society, Angewandte Chemie International Edition, Chemical Society Reviews, Nature Communications, Accounts of Chemical Research, Advanced materials等期刊上累计发表SCI收录论文200余篇，申请/授权专利41/12项，参与编撰专著《分子影像与精准诊断》一本。先后当选“中国青年化学家元素周期表Mc元素”代言人，“中国生物医学工程学会生物医学光子学分会”青年委员，“中国环境诱变剂学会活性氧生物学效应专业委员会”青年委员，新加坡神经医学研究院（NNI）客座研究员, 《材料导报》编委，《中国临床药理学与治疗学》青年编委，江苏省侨联青年委员会第三届委员会常务委员。
代表作
1. Y. Ding, Z. Li, C. Xu, W. Qin, Q. Wu, X. Wang, X. Cheng,* Lin Li,* W. Huang,* “Recent Progress of Fluorogenic Probes/Inhibitors of β-Lactamase and their Applications in Drug-Resistant Bacteria” Angew. Chem. Int. Ed., 2021, 60, 24-40.
2. S. Liew, X. Qin,* J. Zhou, Lin Li,* W. Huang, S.Q. Yao* “Smart Design of Nanomaterials for Mitochondria-targeted Nanotherapeutics” Angew. Chem. Int. Ed., 2021, 60, 2232-2256.
3. Y. Xue,? H. Bai,? B. Fang, B. Peng,* Lin Li,* W. Huang,* N. Voelcker* “Stimulus-cleavable Linker Chemistry in the Field of Controlled Drug Delivery” Chem. Soc. Rev., 2021, DOI: 10.1039/CS-SYN-08-2020-001061.
4. Z. Shi, X. Han, W. Hu,* H. Bai, B. Peng, L. Ji, Q. Fan, Lin Li,* W. Huang,* “Bioapplications of Small Molecular Aza-BODIPY: from Rational Structure Design to in vivo Investigations” Chem. Soc. Rev., 2020, 49, 7533-7567.
5. H. Fang, H. Zhang, Lin Li,* Y. Ni, R. Shi, Z. Li, X. Yang, B. Ma, C. Zhang, Q. Wu, C. Yu, S.Q. Yao,* W. Huang,* “Rational Design of Two-photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues” Angew. Chem. Int. Ed., 2020, 59, 7536-7541.
6. J. Li, X. Li, Y. Yuan, Q. Wang, L. Xie, Y. Dai, W. Wang, Lin Li,* X. Lu*, Q. Fan*, W. Huang “Efficient Polysulfide-based Nanotheranostics for Triple-negative Breast Cancer: Ratiometric Photoacoustics Monitored Tumor Microenvironment-initiated H₂S Therapy” Small, 2020, 16, **.
7. J. Li,^? Y. Liu,^? Y. Xu,^? Lin Li,* Y. Sun,* W. Huang, “Recent Advance in the Development of NIR-II Organic Emitters for Biomedicine” Coordin. Chem. Rev., 2020, 415, 213318.
8. L. Wang,^? W. Du,^? Z. Hu, K. Uvdal, Lin Li,* W. Huang,* “Hybrid Rhodamine Fluorophores in the Visible-NIR Region for Biological Imaging” Angew. Chem. Int. Ed., 2019, 58, 14026-14043.
9. P. Yuan, X. Mao, X. Wu, S. Liew, Lin Li,* S.Q. Yao,* “Mitochondria-targeted Intracellular Delivery of Native Proteins by Using Biodegradable Silica Nanoparticles” Angew. Chem. Int. Ed., 2019, 58, 7657-7661.
10. X. Qin,^? C. Yu,^? J. Wei, C. Zhang, Q. Wu, J. Liu, Lin Li,* S.Q. Yao,* W. Huang,* “Rational Design of Nanocarriers with Stimuli-response for Intracellular Protein Delivery” Adv. Mater., 2019, 31(46), **.
11. S.B. Du, S.S. Liew, Lin Li,* S.Q. Yao,* “Bypassing Endocytosis: Direct Cytosolic Delivery of Proteins” J. Am. Chem. Soc., 2018, 140, 15986-15996.
12. L. Qian, J. Fu, P. Yuan, S. Du, W. Huang, Lin Li,* S.Q. Yao,* “Intracellular Delivery of Native Proteins Facilitated by Cell-Penetrating Poly(disulfide)s” Angew. Chem. Int. Ed., 2018, 57, 1532-1536 (Front Cover).
13. L. Qian, Lin Li,* S.Q. Yao,* “Two-photon Small Molecule Enzymatic Probes” Acc. Chem. Res., 2016, 49, 626-634.
14. Lin Li, C.-W. Zhang, J. Ge, L. Qian, K.-L. Lim, S.Q. Yao,* “A Small Molecule Probe Capable of Selective Profiling and Imaging of Monoamine Oxidase B (MAO-B) Activities in Parkinson’s Disease Models” Angew. Chem. Int. Ed., 2015, 54, 10821-10825.
15. Lin Li, C.-W. Zhang, G.Y.J. Chen, B.W. Zhu, C. Chai, Q.-H. Xu, E.-K. Tan, Q. Zhu, K.-L. Lim,* S.Q. Yao,* “A Sensitive Two-photon Probe to Selectively Detect Monoamine Oxidase B Activity in Parkinson's Disease Models” Nat. Commun., 2014, 5, 3276.
16. Lin Li, X.-Q. Shen, Q.-H. Xu, S.Q. Yao,* “A Switchable Two-photon Membrane Tracer Capable of Imaging Membrane-Associated Protein Tyrosine Phosphatase Activities” Angew. Chem. Int. Ed., 2013, 52, 424-428.
17. Lin Li, J.-Y. Ge, H. Wu, Q.-H. Xu, S.Q. Yao,* “Organelle-specific Detection of Phosphatase Activities with Two-photon Fluorogenic Probes in Cells and Tissues” J. Am. Chem. Soc., 2012, 134, 12157-12167.