姚陈娟，博士

　　学历和职历：

　　南通医学院卫生系 学士学位

　　江苏省通州市卫生防疫站 医师

　　 南通医学院卫生系劳动卫生学教研室 助教

　　日本德岛大学 访问学者

　　2002.4-2006.3 日本德岛大学 博士学位

　　2006.4-2008.3 日本德岛大学 助教

　　2009.4- 南通大学公共卫生学院 教授

　　2010.4-2011.3 美国加州大学旧金山分校 博士后

　　研究方向：有害物质毒性的分子机制

　　科研项目：

　　1．砷的生物转运及其调控机制研究，国家自然科学基金项目（20877045）主持人

　　2．锌离子抑制细胞和组织吸收三价无机砷机制研究 国家自然科学基金项目（21277078）第二参加者

　　近三年发表的论文：

　　1．Anderson MO, Zhang J, Liu Y, Yao C, Phuan PW, Verkman AS．Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B．J Med Chem．2012 Jun 28;55(12):5942-50．Epub 2012 Jun 19．PubMed PMID．22694147.

　　2．Yao C, Anderson MO, Zhang J, Yang B, Phuan PW, Verkman AS．Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration．J Am Soc Nephrol．2012 Jul;23(7):1210-20．Epub 2012 Apr 5．PubMed PMID．22491419; PubMed Central PMCID．PMC3380644.

　　3．Davison HR, Taylor S, Drake C, Phuan PW, Derichs N, Yao C, Jones EF, Sutcliffe J, Verkman AS, Kurth MJ．Functional fluorescently labeled bithiazole ΔF508-CFTR corrector imaged in whole body slices in mice．Bioconjug Chem．2011 Dec 21;22(12):2593-9． Epub 2011 Nov 18．PubMed PMID．22034937; PubMed Central PMCID: PMC3245868.

　　4．Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS．Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease．J Med Chem．2011 Aug 11;54(15):5468-77．Epub 2011 Jul 12．PubMed PMID．21707078; PubMed Central PMCID．PMC3314378.

　　5：Purwanti N, Tsuji D, Azlina A, Karabasil MR, Javkhlan P, Hasegawa T, Yao C, Akamatsu T, Itoh K, Hosoi K．Induction of Sca-1 in the duct cells of the mouse submandibular gland by obstruction of the main excretory duct．J Oral Pathol Med．2011 Sep;40(8):651-8．doi．10.1111/j.1600-0714.2011.01011.x．Epub 2011 Feb 25． PubMed PMID．21884259.

　　6．Purwanti N, Karabasil MR, Matsuo S, Chen G, Javkhlan P, Azlina A, Hasegawa T, Yao C, Akamatsu T, Hosoi K．Induction of Sca-1 via activation of STAT3 system in the duct cells of the mouse submandibular gland by ligation of the main excretory duct．Am J Physiol Gastrointest Liver Physiol．2011 Nov;301(5):G814-24．Epub 2011 Aug 25．PubMed PMID．21868636.

　　7．Hosoi K, Yao C．[Suppression of aquaporin 5 gene expression by endotoxin via cross-coupling of transcription factors]．Seikagaku．2011 Jul;83(7):632-8．Review．Japanese．PubMed PMID． 21866876.

　　8．Hasegawa T, Azlina A, Javkhlan P, Yao C, Akamatsu T, Hosoi K．Novel phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling in salivary gland cells．Am J Physiol Cell Physiol．2011 Sep;301(3):C667-78．Epub 2011 Jun 1．PubMed PMID．21633078.

　　9．Karabasil MR, Hasegawa T, Azlina A, Purwanti N, Yao C, Akamatsu T, Tomioka S, Hosoi K．Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking and cellular localization in the submandibular gland of rats．Biol Cell．2011 Feb;103(2):69-86．PubMed PMID．21138418.

　　10．Javkhlan P, Hiroshima Y, Azlina A, Hasegawa T, Yao C, Akamatsu T, Kido J, Nagata T, Hosoi K． Lipopolysaccharide-mediated induction of calprotectin in the submandibular and parotid glands of mice．Inflammation．2011 Dec;34(6):668-80．PubMed PMID． 21125321.

　　11．Azlina A, Javkhlan P, Hiroshima Y, Hasegawa T, Yao C, Akamatsu T, Hosoi K．Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation．Am J Physiol Gastrointest Liver Physiol．2010 Nov;299(5):G1106-17．Epub 2010 Aug 5．PubMed PMID．20689061.

　　12．Yao C, Purwanti N, Karabasil MR, Azlina A, Javkhlan P, Hasegawa T, Akamatsu T, Hosoi T, Ozawa K, Hosoi K．Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kappaB and p-c-Jun/c-Fos．Am J Pathol．2010 Aug;177(2):724-34．Epub 2010 Jun 3．PubMed PMID．20522648; PubMed Central PMCID: PMC2913374.

　　13．Karabasil MR, Hasegawa T, Azlina A, Purwanti N, Purevjav J, Yao C, Akamatsu T, Hosoi K．Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif ((152)SRRTS) in MDCK-II cells．J Med Invest．2009 Feb;56(1-2):55-63．PubMed PMID．19262015.

　　14．Karabasil MR, Murdiastuti K, Purwanti N, Azlina A, Javkhlan P, Hasegawa T, Yao C, Akamatsu T, Hosoi K．Effects of natural point mutation of rat aquaporin 5 expressed in vitro on its capacity of water permeability and membrane trafficking．J Med Invest．2009;56 Suppl:398-400．PubMed PMID．20224238.

　　15．Wang C, Chen G, Jiang J, Qiu L, Hosoi K, Yao C．Aquaglyceroporins are involved in uptake of arsenite into murine gastrointestinal tissues．J Med Invest．2009;56 Suppl:343-6．PubMed PMID． 20224220.

　　16．Javkhlan P, Hiroshima Y, Azlina A, Hasegawa T, Yao C, Akamatsu T, Kido J, Nagata T, Hosoi K．Induction of calprotectin mRNAs by lipopolysaccharide in the salivary gland of mice．J Med Invest．2009;56 Suppl:287-9．PubMed PMID．20224205.

　　17．Azlina A, Li X, Javkhlan P, Hasegawa T, Yao C, Akamatsu T, Hosoi K．Down-regulation of submandibular gland AQP5 following parasympathetic denervation in rats．J Med Invest．2009;56 Suppl:273-6． PubMed PMID．20224200.

　　18．Purwanti N, Azlina A, Karabasil MR, Hasegawa T, Yao C, Akamatsu T, Hosoi K．Involvement of the IL-6/STAT3/Sca-1 system in proliferation of duct cells following duct ligation in the submandibular gland of mice．J Med Invest．2009;56 Suppl:253-4．PubMed PMID． 20224192.

　　19．Akamatsu T, Azlina A, Javkhlan P, Hasegawa T, Yao C, Hosoi K．Salivary gland development．its mediation by a subtilisin-like proprotein convertase, PACE4．J Med Invest．2009;56 Suppl:241-6．Review．PubMed PMID．20224189.

　　20.Aquaglyceroporins are involved in uptake of arsenite into murine gastrointestinal tissues．J Med Invest．2009;56 Suppl:343-6.通讯作者

　　21．细菌脂多糖经p38丝裂原激活蛋白激酶通路调节claudin-11基因的表达 毒理学杂志, 2009(2):104-107．通讯作者

　　22．细菌脂多糖诱导单核细胞趋化蛋白-1在小鼠睾丸中表达 中国免疫学杂志,2009(12):1105-1107．第三

　　23．三价无机砷在大小小鼠组织中蓄积差异研究 中华预防医学杂志,2009,43(10):932-933．通讯作者

　　24．双酚A在染毒雄性大鼠血清中时间-浓度关系 中华预防医学杂志,2010,44(1):30-33．通讯作者

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