胡燚教授



联系方式


电子邮箱
huyi@njtech.edu.cn


研究领域
生物催化、化学催化、生物-化学组合合成技术在生物炼制、医药及其中间体、精细化学品等绿色合成中的应用研究

部门
工业生物技术创新中心




主要课程
《生物炼制》，《高等有机化学》与《药物合成反应》

个人简介
胡? 燚（yi），1975年9月生，教授。2005年3月获得浙江大学有机化学专业博士学位，2012-2013年在美国The Scripps Research Institute 做访问****研究工作。主要研究方向为生物催化、化学催化、生物-化学组合合成技术在生物炼制、医药及其中间体、精细化学品等绿色合成中的应用研究。

讲授课程：

?? 《生物炼制》，《高等有机化学》与《药物合成反应》。

科研项目：

???作为项目负责人完成了材料化学工程国家重点实验室重点课题—生物乙醇脱水制乙烯高性能分子筛催化剂复合改性和反应器设计研究（ZK200815），江苏省自然科学基金—生物乙醇脱水制乙烯高性能分子筛催化剂及其反应器研究（BK**），国家自然科学基金青年基金项目—功能化离子液体修饰介孔材料在酶固定化中的应用研究（**），中石化科技开发项目—熔盐循环等温固定床数值模拟及中试实验研究（L411003）。

???目前作为子课题负责人承担国家863计划重大项目—手性醇的不对称合成技术（2011AA02A209，2011-2015）、国家发改委高技术产业化项目—酶法生产百吨级左旋帕罗醇示范工程等项目的研究工作。共发表学术论文80余篇，获授权发明专利10余项。
近年来部分论文：

(1) Yi Hu, Jiao Yang, Ru Jia, Yan Ding. Shuang Li, He Huang*. Chemical modification with functionalized ionic liquids: a novel method to improve the enzymatic properties of Candida rugosa lipase. Bioprocess. Biosyst. Eng., DOI: 10.1007/s00449-014-1134-4.?

(2) Ru Jia, Yi Hu*, He Huang*. Improving the catalytic performance of Porcine pancreatic lipase in the presence of [MMIm][MeSO4] with the modification of functional ionic liquids. Process Biochem., DOI: org/10.1016/j.procbio.2014.01.

(3) Weiming Liu, Jixing Luo, Xiaojian Zhuang, Wenhe Shen, Yang Zhang, Shuang Li , Yi Hu*, He Huang*. Efficient preparation of enantiopure l-tert-leucine through immobilized penicillin G acylase catalyzed kinetic resolution in aqueous medium. Biochem. Eng. J., 2014, 83, 116.

(4) Bin Zou, Yi Hu*, Fengjie Cui, Ling Jiang, Dinghua Yu, He Huang*. Effect of surface modification of low cost mesoporous SiO2 carriers on the properties of immobilized lipase. J. Colloid. Interf. Sci., 2014, 417, 210.

(5) Ru Jia, Yi Hu*, Ling Jiang, He Huang*. Chemical modification for improving activity and stability of lipase B from Candida antarctica with imidazolium-functional ionic liquids. Org. Biomol. Chem., 2013, 11, 7192.

(6) Ru Jia, Yi Hu, Luo Liu, Ling Jiang, Bin Zou, He Huang*. Enhancing catalytic performance of Porcine pancreatic lipase by covalent modification using functional ionic liquids. ACS Catal., 2013, 3, 1976.

(7) Bin Zou, Yi Hu, Ling Jiang, Jiao Yang, Ru Jia, He Huang*. Mesoporous material SBA-15 modified by amino acid ionic liquid to immobilize lipase via ionic bonding and cross-linking method. Ind. Eng. Chem. Res., 2013, 52, 2844.

(8) Jiao Yang, Yi Hu, Ling Jiang, Bin Zou, Ru Jia, He Huang*. Enhancing the catalytic properties of porcine pancreatic lipase by immobilization on SBA-15 modified by functionalized ionic liquid. Biochem. Eng. J., 2013, 70, 46.

(9) Xiangjun Jiang, Yi Hu, Lin Jiang, Bin Zou, He Huang*. Optimization of enzymatic synthesis of L-ascorbyl palmitate by solvent engineering and statistical experimental designs. Biotechnol. Bioproc. Eng., 2013, 18, 350.

(10) Xiangjun Jiang, Yi Hu, Lin Jiang, Jihong Gong, He Huang*. Synthesis of vitamin E succinate using Candida rugosa lipase in organic medium. Chem. Res. Chin. Univ., 2013, 29, 223.

(11) Yi Hu, Xiangjun Jiang, Suwen Wu, Ling Jian, He Huang*.Synthesis of vitamin E succinate by interfacial activated Candida rugosa lipase encapsulated in sol-gel materials. Chin. J. Catal., 2013, 34, 1608.

(12) Xiaochen Wang, Yi Hu, Samuel Bonacorsi, Yang Hong, Richard Burrell, Jinquan Yu*. Pd(II)-Catalyzed C?H iodination using molecular I2 as the sole oxidant. J. Am. Chem. Soc., 2013, 135, 10326.

(13) 胡燚, 杨姣, 唐苏苏, 初旭明, 邹彬, 黄和*. 氨基功能化离子液体修饰的SBA-15共价固定Burkholderia cepacia脂肪酶. 高等学校化学学报, 2013, 34, 1195.

(14) 丁雁, 黄和, 胡燚*. 脂肪酶催化C-C键形成反应研究进展, 有机化学, Chin. J. Org. Chem. 2013, 33, 905.

(15) Yi Hu, Susu Tang, Ling Jiang, Bin Zou, Jiao Yang, He Huang*. Immobilization of Burkholderia cepacia lipase on functionalized ionic liquids modified mesoporous silica SBA-15. Process Biochem., 2012, 47, 2291.

(16) Susu Tang, Yi Hu*, Dinghua Yu, Bin Zou, Ling Jiang, Immobilization of Burkholderia Cepacia lipase on functionalized ionic liquids modified mesoporous silica SBA-15. Chin. J. Catal., 2012, 33, 1565.

(17) Weiming Liu, Yi Hu, Ling Jiang, Bin Zou, He Huang*, Synthesis of methyl (R)-3-(4-fluorophenyl)glutarate via enzymatic desymmetrization of a prochiral diester. Process Biochem., 2012, 47,1037.

(18) Bin Zou, Yi Hu*, Dinghua Yu, Ling Jiang, Weiming Liu, Ping Song, Functional ionic liquid modified mesoporous silica SBA-15: a novel, designable and efficient carrier for porcine pancreas lipase. Colloids and Surface B: Biointerfaces, 2011, 93.

(19) Xinjiang Huang, Yi Hu*, Dinghua Yu, Yuwang Han, Effect of fusel on dehydration reaction of ethanol to ethylene catalyzed by La/HZSM-5. Chem. Ind. Eng. Soc. Chin., 2011, 62, 97.??

(20) Bin Zou, Yi Hu, Dinghua Yu, Jiaojiao Xia, Susu Tang, Weiming Liu, He Huang*，Immobilization of porcine pancreatic lipase onto ionic liquid modified mesoporous silica SBA-15. Biochem. Eng. J., 2010, 53, 150.

(21) Yi Hu, Weiming Liu, Bin Zou, Susu Tang, He Huang*. Enzyme immobilization on mesoporous materials. Prog. Chem., 2010, 22, 1656.

(22) Yaochi Hu, Nina Zhan, Chang Dou, He Huang, Yuwang Han, Dinghua Yu，Yi Hu*. Selective dehydration of bio-ethanol to ethylene catalyzed by lanthanum-phosphorous-modified HZSM-5: influence of the fusel. Biotechnol. J., 2010, 11, 1186.

(23) Nina Zhan, Yi Hu, Heng Li, Dinghua Yu, Yuwang Han, He Huang*. Lanthanum-phosphorous modified HZSM-5 catalysts in dehydration of ethanolto ethylene: a comparative analysis. Catal. Commun., 2010, 11, 633.

(24) Xinjiang Huang, Kaimei Fu, Yaochi Hu, Bin zou, Yi Hu*, Alkylation of benzene with 1-butylene over βzeolite modified by Fe or La. Chem. Ind. Eng. Soc. Chin., 2009, 60, 2497.

(25) Yi Hu, Tao Xie, Kaimei Fu, Hui Kang, Ping Wei, He Huang*, A convenient synthesis of 5-arylidenethiazolidine-2,4-diones catalyzed by alkaline ionic liquid. Heterocycles, 2009, 78, 757.?

(26)Yi Hu, Hui Kang, Biwen Zeng, Ping Wei, He Huang*. Facile synthesis of 3-arylidene-1,3-dihydroindol-2-ones catalyzed by br?nsted acidic ionic liquids. J. Chem. Res., 2008, 642.

(27) Yi Hu*, Heng Li, He Huang, Ping Wei, Advance of liquid-phase organic synthesis using functional ionic liquids as supports. Chin. J. Org. Chem., 2007, 27, 1188.

(28)Yi Hu*, Ping Wei, Pingkai Ouyang, ZhenChu Chen, Organic synthesis in ionic liquids: condensation of 3-methyl-1-phenyl-5-pyrazolone with carbonyl compounds catalyzed by ethylenediammonium diacetate (EDDA). Chin. Chem. Lett., 2006, 17, 299.

(29) Yi Hu*, Ping Wei, He Huang and Pingkai Ouyang, Synthesis of 2-aminothiophenes on ionic liquids-phase-support using the Gewald reaction. Synth.Commun., 2006, 36, 1543.

(30) Yi Hu*, Ping Wei, He Huang, Shiqing Han and Pingkai Ouyang, Microwave-assisted Gewald synthesis of 2-aminothiophenes using functional ionic liquid as soluble support. Heterocycles, 2006, 68, 375.