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南京工业大学生物与制药工程学院导师教师师资介绍简介-纪晓俊

本站小编 Free考研考试/2021-03-20

主要课程
1、代谢工程(本科生) 2、合成生物学(研究生)
个人简介
纪晓俊,教授,博士生导师。 国家自然科学基金优秀青年科学基金获得者。兼任中国化工学会生物化工专业委员会副秘书长,Frontiers in Bioengineering and Biotechnology副主编。
2001年9月至2009年12月在南京工业大学本硕博连读,先后获得生物工程学士和生物化工博士学位,博士论文获全国百篇优秀博士论文提名奖。留校工作后承担生物化工领域的教学和科研工作,历任讲师(2010)、副教授(2012)、教授(2018)、博士生导师(2019),先后获得霍英东教育基金会青年教师奖、侯德榜化工科技青年奖等奖励,并先后入选江苏省“333工程”中青年科技带头人、江苏省“六大人才高峰”高层次人才等。2016年8月-2017年8月受国家留学基金委资助在瑞典查尔姆斯理工大学Jens Nielsen教授领导的系统与合成生物学实验室(www.sysbio.se)从事访问研究。
研究方向为代谢工程与合成生物技术指导的生物制造过程,围绕着丝状真菌和非常规酵母两类重要的工业微生物,通过改造或从头设计微生物细胞的代谢途径,实现功能性微生物代谢产物的先进生物制造,进一步通过设计新工艺及新型生物反应器,实现生物制造过程的强化及放大,研究成果获得了国家技术发明二等奖等奖励。
先后作为项目负责人,主持国家自然科学基金项目4项(优青1项、面上2项、青年1项)、863重大项目课题、973项目子课题、国家重点研发项目子课题各1项,以及江苏省自然科学基金、中国石化科技开发项目等多项省部级课题。在生物化工主流期刊Trends in Biotechnology, Biotechnology Advances, ACS Synthetic Biology, Biotechnology and Bioengineering, AIChE Journal, Chemical Engineering Science等以第一/通讯作者发表SCI收录论文60余篇,被Chemical Reviews、PNAS等他引2500余次,并受邀主编出版译著1部,参编教育部规划教材1部,参编Springer和Wiley出版社英文著作3部。
学生培养
1. 指导3名本科生获江苏省优秀本科毕业(设计)论文(2013,2016,2019)
2. 指导1名研究生获得江苏省优秀硕士学位论文(2017)
3. 指导8名研究生获得国家奖学金
教材著作
1. 参编,《发酵工程》(徐岩,主编),普通高等教育“十一五”国家级规划教材,高等教育出版社,2011,ISBN: 978-7-04-032229-3.
2. 纪晓俊,任路静,黄和,译,《单细胞油脂:微生物及藻类来源的油脂》,Zvi Cohen,Colin Ratledge著,化学工业出版社,2015,ISBN: 978-7-12-223260-1.
3. Ji Xiao-Jun, Huang He*, Nie Zhi-Kui, Qu Liang, Xu Qing, Tsao GT. Fuels and Chemicals from Hemicellulose Sugars. In: Bai F-W, Liu C-G, Huang H, Tsao GT, editors. Biotechnology in China III: Biofuels and Bioenergy, Springer Berlin / Heidelberg; 2012. p. 199-224.
4. Ji Xiao-Jun*, Huang He. Bio-based Butanediols Production: the Contributions of Catalysis, Metabolic Engineering, and Synthetic Biology. In: Bisaria, V.S., Kondo, A., editors. Bioprocessing of Renewable Resources to Commodity Bioproducts, Wiley-VCH Verlag GmbH, Weinheim, 2014. p. 263-390.
5. Wang Wei-Jian, Huang He, Ji Xiao-Jun*. Systems and Synthetic Biotechnology for the Production of Polyunsaturated Fatty Acids. In: Liu, L., Chen, J., editors. Systems and Synthetic Biotechnology for Production of Nutraceuticals, Springer Berlin / Heidelberg; 2020.
代表性论文
更多参见: ResearcherID: http://www.researcherid.com/rid/E-6447-2012
1. Ji XJ*, Huang H*. Engineering microbes to produce polyunsaturated fatty acids. Trends in Biotechnology, 2019; 37: 344-346.
2. Shi TQ, Gao J, Wang WJ, Wang KF, Xu GQ, Huang H, Ji XJ*. CRISPR/Cas9-based genome-editing in the filamentous fungus Fusarium fujikuroi and its application in strain engineering for gibberellic acid production. ACS Synthetic Biology, 2019; 8: 445-454.
3. Ma YR, Wang KF, Wang WJ, Ding Y, Shi TQ, Huang H, Ji XJ*. Advances in the metabolic engineering of Yarrowia lipolytica for the production of terpenoids. Bioresource Technology, 2019;281: 449-456.
4. Ding Y, Wang KF, Wang WJ, Ma R, Shi TQ, Huang H, Ji XJ*. Increasing the homologous recombination efficiency of eukaryotic microorganisms for enhanced genome engineering. Applied Microbiology and Biotechnology, 2019; 103: 4313-4324.
5. Liu HH, Wang C, Lu XY, Huang H, Tian Y*, Ji XJ*. Improved production of arachidonic acid by combined pathway engineering and synthetic enzyme fusion in Yarrowia lipolytica. Journal of Agricultural and Food Chemistry, 2019; 67: 9851-9857.
6. Shi TQ, Huang H, Kerkhoven EJ*, Ji XJ*. Advancing metabolic engineering of Yarrowia lipolytica using the CRISPR/Cas system. Applied Microbiology and Biotechnology, 2018;102:9541-9548.
7. Shi K, Gao Z, Lin L, Wang WJ, Shi XQ, Yu X, Song P, Ren LJ, Huang H, Ji XJ*. Manipulating the generation of reactive oxygen species through intermittent hypoxic stress for enhanced accumulation of arachidonic acid-rich lipids. Chemical Engineering Science, 2018;186:36-43.
8. Yu Y, Zhang L, Li T, Wu N, Jiang L, Ji XJ*, Huang H*. How nitrogen sources influence Mortierella alpina aging: From the lipid droplet proteome to the whole-cell proteome and metabolome. Journal of Proteomics, 2018; 179: 140-149.
9. Guo DS, Ji XJ*, Ren LJ, Li GL, Sun XM, Chen KQ, Gao S, Huang H*. Development of a scale-up strategy for fermentative production of docosahexaenoic acid by Schizochytrium sp. Chemical Engineering Science, 2018;176:600-608.
10. Guo DS, Ji XJ*, Ren LJ, Li GL, Huang H*. Improving docosahexaenoic acid production by Schizochytrium sp. using a newly designed high-oxygen-supply bioreactor. AIChE Journal, 2017; 63, 4278-4286.
11. Shi TQ, Liu GN, Ji RY, Shi K, Song P, Ren LJ, Huang H, Ji XJ*. CRISPR/Cas9-based genome editing of the filamentous fungi: the state of the art. Applied Microbiology and Biotechnology, 2017; 101: 7435-7443.
12. Sun ML, Madzak C, Liu HH, Song P, Ren LJ, Huang H, Ji XJ*. Engineering Yarrowia lipolytica for efficient γ-linolenic acid production. Biochemical Engineering Journal, 2017;117:172-180.
13. Liu HH, Madzak C, Sun ML, Ren LJ, Song P, Huang H, Ji XJ*. Engineering Yarrowia lipolytica for arachidonic acid production through rapid assembly of metabolic pathway. Biochemical Engineering Journal, 2017;119:52-58.
14. Liu HH, Zeng SY, Shi TQ, Ding Y, Ren LJ, Song P, Huang H, Ji XJ*. A Yarrowia lipolytica strain engineered for arachidonic acid production counteracts metabolic burden by redirecting carbon flux towards intracellular fatty acid accumulation at the expense of organic acids secretion. Biochemical Engineering Journal, 2017; 128: 201-209.
15. Tong YJ, Ji XJ*, Shen MQ, Liu LG, Nie ZK, Huang H*. Constructing a synthetic constitutive metabolic pathway in Escherichia coli for (R, R)-2,3-butanediol production. Applied Microbiology and Biotechnology, 2016;100:637-647.
16. Ji XJ#*, Liu LG#, Shen MQ, Nie ZK, Tong YJ, Huang H*. Constructing a synthetic metabolic pathway in Escherichia coli to produce the enantiomerically pure (R, R)-2,3-butanediol. Biotechnology and Bioengineering, 2015;112:1056-1059.
17. Zhang AH, Ji XJ*, Wu WJ, Ren LJ, Yu YD, Huang H*. Lipid fraction and intracellular metabolite analysis reveal the mechanism of arachidonic acid-rich oil accumulation in the aging process of Mortierella alpina. Journal of Agricultural and Food Chemistry, 2015; 63: 9812-9819.
18. Liu HH, Ji XJ*, Huang H*. Biotechnological applications of Yarrowia lipolytica: Past, present and future. Biotechnology Advances, 2015; 33: 1522-1546.
19. Ji XJ, Huang H*, Nie ZK, Qu L, Xu Q, Tsao GT. Fuels and chemicals from hemicellulose sugars. Advances in Biochemical Engineering/Biotechnology, 2012; 128: 199-224.
Ji XJ, Huang H*, Ouyang PK. Microbial 2,3-butanediol production: a state-of-the-art review. Biotechnology Advances, 2011;29:351-364.
荣誉奖励
1. 国家优秀青年科学基金获得者(2019)
2. 侯德榜化工科学技术奖青年奖(2016)
3. 霍英东教育基金会青年教师奖(2014)
4. 全国百篇优秀博士论文提名奖(2012)
5. 江苏省“六大人才高峰”高层次人才(2018)
6. 江苏省“333工程”中青年科技带头人(2016)
7. 江苏省“青蓝工程”优秀青年骨干教师(2014)
8. 南工教书育人先进个人(2018)
9. 南工精英九思奖(2014)
10. 南工集团奖教金(2013)
11. 南工才俊计划(2012)
科研获奖
1. 纪晓俊(3/6),生物法制备二十二碳六烯酸油脂关键技术及应用,国家技术发明二等奖,2018年
2. 纪晓俊(3/6),生物法制备二十二碳六烯酸油脂关键技术及应用,教育部技术发明一等奖,2017年
3. 纪晓俊(3/6),利用生物质可再生资源制造2,3-丁二醇及其高值衍生物的关键技术及应用,中国石油和化学工业联合会技术发明一等奖,2010年


联系方式
南京市江北新区浦珠南路30号南京工业大学77号信箱(邮编: 211816)
电话:
E-mail: xiaojunji@njtech.edu.cn
办公地点:生工楼A1-308


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