何明芳副教授



联系方式
+86-

电子邮箱
mingfanghe@njtech.edu.cn


研究领域
人源化肿瘤异种移植模型；化学生物学的血管新生调控的机制研究；基于模式动物斑马鱼平台的药物活性筛选及药物代谢的研究

部门
制药工程系




主要课程


个人简介
联系方式
办公地点：南京市浦珠南路30号，南京工业大学生工学科群楼A1-401，B1-602
电话：+86-
Email：mingfanghe@njtech.edu.cn;
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教育经历
2004/08-2009/08，香港中文大学，生物系，博士
1997/09-2000/06，中国药科大学，中药学院，硕士
1993/09-1997/06，中国药科大学，中药学院，本科
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工作经历
2015/03-至今，南京工业大学，生物与制药工程学院，副教授，硕导
2009/09-2015/02，南京工业大学，药学院，副教授，硕导
2010/08-2011/01，美国乔治亚医学院，生物技术与基因组医学中心，访问****
2004/03-2004/04，香港浸会大学，中医药学院，研究助理
2003/05-2004/07，南京工业大学，制药与生命科学院，讲师
2000/08-2003/04，南京工业大学，制药与生命科学院，助教
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荣誉
指导2014年度校优秀硕士学术学位论文一名 （学生姓名：高晓平；论文题目：基于斑马鱼模型的7种抗肿瘤活性化合物的毒性评估及金诺芬的抗血管新生活性研究）
指导2018年度校优秀硕士专业学位论文一名（学生姓名：张贺忠；论文题目：对香豆酸甲酯的抗血管新生活性研究）
优秀论文三等奖 第三届中药现代化新剂型新技术国际学术会议暨第二届医院中药药学学术研讨会，北京，2009年9月
口述报告一等奖 香港-澳门中药研究生论坛，香港国际会展中心，2006年8月17号
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学术兼职
世界中医药学会联合会中药新剂型给药系统专业委员会理事
Journal of Ethnopharmacology , RCS Advances, Toxicology and Applied Pharmacology, Scientific Reports, Chemosphere杂志的通讯评审
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研究方向

人源化肿瘤异种移植模型的建立，以及用于研究肿瘤与微环境相互作用，抗肿瘤药物的评价。
基于化学生物学的血管新生调控的机制研究；
基于模式动物斑马鱼平台的药物活性筛选（血管新生，色素形成，脑出血，骨骼发育，wnt信号通路，BMP信号通路）、毒性评价（心脏、骨骼、肢体）及药物代谢的研究。

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主持科研项目情况

江苏省科技厅重点研发计划临床前沿技术(Co-PI)，BE**，基于多组学技术支撑斑马鱼PDX模型的进展期胃癌精准化疗模式的研究，2018-2021
江苏省科技厅重点研发计划临床前沿技术(Co-PI)，BE**，基于多组学特征谱的胃癌分子分型技术和精准诊疗研究，2017-2020
江苏省六大人才高峰C类，SWYY-024，病人来源的斑马鱼异种移植模型指导前列腺癌个性化治疗，2016.10-2019.9
江苏省科技厅重点研发计划规范化诊疗项目（Co-PI），BE**，中晚期帕金森病脑深部刺激手术规范化诊疗研究，2016-2019
江苏省科技厅重点研发计划社会发展面上项目，BE**，循环肿瘤细胞特异性标志物的发现-前列腺癌的早期诊断和个性化治疗的关键技术研究，2015-2018
雷公藤片标准中雷公藤甲素含量测定方法验证及片剂中雷公藤甲素的稳定性研究。
教育部博士点新教师基金，005，姜科中二苯基庚烷类新型血管新生抑制剂的研究，2013-2015
江苏省自然科学基金，BK**，益智仁抗血管新生抗癌新功效的研究，2011-2014

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代表性著作
学术论文

Lin QH, Qu W, Xu J, Feng F*, He MF*. 1-Methoxycarbony-β-carboline from Picrasma quassioides exerts anti-angiogenic properties in HUVECs in vitro and zebrafish in vivo. Chinese Journal of Nature Medicines, 2018; 16(8): 599-609.
Zhang HZ, Li CY, Wu JQ, Wang RX, Wei P, Liu MH, He MF*. Anti-angiogenic activity of para-coumaric acid methyl ester on HUVECs in vitro and zebrafish in vivo. Phytomedicine, 2018; 48: 10-20.
Wu JQ#, Zhai J#, Li CY, Tan AM, Wei P, Shen LZ*, and He MF*. Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer. Journal of Experimental & Clinical Cancer Research 2017; 36(1): 160.
Li K, Wu JQ, Jiang LL, Shen LZ, Li JY, He ZH, Wei P, Lv Z, and He MF*. Developmental toxicity of 2,4-dichlorophenoxyacetic acid in zebrafish embryos. Chemosphere 2017; 171: 40-48.
Jiang LL, Liu MH, Li JY, He ZH, Li H, Shen N, Wei P, and He MF*. Mycophenolic acid-induced developmental defects in zebrafish embryos. International Journal of Toxicology. 2016; 35(6): 712-718.
Jiang LL, Li K, Lin QH, Ren J, He ZH, Li H, Shen N, Wei P, Feng F, and He MF*. Gambogic acid causes fin developmental defect in zebrafish embryo partially via retinoic acid signaling. Reproductive Toxicology 2016; 63: 161-168.
Wang YC, Wu YN, Wang SL, Lin QH, He MF, Liu QL, and Wang JH. Docosahexaenoic acid modulates invasion and metastasis of human ovarian cancer via multiple molecular pathways. International Journal of Gynecological Cancer 2016; 26(6):994-1003.
Liu T, Jiang LL, He MF, Zhu Z, Wang DB, Song TS, Tan WM, Ouyang P and Xie J. Green synthesis of reduced graphene oxide by a GRAS strain Bacillus subtilis 168 with high biocompatibility to zebrafish embryos. RSC Advances 2015; 5(74): 60024-60032.
Wang J, Ma R, Sharma A, He M, Xue J, Wu J, Dun B, Li G, Wang X, Ji M, She JX, Tang J. Inflammatory serum proteins are severely altered in metastatic gastric adenocarcinoma patients from the Chinese population. PLoS One 2015; 10(4): e**.
陈丽晓, 何明芳, 高晓平, 蒋玲玲, 殷志琦, 濮存海. 基于斑马鱼模型探讨猪牙皂皂苷类药物急性毒性与结构的关系. 药学服务与研究, 2015; 15(6):466-468.
高晓平, 陈丽晓, 殷志琦, 蒋玲玲, 林清华, 何明芳*. 益智仁中二苯基庚烷类化合物的血管生成抑制活性. 中国药科大学学报, 2015; 46(1): 85-88.
He MF, Gao XP, Li SC, He ZH, Chen N, Wang YB, She JX*. Anti-angiogenic effect of auranofin on HUVECs in vitro and zebrafish in vivo. European Journal of Pharmacology 2014; 740:240-247.
Xu H, Wu J, Chen B, Li M, Tian Y, He M, Xue J, Wang J, Bai S, Sharma A, Liu H, Tang J*, She JX*. Serum dickkopf (DKK1) is significantly lower in patients with lung cancer but is rapidly normalized after treatment. American Journal of Translational Research 2014; 6(6): 850-856.
Zhi W, Ferris D, Sharma A, Purohit S, Santos C, He M, Ghamande S, She JX*. Twelve serum proteins progressively increase with disease stage in squamous cell cervical cancer patients. International Journal of Gynecological Cancer 2014; 24(6): 1085-1092.
Gao XP, Feng F, Zhang XQ, Liu XX, Wang YB, She JX, He ZH, and He MF*. Toxicity assessment of 7 anticancer compounds in zebrafish. International Journal of Toxicology 2014; 33(2): 98-105.
Wang NN, Zhao LJ, Wu LN, He MF, Qu JW, Zhao YB, Zhao WZ, Li JS, Wang JH*. Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line. Asian Pacific Journal of Cancer Prevention 2013; 14(9):4983-4988.
Dun B, Xu H, Sharma A, Liu H, Yu H, Yi B, Liu X, He M, Zeng L, She JX*. Delineation of biological and molecular mechanisms underlying the diverse anticancer activities of mycophenolic acid. International Journal of Experimental Pathology 2013; 6(12):2880-2886.
Wang J, Sharma A, Ghamande SA, Bush S, Ferris D, Zhi W, He M, Wang M, Wang X, Miller E, Hopkins D, Macfee M, Guan R, Tang J, and She JX*. Serum protein profile at remission can accurately assess therapeutic outcomes and survival for serous ovarian cancer. PLoS One 2013;8(11):e78393.
王楠, 马蓉, 吴建中, 高晓平, 陆益彬, 赵丽君, 薛璟, 佘金雄, 何明芳*. 宫颈癌的发病机制、诊断及治疗进展. 中国肿瘤外科杂志, 2013; 5(2):121-124.
Jiang B, Wang WJ, Li MP, Huang XJ, Huang F, Gao H, Sun PH, He MF, Jiang ZJ, Zhang XQ*, and Ye WC*. New eudesmane sesquiterpenes from Alpinia oxyphylla and determination of their inhibitory effects on microgia. Bioorganic & Medicinal Chemistry Letters 2013; 23(13):3879-3883.
Lu S, Purohit S, Sharma A, Zhi W, He M, Wang Y, Li CJ, She JX*. Serum insulin-like growth factor binding protein 6 (IGFBP6) is increased in patients with type 1 diabetes and its complications. International Journal of Clinical and Experimental Medicine 2012; 5(3): 229-237.
何明芳, 薛璟, 吴建中, 马蓉, 路婉君, 佘金雄*. 液相芯片技术在检测肺癌患者血清VEGF中的应用. 临床检验杂志, 2012; 30(12):969-970.
Zhou Y?, He MF?, Choi FFK, He ZH, Song JZ, Qiao CF, Li SL, and Xu HX*. A high-sensitivity UPLC-MS/MS method for simultaneous determination and confirmation of triptolide in zebrafish embryos. Biomedical Chromatography 2011; 25(8): 851-857. (?共同第一作者)
He ZH, Zhou R, He MF, Lau CBS, Yue GGL, Ge W*, and But PPH*. Anti-angiogenic effect and mechanism of rhein from Rhizoma Rhei. Phytomedicine 2011; 18, 470-478.
Law SKY, Simmons MP, Techen N, Khan IA, He MF, Shaw PC, and But PPH*. Molecular analyses of the Chinese herb Leigongteng (Tripterygium wilfordii Hook.F.) Phytochemistry 2011; 72, 21-26.
He ZH, Ge W, Yue GGL, Lau CBS, He MF*, and But PPH*. Anti-angiogenic effects of the fruit of Alpinia oxyphylla. Journal of Ethnopharmacology 2010; 132, 443-449. (*共同通讯作者)
He MF, Huang YH, Wu LW*, Ge W, Shaw PC, and But PPH*. Triptolide functions as a potent angiogenesis inhibitor. International Journal of Cancer 2010; 126(1), 266-278. (编辑推荐论文)
He MF, Liu L, Ge W, Shaw, PC, Jiang R, Wu LH, and But PPH.* Antiangiogenic activity of Tripterygium wilfordii and its terpenoids. Journal of Ethnopharmacology 2009; 121(1), 61-68.
He ZH, He MF, Ma SC, and But PPH.* Anti-angiogenic effects of rhubarb and its anthraquinone derivatives. Journal of Ethnopharmacology 2009; 121, 313-317.
Liang Z, He M, Fong W, Jiang Z, Zhao Z*. A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential. Phytomedicine 2008; 15, 259-267.
濮存海, 何明芳, 张晓骞,沈佳. HPLC测定雷公藤总萜片中雷公藤内酯醇的含量. 中国中药杂志 2005; 30(4) : 266-267.
肖明芳, 何明芳, 吕浩, 应汉杰. 高效液相色谱法测定酶转化液中胞苷三磷酸及其相关物质。色谱 2005; 23(5): 564.
王奇志，何明芳，梁敬钰. 哥纳香属植物化学成分和生理活性的研究进展. 中草药 2003; 34(3): 277-280.
常永慧，刘波，应汉杰，何明芳. 分子印迹技术制备石油有机硫组分固相萃取剂的研究. 离子交换与吸附 2003; 19(5): 450-456.
肖林平, 徐正军，何明芳，应汉杰. ?NH-1分离5’-核苷酸的研究. 离子交换与吸附 ?2003; 19 (5): 430-436.
何明芳，孟正木，沃联群. 积雪草化学成分的研究. 中国药科大学学报 2000; 31(2): 91-93.
陈晓芳，何明芳，张颖，孟正木. 女贞子化学成分的研究. 中国药科大学学报 2000;31(3): 169-170.

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会议论文

He MF, Huang YH, Ge W, Shaw PC, But PPH, and Wu LW. Triptolide functions as a potent angiogenesis inhibitor. Asia-Pacific Conference of Tumor Biology and Medicine, Xi-An, China, Oct 24-27, 2009.
He MF, Huang YH, But PPH, and Wu LW. Triptolide inhibits tumor angiogenesis via blocking endothelial receptor-mediated signaling pathways. The Society of Chinese Bioscientists in American 12th International Symposium, Taipei, Taiwan, June 14-18, 2009.
But PPH, Shaw PC, Law KY, He MF, Cheng L, Jiang RW, Xu HX, Simmons MP, Khan IA, Techen N. Molecular authentication of thunder god’s vine (Tripterygium wilfordii). 5th Oxford International Conference on the Science of Botanicals (ICSB), Mississippi, USA, Aug 21-24,2006.
He MF, But PPH, Shaw PC, Jiang RW, and Xu HX. Antiangiogenic agents from Tripterygium wilfordii. Hong Kong-Macau Postgraduate Symposium on Chinese Medicine, Hong Kong, China, 17th August, 2006
He MF, But PPH, Shaw PC, Jiang RW, and Xu HX. Antiangiogenic agents from Tripterygium wilfordii. The 47th Annual Meeting of the American Society of Pharmacognosy, Arlington, Virginia, USA, Aug 5-9, 2006

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书籍

He MF, Jiang LL. (01/01/2016) Toxic and beneficial effects of dextromethorphan on central nervous system, in: Xin Wang (Eds.), Dextromethorphan: Pharmacology, Clinical Uses and Health Effects. Nova Science Publishers Inc., New York, Chapter 5. (ISBN:?978-1-63484-016-3)
助编及编委。 周荣汉，段金廒。 2005，植物化学分类学。上海科技出版社，中国上海。

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专利

何明芳，张晓欢，李崇勇。一种光化学诱导斑马鱼缺血性脑卒中模型的应用。（申请号5.9）
何明芳，张贺忠，李崇勇。香豆酸甲酯在制备抗血管新生药物中的用途。（公开号：CNA）
何明芳，蒋玲玲，林清华，冯峰。异甘草苷在制备治疗皮肤创伤愈合药物中的应用。（申请号：5.6；公开号：A）
何明芳，高晓平，佘金雄。一种模式动物斑马鱼鱼苗评价药物急性毒性的方法。（已授权，专利号：ZL1.3）
何明芳，高晓平，佘金雄，刘晓昕。金诺芬在制备抗血管生成类药物中的应用。（申请号：8.7；公开号：A ）